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Volumn 89, Issue , 2016, Pages 126-136

Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances

Author keywords

Cas9; CRISPR; Hansenula polymorpha; Kluyveromyces lactis; Pichia pastoris; Synthetic biology; Yarrowia lipolytica; Yeast

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; CRISPR ASSOCIATED PROTEIN; FOOD ADDITIVE; GENOMIC DNA; RECOMBINASE; ZINC FINGER NUCLEASE;

EID: 84960124110     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2015.12.001     Document Type: Article
Times cited : (179)

References (179)
  • 1
    • 0023392267 scopus 로고
    • A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
    • Alani E., et al. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics 1987, 116:541-545.
    • (1987) Genetics , vol.116 , pp. 541-545
    • Alani, E.1
  • 2
    • 0029278832 scopus 로고
    • Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome
    • Albert H., et al. Site-specific integration of DNA into wild-type and mutant lox sites placed in the plant genome. Plant J. 1995, 7:649-659.
    • (1995) Plant J. , vol.7 , pp. 649-659
    • Albert, H.1
  • 3
    • 70349281876 scopus 로고    scopus 로고
    • Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?
    • Alper H., Stephanopoulos G. Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?. Nat. Rev. Microbiol. 2009, 7:715-723.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 715-723
    • Alper, H.1    Stephanopoulos, G.2
  • 4
    • 24644515752 scopus 로고    scopus 로고
    • Tuning genetic control through promoter engineering
    • Alper H., et al. Tuning genetic control through promoter engineering. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:12678-12683.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 12678-12683
    • Alper, H.1
  • 5
    • 33745454125 scopus 로고    scopus 로고
    • Synthetic biology: new engineering rules for an emerging discipline
    • Andrianantoandro E., et al. Synthetic biology: new engineering rules for an emerging discipline. Mol. Syst. Biol. 2006, 2(2006).
    • (2006) Mol. Syst. Biol. , vol.2 , Issue.2006
    • Andrianantoandro, E.1
  • 6
    • 3042559648 scopus 로고    scopus 로고
    • Mutant loxP vectors for selectable marker recycle and conditional knock-outs
    • Arakawa H., et al. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol. 2001, 1:7.
    • (2001) BMC Biotechnol. , vol.1 , pp. 7
    • Arakawa, H.1
  • 7
    • 84929572600 scopus 로고    scopus 로고
    • Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae
    • Bao Z., et al. Homology-integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth. Biol. 2015, 4:585-594.
    • (2015) ACS Synth. Biol. , vol.4 , pp. 585-594
    • Bao, Z.1
  • 9
    • 0027237665 scopus 로고
    • A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae
    • Baudin A., et al. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res. 1993, 21:3329-3330.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 3329-3330
    • Baudin, A.1
  • 10
    • 84938872453 scopus 로고    scopus 로고
    • Polycistronic expression of a beta-carotene biosynthetic pathway in Saccharomyces cerevisiae coupled to beta-ionone production
    • Beekwilder J., et al. Polycistronic expression of a beta-carotene biosynthetic pathway in Saccharomyces cerevisiae coupled to beta-ionone production. J. Biotechnol. 2014, 192 Pt B:383-392.
    • (2014) J. Biotechnol. , vol.192 , pp. 383-392
    • Beekwilder, J.1
  • 11
    • 0025122333 scopus 로고
    • Signal-mediated import of bacteriophage T7 RNA polymerase into the Saccharomyces cerevisiae nucleus and specific transcription of target genes
    • Benton B.M., et al. Signal-mediated import of bacteriophage T7 RNA polymerase into the Saccharomyces cerevisiae nucleus and specific transcription of target genes. Mol. Cell. Biol. 1990, 10:353-360.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 353-360
    • Benton, B.M.1
  • 12
    • 84879383647 scopus 로고    scopus 로고
    • Combinatorial mutagenesis and selection to understand and improve yeast promoters
    • Berg L., et al. Combinatorial mutagenesis and selection to understand and improve yeast promoters. BioMed Res. Int. 2013, 2013:e926985.
    • (2013) BioMed Res. Int. , vol.2013 , pp. e926985
    • Berg, L.1
  • 13
    • 0000007230 scopus 로고
    • Transformation of the yeast Kluyveromyces lactis by new vectors derived from the 1.6 μm circular plasmid pKD1
    • Bianchi M.M., et al. Transformation of the yeast Kluyveromyces lactis by new vectors derived from the 1.6 μm circular plasmid pKD1. Curr. Genet. 1987, 12:185-192.
    • (1987) Curr. Genet. , vol.12 , pp. 185-192
    • Bianchi, M.M.1
  • 14
    • 0035656862 scopus 로고    scopus 로고
    • Efficient homolactic fermentation by Kluyveromyces lactis strains defective in pyruvate utilization and transformed with the heterologous LDH gene
    • Bianchi M.M., et al. Efficient homolactic fermentation by Kluyveromyces lactis strains defective in pyruvate utilization and transformed with the heterologous LDH gene. Appl. Environ. Microbiol. 2001, 67:5621-5625.
