메뉴 건너뛰기




Volumn 13, Issue 1, 2015, Pages

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Author keywords

Chronic fatigue syndrome; Fatigue; Immune; Inflammation; Mitochondria; Multiple sclerosis; Oxidative stress; Parkinson's disease; Toll like receptor

Indexed keywords

ADENOSINE TRIPHOSPHATE; AUTOANTIBODY; CYTOCHROME C OXIDASE; FAS ANTIGEN; GADOLINIUM; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; LACTIC ACID; MITOCHONDRIAL DNA; MONOCLONAL ANTIBODY; NEUROTOXIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SEX HORMONE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UBIQUINOL CYTOCHROME C REDUCTASE; CYTOKINE;

EID: 84924034349     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-014-0259-2     Document Type: Article
Times cited : (137)

References (404)
  • 1
    • 84882683009 scopus 로고    scopus 로고
    • A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
    • Morris G, Anderson G, Galecki P, Berk M, Maes M. A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior. BMC Med. 2013;11:64.
    • (2013) BMC Med , vol.11 , pp. 64
    • Morris, G.1    Anderson, G.2    Galecki, P.3    Berk, M.4    Maes, M.5
  • 2
    • 80053910519 scopus 로고    scopus 로고
    • Biological mechanisms of chronic fatigue
    • Norheim K, Jonsson G, Omdal R. Biological mechanisms of chronic fatigue. Rheumatology. 2011;50:1009-18.
    • (2011) Rheumatology , vol.50 , pp. 1009-1018
    • Norheim, K.1    Jonsson, G.2    Omdal, R.3
  • 3
    • 84892167181 scopus 로고    scopus 로고
    • Toll-like receptor status in obesity and metabolic syndrome: a translational perspective
    • Jialal I, Kaur H, Devaraj S. Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J Clin Endocrinol Metab. 2014;99:39-48.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 39-48
    • Jialal, I.1    Kaur, H.2    Devaraj, S.3
  • 4
    • 84880925130 scopus 로고    scopus 로고
    • Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway
    • Lucas K, Maes M. Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol Neurobiol. 2013;48:190-204.
    • (2013) Mol Neurobiol , vol.48 , pp. 190-204
    • Lucas, K.1    Maes, M.2
  • 6
    • 84874377185 scopus 로고    scopus 로고
    • A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome
    • Morris G, Maes M. A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome. Metab Brain Dis. 2013;28:523-40.
    • (2013) Metab Brain Dis , vol.28 , pp. 523-540
    • Morris, G.1    Maes, M.2
  • 7
    • 84896362511 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress and immune-inflammatory pathways in patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
    • Morris G, Maes M. Oxidative and nitrosative stress and immune-inflammatory pathways in patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS). Curr Neuropharmacol. 2014;12:168-85.
    • (2014) Curr Neuropharmacol , vol.12 , pp. 168-185
    • Morris, G.1    Maes, M.2
  • 8
    • 0036267207 scopus 로고    scopus 로고
    • Atypical inflammation in the central nervous system in prion disease
    • Perry VH, Cunningham C, Boche D. Atypical inflammation in the central nervous system in prion disease. Curr Opin Neurol. 2002;15:349-54.
    • (2002) Curr Opin Neurol , vol.15 , pp. 349-354
    • Perry, V.H.1    Cunningham, C.2    Boche, D.3
  • 9
    • 3242710339 scopus 로고    scopus 로고
    • The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease
    • Perry VH. The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease. Brain Behav Immun. 2004;18:407-13.
    • (2004) Brain Behav Immun , vol.18 , pp. 407-413
    • Perry, V.H.1
  • 10
    • 77953217054 scopus 로고    scopus 로고
    • Bacterial lipoproteins can disseminate from the periphery to inflame the brain
    • Londoño D, Cadavid D. Bacterial lipoproteins can disseminate from the periphery to inflame the brain. Am J Pathol. 2010;176:2848-57.
    • (2010) Am J Pathol , vol.176 , pp. 2848-2857
    • Londoño, D.1    Cadavid, D.2
  • 11
    • 77956230017 scopus 로고    scopus 로고
    • Contribution of systemic inflammation to chronic neurodegeneration
    • Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol. 2010;120:277-86.
    • (2010) Acta Neuropathol , vol.120 , pp. 277-286
    • Perry, V.H.1
  • 17
    • 84887962217 scopus 로고    scopus 로고
    • Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics
    • Morris G, Maes M. Myalgic encephalomyelitis/chronic fatigue syndrome and encephalomyelitis disseminata/multiple sclerosis show remarkable levels of similarity in phenomenology and neuroimmune characteristics. BMC Med. 2013;11:205.
    • (2013) BMC Med , vol.11 , pp. 205
    • Morris, G.1    Maes, M.2
  • 18
    • 77953188808 scopus 로고    scopus 로고
    • Fatigue in Parkinson's disease: a short update
    • Beiske AG, Svensson E. Fatigue in Parkinson's disease: a short update. Acta Neurol Scand Suppl. 2010;190:78-81.
    • (2010) Acta Neurol Scand Suppl , vol.190 , pp. 78-81
    • Beiske, A.G.1    Svensson, E.2
  • 19
    • 84884354746 scopus 로고    scopus 로고
    • So depression is an inflammatory disease, but where does the inflammation come from?
    • Berk M, Williams L, Jacka F, O'Neil A, Pasco J, Moylan S, et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Med. 2013;11:200.
    • (2013) BMC Med , vol.11 , pp. 200
    • Berk, M.1    Williams, L.2    Jacka, F.3    O'Neil, A.4    Pasco, J.5    Moylan, S.6
  • 20
    • 84862993854 scopus 로고    scopus 로고
    • Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    • Maes M, Berk M, Goehler L, Song C, Anderson G, Galecki P, et al. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med. 2012;10:66.
    • (2012) BMC Med , vol.10 , pp. 66
    • Maes, M.1    Berk, M.2    Goehler, L.3    Song, C.4    Anderson, G.5    Galecki, P.6
  • 21
    • 84901253775 scopus 로고    scopus 로고
    • Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
    • Kreisel T, Frank M, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 2014;19:699-709.
    • (2014) Mol Psychiatry , vol.19 , pp. 699-709
    • Kreisel, T.1    Frank, M.2    Licht, T.3    Reshef, R.4    Ben-Menachem-Zidon, O.5    Baratta, M.V.6
  • 22
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission
    • Steiner J, Walter M, Gos T, Guillemin G, Bernstein H, Sarnyai Z, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission. J Neuroinflammation. 2011;8:1-9.
    • (2011) J Neuroinflammation , vol.8 , pp. 1-9
    • Steiner, J.1    Walter, M.2    Gos, T.3    Guillemin, G.4    Bernstein, H.5    Sarnyai, Z.6
  • 23
    • 57149109353 scopus 로고    scopus 로고
    • Prevalence, severity, and predictors of fatigue in subjects with primary Sjögren's syndrome
    • Segal B, Thomas W, Rogers T, Leon JM, Hughes P, Patel D, et al. Prevalence, severity, and predictors of fatigue in subjects with primary Sjögren's syndrome. Arthritis Rheum. 2008;59:1780-7.
    • (2008) Arthritis Rheum , vol.59 , pp. 1780-1787
    • Segal, B.1    Thomas, W.2    Rogers, T.3    Leon, J.M.4    Hughes, P.5    Patel, D.6
  • 24
  • 25
    • 79955852867 scopus 로고    scopus 로고
    • Self-management of fatigue in rheumatoid arthritis: a randomised controlled trial of group cognitive-behavioural therapy
    • Hewlett S, Ambler N, Almeida C, Cliss A, Hammond A, Kitchen K, et al. Self-management of fatigue in rheumatoid arthritis: a randomised controlled trial of group cognitive-behavioural therapy. Ann Rheum Dis. 2011;70:1060-7.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1060-1067
    • Hewlett, S.1    Ambler, N.2    Almeida, C.3    Cliss, A.4    Hammond, A.5    Kitchen, K.6
  • 26
    • 0346365086 scopus 로고    scopus 로고
    • Explaining how a "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis
    • Sattar N, McCarey D, Capell H, McInnes I. Explaining how a "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation. 2003;108:2957-63.
    • (2003) Circulation , vol.108 , pp. 2957-2963
    • Sattar, N.1    McCarey, D.2    Capell, H.3    McInnes, I.4
  • 27
    • 67649833745 scopus 로고    scopus 로고
    • Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis
    • Ku I, Imboden J, Hsue P, Ganz P. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circ J. 2009;73:977-85.
    • (2009) Circ J , vol.73 , pp. 977-985
    • Ku, I.1    Imboden, J.2    Hsue, P.3    Ganz, P.4
  • 28
    • 66449089455 scopus 로고    scopus 로고
    • Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    • Munoz L, Janko C, Grossmayer G, Frey B, Voll R, Kern P, et al. Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum. 2009;60:1733-42.
    • (2009) Arthritis Rheum , vol.60 , pp. 1733-1742
    • Munoz, L.1    Janko, C.2    Grossmayer, G.3    Frey, B.4    Voll, R.5    Kern, P.6
  • 29
    • 77952509491 scopus 로고    scopus 로고
    • Cytokine networks in systemic lupus erythematosus
    • Lee HM, Sugino H, Nishimoto N. Cytokine networks in systemic lupus erythematosus. J Biomed Biotechnol. 2010;2010:676284.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 676284
    • Lee, H.M.1    Sugino, H.2    Nishimoto, N.3
  • 30
  • 31
    • 84875381733 scopus 로고    scopus 로고
    • Emerging avenues linking inflammation, angiogenesis and Sjögren's syndrome
    • Lisi S, Sisto M, D'Amore M, Lofrumento D, Ribatti D. Emerging avenues linking inflammation, angiogenesis and Sjögren's syndrome. Cytokine. 2013;61:693-703.
    • (2013) Cytokine , vol.61 , pp. 693-703
    • Lisi, S.1    Sisto, M.2    D'Amore, M.3    Lofrumento, D.4    Ribatti, D.5
  • 32
    • 70449650511 scopus 로고    scopus 로고
    • Neurological manifestations of systemic lupus erythematosus in children and adults
    • Muscal E, Brey R. Neurological manifestations of systemic lupus erythematosus in children and adults. Neurol Clin. 2010;28:61-73.
    • (2010) Neurol Clin , vol.28 , pp. 61-73
    • Muscal, E.1    Brey, R.2
  • 34
    • 84864402381 scopus 로고    scopus 로고
    • Psychiatric symptoms in systemic lupus erythematosus: a systematic review
    • Meszaros Z, Perl A, Faraone S. Psychiatric symptoms in systemic lupus erythematosus: a systematic review. J Clin Psychiatry. 2012;73:993-1001.
    • (2012) J Clin Psychiatry , vol.73 , pp. 993-1001
    • Meszaros, Z.1    Perl, A.2    Faraone, S.3
  • 37
    • 0033791290 scopus 로고    scopus 로고
    • Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis
    • Akhyani N, Berti R, Brennan MB, Soldan SS, Eaton JM, McFarland HF, et al. Tissue distribution and variant characterization of human herpesvirus (HHV)-6: increased prevalence of HHV-6A in patients with multiple sclerosis. J Infect Dis. 2000;182:1321-5.
    • (2000) J Infect Dis , vol.182 , pp. 1321-1325
    • Akhyani, N.1    Berti, R.2    Brennan, M.B.3    Soldan, S.S.4    Eaton, J.M.5    McFarland, H.F.6
  • 38
    • 84891866326 scopus 로고    scopus 로고
    • Environmental toxins and Parkinson's disease
    • Goldman S. Environmental toxins and Parkinson's disease. Annu Rev Pharmacol Toxicol. 2014;54:141-64.
    • (2014) Annu Rev Pharmacol Toxicol , vol.54 , pp. 141-164
    • Goldman, S.1
  • 39
    • 61449125226 scopus 로고    scopus 로고
    • Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer
    • Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009;3:73-80.
    • (2009) Recent Pat Inflamm Allergy Drug Discov , vol.3 , pp. 73-80
    • Khansari, N.1    Shakiba, Y.2    Mahmoudi, M.3
  • 40
    • 70349509441 scopus 로고    scopus 로고
    • NF-kappaB activation in endothelial cells is critical for the activity of angiostatic agents
    • Tabruyn SP, Mémet S, Avé P, Verhaeghe C, Mayo KH, Struman I, et al. NF-kappaB activation in endothelial cells is critical for the activity of angiostatic agents. Mol Cancer Ther. 2009;8:2645-54.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2645-2654
    • Tabruyn, S.P.1    Mémet, S.2    Avé, P.3    Verhaeghe, C.4    Mayo, K.H.5    Struman, I.6
  • 41
    • 10744225575 scopus 로고    scopus 로고
    • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation
    • Schmidt C, Peng B, Li Z, Sclabas GM, Fujioka S, Niu J, et al. Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. Mol Cell. 2003;12:1287-300.
    • (2003) Mol Cell , vol.12 , pp. 1287-1300
    • Schmidt, C.1    Peng, B.2    Li, Z.3    Sclabas, G.M.4    Fujioka, S.5    Niu, J.6
  • 42
    • 84883260610 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis
    • Sultani M, Stringer AM, Bowen JM, Gibson RJ. Anti-inflammatory cytokines: important immunoregulatory factors contributing to chemotherapy-induced gastrointestinal mucositis. Chemother Res Pract. 2012;2012:490804.
    • (2012) Chemother Res Pract , vol.2012 , pp. 490804
    • Sultani, M.1    Stringer, A.M.2    Bowen, J.M.3    Gibson, R.J.4
  • 44
    • 33646831500 scopus 로고    scopus 로고
    • NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
    • Anrather J, Racchumi G, Iadecola C. NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem. 2006;281:5657-67.
    • (2006) J Biol Chem , vol.281 , pp. 5657-5667
    • Anrather, J.1    Racchumi, G.2    Iadecola, C.3
  • 45
    • 35649021206 scopus 로고    scopus 로고
    • Pathobiology of oral mucositis: novel insights and opportunities
    • Sonis ST. Pathobiology of oral mucositis: novel insights and opportunities. J Support Oncol. 2007;5:3-11.
    • (2007) J Support Oncol , vol.5 , pp. 3-11
    • Sonis, S.T.1
  • 46
    • 5144229908 scopus 로고    scopus 로고
    • A biological approach to mucositis
    • Sonis ST. A biological approach to mucositis. J Support Oncol. 2004;2:21-32. discussion 35-6.
    • (2004) J Support Oncol , vol.2 , pp. 21-32
    • Sonis, S.T.1
  • 47
    • 78650894319 scopus 로고    scopus 로고
    • Crosstalk of reactive oxygen species and NF-ΚB signaling
    • Morgan MJ, Liu ZG. Crosstalk of reactive oxygen species and NF-ΚB signaling. Cell Res. 2011;21:103-15.
    • (2011) Cell Res , vol.21 , pp. 103-115
    • Morgan, M.J.1    Liu, Z.G.2
  • 48
    • 79954989975 scopus 로고    scopus 로고
    • Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    • Maes M, Kubera M, Obuchowiczwa E, Goehler L, Brzeszcz J. Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways. Neuro Endocrinol Lett. 2011;32:7-24.
    • (2011) Neuro Endocrinol Lett , vol.32 , pp. 7-24
    • Maes, M.1    Kubera, M.2    Obuchowiczwa, E.3    Goehler, L.4    Brzeszcz, J.5
  • 49
    • 33845967496 scopus 로고    scopus 로고
    • Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins
    • Maes M, Mihaylova I, Leunis JC. Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins. Neuro Endocrinol Lett. 2006;27:615-21.
    • (2006) Neuro Endocrinol Lett , vol.27 , pp. 615-621
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 50
    • 0033831517 scopus 로고    scopus 로고
    • Infections as a major preventable cause of human cancer
    • Kuper H, Adami HO, Trichopoulos D. Infections as a major preventable cause of human cancer. J Intern Med. 2000;248:171-83.
    • (2000) J Intern Med , vol.248 , pp. 171-183
    • Kuper, H.1    Adami, H.O.2    Trichopoulos, D.3
  • 52
    • 77957899771 scopus 로고    scopus 로고
    • Targeting Toll-like receptors for treatment of SLE
    • Horton C, Pan Z, Farris A. Targeting Toll-like receptors for treatment of SLE. Mediators Inflamm. 2010; 2010. doi:10.1155/2010/498980.
