메뉴 건너뛰기




Volumn 121, Issue 1, 2008, Pages 1-6

IDO: A double-edged sword for TH1/TH2 regulation

Author keywords

Dendritic cells; Immune diseases; Immune regulation; T cells; Tryptophan

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE;

EID: 54049133593     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2008.08.008     Document Type: Review
Times cited : (108)

References (70)
  • 1
    • 0036690151 scopus 로고    scopus 로고
    • Endogenous kynurenines as targets for drug discovery and development
    • Stone T.W., and Darlington L.G. Endogenous kynurenines as targets for drug discovery and development. Nat Rev Drug Discov 1 (2002) 609-620
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 609-620
    • Stone, T.W.1    Darlington, L.G.2
  • 2
    • 5044220930 scopus 로고    scopus 로고
    • IDO expression by dendritic cells: tolerance and tryptophan catabolism
    • Mellor A.L., and Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 4 (2004) 762-774
    • (2004) Nat Rev Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 3
    • 33745819629 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses
    • Beutelspacher S.C., Tan P.H., McClure M.O., Larkin D.F., Lechler R.I., and George A.J. Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses. Am J Transplant 6 (2006) 1320-1330
    • (2006) Am J Transplant , vol.6 , pp. 1320-1330
    • Beutelspacher, S.C.1    Tan, P.H.2    McClure, M.O.3    Larkin, D.F.4    Lechler, R.I.5    George, A.J.6
  • 4
    • 8444253637 scopus 로고    scopus 로고
    • Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase
    • Odemuyiwa S.O., Ghahary A., Li Y., Puttagunta L., Lee J.E., Musat-Marcu S., et al. Cutting edge: human eosinophils regulate T cell subset selection through indoleamine 2,3-dioxygenase. J Immunol 173 (2004) 5909-5913
    • (2004) J Immunol , vol.173 , pp. 5909-5913
    • Odemuyiwa, S.O.1    Ghahary, A.2    Li, Y.3    Puttagunta, L.4    Lee, J.E.5    Musat-Marcu, S.6
  • 5
    • 0842286646 scopus 로고    scopus 로고
    • IDO and tolerance to tumors
    • Munn D.H., and Mellor A.L. IDO and tolerance to tumors. Trends Mol Med 10 (2004) 15-18
    • (2004) Trends Mol Med , vol.10 , pp. 15-18
    • Munn, D.H.1    Mellor, A.L.2
  • 6
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C., Pilotte L., Theate I., Stroobant V., Colau D., Parmentier N., et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 9 (2003) 1269-1274
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3    Stroobant, V.4    Colau, D.5    Parmentier, N.6
  • 7
    • 33746912362 scopus 로고    scopus 로고
    • 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity
    • Agaugue S., Perrin-Cocon L., Coutant F., Andre P., and Lotteau V. 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol 177 (2006) 2061-2071
    • (2006) J Immunol , vol.177 , pp. 2061-2071
    • Agaugue, S.1    Perrin-Cocon, L.2    Coutant, F.3    Andre, P.4    Lotteau, V.5
  • 8
    • 33644649659 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation
    • Munn D.H. Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation. Curr Opin Immunol 18 (2006) 220-225
    • (2006) Curr Opin Immunol , vol.18 , pp. 220-225
    • Munn, D.H.1
  • 9
    • 36549073623 scopus 로고    scopus 로고
    • Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
    • Puccetti P., and Fallarino F. Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism. Blood Cells Mol Dis 40 (2008) 101-105
    • (2008) Blood Cells Mol Dis , vol.40 , pp. 101-105
    • Puccetti, P.1    Fallarino, F.2
  • 10
    • 37549061827 scopus 로고    scopus 로고
    • Creating immune privilege: active local suppression that benefits friends, but protects foes
    • Mellor A.L., and Munn D.H. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol 8 (2008) 74-80
    • (2008) Nat Rev Immunol , vol.8 , pp. 74-80
    • Mellor, A.L.1    Munn, D.H.2
  • 11
    • 34547884318 scopus 로고    scopus 로고
    • Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells
    • Terness P., Kallikourdis M., Betz A.G., Rabinovich G.A., Saito S., and Clark D.A. Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells. Am J Reprod Immunol 58 (2007) 238-254
    • (2007) Am J Reprod Immunol , vol.58 , pp. 238-254
    • Terness, P.1    Kallikourdis, M.2    Betz, A.G.3    Rabinovich, G.A.4    Saito, S.5    Clark, D.A.6
  • 12
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • Katz J.B., Muller A.J., and Prendergast G.C. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev 222 (2008) 206-221
    • (2008) Immunol Rev , vol.222 , pp. 206-221
    • Katz, J.B.1    Muller, A.J.2    Prendergast, G.C.3
  • 13
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn D.H., and Mellor A.L. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J Clin Invest 117 (2007) 1147-1154
    • (2007) J Clin Invest , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 14
    • 34748835898 scopus 로고    scopus 로고
    • IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    • Puccetti P., and Grohmann U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol 7 (2007) 817-823
    • (2007) Nat Rev Immunol , vol.7 , pp. 817-823
    • Puccetti, P.1    Grohmann, U.2
  • 15
    • 32344435015 scopus 로고    scopus 로고
    • The immunoregulatory role of IDO-producing human dendritic cells revisited
    • Terness P., Chuang J.J., and Opelz G. The immunoregulatory role of IDO-producing human dendritic cells revisited. Trends Immunol 27 (2006) 68-73
    • (2006) Trends Immunol , vol.27 , pp. 68-73
    • Terness, P.1    Chuang, J.J.2    Opelz, G.3
  • 16
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells
    • Fallarino F., Grohmann U., You S., McGrath B.C., Cavener D.R., Vacca C., et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor ζ-chain and induce a regulatory phenotype in naive T cells. J Immunol 176 (2006) 6752-6761
    • (2006) J Immunol , vol.176 , pp. 6752-6761
    • Fallarino, F.1    Grohmann, U.2    You, S.3    McGrath, B.C.4    Cavener, D.R.5    Vacca, C.6
  • 17
    • 34247202224 scopus 로고    scopus 로고
    • Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines
    • MacKenzie C.R., Heseler K., Muller A., and Daubener W. Role of indoleamine 2,3-dioxygenase in antimicrobial defence and immuno-regulation: tryptophan depletion versus production of toxic kynurenines. Curr Drug Metab 8 (2007) 237-244
    • (2007) Curr Drug Metab , vol.8 , pp. 237-244
    • MacKenzie, C.R.1    Heseler, K.2    Muller, A.3    Daubener, W.4
  • 18
    • 33747119866 scopus 로고    scopus 로고
    • 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms
    • Choi B.K., Asai T., Vinay D.S., Kim Y.H., and Kwon B.S. 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. Cytokine 34 (2006) 233-242
    • (2006) Cytokine , vol.34 , pp. 233-242
    • Choi, B.K.1    Asai, T.2    Vinay, D.S.3    Kim, Y.H.4    Kwon, B.S.5
  • 19
    • 0345490963 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice
    • Gurtner G.J., Newberry R.D., Schloemann S.R., McDonald K.G., and Stenson W.F. Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice. Gastroenterology 125 (2003) 1762-1773
    • (2003) Gastroenterology , vol.125 , pp. 1762-1773
    • Gurtner, G.J.1    Newberry, R.D.2    Schloemann, S.R.3    McDonald, K.G.4    Stenson, W.F.5
  • 20
    • 27644587079 scopus 로고    scopus 로고
    • Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite
    • Platten M., Ho P.P., Youssef S., Fontoura P., Garren H., Hur E.M., et al. Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science 310 (2005) 850-855
    • (2005) Science , vol.310 , pp. 850-855
    • Platten, M.1    Ho, P.P.2    Youssef, S.3    Fontoura, P.4    Garren, H.5    Hur, E.M.6
  • 21
    • 33645499663 scopus 로고    scopus 로고
    • Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    • Orabona C., Puccetti P., Vacca C., Bicciato S., Luchini A., Fallarino F., et al. Toward the identification of a tolerogenic signature in IDO-competent dendritic cells. Blood 107 (2006) 2846-2854
    • (2006) Blood , vol.107 , pp. 2846-2854