    • (2001) Appl. Environ. Microbiol. , vol.67 , pp. 5621-5625
    • Bianchi, M.M.1
  • 15
    • 0028012040 scopus 로고
    • Two upstream activation sequences control the expression of the XPR2 gene in the yeast Yarrowia lipolytica
    • Blanchin-Roland S., et al. Two upstream activation sequences control the expression of the XPR2 gene in the yeast Yarrowia lipolytica. Mol. Cell. Biol. 1994, 14:327-338.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 327-338
    • Blanchin-Roland, S.1
  • 16
    • 83055177124 scopus 로고    scopus 로고
    • Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach
    • Blazeck J., et al. Tuning gene expression in Yarrowia lipolytica by a hybrid promoter approach. Appl. Environ. Microbiol. 2011, 77:7905-7914.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 7905-7914
    • Blazeck, J.1
  • 17
    • 84866744379 scopus 로고    scopus 로고
    • Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters
    • Blazeck J., et al. Controlling promoter strength and regulation in Saccharomyces cerevisiae using synthetic hybrid promoters. Biotechnol. Bioeng. 2012, 109:2884-2895.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 2884-2895
    • Blazeck, J.1
  • 18
    • 84876680533 scopus 로고    scopus 로고
    • Generalizing a hybrid synthetic promoter approach in Yarrowia lipolytica
    • Blazeck J., et al. Generalizing a hybrid synthetic promoter approach in Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2012, 97:3037-3052.
    • (2012) Appl. Microbiol. Biotechnol. , vol.97 , pp. 3037-3052
    • Blazeck, J.1
  • 19
    • 84892840633 scopus 로고    scopus 로고
    • Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production
    • Blazeck J., et al. Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production. Nat. Commun. 2014, 5:3131.
    • (2014) Nat. Commun. , vol.5 , pp. 3131
    • Blazeck, J.1
  • 20
    • 84863634266 scopus 로고    scopus 로고
    • Construction of synthetic regulatory networks in yeast
    • Blount B.A., et al. Construction of synthetic regulatory networks in yeast. FEBS Lett. 2012, 586:2112-2121.
    • (2012) FEBS Lett. , vol.586 , pp. 2112-2121
    • Blount, B.A.1
  • 21
    • 0028940737 scopus 로고
    • Plasmid reorganization during integrative transformation in Hansenula polymorpha
    • Bogdanova A.I., et al. Plasmid reorganization during integrative transformation in Hansenula polymorpha. Yeast 1995, 11:343-353.
    • (1995) Yeast , vol.11 , pp. 343-353
    • Bogdanova, A.I.1
  • 22
    • 0033402046 scopus 로고    scopus 로고
    • Glycosylation of Pichia pastoris-derived proteins
    • Bretthauer R.K., Castellino F.J. Glycosylation of Pichia pastoris-derived proteins. Biotechnol. Appl. Biochem. 1999, 30(Pt 3):193-200.
    • (1999) Biotechnol. Appl. Biochem. , vol.30 , Issue.Pt 3 , pp. 193-200
    • Bretthauer, R.K.1    Castellino, F.J.2
  • 23
    • 0003998126 scopus 로고    scopus 로고
    • Production of Insulin-like Growth Factor-1 in Methylotrophic Yeast Cells. Google Patents
    • Brierley, R.A. et al., 1997. Production of Insulin-like Growth Factor-1 in Methylotrophic Yeast Cells. Google Patents.
    • (1997)
    • Brierley, R.A.1
  • 24
    • 0018955095 scopus 로고
    • Replication and recombination functions associated with the yeast plasmid, 2μ circle
    • Broach J.R., Hicks J.B. Replication and recombination functions associated with the yeast plasmid, 2μ circle. Cell 1980, 21:501-508.
    • (1980) Cell , vol.21 , pp. 501-508
    • Broach, J.R.1    Hicks, J.B.2
  • 25
    • 15444377148 scopus 로고
    • Yeast systems for the commercial production of heterologous proteins
    • Buckholz R.G., Gleeson M.A. Yeast systems for the commercial production of heterologous proteins. Biotechnology (NY) 1991, 9:1067-1072.
    • (1991) Biotechnology (NY) , vol.9 , pp. 1067-1072
    • Buckholz, R.G.1    Gleeson, M.A.2
  • 26
    • 84899079198 scopus 로고    scopus 로고
    • A brief history of synthetic biology
    • Cameron D.E., et al. A brief history of synthetic biology. Nat. Rev. Microbiol. 2014, 12:381-390.
    • (2014) Nat. Rev. Microbiol. , vol.12 , pp. 381-390
    • Cameron, D.E.1
  • 27
    • 80051535219 scopus 로고    scopus 로고
    • Genome engineering with zinc-finger nucleases
    • Carroll D. Genome engineering with zinc-finger nucleases. Genetics 2011, 188:773-782.
    • (2011) Genetics , vol.188 , pp. 773-782
    • Carroll, D.1
  • 28
    • 0033955337 scopus 로고    scopus 로고
    • Heterologous protein expression in the methylotrophic yeast Pichia pastoris
    • Cereghino J.L., Cregg J.M. Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol. Rev. 2000, 24:45-66.
    • (2000) FEMS Microbiol. Rev. , vol.24 , pp. 45-66
    • Cereghino, J.L.1    Cregg, J.M.2
  • 29
    • 84887618970 scopus 로고    scopus 로고
    • Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks
    • Chen Y., Nielsen J. Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks. Curr. Opin. Biotechnol. 2013, 24:965-972.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 965-972
    • Chen, Y.1    Nielsen, J.2
  • 30
    • 0038142203 scopus 로고    scopus 로고
    • Isolation and characterization of the TRP1 gene from the yeast Yarrowia lipolytica and multiple gene disruption using a TRP blaster
    • Cheon S.A., et al. Isolation and characterization of the TRP1 gene from the yeast Yarrowia lipolytica and multiple gene disruption using a TRP blaster. Yeast 2003, 20:677-685.