    • (2010) Mediators Inflamm 2010
    • Horton, C.1    Pan, Z.2    Farris, A.3
  • 54
    • 33644817756 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    • Dutta R, McDonough J, Yin X, Peterson J, Chang A, Torres T, et al. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol. 2006;59:478-89.
    • (2006) Ann Neurol , vol.59 , pp. 478-489
    • Dutta, R.1    McDonough, J.2    Yin, X.3    Peterson, J.4    Chang, A.5    Torres, T.6
  • 56
    • 84895857954 scopus 로고    scopus 로고
    • Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways
    • Morris G, Maes M. Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways. Metab Brain Dis. 2014;29:19-36.
    • (2014) Metab Brain Dis , vol.29 , pp. 19-36
    • Morris, G.1    Maes, M.2
  • 57
    • 84864294525 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    • Booth NE, Myhill S, McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Int J Clin Exp Med. 2012;5:208-20.
    • (2012) Int J Clin Exp Med , vol.5 , pp. 208-220
    • Booth, N.E.1    Myhill, S.2    McLaren-Howard, J.3
  • 58
    • 84870330099 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit
    • Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit. Int J Clin Exp Med. 2013;6:1-15.
    • (2013) Int J Clin Exp Med , vol.6 , pp. 1-15
    • Myhill, S.1    Booth, N.E.2    McLaren-Howard, J.3
  • 59
    • 0033406026 scopus 로고    scopus 로고
    • Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl
    • Behan WM, McDonald M, Darlington LG, Stone TW. Oxidative stress as a mechanism for quinolinic acid-induced hippocampal damage: protection by melatonin and deprenyl. Br J Pharmacol. 1999;128:1754-60.
    • (1999) Br J Pharmacol , vol.128 , pp. 1754-1760
    • Behan, W.M.1    McDonald, M.2    Darlington, L.G.3    Stone, T.W.4
  • 60
    • 77949373158 scopus 로고    scopus 로고
    • Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome
    • Jones DE, Hollingsworth KG, Taylor R, Blamire AM, Newton JL. Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome. J Intern Med. 2010;267:394-401.
    • (2010) J Intern Med , vol.267 , pp. 394-401
    • Jones, D.E.1    Hollingsworth, K.G.2    Taylor, R.3    Blamire, A.M.4    Newton, J.L.5
  • 62
    • 41749104745 scopus 로고    scopus 로고
    • Complex I deficiency in Parkinson's disease frontal cortex
    • Parker Jr WD, Parks JK, Swerdlow RH. Complex I deficiency in Parkinson's disease frontal cortex. Brain Res. 2008;1189:215-8.
    • (2008) Brain Res , vol.1189 , pp. 215-218
    • Parker, W.D.1    Parks, J.K.2    Swerdlow, R.H.3
  • 63
    • 0031031845 scopus 로고    scopus 로고
    • Platelet mitochondrial respiratory chain function in Parkinson's disease
    • Blake C, Spitz E, Leehey M, Hoffer B, Boyson S. Platelet mitochondrial respiratory chain function in Parkinson's disease. Mov Disord. 1997;12:3-8.
    • (1997) Mov Disord , vol.12 , pp. 3-8
    • Blake, C.1    Spitz, E.2    Leehey, M.3    Hoffer, B.4    Boyson, S.5
  • 64
    • 33845332016 scopus 로고    scopus 로고
    • Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: preliminary study
    • Shinde S, Pasupathy K. Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: preliminary study. Neurol India. 2006;54:390-3.
    • (2006) Neurol India , vol.54 , pp. 390-393
    • Shinde, S.1    Pasupathy, K.2
  • 65
    • 84876952909 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, oxidative stress, and major depressive disorder
    • Tobe EH. Mitochondrial dysfunction, oxidative stress, and major depressive disorder. Neuropsychiatr Dis Treat. 2013;9:567-73.
    • (2013) Neuropsychiatr Dis Treat , vol.9 , pp. 567-573
    • Tobe, E.H.1
  • 67
    • 84868528207 scopus 로고    scopus 로고
    • Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus
    • Perl A, Hanczko R, Doherty E. Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. Methods Mol Biol. 2012;900:61-89.
    • (2012) Methods Mol Biol , vol.900 , pp. 61-89
    • Perl, A.1    Hanczko, R.2    Doherty, E.3
  • 68
    • 16644377980 scopus 로고    scopus 로고
    • Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus
    • Perl A, Nagy G, Gergely P, Puskas F, Qian Y, Banki K. Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. Methods Mol Med. 2004;102:87-114.
    • (2004) Methods Mol Med , vol.102 , pp. 87-114
    • Perl, A.1    Nagy, G.2    Gergely, P.3    Puskas, F.4    Qian, Y.5    Banki, K.6
  • 69
    • 34247360451 scopus 로고    scopus 로고
    • Nitric oxide, mitochondrial hyperpolarization, and T cell activation
    • Nagy G, Koncz A, Fernandez D, Perl A. Nitric oxide, mitochondrial hyperpolarization, and T cell activation. Free Radic Biol Med. 2007;42:1625-31.
    • (2007) Free Radic Biol Med , vol.42 , pp. 1625-1631
    • Nagy, G.1    Koncz, A.2    Fernandez, D.3    Perl, A.4
  • 70
    • 84875454933 scopus 로고    scopus 로고
    • Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: prospects for chemoprevention trials
    • Pagano G, Castello G, Pallardó FV. Sjøgren's syndrome-associated oxidative stress and mitochondrial dysfunction: prospects for chemoprevention trials. Free Radic Res. 2013;47:71-3.
    • (2013) Free Radic Res , vol.47 , pp. 71-73
    • Pagano, G.1    Castello, G.2    Pallardó, F.V.3
  • 71
    • 84874438062 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption ionization-imaging mass spectrometry: a new methodology to study human osteoarthritic cartilage
    • Cillero-Pastor B, Eijkel GB, Kiss A, Blanco FJ, Heeren RM. Matrix-assisted laser desorption ionization-imaging mass spectrometry: a new methodology to study human osteoarthritic cartilage. Arthritis Rheum. 2013;65:710-20.
    • (2013) Arthritis Rheum , vol.65 , pp. 710-720
    • Cillero-Pastor, B.1    Eijkel, G.B.2    Kiss, A.3    Blanco, F.J.4    Heeren, R.M.5
  • 72
    • 54249104477 scopus 로고    scopus 로고
    • Nitric oxide in inflammation and pain associated with osteoarthritis
    • Abramson SB. Nitric oxide in inflammation and pain associated with osteoarthritis. Arthritis Res Ther. 2008;10:S2.
    • (2008) Arthritis Res Ther , vol.10 , pp. S2
    • Abramson, S.B.1
  • 73
    • 84898657047 scopus 로고    scopus 로고
    • Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines
    • Rose S, Frye RE, Slattery J, Wynne R, Tippett M, Melnyk S, et al. Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines. Transl Psychiatry. 2014;4:e377.
    • (2014) Transl Psychiatry , vol.4 , pp. e377
    • Rose, S.1    Frye, R.E.2    Slattery, J.3    Wynne, R.4    Tippett, M.5    Melnyk, S.6
  • 74
    • 84867031150 scopus 로고    scopus 로고
    • Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
    • Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, et al. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain. 2012;5:35.
    • (2012) Mol Brain , vol.5 , pp. 35
    • Imaizumi, Y.1    Okada, Y.2    Akamatsu, W.3    Koike, M.4    Kuzumaki, N.5    Hayakawa, H.6
  • 75
    • 84855394783 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial dysfunction, and aging
    • Cui H, Kong Y, Zhang H. Oxidative stress, mitochondrial dysfunction, and aging. J Signal Transduct. 2012;2012:646354.
    • (2012) J Signal Transduct , vol.2012 , pp. 646354
    • Cui, H.1    Kong, Y.2    Zhang, H.3
  • 76
    • 35549009775 scopus 로고    scopus 로고
    • Treating fatigue
    • Lapierre Y, Hum S. Treating fatigue. Int MS J. 2007;14:64-71.
    • (2007) Int MS J , vol.14 , pp. 64-71
    • Lapierre, Y.1    Hum, S.2
  • 77
    • 0038518191 scopus 로고    scopus 로고
    • Fatigue associated with multiple sclerosis: diagnosis, impact and management
    • Bakshi R. Fatigue associated with multiple sclerosis: diagnosis, impact and management. Mult Scler. 2003;9:219-27.
    • (2003) Mult Scler , vol.9 , pp. 219-227
    • Bakshi, R.1
  • 78
    • 59349108588 scopus 로고    scopus 로고
    • Longitudinal correlates of fatigue in multiple sclerosis
    • Patrick E, Christodoulou C, Krupp LB, New York State MS Consortium. Longitudinal correlates of fatigue in multiple sclerosis. Mult Scler. 2009;15:258-61.
    • (2009) Mult Scler , vol.15 , pp. 258-261
  • 79
    • 18744380337 scopus 로고    scopus 로고
    • Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters
    • Flachenecker P, Kümpfel T, Kallmann B, Gottschalk M, Grauer O, Rieckmann P, et al. Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters. Mult Scler. 2002;8:523-6.
    • (2002) Mult Scler , vol.8 , pp. 523-526
    • Flachenecker, P.1    Kümpfel, T.2    Kallmann, B.3    Gottschalk, M.4    Grauer, O.5    Rieckmann, P.6
  • 80
    • 0033996680 scopus 로고    scopus 로고
    • Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors
    • Iriarte J, Subira ML, Castro P. Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. Mult Scler. 2000;6:124-30.
    • (2000) Mult Scler , vol.6 , pp. 124-130
    • Iriarte, J.1    Subira, M.L.2    Castro, P.3
  • 81
    • 15544386641 scopus 로고    scopus 로고
    • Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS?
    • Tellez N, Rio J, Tintoré M, Nos C, Galán I, Montalban X. Does the Modified Fatigue Impact Scale offer a more comprehensive assessment of fatigue in MS? Mult Scler. 2005;11:198-202.
    • (2005) Mult Scler , vol.11 , pp. 198-202
    • Tellez, N.1    Rio, J.2    Tintoré, M.3    Nos, C.4    Galán, I.5    Montalban, X.6
  • 83
    • 84909992655 scopus 로고    scopus 로고
    • Differential effects of fingolimod on B-cell populations in multiple sclerosis
    • Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, et al. Differential effects of fingolimod on B-cell populations in multiple sclerosis. Mult Scler. 2014;20:1371-80.
    • (2014) Mult Scler , vol.20 , pp. 1371-1380
    • Nakamura, M.1    Matsuoka, T.2    Chihara, N.3    Miyake, S.4    Sato, W.5    Araki, M.6
  • 87
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations
    • Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wietzerbin J. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations. Acta Neurol Scand. 1988;78:318-23.
    • (1988) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 88
    • 0026066932 scopus 로고
    • Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis
    • Maimone D, Gregory S, Arnason BG, Reder AT. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol. 1991;32:67-74.
    • (1991) J Neuroimmunol , vol.32 , pp. 67-74
    • Maimone, D.1    Gregory, S.2    Arnason, B.G.3    Reder, A.T.4
  • 89
    • 0029762023 scopus 로고    scopus 로고
    • Review: cytokines and the pathogenesis of multiple sclerosis
    • Navikas V, Link H. Review: cytokines and the pathogenesis of multiple sclerosis. J Neurosci Res. 1996;45:322-33.
    • (1996) J Neurosci Res , vol.45 , pp. 322-333
    • Navikas, V.1    Link, H.2
  • 90
    • 79959864896 scopus 로고    scopus 로고
    • Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression
    • Gold SM, Krüger S, Ziegler KJ, Krieger T, Schulz KH, Otte C, et al. Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression. J Neurol Neurosurg Psychiatry. 2011;82:814-8.
    • (2011) J Neurol Neurosurg Psychiatry , vol.82 , pp. 814-818
    • Gold, S.M.1    Krüger, S.2    Ziegler, K.J.3    Krieger, T.4    Schulz, K.H.5    Otte, C.6
  • 94
    • 55549100952 scopus 로고    scopus 로고
    • Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    • Andersson A, Covacu R, Sunnemark D, Danilov AI, Dal Bianco A, Khademi M, et al. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J Leukoc Biol. 2008;84:1248-55.
    • (2008) J Leukoc Biol , vol.84 , pp. 1248-1255
    • Andersson, A.1    Covacu, R.2    Sunnemark, D.3    Danilov, A.I.4    Dal Bianco, A.5    Khademi, M.6
  • 95
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol. 2002;61:1013-21.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Noort, J.M.4
  • 96
    • 84899519853 scopus 로고    scopus 로고
    • Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment
    • Gironi M, Borgiani B, Mariani E, Cursano C, Mendozzi L, Cavarretta R, et al. Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment. J Immunol Res. 2014;2014:961863.
    • (2014) J Immunol Res , vol.2014 , pp. 961863
    • Gironi, M.1    Borgiani, B.2    Mariani, E.3    Cursano, C.4    Mendozzi, L.5    Cavarretta, R.6
  • 97
    • 84855301917 scopus 로고    scopus 로고
    • Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis
    • Miller E, Walczak A, Saluk J, Ponczek MB, Majsterek I. Oxidative modification of patient's plasma proteins and its role in pathogenesis of multiple sclerosis. Clin Biochem. 2012;45:26-30.
    • (2012) Clin Biochem , vol.45 , pp. 26-30
    • Miller, E.1    Walczak, A.2    Saluk, J.3    Ponczek, M.B.4    Majsterek, I.5
  • 98
    • 53049093018 scopus 로고    scopus 로고
    • Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity
    • Gonsette RE. Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J Neurol Sci. 2008;274:48-53.
    • (2008) J Neurol Sci , vol.274 , pp. 48-53
    • Gonsette, R.E.1
  • 99
    • 79960012015 scopus 로고    scopus 로고
    • The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease
    • Stavropoulou C, Zachaki S, Alexoudi A, Chatzi I, Georgakakos VN, Terzoudi GI, et al. The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease. Free Radic Biol Med. 2011;51:713-8.
    • (2011) Free Radic Biol Med , vol.51 , pp. 713-718
    • Stavropoulou, C.1    Zachaki, S.2    Alexoudi, A.3    Chatzi, I.4    Georgakakos, V.N.5    Terzoudi, G.I.6
  • 100
    • 84878752933 scopus 로고    scopus 로고
    • Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis
    • Fiorini A, Koudriavtseva T, Bucaj E, Coccia R, Foppoli C, Giorgi A, et al. Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis. PLoS One. 2013;8:e65184.
    • (2013) PLoS One , vol.8 , pp. e65184
    • Fiorini, A.1    Koudriavtseva, T.2    Bucaj, E.3    Coccia, R.4    Foppoli, C.5    Giorgi, A.6
  • 101
    • 84866042186 scopus 로고    scopus 로고
    • Oxidative stress in multiple sclerosis patients in clinical remission: association with the expanded disability status scale
    • Oliveira SR, Kallaur AP, Simão AN, Morimoto HK, Lopes J, Panis C, et al. Oxidative stress in multiple sclerosis patients in clinical remission: association with the expanded disability status scale. J Neurol Sci. 2012;321:49-53.
    • (2012) J Neurol Sci , vol.321 , pp. 49-53
    • Oliveira, S.R.1    Kallaur, A.P.2    Simão, A.N.3    Morimoto, H.K.4    Lopes, J.5    Panis, C.6
  • 102
    • 84894124471 scopus 로고    scopus 로고
    • Erythrocytes' antioxidative capacity as a potential marker of oxidative stress intensity in neuroinflammation
    • Ljubisavljevic S, Stojanovic I, Cvetkovic T, Vojinovic S, Stojanov D, Stojanovic D, et al. Erythrocytes' antioxidative capacity as a potential marker of oxidative stress intensity in neuroinflammation. J Neurol Sci. 2014;337:8-13.
