Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 3, 2009, Pages 467-471

  Ball, Helen J ^a   Yuasa, Hajime J ^a   Austin, Christopher J D ^a   Weiser, Silvia ^a   Hunt, Nicholas H ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Gene duplication; Indoleamine 2,3 dioxygenase; Kynurenine pathway; Tryptophan metabolism

Indexed keywords

ENZYME; INDOLEAMINE 2,3 DIOXYGENASE 1; INDOLEAMINE 2,3 DIOXYGENASE 2; KYNURENINE; MESSENGER RNA; TRYPTOPHAN; UNCLASSIFIED DRUG;

CELLULAR IMMUNITY; ENZYME ACTIVITY; HUMAN; IMMUNE RESPONSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SHORT SURVEY; TRYPTOPHAN METABOLISM;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KIDNEY; KYNURENINE; LIVER; MALE; MICE; REPRODUCTION; SUBSTRATE SPECIFICITY; TRYPTOPHAN; TRYPTOPHAN OXYGENASE;

MURINAE;

EID: 58149308592     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.01.005     Document Type: Short Survey

References (14)

1. Baban B., Chandler P., McCool D., Marshall B., Munn D.H., and Mellor A.L. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J. Reprod. Immunol. 61 2 (2004) 67-77
2. Ball H.J., Sanchez-Perez A., Weiser S., Austin C.J., Astelbauer F., Miu J., et al. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 396 1 (2007) 203-213
3. Hansen A.M., Ball H.J., Mitchell A.J., Miu J., Takikawa O., and Hunt N.H. Increased expression of indoleamine 2,3-dioxygenase in murine malaria infection is predominantly localised to the vascular endothelium. Int. J. Parasitol. 34 12 (2004) 1309-1319
4. Heyes M.P., Rubinow D., Lane C., and Markey S.P. Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome. Ann. Neurol. 26 2 (1989) 275-277
5. Hou D.Y., Muller A.J., Sharma M.D., DuHadaway J., Banerjee T., Johnson M., et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res. 67 2 (2007) 792-801
6. MacKenzie C.R., Heseler K., Muller A., and Daubener W. Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines. Curr. Drug Metab. 8 3 (2007) 237-244
7. Metz R., Duhadaway J.B., Kamasani U., Laury-Kleintop L., Muller A.J., and Prendergast G.C. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 67 15 (2007) 7082-7087
8. Munn D.H., Zhou M., Attwood J.T., Bondarev I., Conway S.J., Marshall B., et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281 5380 (1998) 1191-1193
9. Munn D.H., Sharma M.D., Hou D., Baban B., Lee J.R., Antonia S.J., et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114 2 (2004) 280-290
10. Murray M.F. The human indoleamine 2,3-dioxygenase gene and related human genes. Curr. Drug Metab. 8 3 (2007) 197-200
11. Perkins M.N., and Stone T.W. Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system. J. Pharmacol. Exp. Ther. 226 2 (1983) 551-557
12. Sanni L.A., Thomas S.R., Tattam B.N., Moore D.E., Chaudhri G., Stocker R., et al. Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria. Am. J. Pathol. 152 2 (1998) 611-619
13. Takikawa O., Kuroiwa T., Yamazaki F., and Kido R. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. J. Biol. Chem. 263 4 (1988) 2041-2048
14. Yuasa H.J., Takubo M., Takahashi A., Hasegawa T., Noma H., and Suzuki T. Evolution of vertebrate indoelamine 2,3-dioxygenases. J. Mol. Evol. 65 6 (2007) 705-714