    • (2003) Yeast , vol.20 , pp. 677-685
    • Cheon, S.A.1
  • 31
    • 70349921097 scopus 로고    scopus 로고
    • New selectable host-marker systems for multiple genetic manipulations based on TRP1, MET2 and ADE2 in the methylotrophic yeast Hansenula polymorpha
    • Cheon S.A., et al. New selectable host-marker systems for multiple genetic manipulations based on TRP1, MET2 and ADE2 in the methylotrophic yeast Hansenula polymorpha. Yeast 2009, 26:507-521.
    • (2009) Yeast , vol.26 , pp. 507-521
    • Cheon, S.A.1
  • 32
    • 84860353068 scopus 로고    scopus 로고
    • Remodeling of the glycosylation pathway in the methylotrophic yeast Hansenula polymorpha to produce human hybrid-type N-glycans
    • Cheon S.A., et al. Remodeling of the glycosylation pathway in the methylotrophic yeast Hansenula polymorpha to produce human hybrid-type N-glycans. J. Microbiol. 2012, 50:341-348.
    • (2012) J. Microbiol. , vol.50 , pp. 341-348
    • Cheon, S.A.1
  • 33
    • 77955296289 scopus 로고    scopus 로고
    • Ecallantide for the treatment of acute attacks in hereditary angioedema
    • Cicardi M., et al. Ecallantide for the treatment of acute attacks in hereditary angioedema. N. Engl. J. Med. 2010, 363:523-531.
    • (2010) N. Engl. J. Med. , vol.363 , pp. 523-531
    • Cicardi, M.1
  • 34
    • 0019162013 scopus 로고
    • Isolation of a yeast centromere and construction of functional small circular chromosomes
    • Clarke L., Carbon J. Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature 1980, 287:504-509.
    • (1980) Nature , vol.287 , pp. 504-509
    • Clarke, L.1    Carbon, J.2
  • 35
    • 32044463134 scopus 로고    scopus 로고
    • Kluyveromyces lactis LAC4 promoter variants that lack function in bacteria but retain full function in K. lactis
    • Colussi P.A., Taron C.H. Kluyveromyces lactis LAC4 promoter variants that lack function in bacteria but retain full function in K. lactis. Appl. Environ. Microbiol. 2005, 71:7092-7098.
    • (2005) Appl. Environ. Microbiol. , vol.71 , pp. 7092-7098
    • Colussi, P.A.1    Taron, C.H.2
  • 36
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong L., et al. Multiplex genome engineering using CRISPR/Cas systems. Science 2013, 339:819-823.
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 37
    • 0034734850 scopus 로고    scopus 로고
    • Constitutive expression of recombinant proteins in the methylotrophic yeast Hansenula polymorpha using the PMA1 promoter
    • Cox H., et al. Constitutive expression of recombinant proteins in the methylotrophic yeast Hansenula polymorpha using the PMA1 promoter. Yeast 2000, 16:1191-1203.
    • (2000) Yeast , vol.16 , pp. 1191-1203
    • Cox, H.1
  • 38
    • 0022395208 scopus 로고
    • Pichia pastoris as a host system for transformations
    • Cregg J.M., et al. Pichia pastoris as a host system for transformations. Mol. Cell. Biol. 1985, 5:3376-3385.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 3376-3385
    • Cregg, J.M.1
  • 39
    • 84900873278 scopus 로고    scopus 로고
    • Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering
    • Crook N.C., et al. Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering. ACS Synth. Biol. 2014, 3:307-313.
    • (2014) ACS Synth. Biol. , vol.3 , pp. 307-313
    • Crook, N.C.1
  • 40
    • 84881004490 scopus 로고    scopus 로고
    • Use of expression-enhancing terminators in Saccharomyces cerevisiae to increase mRNA half-life and improve gene expression control for metabolic engineering applications
    • Curran K.A., et al. Use of expression-enhancing terminators in Saccharomyces cerevisiae to increase mRNA half-life and improve gene expression control for metabolic engineering applications. Metab. Eng. 2013, 19:88-97.
    • (2013) Metab. Eng. , vol.19 , pp. 88-97
    • Curran, K.A.1
  • 41
    • 84901388705 scopus 로고    scopus 로고
    • Design of synthetic yeast promoters via tuning of nucleosome architecture
    • Curran K.A., et al. Design of synthetic yeast promoters via tuning of nucleosome architecture. Nat. Commun. 2014, 5:4002.
    • (2014) Nat. Commun. , vol.5 , pp. 4002
    • Curran, K.A.1
  • 42
    • 84937125907 scopus 로고    scopus 로고
    • Short synthetic terminators for improved heterologous gene expression in yeast
    • Curran K.A., et al. Short synthetic terminators for improved heterologous gene expression in yeast. ACS Synth. Biol. 2015.
    • (2015) ACS Synth. Biol.
    • Curran, K.A.1
  • 43
    • 0000375573 scopus 로고
    • A high-frequency transformation system for the yeast Kluyveromyces lactis
    • Das S., Hollenberg C.P. A high-frequency transformation system for the yeast Kluyveromyces lactis. Curr. Genet. 1982, 6:123-128.
    • (1982) Curr. Genet. , vol.6 , pp. 123-128
    • Das, S.1    Hollenberg, C.P.2
  • 44
    • 84960422682 scopus 로고
    • Process for Transformation of Yarrowia lipolytica
    • US Patent Application US4880741.