    • (2014) J Neurol Sci , vol.337 , pp. 8-13
    • Ljubisavljevic, S.1    Stojanovic, I.2    Cvetkovic, T.3    Vojinovic, S.4    Stojanov, D.5    Stojanovic, D.6
  • 103
    • 63849213783 scopus 로고    scopus 로고
    • Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    • Centonze D, Muzio L, Rossi S, Cavasinni F, De Chiara V, Bergami A, et al. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J Neurosci. 2009;29:3442-52.
    • (2009) J Neurosci , vol.29 , pp. 3442-3452
    • Centonze, D.1    Muzio, L.2    Rossi, S.3    Cavasinni, F.4    Chiara, V.5    Bergami, A.6
  • 104
    • 0034662806 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis
    • Lu F, Selak M, O'Connor J, Croul S, Lorenzana C, Butunoi C, et al. Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis. J Neurol Sci. 2000;177:95-103.
    • (2000) J Neurol Sci , vol.177 , pp. 95-103
    • Lu, F.1    Selak, M.2    O'Connor, J.3    Croul, S.4    Lorenzana, C.5    Butunoi, C.6
  • 105
    • 56549086013 scopus 로고    scopus 로고
    • Review: mitochondria and disease progression in multiple sclerosis
    • Mahad D, Lassmann H, Turnbull D. Review: mitochondria and disease progression in multiple sclerosis. Neuropathol Appl Neurobiol. 2008;34:577-89.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 577-589
    • Mahad, D.1    Lassmann, H.2    Turnbull, D.3
  • 106
    • 84924043802 scopus 로고    scopus 로고
    • Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis
    • Reinke S, Broadhurst D, Sykes B, Baker G, Catz I, Warren K, et al. Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis. Mult Scler. 2014;20:1396-400.
    • (2014) Mult Scler , vol.20 , pp. 1396-1400
    • Reinke, S.1    Broadhurst, D.2    Sykes, B.3    Baker, G.4    Catz, I.5    Warren, K.6
  • 107
    • 39349098408 scopus 로고    scopus 로고
    • Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid
    • Lutz NW, Viola A, Malikova I, Confort-Gouny S, Audoin B, Ranjeva JP, et al. Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid. PLoS One. 2007;2:e595.
    • (2007) PLoS One , vol.2 , pp. e595
    • Lutz, N.W.1    Viola, A.2    Malikova, I.3    Confort-Gouny, S.4    Audoin, B.5    Ranjeva, J.P.6
  • 108
    • 79959348652 scopus 로고    scopus 로고
    • Metabolic profiling in multiple sclerosis and other disorders by quantitative analysis of cerebrospinal fluid using nuclear magnetic resonance spectroscopy
    • Lutz NW, Cozzone PJ. Metabolic profiling in multiple sclerosis and other disorders by quantitative analysis of cerebrospinal fluid using nuclear magnetic resonance spectroscopy. Curr Pharm Biotechnol. 2011;12:1016-25.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 1016-1025
    • Lutz, N.W.1    Cozzone, P.J.2
  • 109
    • 84891469143 scopus 로고    scopus 로고
    • Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging
    • Genova H, Rajagopalan V, DeLuca J, Das A, Binder A, Arjunan A, et al. Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging. PLos One. 2013;8:78811.
    • (2013) PLos One , vol.8 , pp. 78811
    • Genova, H.1    Rajagopalan, V.2    DeLuca, J.3    Das, A.4    Binder, A.5    Arjunan, A.6
  • 110
    • 67650550302 scopus 로고    scopus 로고
    • The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI
    • Kohl AD, Wylie GR, Genova HM, Hillary FG, Deluca J. The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI. Brain Inj. 2009;23:420-32.
    • (2009) Brain Inj , vol.23 , pp. 420-432
    • Kohl, A.D.1    Wylie, G.R.2    Genova, H.M.3    Hillary, F.G.4    Deluca, J.5
  • 112
    • 1642333956 scopus 로고    scopus 로고
    • Fatigue in neurological disorders
    • Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978-88.
    • (2004) Lancet , vol.363 , pp. 978-988
    • Chaudhuri, A.1    Behan, P.O.2
  • 113
    • 84921434239 scopus 로고    scopus 로고
    • Gray matters in multiple sclerosis: cognitive impairment and structural MRI
    • Messina S, Patti F. Gray matters in multiple sclerosis: cognitive impairment and structural MRI. Mult Scler Int. 2014;2014:609694.
    • (2014) Mult Scler Int , vol.2014 , pp. 609694
    • Messina, S.1    Patti, F.2
  • 114
    • 77955603930 scopus 로고    scopus 로고
    • MR imaging of gray matter involvement in multiple sclerosis: implications for understanding disease pathophysiology and monitoring treatment efficacy
    • Filippi M, Rocca M. MR imaging of gray matter involvement in multiple sclerosis: implications for understanding disease pathophysiology and monitoring treatment efficacy. AJNR Am J Neuroradiol. 2010;31:1171-7.
    • (2010) AJNR Am J Neuroradiol , vol.31 , pp. 1171-1177
    • Filippi, M.1    Rocca, M.2
  • 115
    • 45849104594 scopus 로고    scopus 로고
    • A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes
    • Ceccarelli A, Rocca M, Pagani E, Colombo B, Martinelli V, Comi G, et al. A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes. Neuroimage. 2008;42:315-22.
    • (2008) Neuroimage , vol.42 , pp. 315-322
    • Ceccarelli, A.1    Rocca, M.2    Pagani, E.3    Colombo, B.4    Martinelli, V.5    Comi, G.6
  • 117
    • 2442423348 scopus 로고    scopus 로고
    • Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes
    • Dalton C, Chard D, Davies G, Miszkiel K, Altmann D, Fernando K, et al. Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes. Brain. 2004;127:1101-7.
    • (2004) Brain , vol.127 , pp. 1101-1107
    • Dalton, C.1    Chard, D.2    Davies, G.3    Miszkiel, K.4    Altmann, D.5    Fernando, K.6
  • 119
    • 79953004108 scopus 로고    scopus 로고
    • Progressive multiple sclerosis and gray matter pathology: an MRI perspective
    • Inglese M, Oesingmann N, Casaccia P, Fleysher L. Progressive multiple sclerosis and gray matter pathology: an MRI perspective. Mt Sinai J Med. 2011;78:258-67.
    • (2011) Mt Sinai J Med , vol.78 , pp. 258-267
    • Inglese, M.1    Oesingmann, N.2    Casaccia, P.3    Fleysher, L.4
  • 120
    • 84857735182 scopus 로고    scopus 로고
    • Clinical correlates of grey matter pathology in multiple sclerosis
    • Horakova D, Kalincik T, Dusankova J, Dolezal O. Clinical correlates of grey matter pathology in multiple sclerosis. BMC Neurol. 2012;12:10.
    • (2012) BMC Neurol , vol.12 , pp. 10
    • Horakova, D.1    Kalincik, T.2    Dusankova, J.3    Dolezal, O.4
  • 122
    • 70349084196 scopus 로고    scopus 로고
    • Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
    • Calabrese M, Agosta F, Rinaldi F, Mattisi I, Grossi P, Favaretto A, et al. Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch Neurol. 2009;66:1144-50.
    • (2009) Arch Neurol , vol.66 , pp. 1144-1150
    • Calabrese, M.1    Agosta, F.2    Rinaldi, F.3    Mattisi, I.4    Grossi, P.5    Favaretto, A.6
  • 123
    • 84924034678 scopus 로고    scopus 로고
    • Cerebellar and brain gray-matter damage predicts fatigue in multiple sclerosis (P6. 120)
    • Damasceno A, Damasceno B, Cendes F. Cerebellar and brain gray-matter damage predicts fatigue in multiple sclerosis (P6. 120). Neurology. 2014;82:6-120.
    • (2014) Neurology , vol.82 , pp. 6-120
    • Damasceno, A.1    Damasceno, B.2    Cendes, F.3
  • 125
    • 33846992291 scopus 로고    scopus 로고
    • Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T
    • Inglese M, Park S, Johnson G, Babb J, Miles L, Jaggi H, et al. Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T. Arch Neurol. 2007;64:196-202.
    • (2007) Arch Neurol , vol.64 , pp. 196-202
    • Inglese, M.1    Park, S.2    Johnson, G.3    Babb, J.4    Miles, L.5    Jaggi, H.6
  • 126
    • 35648971616 scopus 로고    scopus 로고
    • Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability
    • Tedeschi G, Dinacci D, Lavorgna L, Prinster A, Savettieri G, Quattrone A, et al. Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability. J Neurol Sci. 2007;263:15-9.
    • (2007) J Neurol Sci , vol.263 , pp. 15-19
    • Tedeschi, G.1    Dinacci, D.2    Lavorgna, L.3    Prinster, A.4    Savettieri, G.5    Quattrone, A.6
  • 127
    • 0030873086 scopus 로고    scopus 로고
    • Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18 F-fluorodeoxyglucose positron emission tomography study
    • Roelcke U, Kappos L, Lechner-Scott J, Brunnschweiler H, Huber S, Ammann W, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18 F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566-71.
    • (1997) Neurology , vol.48 , pp. 1566-1571
    • Roelcke, U.1    Kappos, L.2    Lechner-Scott, J.3    Brunnschweiler, H.4    Huber, S.5    Ammann, W.6
  • 128
    • 0031717172 scopus 로고    scopus 로고
    • High-resolution fluorodeoxyglucose positron emission tomography shows both global and regional cerebral hypometabolism in multiple sclerosis
    • Bakshi R, Miletich RS, Kinkel PR, Emmet ML, Kinkel WR. High-resolution fluorodeoxyglucose positron emission tomography shows both global and regional cerebral hypometabolism in multiple sclerosis. J Neuroimaging. 1998;8:228-34.
    • (1998) J Neuroimaging , vol.8 , pp. 228-234
    • Bakshi, R.1    Miletich, R.S.2    Kinkel, P.R.3    Emmet, M.L.4    Kinkel, W.R.5
  • 129
    • 0034620499 scopus 로고    scopus 로고
    • Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS
    • Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbaek S, Holm S, et al. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology. 2000;54:558-64.
    • (2000) Neurology , vol.54 , pp. 558-564
    • Blinkenberg, M.1    Rune, K.2    Jensen, C.V.3    Ravnborg, M.4    Kyllingsbaek, S.5    Holm, S.6
  • 131
    • 77957594342 scopus 로고    scopus 로고
    • Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing-remitting multiple sclerosis
    • Calabrese M, Rinaldi F, Grossi P, Mattisi I, Bernardi V, Favaretto A, et al. Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing-remitting multiple sclerosis. Mult Scler. 2010;16:1220-8.
    • (2010) Mult Scler , vol.16 , pp. 1220-1228
    • Calabrese, M.1    Rinaldi, F.2    Grossi, P.3    Mattisi, I.4    Bernardi, V.5    Favaretto, A.6
  • 132
    • 84884974909 scopus 로고    scopus 로고
    • Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE
    • Moreno M, Guo F, Ko E, Bannerman P, Soulika A, Pleasure D. Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. 2013;333:55-9.
    • (2013) J Neurol Sci , vol.333 , pp. 55-59
    • Moreno, M.1    Guo, F.2    Ko, E.3    Bannerman, P.4    Soulika, A.5    Pleasure, D.6
  • 133
    • 84924079884 scopus 로고    scopus 로고
    • Characteristics of a reactive astrogliosis in multiple sclerosis
    • Brosnan C. Characteristics of a reactive astrogliosis in multiple sclerosis. Revista Espanola De Esclerosis Multiple. 2013;28:10-8. Available at: http://www.revistaesclerosis.es/pdf/partes/v5_28dic13_02.pdf.
    • (2013) Revista Espanola De Esclerosis Multiple , vol.28 , pp. 10-18
    • Brosnan, C.1
  • 136
    • 84875932474 scopus 로고    scopus 로고
    • Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
    • Stobart J, Anderson C. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Front Cell Neurosci. 2013;7:38.
    • (2013) Front Cell Neurosci , vol.7 , pp. 38
    • Stobart, J.1    Anderson, C.2
  • 137
    • 77649189116 scopus 로고    scopus 로고
    • Astrocytes: biology and pathology
    • Sofroniew M, Vinters H. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119:7-35.
    • (2010) Acta Neuropathol , vol.119 , pp. 7-35
    • Sofroniew, M.1    Vinters, H.2
  • 140
    • 84878954435 scopus 로고    scopus 로고
    • Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions
    • Morris G, Maes M. Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions. Neuro Endocrinol Lett. 2013;34:185-99.
    • (2013) Neuro Endocrinol Lett , vol.34 , pp. 185-199
    • Morris, G.1    Maes, M.2
  • 144
    • 84857359512 scopus 로고    scopus 로고
    • Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopteri
    • Maes M, Twisk FN, Kubera M, Ringel K. Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopteri. J Affect Disord. 2012;136:933-9.
    • (2012) J Affect Disord , vol.136 , pp. 933-939
    • Maes, M.1    Twisk, F.N.2    Kubera, M.3    Ringel, K.4
  • 145
    • 28344433673 scopus 로고    scopus 로고
    • Chronic fatigue syndrome is associated with diminished intracellular perforin
    • Maher KJ, Klimas NG, Fletcher MA. Chronic fatigue syndrome is associated with diminished intracellular perforin. Clin Exp Immunol. 2005;142:505-11.
    • (2005) Clin Exp Immunol , vol.142 , pp. 505-511
    • Maher, K.J.1    Klimas, N.G.2    Fletcher, M.A.3
  • 147
    • 84860867111 scopus 로고    scopus 로고
    • Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis
    • Brenu EW, van Driel ML, Staines DR, Ashton KJ, Hardcastle SL, Keane J, et al. Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis. J Transl Med. 2012;10:88.
    • (2012) J Transl Med , vol.10 , pp. 88
    • Brenu, E.W.1    Driel, M.L.2    Staines, D.R.3    Ashton, K.J.4    Hardcastle, S.L.5    Keane, J.6
  • 148
    • 79957440333 scopus 로고    scopus 로고
    • Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
    • Brenu EW, van Driel ML, Staines DR, Ashton KJ, Ramos SB, Keane J, et al. Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. J Transl Med. 2011;9:81.
    • (2011) J Transl Med , vol.9 , pp. 81
    • Brenu, E.W.1    Driel, M.L.2    Staines, D.R.3    Ashton, K.J.4    Ramos, S.B.5    Keane, J.6
  • 150
    • 0031754489 scopus 로고    scopus 로고
    • Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables
    • Borish L, Schmaling K, DiClementi JD, Streib J, Negri J, Jones JF. Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables. J Allergy Clin Immunol. 1998;102:222-30.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 222-230
    • Borish, L.1    Schmaling, K.2    DiClementi, J.D.3    Streib, J.4    Negri, J.5    Jones, J.F.6
  • 151
    • 0028089163 scopus 로고
    • Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression
    • Patarca R, Klimas N, Lugtendorf S, Antoni M, Fletcher M. Dysregulated expression of tumor necrosis factor in chronic fatigue syndrome: interrelations with cellular sources and patterns of soluble immune mediator expression. Clin Infect Dis. 1994;18:S147-53.
    • (1994) Clin Infect Dis , vol.18 , pp. S147-S153
    • Patarca, R.1    Klimas, N.2    Lugtendorf, S.3    Antoni, M.4    Fletcher, M.5
  • 152
    • 70349443514 scopus 로고    scopus 로고
    • Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects
    • Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. J Pain. 2009;10:1099-112.
    • (2009) J Pain , vol.10 , pp. 1099-1112
    • Light, A.R.1    White, A.T.2    Hughen, R.W.3    Light, K.C.4
  • 153
    • 84855668815 scopus 로고    scopus 로고
    • Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls
    • White AT, Light AR, Hughen RW, Vanhaitsma TA, Light KC. Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls. Psychosom Med. 2012;74:46-54.
    • (2012) Psychosom Med , vol.74 , pp. 46-54
    • White, A.T.1    Light, A.R.2    Hughen, R.W.3    Vanhaitsma, T.A.4    Light, K.C.5
  • 155
    • 77649266722 scopus 로고    scopus 로고
    • Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis/chronic fatigue syndrome
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis/chronic fatigue syndrome. Neuro Endocrinol Lett. 2009;30:715-22.
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 715-722
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 156
    • 76049126501 scopus 로고    scopus 로고
    • Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009;30:470-6.
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 470-476
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 157
    • 79953744583 scopus 로고    scopus 로고
    • Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Sci Monit. 2011;17:SC11-5.