    • Orabona, C.1    Puccetti, P.2    Vacca, C.3    Bicciato, S.4    Luchini, A.5    Fallarino, F.6
  • 23
    • 23444449846 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation
    • Kwidzinski E., Bunse J., Aktas O., Richter D., Mutlu L., Zipp F., et al. Indoleamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J 19 (2005) 1347-1349
    • (2005) FASEB J , vol.19 , pp. 1347-1349
    • Kwidzinski, E.1    Bunse, J.2    Aktas, O.3    Richter, D.4    Mutlu, L.5    Zipp, F.6
  • 24
    • 0037815119 scopus 로고    scopus 로고
    • A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice
    • Grohmann U., Fallarino F., Bianchi R., Orabona C., Vacca C., Fioretti M.C., et al. A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J Exp Med 198 (2003) 153-160
    • (2003) J Exp Med , vol.198 , pp. 153-160
    • Grohmann, U.1    Fallarino, F.2    Bianchi, R.3    Orabona, C.4    Vacca, C.5    Fioretti, M.C.6
  • 25
    • 38449111402 scopus 로고    scopus 로고
    • The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse
    • Saxena V., Ondr J.K., Magnusen A.F., Munn D.H., and Katz J.D. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179 (2007) 5041-5053
    • (2007) J Immunol , vol.179 , pp. 5041-5053
    • Saxena, V.1    Ondr, J.K.2    Magnusen, A.F.3    Munn, D.H.4    Katz, J.D.5
  • 26
    • 34249695524 scopus 로고    scopus 로고
    • Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes
    • Ueno A., Cho S., Cheng L., Wang J., Hou S., Nakano H., et al. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56 (2007) 1686-1693
    • (2007) Diabetes , vol.56 , pp. 1686-1693
    • Ueno, A.1    Cho, S.2    Cheng, L.3    Wang, J.4    Hou, S.5    Nakano, H.6
  • 27
    • 38049115134 scopus 로고    scopus 로고
    • Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    • Romani L., Fallarino F., De Luca A., Montagnoli C., D'Angelo C., Zelante T., et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature 451 (2008) 211-215
    • (2008) Nature , vol.451 , pp. 211-215
    • Romani, L.1    Fallarino, F.2    De Luca, A.3    Montagnoli, C.4    D'Angelo, C.5    Zelante, T.6
  • 29
    • 24944455211 scopus 로고    scopus 로고
    • Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans
    • Clark D.A., Blois S., Kandil J., Handjiski B., Manuel J., and Arck P.C. Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. Am J Reprod Immunol 54 (2005) 203-216
    • (2005) Am J Reprod Immunol , vol.54 , pp. 203-216
    • Clark, D.A.1    Blois, S.2    Kandil, J.3    Handjiski, B.4    Manuel, J.5    Arck, P.C.6
  • 30
    • 40649121252 scopus 로고    scopus 로고
    • Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase
    • Molano A., Illarionov P.A., Besra G.S., Putterman C., and Porcelli S.A. Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase. Immunol Lett 117 (2008) 81-90
    • (2008) Immunol Lett , vol.117 , pp. 81-90
    • Molano, A.1    Illarionov, P.A.2    Besra, G.S.3    Putterman, C.4    Porcelli, S.A.5
  • 31
    • 44349184791 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
    • Xu H., Oriss T.B., Fei M., Henry A.C., Melgert B.N., Chen L., et al. Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation. Proc Natl Acad Sci USA 105 (2008) 6690-6695
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6690-6695
    • Xu, H.1    Oriss, T.B.2    Fei, M.3    Henry, A.C.4    Melgert, B.N.5    Chen, L.6
  • 32
    • 33751193093 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation
    • Chen X., Liu L., Yang P., Wu C., Jin H., Xing L., et al. Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation. Immunol Lett 107 (2006) 140-147
    • (2006) Immunol Lett , vol.107 , pp. 140-147
    • Chen, X.1    Liu, L.2    Yang, P.3    Wu, C.4    Jin, H.5    Xing, L.6
  • 34
    • 33749490571 scopus 로고    scopus 로고
    • Innate immune recognition of, and regulation by DNA
    • Ishii K.J., and Akira S. Innate immune recognition of, and regulation by DNA. Trends Immunol 27 (2006) 525-532
    • (2006) Trends Immunol , vol.27 , pp. 525-532
    • Ishii, K.J.1    Akira, S.2
  • 35
