Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-κB and the generation of reactive oxygen species

Journal of Cellular Biochemistry

Volumn 108, Issue 3, 2009, Pages 716-725

  Ogasawara, Nanako ^a   Oguro, Takashi ^a   Sakabe, Toshitsugu ^a   Matsushima, Miyoko ^a   Takikawa, Osamu ^b   Isobe, Ken Ichi ^c   Nagase, Fumihiko ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marrow derived myeloid dendritic cells; Heme oxygenase 1; Hemoglobin; Indoleamine 2,3 dioxygenase; Inducible nitric oxide synthase; NF B; PI3K; PKC; Reactive oxygen species; Tryptophan

Indexed keywords

ACETYLCYSTEINE; AMITROLE; CATALASE; HEMOGLOBIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2,3 DIOXYGENASE; OXYGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P52; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOSOL; DENDRITIC CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANIMALS; APOPROTEINS; BONE MARROW CELLS; CATTLE; CELL LINE; DENDRITIC CELLS; ENZYME ACTIVATION; ENZYME INDUCTION; HEME; HEMOGLOBINS; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MICE; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES;

EID: 70350140219     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22308     Document Type: Article

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