    • (2011) Med Sci Monit , vol.17 , pp. SC11-SC15
    • Maes, M.1    Kubera, M.2    Uytterhoeven, M.3    Vrydags, N.4    Bosmans, E.5
  • 158
    • 23444438707 scopus 로고    scopus 로고
    • Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
    • Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 2005;39:584-9.
    • (2005) Free Radic Biol Med , vol.39 , pp. 584-589
    • Kennedy, G.1    Spence, V.A.2    McLaren, M.3    Hill, A.4    Underwood, C.5    Belch, J.J.6
  • 159
    • 84865296409 scopus 로고    scopus 로고
    • Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
    • Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, et al. Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed. 2012;25:1073-87.
    • (2012) NMR Biomed , vol.25 , pp. 1073-1087
    • Shungu, D.C.1    Weiduschat, N.2    Murrough, J.W.3    Mao, X.4    Pillemer, S.5    Dyke, J.P.6
  • 160
    • 77956051292 scopus 로고    scopus 로고
    • Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome
    • Miwa K, Fujita M. Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome. Heart Vessels. 2010;25:319-23.
    • (2010) Heart Vessels , vol.25 , pp. 319-323
    • Miwa, K.1    Fujita, M.2
  • 161
    • 41049087200 scopus 로고    scopus 로고
    • Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis
    • Fulle S, Pietrangelo T, Mancinelli R, Saggini R, Fanò G. Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis. J Muscle Res Cell Motil. 2007;28:355-62.
    • (2007) J Muscle Res Cell Motil , vol.28 , pp. 355-362
    • Fulle, S.1    Pietrangelo, T.2    Mancinelli, R.3    Saggini, R.4    Fanò, G.5
  • 164
    • 0032703488 scopus 로고    scopus 로고
    • Impaired oxygen delivery to muscle in chronic fatigue syndrome
    • McCully KK, Natelson BH. Impaired oxygen delivery to muscle in chronic fatigue syndrome. Clin Sci (Lond). 1999;97:603-8. discussion 611-613.
    • (1999) Clin Sci (Lond) , vol.97 , pp. 603-608
    • McCully, K.K.1    Natelson, B.H.2
  • 166
    • 0026685872 scopus 로고
    • Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy
    • Wong R, Lopaschuk G, Zhu G, Walker D, Catellier D, Burton D, et al. Skeletal muscle metabolism in the chronic fatigue syndrome. In vivo assessment by 31P nuclear magnetic resonance spectroscopy. Chest. 1992;102:1716-22.
    • (1992) Chest , vol.102 , pp. 1716-1722
    • Wong, R.1    Lopaschuk, G.2    Zhu, G.3    Walker, D.4    Catellier, D.5    Burton, D.6
  • 167
    • 0021239002 scopus 로고
    • Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome. A 31P nuclear magnetic resonance study
    • Arnold DL, Bore PJ, Radda GK, Styles P, Taylor DJ. Excessive intracellular acidosis of skeletal muscle on exercise in a patient with a post-viral exhaustion/fatigue syndrome. A 31P nuclear magnetic resonance study. Lancet. 1984;1:1367-9.
    • (1984) Lancet , vol.1 , pp. 1367-1369
    • Arnold, D.L.1    Bore, P.J.2    Radda, G.K.3    Styles, P.4    Taylor, D.J.5
  • 169
    • 84901988121 scopus 로고    scopus 로고
    • Association of mitochondrial dysfunction and fatigue: a review of the literature
    • Filler K, Lyon D, Bennett J, McCain N, Elswisk R, Lukkahatai N, et al. Association of mitochondrial dysfunction and fatigue: a review of the literature. BBA Clin. 2014;1:12-23.
    • (2014) BBA Clin , vol.1 , pp. 12-23
    • Filler, K.1    Lyon, D.2    Bennett, J.3    McCain, N.4    Elswisk, R.5    Lukkahatai, N.6
  • 170
    • 77957679024 scopus 로고    scopus 로고
    • Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
    • Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010;8:93.
    • (2010) J Transl Med , vol.8 , pp. 93
    • Vermeulen, R.C.1    Kurk, R.M.2    Visser, F.C.3    Sluiter, W.4    Scholte, H.R.5
  • 171
    • 84892690308 scopus 로고    scopus 로고
    • Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome
    • Vermeulen RC, Vermeulen van Eck IW. Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome. J Transl Med. 2014;12:20.
    • (2014) J Transl Med , vol.12 , pp. 20
    • Vermeulen, R.C.1    Vermeulen van Eck, I.W.2
  • 172
    • 64949160375 scopus 로고    scopus 로고
    • Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study
    • Mathew SJ, Mao X, Keegan KA, Levine SM, Smith EL, Heier LA, et al. Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. NMR Biomed. 2009;22:251-8.
    • (2009) NMR Biomed , vol.22 , pp. 251-258
    • Mathew, S.J.1    Mao, X.2    Keegan, K.A.3    Levine, S.M.4    Smith, E.L.5    Heier, L.A.6
  • 173
    • 77955106514 scopus 로고    scopus 로고
    • Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder
    • Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, et al. Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder. NMR Biomed. 2010;23:643-50.
    • (2010) NMR Biomed , vol.23 , pp. 643-650
    • Murrough, J.W.1    Mao, X.2    Collins, K.A.3    Kelly, C.4    Andrade, G.5    Nestadt, P.6
  • 174
    • 33644759344 scopus 로고    scopus 로고
    • Patients with chronic fatigue syndrome have reduced absolute cortical blood flow
    • Yoshiuchi K, Farkas J, Natelson B. Patients with chronic fatigue syndrome have reduced absolute cortical blood flow. Clin Physiol Funct Imaging. 2006;26:83-6.
    • (2006) Clin Physiol Funct Imaging , vol.26 , pp. 83-86
    • Yoshiuchi, K.1    Farkas, J.2    Natelson, B.3
  • 176
    • 0026785030 scopus 로고
    • Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome
    • Ichise M, Salit IE, Abbey SE, Chung DG, Gray B, Kirsh JC, et al. Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome. Nucl Med Commun. 1992;13:767-72.
    • (1992) Nucl Med Commun , vol.13 , pp. 767-772
    • Ichise, M.1    Salit, I.E.2    Abbey, S.E.3    Chung, D.G.4    Gray, B.5    Kirsh, J.C.6
  • 178
    • 49549098628 scopus 로고    scopus 로고
    • Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome
    • de Lange FP, Koers A, Kalkman JS, Bleijenberg G, Hagoort P, van der Meer JW, et al. Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome. Brain. 2008;131:2172-80.
    • (2008) Brain , vol.131 , pp. 2172-2180
    • Lange, F.P.1    Koers, A.2    Kalkman, J.S.3    Bleijenberg, G.4    Hagoort, P.5    Meer, J.W.6
  • 179
    • 12944316322 scopus 로고    scopus 로고
    • Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome
    • Okada T, Tanaka M, Kuratsune H, Watanabe Y, Sadato N. Mechanisms underlying fatigue: a voxel-based morphometric study of chronic fatigue syndrome. BMC Neurol. 2004;4:14.
    • (2004) BMC Neurol , vol.4 , pp. 14
    • Okada, T.1    Tanaka, M.2    Kuratsune, H.3    Watanabe, Y.4    Sadato, N.5
  • 180
    • 34247123351 scopus 로고    scopus 로고
    • Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain?
    • Kuchinad A, Schweinhardt P, Seminowicz D, Wood P, Chizh B, Bushnell M. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci. 2007;27:4004-7.
    • (2007) J Neurosci , vol.27 , pp. 4004-4007
    • Kuchinad, A.1    Schweinhardt, P.2    Seminowicz, D.3    Wood, P.4    Chizh, B.5    Bushnell, M.6
  • 181
    • 84863705240 scopus 로고    scopus 로고
    • Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3-T MRI study
    • Puri BK, Jakeman PM, Agour M, Gunatilake KD, Fernando KA, Gurusinghe AI, et al. Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3-T MRI study. Br J Radiol. 2011;85:e270-3.
    • (2011) Br J Radiol , vol.85 , pp. e270-e273
    • Puri, B.K.1    Jakeman, P.M.2    Agour, M.3    Gunatilake, K.D.4    Fernando, K.A.5    Gurusinghe, A.I.6
  • 182
    • 34247244642 scopus 로고    scopus 로고
    • Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls
    • Cook DB, O'Connor PJ, Lange G, Steffener J. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage. 2007;36:108-22.
    • (2007) Neuroimage , vol.36 , pp. 108-122
    • Cook, D.B.1    O'Connor, P.J.2    Lange, G.3    Steffener, J.4
  • 183
    • 44449155842 scopus 로고    scopus 로고
    • The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome
    • Caseras X, Mataix-Cols D, Rimes KA, Giampietro V, Brammer M, Zelaya F, et al. The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome. Psychol Med. 2008;38:941-51.
    • (2008) Psychol Med , vol.38 , pp. 941-951
    • Caseras, X.1    Mataix-Cols, D.2    Rimes, K.A.3    Giampietro, V.4    Brammer, M.5    Zelaya, F.6
  • 185
    • 0032575960 scopus 로고    scopus 로고
    • Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data
    • Tirelli U, Chierichetti F, Tavio M, Simonelli C, Bianchin G, Zanco P, et al. Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data. Am J Med. 1998;105:54S-8S.
    • (1998) Am J Med , vol.105 , pp. 54S-58S
    • Tirelli, U.1    Chierichetti, F.2    Tavio, M.3    Simonelli, C.4    Bianchin, G.5    Zanco, P.6
  • 186
    • 84855308705 scopus 로고    scopus 로고
    • A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis
    • Barnden LR, Crouch B, Kwiatek R, Burnet R, Mernone A, Chryssidis S, et al. A brain MRI study of chronic fatigue syndrome: evidence of brainstem dysfunction and altered homeostasis. NMR Biomed. 2011;24:1302-12.
    • (2011) NMR Biomed , vol.24 , pp. 1302-1312
    • Barnden, L.R.1    Crouch, B.2    Kwiatek, R.3    Burnet, R.4    Mernone, A.5    Chryssidis, S.6
  • 187
    • 8844235607 scopus 로고    scopus 로고
    • Is fatigue an independent and persistent symptom in patients with Parkinson disease?
    • Alves G, Wentzel-Larsen T, Larsen JP. Is fatigue an independent and persistent symptom in patients with Parkinson disease? Neurology. 2004;63:1908-11.
    • (2004) Neurology , vol.63 , pp. 1908-1911
    • Alves, G.1    Wentzel-Larsen, T.2    Larsen, J.P.3
  • 188
    • 84924081657 scopus 로고    scopus 로고
    • The parkinson's disease sleep scale (pdss): A new instrument for assessment of sleep, nocturnal disability and daytime sleepiness in parkinson's disease
    • Pal S, Chaudhuri KR, Trenkwalder C, Forbes A, Bridgman K, DiMarco A. The parkinson's disease sleep scale (pdss): A new instrument for assessment of sleep, nocturnal disability and daytime sleepiness in parkinson's disease. Mov Disord. 2002;17:S122.
    • (2002) Mov Disord , vol.17 , pp. S122-S122
    • Pal, S.1    Chaudhuri, K.R.2    Trenkwalder, C.3    Forbes, A.4    Bridgman, K.5    DiMarco, A.6
  • 191
    • 69949153066 scopus 로고    scopus 로고
    • The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
    • Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease. Mov Disord. 2009;24:1641-9.
    • (2009) Mov Disord , vol.24 , pp. 1641-1649
    • Barone, P.1    Antonini, A.2    Colosimo, C.3    Marconi, R.4    Morgante, L.5    Avarello, T.P.6
  • 192
    • 65449121532 scopus 로고    scopus 로고
    • Towards an understanding of fatigue in Parkinson disease
    • Hagell P, Brundin L. Towards an understanding of fatigue in Parkinson disease. J Neurol Neurosurg Psychiatry. 2009;80:489-92.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 489-492
    • Hagell, P.1    Brundin, L.2
  • 193
    • 32544432029 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: diagnosis and management
    • Chaudhuri KR, Healy DG, Schapira AH, National Institute for Clinical Excellence. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 2006;5:235-45.
    • (2006) Lancet Neurol , vol.5 , pp. 235-245
  • 196
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P. Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett. 1995;202:17-20.
    • (1995) Neurosci Lett , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 198
    • 0034788215 scopus 로고    scopus 로고
    • Increase in peripheral CD4 bright + CD8 dull + T cells in Parkinson disease
    • Hisanaga K, Asagi M, Itoyama Y, Iwasaki Y. Increase in peripheral CD4 bright + CD8 dull + T cells in Parkinson disease. Arch Neurol. 2001;58:1580-3.
    • (2001) Arch Neurol , vol.58 , pp. 1580-1583
    • Hisanaga, K.1    Asagi, M.2    Itoyama, Y.3    Iwasaki, Y.4
  • 199
  • 201
    • 71749083139 scopus 로고    scopus 로고
    • Increased serum levels of soluble tumor necrosis factor-alpha receptor-1 in patients with Parkinson's disease
    • Scalzo P, Kümmer A, Cardoso F, Teixeira AL. Increased serum levels of soluble tumor necrosis factor-alpha receptor-1 in patients with Parkinson's disease. J Neuroimmunol. 2009;216:122-5.
    • (2009) J Neuroimmunol , vol.216 , pp. 122-125
    • Scalzo, P.1    Kümmer, A.2    Cardoso, F.3    Teixeira, A.L.4
  • 204
    • 35348966882 scopus 로고    scopus 로고
    • Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    • Tansey MG, McCoy MK, Frank-Cannon TC. Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention. Exp Neurol. 2007;208:1-25.
    • (2007) Exp Neurol , vol.208 , pp. 1-25
    • Tansey, M.G.1    McCoy, M.K.2    Frank-Cannon, T.C.3
  • 206
    • 77953501722 scopus 로고    scopus 로고
    • The role of neuroinflammation on the pathogenesis of Parkinson's disease
    • Chung YC, Ko HW, Bok E, Park ES, Huh SH, Nam JH, et al. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep. 2010;43:225-32.
    • (2010) BMB Rep , vol.43 , pp. 225-232
    • Chung, Y.C.1    Ko, H.W.2    Bok, E.3    Park, E.S.4    Huh, S.H.5    Nam, J.H.6
  • 208
    • 42249115877 scopus 로고    scopus 로고
    • Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
    • Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation. 2008;5:8.
    • (2008) J Neuroinflammation , vol.5 , pp. 8
    • Koprich, J.B.1    Reske-Nielsen, C.2    Mithal, P.3    Isacson, O.4
  • 209
    • 84867629199 scopus 로고    scopus 로고
    • Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum
    • Lindqvist D, Kaufman E, Brundin L, Hall S, Surova Y, Hansson O. Non-motor symptoms in patients with Parkinson's disease - correlations with inflammatory cytokines in serum. PLoS One. 2012;7:e47387.
    • (2012) PLoS One , vol.7 , pp. e47387
    • Lindqvist, D.1    Kaufman, E.2    Brundin, L.3    Hall, S.4    Surova, Y.5    Hansson, O.6
  • 210
    • 79955069801 scopus 로고    scopus 로고
    • Parkinson's disease and systemic inflammation
    • Ferrari CC, Tarelli R. Parkinson's disease and systemic inflammation. Parkinsons Dis. 2011;2011:436813.
    • (2011) Parkinsons Dis , vol.2011 , pp. 436813
    • Ferrari, C.C.1    Tarelli, R.2
  • 211
    • 79953272320 scopus 로고    scopus 로고
    • Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease
    • Farooqui T, Farooqui AA. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. Parkinsons Dis. 2011;2011:247467.
    • (2011) Parkinsons Dis , vol.2011 , pp. 247467
    • Farooqui, T.1    Farooqui, A.A.2
  • 212
    • 68649112842 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress in Parkinson's disease
    • Tsang AH, Chung KK. Oxidative and nitrosative stress in Parkinson's disease. Biochim Biophys Acta. 2009;1792:643-50.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 643-650
    • Tsang, A.H.1    Chung, K.K.2
  • 213
    • 78751502344 scopus 로고    scopus 로고
    • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    • Gao HM, Zhou H, Zhang F, Wilson BC, Kam W, Hong JS. HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. J Neurosci. 2011;31:1081-92.