    • 0033397575 scopus 로고    scopus 로고
    • Effects of CpG DNA on Th1/Th2 balance in asthma
    • Kline J.N. Effects of CpG DNA on Th1/Th2 balance in asthma. Curr Top Microbiol Immunol 247 (2000) 211-225
    • (2000) Curr Top Microbiol Immunol , vol.247 , pp. 211-225
    • Kline, J.N.1
  • 36
    • 22544462499 scopus 로고    scopus 로고
    • -, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma
    • -, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma. J Immunol 175 (2005) 1516-1522
    • (2005) J Immunol , vol.175 , pp. 1516-1522
    • Gordon, J.R.1    Li, F.2    Nayyar, A.3    Xiang, J.4    Zhang, X.5
  • 37
    • 15244349785 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells in immunity
    • Colonna M., Trinchieri G., and Liu Y.J. Plasmacytoid dendritic cells in immunity. Nat Immunol 5 (2004) 1219-1226
    • (2004) Nat Immunol , vol.5 , pp. 1219-1226
    • Colonna, M.1    Trinchieri, G.2    Liu, Y.J.3
  • 38
    • 34249741135 scopus 로고    scopus 로고
    • On watching the watchers: IDO and type I/II IFN
    • Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol 37 (2007) 876-879
    • (2007) Eur J Immunol , vol.37 , pp. 876-879
    • Puccetti, P.1
  • 39
    • 1242319376 scopus 로고    scopus 로고
    • Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections
    • Adams O., Besken K., Oberdorfer C., MacKenzie C.R., Takikawa O., and Daubener W. Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections. J Virol 78 (2004) 2632-2636
    • (2004) J Virol , vol.78 , pp. 2632-2636
    • Adams, O.1    Besken, K.2    Oberdorfer, C.3    MacKenzie, C.R.4    Takikawa, O.5    Daubener, W.6
  • 40
    • 0025944659 scopus 로고
    • Relationship between interferon-γ, indoleamine 2,3-dioxygenase, and tryptophan catabolism
    • Taylor M.W., and Feng G.S. Relationship between interferon-γ, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 5 (1991) 2516-2522
    • (1991) FASEB J , vol.5 , pp. 2516-2522
    • Taylor, M.W.1    Feng, G.S.2
  • 42
    • 0242366613 scopus 로고    scopus 로고
    • In vivo role of IFN-γ produced by antigen-presenting cells in early host defense against intracellular pathogens
    • Suzue K., Asai T., Takeuchi T., and Koyasu S. In vivo role of IFN-γ produced by antigen-presenting cells in early host defense against intracellular pathogens. Eur J Immunol 33 (2003) 2666-2675
    • (2003) Eur J Immunol , vol.33 , pp. 2666-2675
    • Suzue, K.1    Asai, T.2    Takeuchi, T.3    Koyasu, S.4
  • 43
    • 33645986483 scopus 로고    scopus 로고
    • Mycobacteria induce IFN-γ production in human dendritic cells via triggering of TLR2
    • Fricke I., Mitchell D., Mittelstadt J., Lehan N., Heine H., Goldmann T., et al. Mycobacteria induce IFN-γ production in human dendritic cells via triggering of TLR2. J Immunol 176 (2006) 5173-5182
    • (2006) J Immunol , vol.176 , pp. 5173-5182
    • Fricke, I.1    Mitchell, D.2    Mittelstadt, J.3    Lehan, N.4    Heine, H.5    Goldmann, T.6
  • 44
    • 3042545974 scopus 로고    scopus 로고
    • The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
    • Fujii S., Liu K., Smith C., Bonito A.J., and Steinman R.M. The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 199 (2004) 1607-1618
    • (2004) J Exp Med , vol.199 , pp. 1607-1618
    • Fujii, S.1    Liu, K.2    Smith, C.3    Bonito, A.J.4    Steinman, R.M.5
  • 45
    • 0035879313 scopus 로고    scopus 로고
    • IL-12/IL-18-dependent IFN-γ release by murine dendritic cells
    • Stober D., Schirmbeck R., and Reimann J. IL-12/IL-18-dependent IFN-γ release by murine dendritic cells. J Immunol 167 (2001) 957-965
    • (2001) J Immunol , vol.167 , pp. 957-965
    • Stober, D.1    Schirmbeck, R.2    Reimann, J.3
  • 46
    • 0031918989 scopus 로고    scopus 로고
    • Immunobiology of interleukin-12
    • Trinchieri G. Immunobiology of interleukin-12. Immunol Res 17 (1998) 269-278
    • (1998) Immunol Res , vol.17 , pp. 269-278
    • Trinchieri, G.1
  • 47
    • 9644295708 scopus 로고    scopus 로고
    • Issues in T-helper 1 development-resolved and unresolved