    • Davidow, L., Dezeeuw, J., 1984. Process for Transformation of Yarrowia lipolytica. US Patent Application US4880741.
    • (1984)
    • Davidow, L.1    Dezeeuw, J.2
  • 45
    • 0037501357 scopus 로고    scopus 로고
    • Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide
    • de Felipe P., et al. Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide. J. Biol. Chem. 2003, 278:11441-11448.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11441-11448
    • de Felipe, P.1
  • 46
    • 67149116767 scopus 로고    scopus 로고
    • Genome sequence of the recombinant protein production host Pichia pastoris
    • De Schutter K., et al. Genome sequence of the recombinant protein production host Pichia pastoris. Nat. Biotechnol. 2009, 27:561-566.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 561-566
    • De Schutter, K.1
  • 47
    • 84876575031 scopus 로고    scopus 로고
    • Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems
    • DiCarlo J.E., et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Res. 2013.
    • (2013) Nucleic Acids Res.
    • DiCarlo, J.E.1
  • 48
    • 0024329783 scopus 로고
    • The lactose-galactose regulon of Kluyveromyces lactis
    • Dickson R.C., Riley M.I. The lactose-galactose regulon of Kluyveromyces lactis. Biotechnology 1989, 13:19-40.
    • (1989) Biotechnology , vol.13 , pp. 19-40
    • Dickson, R.C.1    Riley, M.I.2
  • 49
    • 0019832964 scopus 로고
    • Genetic regulation: yeast mutants constitutive for beta-galactosidase activity have an increased level of beta-galactosidase messenger ribonucleic acid
    • Dickson R.C., et al. Genetic regulation: yeast mutants constitutive for beta-galactosidase activity have an increased level of beta-galactosidase messenger ribonucleic acid. Mol. Cell. Biol. 1981, 1:1048-1056.
    • (1981) Mol. Cell. Biol. , vol.1 , pp. 1048-1056
    • Dickson, R.C.1
  • 50
    • 84892451538 scopus 로고    scopus 로고
    • Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress
    • Dijkstra A.R., et al. Diversity in robustness of Lactococcus lactis strains during heat stress, oxidative stress, and spray drying stress. Appl. Environ. Microbiol. 2014, 80:603-611.
    • (2014) Appl. Environ. Microbiol. , vol.80 , pp. 603-611
    • Dijkstra, A.R.1
  • 51
    • 0032081572 scopus 로고    scopus 로고
    • Non-conventional yeasts as hosts for heterologous protein production
    • Dominguez A., et al. Non-conventional yeasts as hosts for heterologous protein production. Int. Microbiol. 1998, 1:131-142.
    • (1998) Int. Microbiol. , vol.1 , pp. 131-142
    • Dominguez, A.1
  • 52
    • 78650912707 scopus 로고    scopus 로고
    • Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
    • Doyon Y., et al. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat. Methods 2011, 8:74-79.
    • (2011) Nat. Methods , vol.8 , pp. 74-79
    • Doyon, Y.1
  • 53
    • 70350510820 scopus 로고    scopus 로고
    • RNAi in budding yeast
    • Drinnenberg I.A., et al. RNAi in budding yeast. Science 2009, 326:544-550.
    • (2009) Science , vol.326 , pp. 544-550
    • Drinnenberg, I.A.1
  • 54
    • 3042720475 scopus 로고    scopus 로고
    • Genome evolution in yeasts
    • Dujon B., et al. Genome evolution in yeasts. Nature 2004, 430:35-44.
    • (2004) Nature , vol.430 , pp. 35-44
    • Dujon, B.1
  • 55
    • 84908501374 scopus 로고    scopus 로고
    • The fatty acid transport protein Fat1p is involved in the export of fatty acids from lipid bodies in Yarrowia lipolytica
    • Dulermo R., et al. The fatty acid transport protein Fat1p is involved in the export of fatty acids from lipid bodies in Yarrowia lipolytica. FEMS Yeast Res. 2014, 14:883-896.
    • (2014) FEMS Yeast Res. , vol.14 , pp. 883-896
    • Dulermo, R.1
  • 56
    • 77952163407 scopus 로고    scopus 로고
    • Dicistronic regulation of fluorescent proteins in the budding yeast Saccharomyces cerevisiae
    • Edwards S.R., Wandless T.J. Dicistronic regulation of fluorescent proteins in the budding yeast Saccharomyces cerevisiae. Yeast (Chichester, England) 2010, 27:229-236.
    • (2010) Yeast (Chichester, England) , vol.27 , pp. 229-236
    • Edwards, S.R.1    Wandless, T.J.2
  • 57
    • 0038268049 scopus 로고    scopus 로고
    • A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
    • Epinat J.-C., et al. A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res. 2003, 31:2952-2962.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2952-2962
    • Epinat, J.-C.1
  • 58
    • 0026442489 scopus 로고
    • Chromosomal targeting of replicating plasmids in the yeast Hansenula polymorpha
    • Faber K.N., et al. Chromosomal targeting of replicating plasmids in the yeast Hansenula polymorpha. J. Gen. Microbiol. 1992, 138:2405-2416.
    • (1992) J. Gen. Microbiol. , vol.138 , pp. 2405-2416
    • Faber, K.N.1
  • 59
    • 0028217090 scopus 로고
    • Highly-efficient electrotransformation of the yeast Hansenula polymorpha
    • Faber K.N., et al. Highly-efficient electrotransformation of the yeast Hansenula polymorpha. Curr. Genet. 1994, 25:305-310.