    • (2011) J Neurosci , vol.31 , pp. 1081-1092
    • Gao, H.M.1    Zhou, H.2    Zhang, F.3    Wilson, B.C.4    Kam, W.5    Hong, J.S.6
  • 214
    • 84924034780 scopus 로고    scopus 로고
    • Interaction of High Mobility Group Box-1 (HMGB1) with α-synuclein and its aggregation [abstract]
    • 172.28
    • Ko EA, Min HJ, Shin JS. Interaction of High Mobility Group Box-1 (HMGB1) with α-synuclein and its aggregation [abstract]. J Immunol. 2012;188:172.28.
    • (2012) J Immunol , vol.188
    • Ko, E.A.1    Min, H.J.2    Shin, J.S.3
  • 216
    • 84872595532 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
    • Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, et al. Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia. 2013;61:349-60.
    • (2013) Glia , vol.61 , pp. 349-360
    • Fellner, L.1    Irschick, R.2    Schanda, K.3    Reindl, M.4    Klimaschewski, L.5    Poewe, W.6
  • 217
    • 84875898265 scopus 로고    scopus 로고
    • Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
    • Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, et al. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun. 2013;4:1562.
    • (2013) Nat Commun , vol.4 , pp. 1562
    • Kim, C.1    Ho, D.H.2    Suk, J.E.3    You, S.4    Michael, S.5    Kang, J.6
  • 220
    • 0025831821 scopus 로고
    • Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease
    • Bindoff L, Birch-Machin M, Cartlidge N, Parker Jr W, Turnbull D. Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease. J Neurol Sci. 1991;104:203-8.
    • (1991) J Neurol Sci , vol.104 , pp. 203-208
    • Bindoff, L.1    Birch-Machin, M.2    Cartlidge, N.3    Parker, W.4    Turnbull, D.5
  • 221
    • 0029396976 scopus 로고
    • Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle
    • Penn A, Roberts T, Hodder J, Allen P, Zhu G, Martin W. Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle. Neurology. 1995;45:2097-9.
    • (1995) Neurology , vol.45 , pp. 2097-2099
    • Penn, A.1    Roberts, T.2    Hodder, J.3    Allen, P.4    Zhu, G.5    Martin, W.6
  • 222
    • 0027971104 scopus 로고
    • Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy
    • Blin O, Desnuelle C, Rascol O, Borg M, Paul H, Azulay JP, et al. Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy. J Neurol Sci. 1994;125:95-101.
    • (1994) J Neurol Sci , vol.125 , pp. 95-101
    • Blin, O.1    Desnuelle, C.2    Rascol, O.3    Borg, M.4    Paul, H.5    Azulay, J.P.6
  • 223
    • 0029050583 scopus 로고
    • Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
    • Haas R, Nasirian F, Nakano K, Ward D, Pay M, Hill R, et al. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol. 1995;37:714-22.
    • (1995) Ann Neurol , vol.37 , pp. 714-722
    • Haas, R.1    Nasirian, F.2    Nakano, K.3    Ward, D.4    Pay, M.5    Hill, R.6
  • 224
    • 0026484964 scopus 로고
    • Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group
    • Krige D, Carroll M, Cooper J, Marsden C, Schapira A. Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group. Ann Neurol. 1992;32:782-8.
    • (1992) Ann Neurol , vol.32 , pp. 782-788
    • Krige, D.1    Carroll, M.2    Cooper, J.3    Marsden, C.4    Schapira, A.5
  • 225
    • 33646948530 scopus 로고    scopus 로고
    • Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
    • Keeney PM, Xie J, Capaldi RA, Bennett Jr JP. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci. 2006;26:5256-64.
    • (2006) J Neurosci , vol.26 , pp. 5256-5264
    • Keeney, P.M.1    Xie, J.2    Capaldi, R.A.3    Bennett, J.P.4
  • 227
    • 0033767317 scopus 로고    scopus 로고
    • An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production
    • Rana M, de Coo I, Diaz F, Smeets H, Moraes CT. An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production. Ann Neurol. 2000;48:774-81.
    • (2000) Ann Neurol , vol.48 , pp. 774-781
    • Rana, M.1    Coo, I.2    Diaz, F.3    Smeets, H.4    Moraes, C.T.5
  • 229
    • 0030612117 scopus 로고    scopus 로고
    • Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • Shults CW, Haas RH, Passov D, Beal MF. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997;42:261-4.
    • (1997) Ann Neurol , vol.42 , pp. 261-264
    • Shults, C.W.1    Haas, R.H.2    Passov, D.3    Beal, M.F.4
  • 231
    • 23844456320 scopus 로고    scopus 로고
    • Neuroimaging in Parkinson's disease
    • Brooks D. Neuroimaging in Parkinson's disease. NeuroRx. 2004;1:243-54.
    • (2004) NeuroRx , vol.1 , pp. 243-254
    • Brooks, D.1
  • 232
    • 84894071160 scopus 로고    scopus 로고
    • Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson's disease using anatomic likelihood estimation
    • Shao N, Yang J, Li J, Shang H. Voxelwise meta-analysis of gray matter anomalies in progressive supranuclear palsy and Parkinson's disease using anatomic likelihood estimation. Front Hum Neurosci. 2014;8:63.
    • (2014) Front Hum Neurosci , vol.8 , pp. 63
    • Shao, N.1    Yang, J.2    Li, J.3    Shang, H.4
  • 233
    • 84889834961 scopus 로고    scopus 로고
    • Changes of brain gray matter structure in Parkinson's disease patients with dementia
    • Xia J, Miu J, Ding H, Wang X, Chen H, Wang J, et al. Changes of brain gray matter structure in Parkinson's disease patients with dementia. Neural Regen Res. 2013;8:1276-85.
    • (2013) Neural Regen Res , vol.8 , pp. 1276-1285
    • Xia, J.1    Miu, J.2    Ding, H.3    Wang, X.4    Chen, H.5    Wang, J.6
  • 237
    • 84900015444 scopus 로고    scopus 로고
    • Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementia
    • Lee H, Kwon K, Kim M, Jang J, Suh S, Koh S, et al. Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementia. Parkinsonism Relat Disord. 2014;20:622-6.
    • (2014) Parkinsonism Relat Disord , vol.20 , pp. 622-626
    • Lee, H.1    Kwon, K.2    Kim, M.3    Jang, J.4    Suh, S.5    Koh, S.6
  • 238
    • 77955795377 scopus 로고    scopus 로고
    • Quantitative magnetic resonance spectroscopic imaging in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy
    • Guevara C, Blain C, Stahl D, Lythgoe D, Leigh P, Barker G. Quantitative magnetic resonance spectroscopic imaging in Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. Eur J Neurol. 2010;17:1193-202.
    • (2010) Eur J Neurol , vol.17 , pp. 1193-1202
    • Guevara, C.1    Blain, C.2    Stahl, D.3    Lythgoe, D.4    Leigh, P.5    Barker, G.6
  • 239
    • 31444433505 scopus 로고    scopus 로고
    • Parkinson's disease and brain mitochondrial dysfunction: a functional phosphorus magnetic resonance spectroscopy study
    • Rango M, Bonifati C, Bresolin N. Parkinson's disease and brain mitochondrial dysfunction: a functional phosphorus magnetic resonance spectroscopy study. J Cereb Blood Flow Metab. 2005;26:283-90.
    • (2005) J Cereb Blood Flow Metab , vol.26 , pp. 283-290
    • Rango, M.1    Bonifati, C.2    Bresolin, N.3
  • 241
    • 0034901447 scopus 로고    scopus 로고
    • Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: a PET study of resting-state glucose metabolism
    • Fukuda M, Mentis MJ, Ma Y, Dhawan V, Antonini A, Lang AE, et al. Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: a PET study of resting-state glucose metabolism. Brain. 2001;124:1601-9.
    • (2001) Brain , vol.124 , pp. 1601-1609
    • Fukuda, M.1    Mentis, M.J.2    Ma, Y.3    Dhawan, V.4    Antonini, A.5    Lang, A.E.6
  • 242
    • 34548369547 scopus 로고    scopus 로고
    • Metabolic brain networks associated with cognitive function in Parkinson's disease
    • Huang C, Mattis P, Tang C, Perrine K, Carbon M, Eidelberg D. Metabolic brain networks associated with cognitive function in Parkinson's disease. Neuroimage. 2007;34:714-23.
    • (2007) Neuroimage , vol.34 , pp. 714-723
    • Huang, C.1    Mattis, P.2    Tang, C.3    Perrine, K.4    Carbon, M.5    Eidelberg, D.6
  • 243
    • 67651163735 scopus 로고    scopus 로고
    • Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment
    • Hosokai Y, Nishio Y, Hirayama K, Takeda A, Ishioka T, Sawada Y, et al. Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment. Mov Disord. 2009;24:854-62.
    • (2009) Mov Disord , vol.24 , pp. 854-862
    • Hosokai, Y.1    Nishio, Y.2    Hirayama, K.3    Takeda, A.4    Ishioka, T.5    Sawada, Y.6
  • 244
    • 0036241140 scopus 로고    scopus 로고
    • Relationships among the metabolic patterns that correlate with mnemonic, visuospatial, and mood symptoms in Parkinson's disease
    • Mentis MJ, McIntosh AR, Perrine K, Dhawan V, Berlin B, Feigin A, et al. Relationships among the metabolic patterns that correlate with mnemonic, visuospatial, and mood symptoms in Parkinson's disease. Am J Psychiatry. 2002;159:746-54.
    • (2002) Am J Psychiatry , vol.159 , pp. 746-754
    • Mentis, M.J.1    McIntosh, A.R.2    Perrine, K.3    Dhawan, V.4    Berlin, B.5    Feigin, A.6
  • 245
    • 42049122792 scopus 로고    scopus 로고
    • Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease
    • Huang C, Mattis P, Perrine K, Brown N, Dhawan V, Eidelberg D. Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease. Neurology. 2008;70:1470-7.
    • (2008) Neurology , vol.70 , pp. 1470-1477
    • Huang, C.1    Mattis, P.2    Perrine, K.3    Brown, N.4    Dhawan, V.5    Eidelberg, D.6
  • 246
    • 77955474301 scopus 로고    scopus 로고
    • Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive: probably even at early disease stages
    • Borghammer P, Chakravarty M, Jonsdottir K, Sato N, Matsuda H, Ito K, et al. Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive: probably even at early disease stages. Brain Struct Funct. 2010;214:303-17.
    • (2010) Brain Struct Funct , vol.214 , pp. 303-317
    • Borghammer, P.1    Chakravarty, M.2    Jonsdottir, K.3    Sato, N.4    Matsuda, H.5    Ito, K.6
  • 248
    • 36248979076 scopus 로고    scopus 로고
    • A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies
    • Yong SW, Yoon JK, An YS, Lee PH. A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies. Eur J Neurol. 2007;14:1357-62.
    • (2007) Eur J Neurol , vol.14 , pp. 1357-1362
    • Yong, S.W.1    Yoon, J.K.2    An, Y.S.3    Lee, P.H.4
  • 250
    • 79953248554 scopus 로고    scopus 로고
    • Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI
    • Kamagata K, Motoi Y, Hori M, Suzuki M, Nakanishi A, Shimoji K, et al. Posterior hypoperfusion in Parkinson's disease with and without dementia measured with arterial spin labeling MRI. J Magn Reson Imaging. 2011;33:803-7.
    • (2011) J Magn Reson Imaging , vol.33 , pp. 803-807
    • Kamagata, K.1    Motoi, Y.2    Hori, M.3    Suzuki, M.4    Nakanishi, A.5    Shimoji, K.6
  • 251
    • 84878900279 scopus 로고    scopus 로고
    • Specific treatment of residual fatigue in depressed patients
    • Marin H, Menza MA. Specific treatment of residual fatigue in depressed patients. Psychiatry (Edgmont). 2004;1:12-8.
    • (2004) Psychiatry (Edgmont) , vol.1 , pp. 12-18
    • Marin, H.1    Menza, M.A.2
  • 252
    • 26944452450 scopus 로고    scopus 로고
    • The management of fatigue in depressed patients
    • Marin H, Menza MA. The management of fatigue in depressed patients. Essent Psychopharmacol. 2005;6:185-92.
    • (2005) Essent Psychopharmacol , vol.6 , pp. 185-192
    • Marin, H.1    Menza, M.A.2
  • 254
    • 1542543332 scopus 로고    scopus 로고
    • Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program
    • Morrow GR, Hickok JT, Roscoe JA, Raubertas RF, Andrews PL, Flynn PJ, et al. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program. J Clin Oncol. 2003;21:4635-41.
    • (2003) J Clin Oncol , vol.21 , pp. 4635-4641
    • Morrow, G.R.1    Hickok, J.T.2    Roscoe, J.A.3    Raubertas, R.F.4    Andrews, P.L.5    Flynn, P.J.6
  • 257
    • 7144254437 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled treatment trial of fluoxetine and graded exercise for chronic fatigue syndrome
    • Wearden AJ, Morriss RK, Mullis R, Strickland PL, Pearson DJ, Appleby L, et al. Randomised, double-blind, placebo-controlled treatment trial of fluoxetine and graded exercise for chronic fatigue syndrome. Br J Psychiatry. 1998;172:485-90.
    • (1998) Br J Psychiatry , vol.172 , pp. 485-490
    • Wearden, A.J.1    Morriss, R.K.2    Mullis, R.3    Strickland, P.L.4    Pearson, D.J.5    Appleby, L.6
  • 258
    • 70350488711 scopus 로고    scopus 로고
    • Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment
    • Song C, Halbreich U, Han C, Leonard BE, Luo H. Imbalance between pro- and anti-inflammatory cytokines, and between Th1 and Th2 cytokines in depressed patients: the effect of electroacupuncture or fluoxetine treatment. Pharmacopsychiatry. 2009;42:182-8.
    • (2009) Pharmacopsychiatry , vol.42 , pp. 182-188
    • Song, C.1    Halbreich, U.2    Han, C.3    Leonard, B.E.4    Luo, H.5
  • 259
    • 84855801183 scopus 로고    scopus 로고
    • Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression
    • Leonard B, Maes M. Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev. 2012;36:764-85.
    • (2012) Neurosci Biobehav Rev , vol.36 , pp. 764-785
    • Leonard, B.1    Maes, M.2
  • 260
    • 79954598830 scopus 로고    scopus 로고
    • Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    • Maes M. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:664-75.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 664-675
    • Maes, M.1
  • 261
    • 71749092663 scopus 로고    scopus 로고
    • Depression and immunity: a role for T cells?
    • Miller AH. Depression and immunity: a role for T cells? Brain Behav Immun. 2010;24:1-8.
    • (2010) Brain Behav Immun , vol.24 , pp. 1-8
    • Miller, A.H.1
  • 262
    • 80155165242 scopus 로고    scopus 로고
    • Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression
    • Gárate I, García-Bueno B, Madrigal JL, Bravo L, Berrocoso E, Caso JR, et al. Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression. J Neuroinflammation. 2011;8:151.
    • (2011) J Neuroinflammation , vol.8 , pp. 151
    • Gárate, I.1    García-Bueno, B.2    Madrigal, J.L.3    Bravo, L.4    Berrocoso, E.5    Caso, J.R.6
  • 264
    • 79954578338 scopus 로고    scopus 로고
    • Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders
    • Gardner A, Boles RG. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:730-43.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 730-743
    • Gardner, A.1    Boles, R.G.2
  • 265
    • 84863909421 scopus 로고    scopus 로고
    • Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data
    • Hamilton JP, Etkin A, Furman DJ, Lemus MG, Johnson RF, Gotlib IH. Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data. Am J Psychiatry. 2012;169:693-703.
    • (2012) Am J Psychiatry , vol.169 , pp. 693-703
    • Hamilton, J.P.1    Etkin, A.2    Furman, D.J.3    Lemus, M.G.4    Johnson, R.F.5    Gotlib, I.H.6
  • 266
    • 79960295368 scopus 로고    scopus 로고
    • Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder
    • Kempton MJ, Salvador Z, Munafò MR, Geddes JR, Simmons A, Frangou S, et al. Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder. Arch Gen Psychiatry. 2011;68:675-90.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 675-690
    • Kempton, M.J.1    Salvador, Z.2    Munafò, M.R.3    Geddes, J.R.4    Simmons, A.5    Frangou, S.6
  • 269
    • 84858234657 scopus 로고    scopus 로고
    • Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies
    • Bora E, Fornito A, Pantelis C, Yücel M. Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies. J Affect Disord. 2012;138:9-18.