    • Berenson L.S., Ota N., and Murphy K.M. Issues in T-helper 1 development-resolved and unresolved. Immunol Rev 202 (2004) 157-174
    • (2004) Immunol Rev , vol.202 , pp. 157-174
    • Berenson, L.S.1    Ota, N.2    Murphy, K.M.3
  • 50
    • 34848915783 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
    • Sharma M.D., Baban B., Chandler P., Hou D.Y., Singh N., Yagita H., et al. Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. J Clin Invest 117 (2007) 2570-2582
    • (2007) J Clin Invest , vol.117 , pp. 2570-2582
    • Sharma, M.D.1    Baban, B.2    Chandler, P.3    Hou, D.Y.4    Singh, N.5    Yagita, H.6
  • 51
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • Munn D.H., Sharma M.D., Baban B., Harding H.P., Zhang Y., Ron D., et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 22 (2005) 633-642
    • (2005) Immunity , vol.22 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6
  • 52
    • 35748940007 scopus 로고    scopus 로고
    • Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1
    • Derks R.A., Jankowska-Gan E., Xu Q., and Burlingham W.J. Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1. J Immunol 179 (2007) 3443-3451
    • (2007) J Immunol , vol.179 , pp. 3443-3451
    • Derks, R.A.1    Jankowska-Gan, E.2    Xu, Q.3    Burlingham, W.J.4
  • 53
    • 27744482605 scopus 로고    scopus 로고
    • Maturation of function in dendritic cells for tolerance and immunity
    • Quah B.J., and O'Neill H.C. Maturation of function in dendritic cells for tolerance and immunity. J Cell Mol Med 9 (2005) 643-654
    • (2005) J Cell Mol Med , vol.9 , pp. 643-654
    • Quah, B.J.1    O'Neill, H.C.2
  • 54
    • 27844576217 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines
    • Hwang S.L., Chung N.P., Chan J.K., and Lin C.L. Indoleamine 2,3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines. Cell Res 15 (2005) 167-175
    • (2005) Cell Res , vol.15 , pp. 167-175
    • Hwang, S.L.1    Chung, N.P.2    Chan, J.K.3    Lin, C.L.4
  • 55
    • 0042591467 scopus 로고    scopus 로고
    • Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion
    • Mellor A.L., Baban B., Chandler P., Marshall B., Jhaver K., Hansen A., et al. Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 171 (2003) 1652-1655
    • (2003) J Immunol , vol.171 , pp. 1652-1655
    • Mellor, A.L.1    Baban, B.2    Chandler, P.3    Marshall, B.4    Jhaver, K.5    Hansen, A.6
  • 56
    • 0042930935 scopus 로고    scopus 로고
    • Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation
    • Grohmann U., Bianchi R., Orabona C., Fallarino F., Vacca C., Micheletti A., et al. Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation. J Immunol 171 (2003) 2581-2587
    • (2003) J Immunol , vol.171 , pp. 2581-2587
    • Grohmann, U.1    Bianchi, R.2    Orabona, C.3    Fallarino, F.4    Vacca, C.5    Micheletti, A.6
  • 57
    • 33745304367 scopus 로고    scopus 로고
    • Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO
    • Belladonna M.L., Grohmann U., Guidetti P., Volpi C., Bianchi R., Fioretti M.C., et al. Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. J Immunol 177 (2006) 130-137
    • (2006) J Immunol , vol.177 , pp. 130-137
    • Belladonna, M.L.1    Grohmann, U.2    Guidetti, P.3    Volpi, C.4    Bianchi, R.5    Fioretti, M.C.6
  • 58
    • 36749044869 scopus 로고    scopus 로고
    • 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
    • Hayashi T., Mo J.H., Gong X., Rossetto C., Jang A., Beck L., et al. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci USA 104 (2007) 18619-18624
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18619-18624
    • Hayashi, T.1    Mo, J.H.2    Gong, X.3    Rossetto, C.4    Jang, A.5    Beck, L.6
  • 59
    • 0036341332 scopus 로고    scopus 로고
    • Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis
    • Sakurai K., Zou J.P., Tschetter J.R., Ward J.M., and Shearer G.M. Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. J Neuroimmunol 129 (2002) 186-196
    • (2002) J Neuroimmunol , vol.129 , pp. 186-196