    • (1994) Curr. Genet. , vol.25 , pp. 305-310
    • Faber, K.N.1
  • 61
    • 65349147983 scopus 로고    scopus 로고
    • Microbial factories for recombinant pharmaceuticals
    • Ferrer-Miralles N., et al. Microbial factories for recombinant pharmaceuticals. Microb. Cell Fact. 2009, 8:17.
    • (2009) Microb. Cell Fact. , vol.8 , pp. 17
    • Ferrer-Miralles, N.1
  • 62
    • 0242384024 scopus 로고    scopus 로고
    • New disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica
    • Fickers P., et al. New disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica. J. Microbiol. Methods 2003, 55:727-737.
    • (2003) J. Microbiol. Methods , vol.55 , pp. 727-737
    • Fickers, P.1
  • 63
    • 34250806590 scopus 로고    scopus 로고
    • Citric acid production from sucrose using a recombinant strain of the yeast Yarrowia lipolytica
    • Forster A., et al. Citric acid production from sucrose using a recombinant strain of the yeast Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2007, 75:1409-1417.
    • (2007) Appl. Microbiol. Biotechnol. , vol.75 , pp. 1409-1417
    • Forster, A.1
  • 64
    • 84960403522 scopus 로고    scopus 로고
    • Food and feed enzymes
    • Springer, Berlin, Heidelberg, H. Zorn, P. Czermak (Eds.)
    • Fraatz M., et al. Food and feed enzymes. Biotechnology of Food and Feed Additives 2014, 236-237. Springer, Berlin, Heidelberg. H. Zorn, P. Czermak (Eds.).
    • (2014) Biotechnology of Food and Feed Additives , pp. 236-237
    • Fraatz, M.1
  • 65
    • 85031957980 scopus 로고
    • Vecteur de transformation de la levure Yarrowia lipolytica, procédé de transformation et levure transformée
    • French Patent Application FR2566424 (A1).
    • Gaillardin, C. et al., 1985. Vecteur de transformation de la levure Yarrowia lipolytica, procédé de transformation et levure transformée. French Patent Application FR2566424 (A1).
    • (1985)
    • Gaillardin, C.1
  • 66
    • 84897546295 scopus 로고    scopus 로고
    • Self-processing of ribozyme-flanked RNAs into guide RNAs in vitro and in vivo for CRISPR-mediated genome editing
    • Gao Y., Zhao Y. Self-processing of ribozyme-flanked RNAs into guide RNAs in vitro and in vivo for CRISPR-mediated genome editing. J. Integr. Plant Biol. 2014, 56:343-349.
    • (2014) J. Integr. Plant Biol. , vol.56 , pp. 343-349
    • Gao, Y.1    Zhao, Y.2
  • 67
    • 84921278534 scopus 로고    scopus 로고
    • Compact multi-enzyme pathways in P. pastoris
    • Geier M., et al. Compact multi-enzyme pathways in P. pastoris. Chem. Commun. (Camb.) 2015, 51:1643-1646.
    • (2015) Chem. Commun. (Camb.) , vol.51 , pp. 1643-1646
    • Geier, M.1
  • 68
    • 84894131718 scopus 로고    scopus 로고
    • Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast
    • Geisberg J.V., et al. Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell 2014, 156:812-824.
    • (2014) Cell , vol.156 , pp. 812-824
    • Geisberg, J.V.1
  • 69
    • 0031010051 scopus 로고    scopus 로고
    • Application of yeasts in gene expression studies: a comparison of Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis - a review
    • Gellissen G., Hollenberg C.P. Application of yeasts in gene expression studies: a comparison of Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis - a review. Gene 1997, 190:87-97.
    • (1997) Gene , vol.190 , pp. 87-97
    • Gellissen, G.1    Hollenberg, C.P.2
  • 70
    • 27644574423 scopus 로고    scopus 로고
    • New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - a comparison
    • Gellissen G., et al. New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - a comparison. FEMS Yeast Res. 2005, 5:1079-1096.
    • (2005) FEMS Yeast Res. , vol.5 , pp. 1079-1096
    • Gellissen, G.1
  • 71
    • 0034085404 scopus 로고    scopus 로고
    • Growth of filamentous fungi in submerged culture: problems and possible solutions
    • Gibbs P.A., et al. Growth of filamentous fungi in submerged culture: problems and possible solutions. Crit. Rev. Biotechnol. 2000, 20:17-48.
    • (2000) Crit. Rev. Biotechnol. , vol.20 , pp. 17-48
    • Gibbs, P.A.1
  • 72
    • 67349270900 scopus 로고    scopus 로고
    • Enzymatic assembly of DNA molecules up to several hundred kilobases
    • Gibson D.G., et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 2009, 6:343-345.
    • (2009) Nat. Methods , vol.6 , pp. 343-345
    • Gibson, D.G.1
  • 73
    • 27944461023 scopus 로고    scopus 로고
    • Role of cultivation media in the development of yeast strains for large scale industrial use
    • Hahn-Hägerdal B., et al. Role of cultivation media in the development of yeast strains for large scale industrial use. Microb. Cell Fact. 2005, 4:31.