    • (2012) J Affect Disord , vol.138 , pp. 9-18
    • Bora, E.1    Fornito, A.2    Pantelis, C.3    Yücel, M.4
  • 271
    • 80053630412 scopus 로고    scopus 로고
    • Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study
    • Peng J, Liu J, Nie B, Li Y, Shan B, Wang G, et al. Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study. Eur J Radiol. 2011;80:395-9.
    • (2011) Eur J Radiol , vol.80 , pp. 395-399
    • Peng, J.1    Liu, J.2    Nie, B.3    Li, Y.4    Shan, B.5    Wang, G.6
  • 272
    • 84924039125 scopus 로고    scopus 로고
    • P02-365-Frontotemporal resting state hypoperfusion in patients with major depression-a study using arterial spin labeling
    • Walther S, Höfle O, Federspiel A, Horn H, Strik W, Muller T. P02-365-Frontotemporal resting state hypoperfusion in patients with major depression-a study using arterial spin labeling. Eur Psychiatry. 2011;26:961.
    • (2011) Eur Psychiatry , vol.26 , pp. 961
    • Walther, S.1    Höfle, O.2    Federspiel, A.3    Horn, H.4    Strik, W.5    Muller, T.6
  • 273
    • 84884906662 scopus 로고    scopus 로고
    • Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression
    • Ho T, Wu J, Shin D, Liu T, Tapert S, Yang G, et al. Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression. J Am Acad Child Adolesc Psychiatry. 2013;52:1076-91.
    • (2013) J Am Acad Child Adolesc Psychiatry , vol.52 , pp. 1076-1091
    • Ho, T.1    Wu, J.2    Shin, D.3    Liu, T.4    Tapert, S.5    Yang, G.6
  • 274
    • 84891830687 scopus 로고    scopus 로고
    • Depressive symptoms and regional cerebral blood flow in Alzheimer's disease
    • Terada S, Oshima E, Sato S, Ikeda C, Nagao S, Hayashi S, et al. Depressive symptoms and regional cerebral blood flow in Alzheimer's disease. Psychiatry Res. 2014;221:86-91.
    • (2014) Psychiatry Res , vol.221 , pp. 86-91
    • Terada, S.1    Oshima, E.2    Sato, S.3    Ikeda, C.4    Nagao, S.5    Hayashi, S.6
  • 275
    • 84900395719 scopus 로고    scopus 로고
    • Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: a pseudo-continuous arterial spin labeling (pCASL) study
    • Ota M, Noda T, Sato N, Hattori K, Teraishi T, Hori H, et al. Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: a pseudo-continuous arterial spin labeling (pCASL) study. J Affect Disord. 2014;165:59-63.
    • (2014) J Affect Disord , vol.165 , pp. 59-63
    • Ota, M.1    Noda, T.2    Sato, N.3    Hattori, K.4    Teraishi, T.5    Hori, H.6
  • 277
    • 60049101442 scopus 로고    scopus 로고
    • Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states
    • Hosokawa T, Momose T, Kasai K. Brain glucose metabolism difference between bipolar and unipolar mood disorders in depressed and euthymic states. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:243-50.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 243-250
    • Hosokawa, T.1    Momose, T.2    Kasai, K.3
  • 279
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation. 2011;8:94.
    • (2011) J Neuroinflammation , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3    Guillemin, G.J.4    Bernstein, H.G.5    Sarnyai, Z.6
  • 281
    • 0024420189 scopus 로고
    • The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus
    • Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121-3.
    • (1989) Arch Neurol , vol.46 , pp. 1121-1123
    • Krupp, L.B.1    LaRocca, N.G.2    Muir-Nash, J.3    Steinberg, A.D.4
  • 282
    • 0342305580 scopus 로고
    • Comparison of neurologic and psychologic findings in patients with Lyme disease and chronic fatigue syndrome
    • Krupp LB, Larocca NC, Luft BJ, Halpern JJ. Comparison of neurologic and psychologic findings in patients with Lyme disease and chronic fatigue syndrome. Neurology. 1989;39:144.
    • (1989) Neurology , vol.39 , pp. 144
    • Krupp, L.B.1    Larocca, N.C.2    Luft, B.J.3    Halpern, J.J.4
  • 283
    • 77952822205 scopus 로고    scopus 로고
    • Fatigue in systemic lupus erythematosus and rheumatoid arthritis
    • Ramsey-Goldman R, Rothrock N. Fatigue in systemic lupus erythematosus and rheumatoid arthritis. PM R. 2010;2:384-92.
    • (2010) PM R , vol.2 , pp. 384-392
    • Ramsey-Goldman, R.1    Rothrock, N.2
  • 284
    • 33745766443 scopus 로고    scopus 로고
    • Dimensions of fatigue in systemic lupus erythematosus: relationship to disease status and behavioral and psychosocial factors
    • Da Costa D, Dritsa M, Bernatsky S, Pineau C, Ménard HA, Dasgupta K, et al. Dimensions of fatigue in systemic lupus erythematosus: relationship to disease status and behavioral and psychosocial factors. J Rheumatol. 2006;33:1282-8.
    • (2006) J Rheumatol , vol.33 , pp. 1282-1288
    • Costa, D.1    Dritsa, M.2    Bernatsky, S.3    Pineau, C.4    Ménard, H.A.5    Dasgupta, K.6
  • 285
  • 286
    • 0035089618 scopus 로고    scopus 로고
    • The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus
    • Wang C, Mayo NE, Fortin PR. The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus. J Rheumatol. 2001;28:525-32.
    • (2001) J Rheumatol , vol.28 , pp. 525-532
    • Wang, C.1    Mayo, N.E.2    Fortin, P.R.3
  • 288
    • 57149117336 scopus 로고    scopus 로고
    • Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus
    • Panopalis P, Yazdany J, Gillis JZ, Julian L, Trupin L, Hersh AO, et al. Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus. Arthritis Rheum. 2008;59:1788-95.
    • (2008) Arthritis Rheum , vol.59 , pp. 1788-1795
    • Panopalis, P.1    Yazdany, J.2    Gillis, J.Z.3    Julian, L.4    Trupin, L.5    Hersh, A.O.6
  • 289
    • 0025318722 scopus 로고
    • Submaximal oxygen consumption in liver cirrhosis. Evidence of severe functional aerobic impairment
    • Campillo B, Fouet P, Bonnet JC, Atlan G. Submaximal oxygen consumption in liver cirrhosis. Evidence of severe functional aerobic impairment. J Hepatol. 1990;10:163-7.
    • (1990) J Hepatol , vol.10 , pp. 163-167
    • Campillo, B.1    Fouet, P.2    Bonnet, J.C.3    Atlan, G.4
  • 292
    • 0027301531 scopus 로고
    • Fatigue in systemic lupus erythematosus. Prevalence and relation to disease expression
    • Wysenbeek AJ, Leibovici L, Weinberger A, Guedj D. Fatigue in systemic lupus erythematosus. Prevalence and relation to disease expression. Br J Rheumatol. 1993;32:633-5.
    • (1993) Br J Rheumatol , vol.32 , pp. 633-635
    • Wysenbeek, A.J.1    Leibovici, L.2    Weinberger, A.3    Guedj, D.4
  • 293
    • 0034019099 scopus 로고    scopus 로고
    • Systemic lupus erythematosus in three ethnic groups. VI: Factors associated with fatigue within 5 years of criteria diagnosis
    • Zonana-Nacach A, Roseman JM, McGwin G, Friedman AW, Baethge BA, Reveille JD. Systemic lupus erythematosus in three ethnic groups. VI: Factors associated with fatigue within 5 years of criteria diagnosis. Lupus. 2000; 9:101-109.
    • (2000) Lupus , vol.9 , pp. 101-109
    • Zonana-Nacach, A.1    Roseman, J.M.2    McGwin, G.3    Friedman, A.W.4    Baethge, B.A.5    Reveille, J.D.6
  • 294
    • 84868359403 scopus 로고    scopus 로고
    • Treatment targets in systemic lupus erythematosus: biology and clinical perspective
    • Marian V, Anolik JH. Treatment targets in systemic lupus erythematosus: biology and clinical perspective. Arthritis Res Ther. 2012;14:S3.
    • (2012) Arthritis Res Ther , vol.14 , pp. S3
    • Marian, V.1    Anolik, J.H.2
  • 295
    • 47249145979 scopus 로고    scopus 로고
    • Cytokine blockade-a promising therapeutic option in SLE
    • Aringer M, Feierl E, Smolen J. Cytokine blockade-a promising therapeutic option in SLE. Z Rheumatol. 2008;67:315-7 [in German].
    • (2008) Z Rheumatol , vol.67 , pp. 315-317
    • Aringer, M.1    Feierl, E.2    Smolen, J.3
  • 296
    • 33750516949 scopus 로고    scopus 로고
    • Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity
    • Sabry A, Sheashaa H, El-Husseini A, Mahmoud K, Eldahshan K, George S, et al. Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity. Cytokine. 2006;35:148-53.
    • (2006) Cytokine , vol.35 , pp. 148-153
    • Sabry, A.1    Sheashaa, H.2    El-Husseini, A.3    Mahmoud, K.4    Eldahshan, K.5    George, S.6
  • 297
    • 80052201839 scopus 로고    scopus 로고
    • Cytokine disturbances in systemic lupus erythematosus
    • Jacob N, Stohl W. Cytokine disturbances in systemic lupus erythematosus. Arthritis Res Ther. 2011;13:228.
    • (2011) Arthritis Res Ther , vol.13 , pp. 228
    • Jacob, N.1    Stohl, W.2
  • 298
    • 2942733373 scopus 로고    scopus 로고
    • Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention
    • Aringer M, Smolen J. Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus: a rationale for therapeutic intervention. Lupus. 2004;13:344-7.
    • (2004) Lupus , vol.13 , pp. 344-347
    • Aringer, M.1    Smolen, J.2
  • 299
    • 0027749465 scopus 로고
    • Haematological manifestations of systemic lupus erythematosus
    • Keeling DM, Isenberg DA. Haematological manifestations of systemic lupus erythematosus. Blood Rev. 1993;7:199-207.
    • (1993) Blood Rev , vol.7 , pp. 199-207
    • Keeling, D.M.1    Isenberg, D.A.2
  • 300
    • 77953503390 scopus 로고    scopus 로고
    • Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity
    • Wang G, Pierangeli SS, Papalardo E, Ansari GA, Khan MF. Markers of oxidative and nitrosative stress in systemic lupus erythematosus: correlation with disease activity. Arthritis Rheum. 2010;62:2064-72.
    • (2010) Arthritis Rheum , vol.62 , pp. 2064-2072
    • Wang, G.1    Pierangeli, S.S.2    Papalardo, E.3    Ansari, G.A.4    Khan, M.F.5
  • 301
    • 58149466086 scopus 로고    scopus 로고
    • Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention
    • Kim WU, Sreih A, Bucala R. Toll-like receptors in systemic lupus erythematosus; prospects for therapeutic intervention. Autoimmun Rev. 2009;8:204-8.
    • (2009) Autoimmun Rev , vol.8 , pp. 204-208
    • Kim, W.U.1    Sreih, A.2    Bucala, R.3
  • 302
    • 34247343697 scopus 로고    scopus 로고
    • The role of toll-like receptors in systemic lupus erythematosus
    • Rahman AH, Eisenberg RA. The role of toll-like receptors in systemic lupus erythematosus. Springer Semin Immunopathol. 2006;28:131-43.
    • (2006) Springer Semin Immunopathol , vol.28 , pp. 131-143
    • Rahman, A.H.1    Eisenberg, R.A.2
  • 303
    • 84871861222 scopus 로고    scopus 로고
    • A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus
    • Tiffin N, Adeyemo A, Okpechi I. A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet J Rare Dis. 2013;8:2.
    • (2013) Orphanet J Rare Dis , vol.8 , pp. 2
    • Tiffin, N.1    Adeyemo, A.2    Okpechi, I.3
  • 304
    • 84923082959 scopus 로고    scopus 로고
    • Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis
    • Dhaouadi T, Sfar I, Haouami Y, Abdelmoula L, Turki S, Hassine LB, et al. Polymorphisms of Toll-like receptor-4 and CD14 in systemic lupus erythematosus and rheumatoid arthritis. Biomark Res. 2013;1:20.
    • (2013) Biomark Res , vol.1 , pp. 20
    • Dhaouadi, T.1    Sfar, I.2    Haouami, Y.3    Abdelmoula, L.4    Turki, S.5    Hassine, L.B.6
  • 305
    • 84896525898 scopus 로고    scopus 로고
    • The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs)
    • Morris G, Berk M, Galecki P, Maes M. The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs). Mol Neurobiol. 2014;49:741-56.
    • (2014) Mol Neurobiol , vol.49 , pp. 741-756
    • Morris, G.1    Berk, M.2    Galecki, P.3    Maes, M.4
  • 306
    • 33748524859 scopus 로고    scopus 로고
    • Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies
    • Harel L, Sandborg C, Lee T, von Scheven E. Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies. J Rheumatol. 2006;33:1873-7.
    • (2006) J Rheumatol , vol.33 , pp. 1873-1877
    • Harel, L.1    Sandborg, C.2    Lee, T.3    Scheven, E.4
  • 307
    • 79952117260 scopus 로고    scopus 로고
    • Cortical thickness and subcortical gray matter reductions in neuropsychiatric systemic lupus erythematosus
    • Jung R, Segall J, Grazioplene R, Qualls C, Sibbitt Jr W, Roldan C. Cortical thickness and subcortical gray matter reductions in neuropsychiatric systemic lupus erythematosus. PLos One. 2010;5:9302.
    • (2010) PLos One , vol.5 , pp. 9302
    • Jung, R.1    Segall, J.2    Grazioplene, R.3    Qualls, C.4    Sibbitt, W.5    Roldan, C.6
  • 309
    • 37849007901 scopus 로고    scopus 로고
    • Neurometabolic changes in normal white matter may predict appearance of hyperintense lesions in systemic lupus erythematosus
    • Appenzeller S, Li L, Costallat L, Cendes F. Neurometabolic changes in normal white matter may predict appearance of hyperintense lesions in systemic lupus erythematosus. Lupus. 2007;16:963-71.
    • (2007) Lupus , vol.16 , pp. 963-971
    • Appenzeller, S.1    Li, L.2    Costallat, L.3    Cendes, F.4
  • 310
    • 58149237716 scopus 로고    scopus 로고
    • Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients
    • Appenzeller S, Vasconcelos Faria A, Li L, Costallat L, Cendes F. Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients. Ann Neurol. 2008;64:635-43.
    • (2008) Ann Neurol , vol.64 , pp. 635-643
    • Appenzeller, S.1    Vasconcelos Faria, A.2    Li, L.3    Costallat, L.4    Cendes, F.5
  • 311
    • 21344443693 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy may predict future brain lesions in SLE patients: a functional multi-imaging approach and follow up
    • Castellino G, Govoni M, Padovan M, Colamussi P, Borrelli M, Trotta F. Proton magnetic resonance spectroscopy may predict future brain lesions in SLE patients: a functional multi-imaging approach and follow up. Ann Rheum Dis. 2005;64:1022-7.
    • (2005) Ann Rheum Dis , vol.64 , pp. 1022-1027
    • Castellino, G.1    Govoni, M.2    Padovan, M.3    Colamussi, P.4    Borrelli, M.5    Trotta, F.6
  • 312
    • 38849206398 scopus 로고    scopus 로고
    • Fatigue is associated with cerebral white matter hyperintensities in patients with systemic lupus erythematosus
    • Harboe E, Greve O, Beyer M, Goransson L, Tjensvoll A, Maroni S, et al. Fatigue is associated with cerebral white matter hyperintensities in patients with systemic lupus erythematosus. J Neurol Neurosurg Psychiatry. 2008;79:199-201.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 199-201
    • Harboe, E.1    Greve, O.2    Beyer, M.3    Goransson, L.4    Tjensvoll, A.5    Maroni, S.6
  • 313
    • 84875689027 scopus 로고    scopus 로고
    • Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy
    • Gono T, Kawaguchi Y, Yamanaka H. Discoveries in the pathophysiology of neuropsychiatric lupus erythematosus: consequences for therapy. BMC Med. 2013;11:91.
