Pharmacogenetics meets metabolomics: Discovery of tryptophan as a new endogenous OCT2 substrate related to metformin disposition

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Song, Im Sook ^a   Lee, Do Yup ^b   Shin, Min Hye ^b,c   Kim, Hyunmi ^a   Ahn, Yun Gyong ^b,d   Park, Inmyoung ^b   Kim, Kyoung Heon ^c   Kind, Tobias ^b   Shin, Jae Gook ^a   Fiehn, Oliver ^b   Liu, Kwang Hyeon ^a,b,e  

^a Inje University College of Medicine   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Korea University   (South Korea)

^d Korea Basic Science Institute (KBSI)   (South Korea)

^e Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; ORGANIC CATION TRANSPORTER 2; TRYPTOPHAN; URIDINE; ANTIDIABETIC AGENT; ORGANIC CATION TRANSPORTER; SLC22A2 PROTEIN, HUMAN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISPOSITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FEMALE; GENE; GENE EXPRESSION PROFILING; GENETIC ALGORITHM; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MALE; METABOLOMICS; OCT2 GENE; PHARMACOGENETICS; PRINCIPAL COMPONENT ANALYSIS; PROTEIN TRANSPORT; REGRESSION ANALYSIS; SLC22A2 GENE; CLINICAL TRIAL; DRUG EFFECT; GENETICS; HETEROZYGOTE; HOMOZYGOTE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; FEMALE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; METABOLOMICS; METFORMIN; ORGANIC CATION TRANSPORT PROTEINS; POLYMORPHISM, GENETIC; TRYPTOPHAN;

EID: 84860652339     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036637     Document Type: Article

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