    • (2005) Microb. Cell Fact. , vol.4 , pp. 31
    • Hahn-Hägerdal, B.1
  • 74
    • 47249115376 scopus 로고    scopus 로고
    • Promoter library designed for fine-tuned gene expression in Pichia pastoris
    • Hartner F.S., et al. Promoter library designed for fine-tuned gene expression in Pichia pastoris. Nucleic Acids Res. 2008, 36:e76.
    • (2008) Nucleic Acids Res. , vol.36 , pp. e76
    • Hartner, F.S.1
  • 75
    • 0242655055 scopus 로고    scopus 로고
    • Properties of the Hansenula polymorpha-derived constitutive GAP promoter, assessed using an HSA reporter gene
    • Heo J.H., et al. Properties of the Hansenula polymorpha-derived constitutive GAP promoter, assessed using an HSA reporter gene. FEMS Yeast Res. 2003, 4:175-184.
    • (2003) FEMS Yeast Res. , vol.4 , pp. 175-184
    • Heo, J.H.1
  • 76
    • 0025047590 scopus 로고
    • Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in Gram-negative bacteria
    • Herrero M., et al. Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in Gram-negative bacteria. J. Bacteriol. 1990, 172:6557-6567.
    • (1990) J. Bacteriol. , vol.172 , pp. 6557-6567
    • Herrero, M.1
  • 77
    • 0002123338 scopus 로고
    • The Cre-lox recombination system
    • Springer, Berlin, Heidelberg, F. Eckstein, D.J. Lilley (Eds.)
    • Hoess R.H., Abremski K. The Cre-lox recombination system. Nucleic Acids and Molecular Biology 4 1990, 99-109. Springer, Berlin, Heidelberg. F. Eckstein, D.J. Lilley (Eds.).
    • (1990) Nucleic Acids and Molecular Biology 4 , pp. 99-109
    • Hoess, R.H.1    Abremski, K.2
  • 78
    • 84856618444 scopus 로고    scopus 로고
    • Engineering Yarrowia lipolytica to express secretory invertase with strong FBA1IN promoter
    • Hong S.P., et al. Engineering Yarrowia lipolytica to express secretory invertase with strong FBA1IN promoter. Yeast 2012, 29:59-72.
    • (2012) Yeast , vol.29 , pp. 59-72
    • Hong, S.P.1
  • 79
    • 84935513637 scopus 로고    scopus 로고
    • Efficient multiplexed integration of synergistic alleles and metabolic pathways in yeasts via CRISPR-Cas
    • Horwitz A.A., et al. Efficient multiplexed integration of synergistic alleles and metabolic pathways in yeasts via CRISPR-Cas. Cell Syst. 2015.
    • (2015) Cell Syst.
    • Horwitz, A.A.1
  • 80
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu P.D., et al. Development and applications of CRISPR-Cas9 for genome engineering. Cell 2014, 157:1262-1278.
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1
  • 81
    • 13244277811 scopus 로고    scopus 로고
    • Efficient secretion of human lysozyme from the yeast, Kluyveromyces lactis
    • Iwata T., et al. Efficient secretion of human lysozyme from the yeast, Kluyveromyces lactis. Biotechnol. Lett. 2004, 26:1803-1808.
    • (2004) Biotechnol. Lett. , vol.26 , pp. 1803-1808
    • Iwata, T.1
  • 82
    • 24344480452 scopus 로고    scopus 로고
    • A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast
    • Iyer S., et al. A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast. Mol. Cell. Biol. 2005, 25:8064-8073.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8064-8073
    • Iyer, S.1
  • 83
    • 84923050777 scopus 로고    scopus 로고
    • Implementation of the CRISPR-Cas9 system in fission yeast
    • Jacobs J.Z., et al. Implementation of the CRISPR-Cas9 system in fission yeast. Nat. Commun. 2014, 5:5344.
    • (2014) Nat. Commun. , vol.5 , pp. 5344
    • Jacobs, J.Z.1
  • 84
    • 0025876019 scopus 로고
    • Simultaneous expression of the S and L surface antigens of hepatitis B, and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha
    • Janowicz Z.A., et al. Simultaneous expression of the S and L surface antigens of hepatitis B, and formation of mixed particles in the methylotrophic yeast, Hansenula polymorpha. Yeast 1991, 7:431-443.
    • (1991) Yeast , vol.7 , pp. 431-443
    • Janowicz, Z.A.1
  • 85
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M., et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012, 337:816-821.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1
  • 86
    • 33847375437 scopus 로고    scopus 로고
    • Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures: a quantitative study based on concentration gradients in transient continuous cultures
    • Jungo C., et al. Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures: a quantitative study based on concentration gradients in transient continuous cultures. J. Biotechnol. 2007, 128:824-837.
    • (2007) J. Biotechnol. , vol.128 , pp. 824-837
    • Jungo, C.1
  • 87
    • 63449096194 scopus 로고    scopus 로고
    • A tandem mass spectrometric approach to the identification of O-glycosylated glargine glycoforms in active pharmaceutical ingredient expressed in Pichia pastoris
    • Kannan V., et al. A tandem mass spectrometric approach to the identification of O-glycosylated glargine glycoforms in active pharmaceutical ingredient expressed in Pichia pastoris. Rapid Commun. Mass Spectrom. 2009, 23:1035-1042.
    • (2009) Rapid Commun. Mass Spectrom. , vol.23 , pp. 1035-1042
    • Kannan, V.1
  • 88
    • 84872415347 scopus 로고    scopus 로고
    • Characterization of plasmid burden and copy number in Saccharomyces cerevisiae for optimization of metabolic engineering applications
    • Karim A.S., et al. Characterization of plasmid burden and copy number in Saccharomyces cerevisiae for optimization of metabolic engineering applications. FEMS Yeast Res. 2013, 13:107-116.