    • (2013) BMC Med , vol.11 , pp. 91
    • Gono, T.1    Kawaguchi, Y.2    Yamanaka, H.3
  • 314
    • 82455198797 scopus 로고    scopus 로고
    • NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus
    • Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, et al. NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus. Arthritis Rheum. 2011;63:3952-9.
    • (2011) Arthritis Rheum , vol.63 , pp. 3952-3959
    • Gono, T.1    Takarada, T.2    Fukumori, R.3    Kawaguchi, Y.4    Kaneko, H.5    Hanaoka, M.6
  • 316
    • 0035173156 scopus 로고    scopus 로고
    • A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
    • DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med. 2001;7:1189-93.
    • (2001) Nat Med , vol.7 , pp. 1189-1193
    • DeGiorgio, L.A.1    Konstantinov, K.N.2    Lee, S.C.3    Hardin, J.A.4    Volpe, B.T.5    Diamond, B.6
  • 318
    • 0026846236 scopus 로고
    • Primary Sjögren's syndrome: clinical spectrum and mode of presentation based on an analysis of 50 patients selected from a department of rheumatology
    • Markusse HM, Oudkerk M, Vroom TM, Breedveld FC. Primary Sjögren's syndrome: clinical spectrum and mode of presentation based on an analysis of 50 patients selected from a department of rheumatology. Neth J Med. 1992;40:125-34.
    • (1992) Neth J Med , vol.40 , pp. 125-134
    • Markusse, H.M.1    Oudkerk, M.2    Vroom, T.M.3    Breedveld, F.C.4
  • 319
    • 79952481872 scopus 로고    scopus 로고
    • Primary Sjogren's syndrome: too dry and too tired
    • Ng WF, Bowman SJ. Primary Sjogren's syndrome: too dry and too tired. Rheumatology (Oxford). 2010;49:844-53.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 844-853
    • Ng, W.F.1    Bowman, S.J.2
  • 320
    • 0033623417 scopus 로고    scopus 로고
    • Fatigue in primary Sjögren's syndrome: is there a link with the fibromyalgia syndrome?
    • Giles I, Isenberg D. Fatigue in primary Sjögren's syndrome: is there a link with the fibromyalgia syndrome? Ann Rheum Dis. 2000;59:875-8.
    • (2000) Ann Rheum Dis , vol.59 , pp. 875-878
    • Giles, I.1    Isenberg, D.2
  • 324
    • 84855568775 scopus 로고    scopus 로고
    • Interleukin-1 inhibition and fatigue in primary Sjögren's syndrome-a double blind, randomised clinical trial
    • Norheim K, Harboe E, Goransson L, Omdal R. Interleukin-1 inhibition and fatigue in primary Sjögren's syndrome-a double blind, randomised clinical trial. PLos One. 2012;7:30123.
    • (2012) PLos One , vol.7 , pp. 30123
    • Norheim, K.1    Harboe, E.2    Goransson, L.3    Omdal, R.4
  • 325
    • 80052207310 scopus 로고    scopus 로고
    • Disturbance of cytokine networks in Sjögrens syndrome
    • Youinou P, Pers J. Disturbance of cytokine networks in Sjögrens syndrome. Arthritis Res Ther. 2011;13:227.
    • (2011) Arthritis Res Ther , vol.13 , pp. 227
    • Youinou, P.1    Pers, J.2
  • 326
    • 2942748333 scopus 로고    scopus 로고
    • Circulating cytokines in primary Sjögren's syndrome determined by a multiplex cytokine array system
    • Szodoray P, Alex P, Brun J, Centola M, Jonsson R. Circulating cytokines in primary Sjögren's syndrome determined by a multiplex cytokine array system. Scand J Immunol. 2004;59:592-9.
    • (2004) Scand J Immunol , vol.59 , pp. 592-599
    • Szodoray, P.1    Alex, P.2    Brun, J.3    Centola, M.4    Jonsson, R.5
  • 327
    • 0031975394 scopus 로고    scopus 로고
    • Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome
    • Hagiwara E, Pando J, Ishigatsubo Y, Klinman D. Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol. 1998;25:89-93.
    • (1998) J Rheumatol , vol.25 , pp. 89-93
    • Hagiwara, E.1    Pando, J.2    Ishigatsubo, Y.3    Klinman, D.4
  • 328
    • 70349244787 scopus 로고    scopus 로고
    • Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis
    • Katsifis G, Rekka S, Moutsopoulos N, Pillemer S, Wahl S. Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis. Am J Pathol. 2009;175:1167-77.
    • (2009) Am J Pathol , vol.175 , pp. 1167-1177
    • Katsifis, G.1    Rekka, S.2    Moutsopoulos, N.3    Pillemer, S.4    Wahl, S.5
  • 329
    • 80052224962 scopus 로고    scopus 로고
    • Aspects of innate immunity in Sjögren's syndrome
    • Low HZ, Witte T. Aspects of innate immunity in Sjögren's syndrome. Arthritis Res Ther. 2011;13:218.
    • (2011) Arthritis Res Ther , vol.13 , pp. 218
    • Low, H.Z.1    Witte, T.2
  • 330
    • 77957768966 scopus 로고    scopus 로고
    • Activation of the type I interferon pathway in primary Sjogren's syndrome
    • Mavragani CP, Crow MK. Activation of the type I interferon pathway in primary Sjogren's syndrome. J Autoimmun. 2010;35:225-31.
    • (2010) J Autoimmun , vol.35 , pp. 225-231
    • Mavragani, C.P.1    Crow, M.K.2
  • 332
    • 84866537988 scopus 로고    scopus 로고
    • Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis
    • Bombardieri M, Pitzalis C. Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis. Curr Pharm Biotechnol. 2012;13:1989-96.
    • (2012) Curr Pharm Biotechnol , vol.13 , pp. 1989-1996
    • Bombardieri, M.1    Pitzalis, C.2
  • 334
    • 27644591230 scopus 로고    scopus 로고
    • The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy
    • Mori K, Iijima M, Koike H, Hattori N, Tanaka F, Watanabe H, et al. The wide spectrum of clinical manifestations in Sjögren's syndrome-associated neuropathy. Brain. 2005;128:2518-34.
    • (2005) Brain , vol.128 , pp. 2518-2534
    • Mori, K.1    Iijima, M.2    Koike, H.3    Hattori, N.4    Tanaka, F.5    Watanabe, H.6
  • 337
    • 0026583019 scopus 로고
    • Magnetic resonance imaging of the brain in patients with primary Sjögren's syndrome
    • Manthorpe R, Manthorpe T, Sjöberg S. Magnetic resonance imaging of the brain in patients with primary Sjögren's syndrome. Scand J Rheumatol. 1992;21:148-9.
    • (1992) Scand J Rheumatol , vol.21 , pp. 148-149
    • Manthorpe, R.1    Manthorpe, T.2    Sjöberg, S.3
  • 339
    • 77954696400 scopus 로고    scopus 로고
    • Central nervous system involvement in Sjögren's syndrome: unusual, but not unremarkable-clinical, serological characteristics and outcomes in a large cohort of Italian patients
    • Massara A, Bonazza S, Castellino G, Caniatti L, Trotta F, Borrelli M, et al. Central nervous system involvement in Sjögren's syndrome: unusual, but not unremarkable-clinical, serological characteristics and outcomes in a large cohort of Italian patients. Rheumatology. 2010;49:1540-9.
    • (2010) Rheumatology , vol.49 , pp. 1540-1549
    • Massara, A.1    Bonazza, S.2    Castellino, G.3    Caniatti, L.4    Trotta, F.5    Borrelli, M.6
  • 340
    • 77954722961 scopus 로고    scopus 로고
    • Disruption of brain white matter microstructure in primary Sjögren's syndrome: evidence from diffusion tensor imaging
    • Segal B, Mueller B, Zhu X, Prosser R, Pogatchnik B, Holker E, et al. Disruption of brain white matter microstructure in primary Sjögren's syndrome: evidence from diffusion tensor imaging. Rheumatology. 2010;49:1530-9.
    • (2010) Rheumatology , vol.49 , pp. 1530-1539
    • Segal, B.1    Mueller, B.2    Zhu, X.3    Prosser, R.4    Pogatchnik, B.5    Holker, E.6
  • 341
    • 0027241833 scopus 로고
    • Asymptomatic cerebral involvement in Sjögren's syndrome: MRI findings of 15 cases
    • Pierot L, Sauve C, Leger J, Martin N, Koeger A, Wechsler B, et al. Asymptomatic cerebral involvement in Sjögren's syndrome: MRI findings of 15 cases. Neuroradiology. 1993;35:378-80.
    • (1993) Neuroradiology , vol.35 , pp. 378-380
    • Pierot, L.1    Sauve, C.2    Leger, J.3    Martin, N.4    Koeger, A.5    Wechsler, B.6
  • 342
    • 80054932300 scopus 로고    scopus 로고
    • CNS involvement in primary Sjogren Syndrome: assessment of gray and white matter changes with MRI and voxel-based morphometry
    • Tzarouchi L, Tsifetaki N, Konitsiotis S, Zikou A, Astrakas L, Drosos A, et al. CNS involvement in primary Sjogren Syndrome: assessment of gray and white matter changes with MRI and voxel-based morphometry. AJR Am J Roentgenol. 2011;197:1207-12.
    • (2011) AJR Am J Roentgenol , vol.197 , pp. 1207-1212
    • Tzarouchi, L.1    Tsifetaki, N.2    Konitsiotis, S.3    Zikou, A.4    Astrakas, L.5    Drosos, A.6
  • 343
    • 84908664141 scopus 로고    scopus 로고
    • Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study
    • Lauvsnes M, Beyer M, Appenzeller S, Greve O, Harboe E, Goransson L, et al. Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study. Eur J Neurol. 2014;21:1324-9.
    • (2014) Eur J Neurol , vol.21 , pp. 1324-1329
    • Lauvsnes, M.1    Beyer, M.2    Appenzeller, S.3    Greve, O.4    Harboe, E.5    Goransson, L.6
  • 344
    • 61349183913 scopus 로고    scopus 로고
    • Fatigue in patients with rheumatoid arthritis: what is known and what is needed
    • Repping-Wuts H, van Riel P, van Achterberg T. Fatigue in patients with rheumatoid arthritis: what is known and what is needed. Rheumatology (Oxford). 2009;48:207-9.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 207-209
    • Repping-Wuts, H.1    Riel, P.2    Achterberg, T.3
  • 346
    • 44949181928 scopus 로고    scopus 로고
    • Fatigue as experienced by patients with rheumatoid arthritis (RA): a qualitative study
    • Repping-Wuts H, Uitterhoeve R, van Riel P, van Achterberg T. Fatigue as experienced by patients with rheumatoid arthritis (RA): a qualitative study. Int J Nurs Stud. 2008;45:995-1002.
    • (2008) Int J Nurs Stud , vol.45 , pp. 995-1002
    • Repping-Wuts, H.1    Uitterhoeve, R.2    Riel, P.3    Achterberg, T.4
  • 347
    • 26844489587 scopus 로고    scopus 로고
    • Patients' perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored
    • Hewlett S, Cockshott Z, Byron M, Kitchen K, Tipler S, Pope D, et al. Patients' perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored. Arthritis Rheum. 2005;53:697-702.
    • (2005) Arthritis Rheum , vol.53 , pp. 697-702
    • Hewlett, S.1    Cockshott, Z.2    Byron, M.3    Kitchen, K.4    Tipler, S.5    Pope, D.6
  • 349
    • 84924077888 scopus 로고    scopus 로고
    • Sleep quality in rheumatoid arthritis: relationship between the disease severity, depression, functional status and the quality of life
    • Sariyildiz M, Batmaz I, Bozkurt M, Bez Y, Cetincakmak M, Yazmalar L, et al. Sleep quality in rheumatoid arthritis: relationship between the disease severity, depression, functional status and the quality of life. J Clin Med Res. 2014;6:44.
    • (2014) J Clin Med Res , vol.6 , pp. 44
    • Sariyildiz, M.1    Batmaz, I.2    Bozkurt, M.3    Bez, Y.4    Cetincakmak, M.5    Yazmalar, L.6
  • 350
    • 77955450672 scopus 로고    scopus 로고
    • Correlation of fatigue with clinical parameters and quality of life in rheumatoid arthritis
    • Turan Y, Kocaağa Z, Koçyiğit H, Gürgan A, Bayram KB, Ipek S. Correlation of fatigue with clinical parameters and quality of life in rheumatoid arthritis. Arch Rheumatol. 2010;25:63-7.
    • (2010) Arch Rheumatol , vol.25 , pp. 63-67
    • Turan, Y.1    Kocaağa, Z.2    Koçyiğit, H.3    Gürgan, A.4    Bayram, K.B.5    Ipek, S.6
  • 351
    • 77957894696 scopus 로고    scopus 로고
    • Cytokines of the Th1 and Th2 type in sera of rheumatoid arthritis patients; correlations with anti-Hsp40 immune response and diagnostic markers
    • Tukaj S, Kotlarz A, Jozwik A, Smolenska Z, Bryl E, Witkowski J, et al. Cytokines of the Th1 and Th2 type in sera of rheumatoid arthritis patients; correlations with anti-Hsp40 immune response and diagnostic markers. Acta Biochim Pol. 2010;57:327-32.
    • (2010) Acta Biochim Pol , vol.57 , pp. 327-332
    • Tukaj, S.1    Kotlarz, A.2    Jozwik, A.3    Smolenska, Z.4    Bryl, E.5    Witkowski, J.6
  • 353
    • 79960883879 scopus 로고    scopus 로고
    • Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-alpha therapy
    • Chen D, Chen Y, Chen H, Hsieh C, Lin C, Lan J. Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-alpha therapy. Arthritis Res Ther. 2011;13:R126.
    • (2011) Arthritis Res Ther , vol.13 , pp. R126
    • Chen, D.1    Chen, Y.2    Chen, H.3    Hsieh, C.4    Lin, C.5    Lan, J.6
  • 354
    • 47249153519 scopus 로고    scopus 로고
    • Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics
    • Feldmann M, Maini SR. Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol Rev. 2008;223:7-19.
    • (2008) Immunol Rev , vol.223 , pp. 7-19
    • Feldmann, M.1    Maini, S.R.2
  • 355
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig
    • Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med. 2003;349:1907-15.
    • (2003) N Engl J Med , vol.349 , pp. 1907-1915
    • Kremer, J.M.1    Westhovens, R.2    Leon, M.3    Giorgio, E.4    Alten, R.5    Steinfeld, S.6
  • 356
    • 84867902638 scopus 로고    scopus 로고
    • Efficacy of radiosynovectomy in rheumatoid arthritis
    • Liepe K. Efficacy of radiosynovectomy in rheumatoid arthritis. Rheumatol Int. 2012;32:3219-24.
    • (2012) Rheumatol Int , vol.32 , pp. 3219-3224
    • Liepe, K.1
  • 357
    • 33645902886 scopus 로고    scopus 로고
    • Effect of etanercept on fatigue in patients with recent or established rheumatoid arthritis
    • Moreland LW, Genovese MC, Sato R, Singh A. Effect of etanercept on fatigue in patients with recent or established rheumatoid arthritis. Arthritis Rheum. 2006;55:287-93.
    • (2006) Arthritis Rheum , vol.55 , pp. 287-293
    • Moreland, L.W.1    Genovese, M.C.2    Sato, R.3    Singh, A.4
  • 358
    • 0037231533 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial
    • Weinblatt ME, Keystone EC, Furst DE, Moreland LW, Weisman MH, Birbara CA, et al. Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum. 2003;48:35-45.
    • (2003) Arthritis Rheum , vol.48 , pp. 35-45
    • Weinblatt, M.E.1    Keystone, E.C.2    Furst, D.E.3    Moreland, L.W.4    Weisman, M.H.5    Birbara, C.A.6
  • 359
    • 84855163540 scopus 로고    scopus 로고
    • Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
    • Goh F, Midwood K. Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis. Rheumatology. 2011;51:7-23.