    • Sakurai, K.1    Zou, J.P.2    Tschetter, J.R.3    Ward, J.M.4    Shearer, G.M.5
  • 60
    • 0035995944 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes
    • Alexander A.M., Crawford M., Bertera S., Rudert W.A., Takikawa O., Robbins P.D., et al. Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 51 (2002) 356-365
    • (2002) Diabetes , vol.51 , pp. 356-365
    • Alexander, A.M.1    Crawford, M.2    Bertera, S.3    Rudert, W.A.4    Takikawa, O.5    Robbins, P.D.6
  • 61
    • 19744361967 scopus 로고    scopus 로고
    • Inhibition of allogeneic T-cell responses by dendritic cells expressing transduced indoleamine 2,3-dioxygenase
    • Funeshima N., Fujino M., Kitazawa Y., Hara Y., Hara Y., Hayakawa K., et al. Inhibition of allogeneic T-cell responses by dendritic cells expressing transduced indoleamine 2,3-dioxygenase. J Gene Med 7 (2005) 565-575
    • (2005) J Gene Med , vol.7 , pp. 565-575
    • Funeshima, N.1    Fujino, M.2    Kitazawa, Y.3    Hara, Y.4    Hara, Y.5    Hayakawa, K.6
  • 63
    • 0037090313 scopus 로고    scopus 로고
    • Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
    • Mellor A.L., Keskin D.B., Johnson T., Chandler P., and Munn D.H. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol 168 (2002) 3771-3776
    • (2002) J Immunol , vol.168 , pp. 3771-3776
    • Mellor, A.L.1    Keskin, D.B.2    Johnson, T.3    Chandler, P.4    Munn, D.H.5
  • 64
    • 33745622659 scopus 로고    scopus 로고
    • CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition
    • von Bergwelt-Baildon M.S., Popov A., Saric T., Chemnitz J., Classen S., Stoffel M.S., et al. CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition. Blood 108 (2006) 228-237
    • (2006) Blood , vol.108 , pp. 228-237
    • von Bergwelt-Baildon, M.S.1    Popov, A.2    Saric, T.3    Chemnitz, J.4    Classen, S.5    Stoffel, M.S.6
  • 65
    • 0037136328 scopus 로고    scopus 로고
    • Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
    • Frumento G., Rotondo R., Tonetti M., Damonte G., Benatti U., and Ferrara G.B. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med 196 (2002) 459-468
    • (2002) J Exp Med , vol.196 , pp. 459-468
    • Frumento, G.1    Rotondo, R.2    Tonetti, M.3    Damonte, G.4    Benatti, U.5    Ferrara, G.B.6
  • 67
    • 42449097698 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
    • Jasperson L.K., Bucher C., Panoskaltsis-Mortari A., Taylor P.A., Mellor A.L., Munn D.H., et al. Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality. Blood 111 (2008) 3257-3265
    • (2008) Blood , vol.111 , pp. 3257-3265
    • Jasperson, L.K.1    Bucher, C.2    Panoskaltsis-Mortari, A.3    Taylor, P.A.4    Mellor, A.L.5    Munn, D.H.6
  • 68
    • 46749144173 scopus 로고    scopus 로고
    • Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice
    • Reddy P., Sun Y., Toubai T., Duran-Struuck R., Clouthier S.G., Weisiger E., et al. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest 118 (2008) 2562-2573
    • (2008) J Clin Invest , vol.118 , pp. 2562-2573
    • Reddy, P.1    Sun, Y.2    Toubai, T.3    Duran-Struuck, R.4    Clouthier, S.G.5    Weisiger, E.6
  • 69
    • 31144456173 scopus 로고    scopus 로고
    • Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism
    • Montagnoli C., Fallarino F., Gaziano R., Bozza S., Bellocchio S., Zelante T., et al. Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol 176 (2006) 1712-1723
    • (2006) J Immunol , vol.176 , pp. 1712-1723
    • Montagnoli, C.1    Fallarino, F.2    Gaziano, R.3    Bozza, S.4    Bellocchio, S.5    Zelante, T.6
  • 70
    • 34249725559 scopus 로고    scopus 로고
    • Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
    • Grohmann U., Volpi C., Fallarino F., Bozza S., Bianchi R., Vacca C., et al. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med 13 (2007) 579-586
    • (2007) Nat Med , vol.13 , pp. 579-586
    • Grohmann, U.1    Volpi, C.2    Fallarino, F.3    Bozza, S.4    Bianchi, R.5    Vacca, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.