    • (2013) FEMS Yeast Res. , vol.13 , pp. 107-116
    • Karim, A.S.1
  • 89
    • 79960901502 scopus 로고    scopus 로고
    • Transformation of Saccharomyces cerevisiae and other fungi: Methods and possible underlying mechanism
    • Kawai S., et al. Transformation of Saccharomyces cerevisiae and other fungi: Methods and possible underlying mechanism. Bioeng. Bugs. 2010, 1:395-403.
    • (2010) Bioeng. Bugs. , vol.1 , pp. 395-403
    • Kawai, S.1
  • 90
    • 84864634066 scopus 로고    scopus 로고
    • A synthetic biology framework for programming eukaryotic transcription functions
    • Khalil A.S., et al. A synthetic biology framework for programming eukaryotic transcription functions. Cell 2012, 150:647-658.
    • (2012) Cell , vol.150 , pp. 647-658
    • Khalil, A.S.1
  • 91
    • 0032579854 scopus 로고    scopus 로고
    • Regulation of alcoholic fermentation in batch and chemostat cultures of Kluyveromyces lactis CBS 2359
    • Kiers J., et al. Regulation of alcoholic fermentation in batch and chemostat cultures of Kluyveromyces lactis CBS 2359. Yeast 1998, 14:459-469.
    • (1998) Yeast , vol.14 , pp. 459-469
    • Kiers, J.1
  • 92
    • 79955707349 scopus 로고    scopus 로고
    • High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice
    • Kim J.H., et al. High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. PLoS ONE 2011, 6:e18556.
    • (2011) PLoS ONE , vol.6 , pp. e18556
    • Kim, J.H.1
  • 93
    • 85027909971 scopus 로고    scopus 로고
    • Yeast synthetic biology for the production of recombinant therapeutic proteins
    • Kim H., et al. Yeast synthetic biology for the production of recombinant therapeutic proteins. FEMS Yeast Res. 2014.
    • (2014) FEMS Yeast Res.
    • Kim, H.1
  • 94
    • 4043134527 scopus 로고    scopus 로고
    • Efficient gene targeting in Kluyveromyces lactis
    • Kooistra R., et al. Efficient gene targeting in Kluyveromyces lactis. Yeast 2004, 21:781-792.
    • (2004) Yeast , vol.21 , pp. 781-792
    • Kooistra, R.1
  • 95
    • 84888260046 scopus 로고    scopus 로고
    • Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris
    • Krainer F.W., et al. Knockout of an endogenous mannosyltransferase increases the homogeneity of glycoproteins produced in Pichia pastoris. Sci. Rep. 2013, 3:3279.
    • (2013) Sci. Rep. , vol.3 , pp. 3279
    • Krainer, F.W.1
  • 96
    • 0033927039 scopus 로고    scopus 로고
    • HARO7 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization
    • Krappmann S., et al. HARO7 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization. J. Bacteriol. 2000, 182:4188-4197.
    • (2000) J. Bacteriol. , vol.182 , pp. 4188-4197
    • Krappmann, S.1
  • 97
    • 34447327221 scopus 로고    scopus 로고
    • Glucose-induced production of recombinant proteins in Hansenula polymorpha mutants deficient in catabolite repression
    • Krasovska O.S., et al. Glucose-induced production of recombinant proteins in Hansenula polymorpha mutants deficient in catabolite repression. Biotechnol. Bioeng. 2007, 97:858-870.
    • (2007) Biotechnol. Bioeng. , vol.97 , pp. 858-870
    • Krasovska, O.S.1
  • 99
    • 33645233636 scopus 로고    scopus 로고
    • Immunogenicity of a new, low-cost recombinant hepatitis B vaccine derived from Hansenula polymorpha in adults
    • Kulkarni P.S., et al. Immunogenicity of a new, low-cost recombinant hepatitis B vaccine derived from Hansenula polymorpha in adults. Vaccine 2006, 24:3457-3460.
    • (2006) Vaccine , vol.24 , pp. 3457-3460
    • Kulkarni, P.S.1
  • 100
    • 84886993480 scopus 로고    scopus 로고
    • CRISPR interference (CRISPRi) for sequence-specific control of gene expression
    • Larson M.H., et al. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat. Protoc. 2013, 8:2180-2196.
    • (2013) Nat. Protoc. , vol.8 , pp. 2180-2196
    • Larson, M.H.1
  • 101
    • 19344370279 scopus 로고    scopus 로고
    • An episomal expression vector for screening mutant gene libraries in Pichia pastoris
    • Lee C.C., et al. An episomal expression vector for screening mutant gene libraries in Pichia pastoris. Plasmid 2005, 54:80-85.
    • (2005) Plasmid , vol.54 , pp. 80-85
    • Lee, C.C.1
  • 102
    • 84942013003 scopus 로고    scopus 로고
    • A highly characterized yeast toolkit for modular, multipart assembly
    • Lee M.E., et al. A highly characterized yeast toolkit for modular, multipart assembly. ACS Synth. Biol. 2015.
    • (2015) ACS Synth. Biol.