    • (2011) Rheumatology , vol.51 , pp. 7-23
    • Goh, F.1    Midwood, K.2
  • 360
    • 70449625015 scopus 로고    scopus 로고
    • The role of toll-like receptors in rheumatoid arthritis
    • Huang Q, Pope R. The role of toll-like receptors in rheumatoid arthritis. Curr Rheumatol Rep. 2009;11:357-64.
    • (2009) Curr Rheumatol Rep , vol.11 , pp. 357-364
    • Huang, Q.1    Pope, R.2
  • 361
    • 65649087479 scopus 로고    scopus 로고
    • Toll-like receptors and rheumatoid arthritis
    • Brentano F, Kyburz D, Gay S. Toll-like receptors and rheumatoid arthritis. Methods Mol Biol. 2009;517:329-43.
    • (2009) Methods Mol Biol , vol.517 , pp. 329-343
    • Brentano, F.1    Kyburz, D.2    Gay, S.3
  • 362
    • 85015793026 scopus 로고    scopus 로고
    • Oxidative stress in rheumatoid arthritis
    • Springer Science+Business Media; 2013. [Alcaraz MJ (Series Editor): Oxidative Stress in Applied Basic Research and Clinical Practice].
    • Szabo-Taylor K, Nagy G, Eggleton P, Winyard P. Oxidative stress in rheumatoid arthritis. In: Studies on Arthritis and Joint Disorders. Springer Science+Business Media; 2013. p. 145-67 [Alcaraz MJ (Series Editor): Oxidative Stress in Applied Basic Research and Clinical Practice].
    • Studies on Arthritis and Joint Disorders , pp. 145-167
    • Szabo-Taylor, K.1    Nagy, G.2    Eggleton, P.3    Winyard, P.4
  • 363
    • 84868314096 scopus 로고    scopus 로고
    • Oxidative stress as a potential biomarker for determining disease activity in patients with rheumatoid arthritis
    • Kundu S, Ghosh P, Datta S, Ghosh A, Chattopadhyay S, Chatterjee M. Oxidative stress as a potential biomarker for determining disease activity in patients with rheumatoid arthritis. Free Radic Res. 2012;46:1482-9.
    • (2012) Free Radic Res , vol.46 , pp. 1482-1489
    • Kundu, S.1    Ghosh, P.2    Datta, S.3    Ghosh, A.4    Chattopadhyay, S.5    Chatterjee, M.6
  • 364
    • 80054699494 scopus 로고    scopus 로고
    • Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity
    • Hassan S, Gheita T, Kenawy S, Fahim A, El-Sorougy I, Abdou M. Oxidative stress in systemic lupus erythematosus and rheumatoid arthritis patients: relationship to disease manifestations and activity. Int J Rheum Dis. 2011;14:325-31.
    • (2011) Int J Rheum Dis , vol.14 , pp. 325-331
    • Hassan, S.1    Gheita, T.2    Kenawy, S.3    Fahim, A.4    El-Sorougy, I.5    Abdou, M.6
  • 365
    • 0034142176 scopus 로고    scopus 로고
    • Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases
    • Tak P, Zvaifler N, Green D, Firestein G. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000;21:78-82.
    • (2000) Immunol Today , vol.21 , pp. 78-82
    • Tak, P.1    Zvaifler, N.2    Green, D.3    Firestein, G.4
  • 366
    • 25144461499 scopus 로고    scopus 로고
    • Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes
    • Da Sylva T, Connor A, Mburu Y, Keystone E, Wu G. Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes. Arthritis Res Ther. 2005;7:844-51.
    • (2005) Arthritis Res Ther , vol.7 , pp. 844-851
    • Sylva, T.1    Connor, A.2    Mburu, Y.3    Keystone, E.4    Wu, G.5
  • 368
    • 84881187968 scopus 로고    scopus 로고
    • Mitochondrial respiratory chain dysfunction modulates metalloproteases-1,-3 and-13 in human normal chondrocytes in culture
    • Cillero-Pastor B, Rego-Perez I, Oreiro N, Fernandez-Lopez C, Blanco F. Mitochondrial respiratory chain dysfunction modulates metalloproteases-1,-3 and-13 in human normal chondrocytes in culture. BMC Musculoskelet Disord. 2013;14:1-10.
    • (2013) BMC Musculoskelet Disord , vol.14 , pp. 1-10
    • Cillero-Pastor, B.1    Rego-Perez, I.2    Oreiro, N.3    Fernandez-Lopez, C.4    Blanco, F.5
  • 371
    • 0037668545 scopus 로고    scopus 로고
    • Pathogenesis of systemic lupus erythematosus
    • Mok CC, Lau CS. Pathogenesis of systemic lupus erythematosus. J Clin Pathol. 2003;56:481-90.
    • (2003) J Clin Pathol , vol.56 , pp. 481-490
    • Mok, C.C.1    Lau, C.S.2
  • 372
    • 84993808220 scopus 로고    scopus 로고
    • Current aspects of pathogenesis in Sjögren's syndrome
    • Voulgarelis M, Tzioufas AG. Current aspects of pathogenesis in Sjögren's syndrome. Ther Adv Musculoskelet Dis. 2010;2:325-34.
    • (2010) Ther Adv Musculoskelet Dis , vol.2 , pp. 325-334
    • Voulgarelis, M.1    Tzioufas, A.G.2
  • 374
    • 84908405329 scopus 로고    scopus 로고
    • Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012
    • Bakken I, Tveito K, Gunnes N, Ghaderi S, Stoltenberg C, Trogstad L, et al. Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012. BMC Med. 2014;12:167.
    • (2014) BMC Med , vol.12 , pp. 167
    • Bakken, I.1    Tveito, K.2    Gunnes, N.3    Ghaderi, S.4    Stoltenberg, C.5    Trogstad, L.6
  • 378
    • 84858447329 scopus 로고    scopus 로고
    • The influence of sex and gender on the immune response
    • Oertelt-Prigione S. The influence of sex and gender on the immune response. Autoimmun Rev. 2012;11:A479-85.
    • (2012) Autoimmun Rev , vol.11 , pp. A479-A485
    • Oertelt-Prigione, S.1
  • 379
    • 79959962195 scopus 로고    scopus 로고
    • Non-reproductive effects of sex steroids: their immunoregulatory role
    • Munoz-Cruz S, Togno-Pierce C, Morales-Montor J. Non-reproductive effects of sex steroids: their immunoregulatory role. Curr Top Med Chem. 2011;11:1714-27.
    • (2011) Curr Top Med Chem , vol.11 , pp. 1714-1727
    • Munoz-Cruz, S.1    Togno-Pierce, C.2    Morales-Montor, J.3
  • 380
    • 84872550311 scopus 로고    scopus 로고
    • The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates
    • Berghella A, Contasta I, Del Beato T, Pellegrini P. The discovery of how gender influences age immunological mechanisms in health and disease, and the identification of ageing gender-specific biomarkers, could lead to specifically tailored treatment and ultimately improve therapeutic success rates. Immun Ageing. 2012;9:24.
    • (2012) Immun Ageing , vol.9 , pp. 24
    • Berghella, A.1    Contasta, I.2    Beato, T.3    Pellegrini, P.4
  • 381
    • 79960559114 scopus 로고    scopus 로고
    • Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats
    • Sárvári M, Hrabovszky E, Kalló I, Solymosi N, Tóth K, Likó I, et al. Estrogens regulate neuroinflammatory genes via estrogen receptors α and β in the frontal cortex of middle-aged female rats. J Neuroinflammation. 2011;8:82.
    • (2011) J Neuroinflammation , vol.8 , pp. 82
    • Sárvári, M.1    Hrabovszky, E.2    Kalló, I.3    Solymosi, N.4    Tóth, K.5    Likó, I.6
  • 382
    • 79959660248 scopus 로고    scopus 로고
    • Interdisciplinary approaches to achieving gendered innovations in science, medicine, and engineering
    • Schiebinger L, Schraudner M. Interdisciplinary approaches to achieving gendered innovations in science, medicine, and engineering. Interdisc Science Rev. 2011;36:154-67.
    • (2011) Interdisc Science Rev , vol.36 , pp. 154-167
    • Schiebinger, L.1    Schraudner, M.2
  • 383
    • 0037205080 scopus 로고    scopus 로고
    • Aluminum-containing vaccine associated adverse events: role of route of administration and gender
    • Pittman P. Aluminum-containing vaccine associated adverse events: role of route of administration and gender. Vaccine. 2002;20:S48-50.
    • (2002) Vaccine , vol.20 , pp. S48-S50
    • Pittman, P.1
  • 384
    • 61849131114 scopus 로고    scopus 로고
    • Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination
    • Reif D, Motsinger-Reif A, McKinney B, Rock M, Crowe J, Moore J. Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination. Genes Immun. 2008;10:112-9.
    • (2008) Genes Immun , vol.10 , pp. 112-119
    • Reif, D.1    Motsinger-Reif, A.2    McKinney, B.3    Rock, M.4    Crowe, J.5    Moore, J.6
  • 385
    • 84875961782 scopus 로고    scopus 로고
    • Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum
    • Vera-Lastra O, Medina G, Cruz-Dominguez M, Jara L, Shoenfeld Y. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld's syndrome): clinical and immunological spectrum. Expert Rev Clin Immunol. 2013;9:361-73.
    • (2013) Expert Rev Clin Immunol , vol.9 , pp. 361-373
    • Vera-Lastra, O.1    Medina, G.2    Cruz-Dominguez, M.3    Jara, L.4    Shoenfeld, Y.5
  • 386
    • 54549089947 scopus 로고    scopus 로고
    • Chronic fatigue syndrome with autoantibodies-the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant
    • Nancy A, Shoenfeld Y. Chronic fatigue syndrome with autoantibodies-the result of an augmented adjuvant effect of hepatitis-B vaccine and silicone implant. Autoimmun Rev. 2008;8:52-5.
    • (2008) Autoimmun Rev , vol.8 , pp. 52-55
    • Nancy, A.1    Shoenfeld, Y.2
  • 387
    • 56149119563 scopus 로고    scopus 로고
    • Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    • Kool M, Petrilli V, De Smedt T, Rolaz A, Hammad H, van Nimwegen M, et al. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol. 2008;181:3755-9.
    • (2008) J Immunol , vol.181 , pp. 3755-3759
    • Kool, M.1    Petrilli, V.2    Smedt, T.3    Rolaz, A.4    Hammad, H.5    Nimwegen, M.6
  • 388
    • 84861928351 scopus 로고    scopus 로고
    • Involvement of Toll-like receptor in silica-induced tumor necrosis factor alpha release from human macrophage cell line
    • Yan Z, Zhang Q, Xu L, Wu W, Ren W, Liu LH, et al. Involvement of Toll-like receptor in silica-induced tumor necrosis factor alpha release from human macrophage cell line. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010;28:427-9 [in Chinese].
    • (2010) Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi , vol.28 , pp. 427-429
    • Yan, Z.1    Zhang, Q.2    Xu, L.3    Wu, W.4    Ren, W.5    Liu, L.H.6
  • 389
  • 390
    • 84894067335 scopus 로고    scopus 로고
    • Suboptimal dosing of rituximab in male and female patients with DLBCL
    • Pfreundschuh M, Muller C, Zeynalova S, Kuhnt E, Wiesen M, Held G, et al. Suboptimal dosing of rituximab in male and female patients with DLBCL. Blood. 2013;123:640-6.
    • (2013) Blood , vol.123 , pp. 640-646
    • Pfreundschuh, M.1    Muller, C.2    Zeynalova, S.3    Kuhnt, E.4    Wiesen, M.5    Held, G.6
  • 391
    • 53249086413 scopus 로고    scopus 로고
    • Gender differences in pharmacological response
    • Anderson G. Gender differences in pharmacological response. Int Rev Neurobiol. 2014;83:1-10.
    • (2014) Int Rev Neurobiol , vol.83 , pp. 1-10
    • Anderson, G.1
  • 392
    • 84886935582 scopus 로고    scopus 로고
    • Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi
    • Sivro A, Lajoie J, Kimani J, Jaoko W, Plummer F, Fowke K, et al. Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi. Kenya Immun Ageing. 2013;10:42.
    • (2013) Kenya. Immun Ageing , vol.10 , pp. 42
    • Sivro, A.1    Lajoie, J.2    Kimani, J.3    Jaoko, W.4    Plummer, F.5    Fowke, K.6
  • 393
    • 77950327120 scopus 로고    scopus 로고
    • Rituximab in autoimmune hematologic diseases: not just a matter of B cells
    • Stasi R. Rituximab in autoimmune hematologic diseases: not just a matter of B cells. Semin Hematol. 2010;47:170-9.
    • (2010) Semin Hematol , vol.47 , pp. 170-179
    • Stasi, R.1
  • 394
    • 84863072278 scopus 로고    scopus 로고
    • Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid
    • Tsuda M, Moritoki Y, Lian Z, Zhang W, Yoshida K, Wakabayashi K, et al. Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Hepatology. 2012;55:512-21.
    • (2012) Hepatology , vol.55 , pp. 512-521
    • Tsuda, M.1    Moritoki, Y.2    Lian, Z.3    Zhang, W.4    Yoshida, K.5    Wakabayashi, K.6
  • 396
    • 77954756885 scopus 로고    scopus 로고
    • Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab
    • Yamamoto A, Sato K, Miyoshi F, Shindo Y, Yoshida Y, Yokota K, et al. Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab. Mod Rheumatol. 2009;20:183-7.
    • (2009) Mod Rheumatol , vol.20 , pp. 183-187
    • Yamamoto, A.1    Sato, K.2    Miyoshi, F.3    Shindo, Y.4    Yoshida, Y.5    Yokota, K.6
  • 398
    • 84893781908 scopus 로고    scopus 로고
    • Updated review of complementary and alternative medicine treatments for systemic lupus erythematosus
    • Greco CM, Nakajima C, Manzi S. Updated review of complementary and alternative medicine treatments for systemic lupus erythematosus. Curr Rheumatol Rep. 2013;15:378.
    • (2013) Curr Rheumatol Rep , vol.15 , pp. 378
    • Greco, C.M.1    Nakajima, C.2    Manzi, S.3
  • 399
    • 84862769027 scopus 로고    scopus 로고
    • New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates-Nrf2 activators and GSK-3 inhibitors
    • Maes M, Fišar Z, Medina M, Scapagnini G, Nowak G, Berk M. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates-Nrf2 activators and GSK-3 inhibitors. Inflammopharmacology. 2012;20:127-50.
    • (2012) Inflammopharmacology , vol.20 , pp. 127-150
    • Maes, M.1    Fišar, Z.2    Medina, M.3    Scapagnini, G.4    Nowak, G.5    Berk, M.6
  • 400
    • 2342445103 scopus 로고    scopus 로고
    • Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes
    • Puri BK, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004;58:297-9.
    • (2004) Int J Clin Pract , vol.58 , pp. 297-299
    • Puri, B.K.1    Holmes, J.2    Hamilton, G.3
  • 401
    • 3442892957 scopus 로고    scopus 로고
    • The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus
    • Duffy EM, Meenagh GK, McMillan SA, Strain JJ, Hannigan BM, Bell AL. The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus. J Rheumatol. 2004;31:1551-6.
    • (2004) J Rheumatol , vol.31 , pp. 1551-1556
    • Duffy, E.M.1    Meenagh, G.K.2    McMillan, S.A.3    Strain, J.J.4    Hannigan, B.M.5    Bell, A.L.6
  • 402
    • 0033977185 scopus 로고    scopus 로고
    • n-3 fatty acid supplements in rheumatoid arthritis
    • Kremer JM. n-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr. 2000;71:349S-51S.
    • (2000) Am J Clin Nutr , vol.71 , pp. 349S-351S
    • Kremer, J.M.1
  • 403
    • 84904876004 scopus 로고    scopus 로고
    • Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study
    • Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-75.
    • (2014) J Affect Disord , vol.167 , pp. 368-375
    • Lopresti, A.L.1    Maes, M.2    Maker, G.L.3    Hood, S.D.4    Drummond, P.D.5
  • 404
    • 84867891335 scopus 로고    scopus 로고
    • A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis
    • Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26:1719-25.
    • (2012) Phytother Res , vol.26 , pp. 1719-1725
    • Chandran, B.1    Goel, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.