    • Lee, M.E.1
  • 103
    • 79960034141 scopus 로고    scopus 로고
    • Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
    • Li T., et al. Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Res. 2011, 39:6315-6325.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6315-6325
    • Li, T.1
  • 104
    • 84862786191 scopus 로고    scopus 로고
    • Internal ribosome entry site mediates protein synthesis in yeast Pichia pastoris
    • Liang S., et al. Internal ribosome entry site mediates protein synthesis in yeast Pichia pastoris. Biotechnol. Lett. 2012, 34:957-964.
    • (2012) Biotechnol. Lett. , vol.34 , pp. 957-964
    • Liang, S.1
  • 105
    • 84876355027 scopus 로고    scopus 로고
    • Coordinated induction of multi-gene pathways in Saccharomyces cerevisiae
    • Liang J., et al. Coordinated induction of multi-gene pathways in Saccharomyces cerevisiae. Nucleic Acids Res. 2013, 41:e54.
    • (2013) Nucleic Acids Res. , vol.41 , pp. e54
    • Liang, J.1
  • 106
    • 84905757148 scopus 로고    scopus 로고
    • Microbial tolerance engineering toward biochemical production: from lignocellulose to products
    • Ling H., et al. Microbial tolerance engineering toward biochemical production: from lignocellulose to products. Curr. Opin. Biotechnol. 2014, 29:99-106.
    • (2014) Curr. Opin. Biotechnol. , vol.29 , pp. 99-106
    • Ling, H.1
  • 107
    • 68349141537 scopus 로고    scopus 로고
    • Disruption of the OCH1 and MNN1 genes decrease N-glycosylation on glycoprotein expressed in Kluyveromyces lactis
    • Liu B., et al. Disruption of the OCH1 and MNN1 genes decrease N-glycosylation on glycoprotein expressed in Kluyveromyces lactis. J. Biotechnol. 2009, 143:95-102.
    • (2009) J. Biotechnol. , vol.143 , pp. 95-102
    • Liu, B.1
  • 108
    • 84887624541 scopus 로고    scopus 로고
    • Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces
    • Liu L., et al. Frontiers of yeast metabolic engineering: diversifying beyond ethanol and Saccharomyces. Curr. Opin. Biotechnol. 2013, 24:1023-1030.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 1023-1030
    • Liu, L.1
  • 109
    • 84920169061 scopus 로고    scopus 로고
    • Increasing expression level and copy number of a Yarrowia lipolytica plasmid through regulated centromere function
    • Liu L., et al. Increasing expression level and copy number of a Yarrowia lipolytica plasmid through regulated centromere function. FEMS Yeast Res. 2014, 14:1124-1127.
    • (2014) FEMS Yeast Res. , vol.14 , pp. 1124-1127
    • Liu, L.1
  • 110
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • Longtine M.S., et al. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998, 14:953-961.
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1
  • 111
    • 84937759575 scopus 로고    scopus 로고
    • Yarrowia lipolytica: recent achievements in heterologous protein expression and pathway engineering
    • Madzak C. Yarrowia lipolytica: recent achievements in heterologous protein expression and pathway engineering. Appl. Microbiol. Biotechnol. 2015, 99:4559-4577.
    • (2015) Appl. Microbiol. Biotechnol. , vol.99 , pp. 4559-4577
    • Madzak, C.1
  • 112
    • 0032898514 scopus 로고    scopus 로고
    • Functional analysis of upstream regulating regions from the Yarrowia lipolytica XPR2 promoter
    • Madzak C., et al. Functional analysis of upstream regulating regions from the Yarrowia lipolytica XPR2 promoter. Microbiology 1999, 145:75-87.
    • (1999) Microbiology , vol.145 , pp. 75-87
    • Madzak, C.1
  • 113
    • 0344002683 scopus 로고    scopus 로고
    • Strong hybrid promoters and integrative expression/secretion vectors for quasi-constitutive expression of heterologous proteins in the yeast Yarrowia lipolytica
    • Madzak C., et al. Strong hybrid promoters and integrative expression/secretion vectors for quasi-constitutive expression of heterologous proteins in the yeast Yarrowia lipolytica. J. Mol. Microbiol. Biotechnol. 2000, 2:207-216.
    • (2000) J. Mol. Microbiol. Biotechnol. , vol.2 , pp. 207-216
    • Madzak, C.1
  • 114
    • 84930638003 scopus 로고    scopus 로고
    • CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae
    • Mans R., et al. CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae. FEMS Yeast Res. 2015, 15.
    • (2015) FEMS Yeast Res. , pp. 15
    • Mans, R.1
  • 115
    • 0029894775 scopus 로고    scopus 로고
    • Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin
    • Markland W., et al. Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin. Biochemistry 1996, 35:8058-8067.
    • (1996) Biochemistry , vol.35 , pp. 8058-8067
    • Markland, W.1
  • 116
    • 49949115796 scopus 로고    scopus 로고
    • Overexpression of the riboflavin biosynthetic pathway in Pichia pastoris
    • Marx H., et al. Overexpression of the riboflavin biosynthetic pathway in Pichia pastoris. Microb. Cell Fact. 2008, 7:23.
    • (2008) Microb. Cell Fact. , vol.7 , pp. 23
    • Marx, H.1
  • 117
    • 33746049809 scopus 로고    scopus 로고
    • Purine biosynthesis, riboflavin production, and trophic-phase span are controlled by a myb-related transcription factor in the fungus Ashbya gossypii
    • Mateos L., et al. Purine biosynthesis, riboflavin production, and trophic-phase span are controlled by a myb-related transcription factor in the fungus Ashbya gossypii. Appl. Environ. Microbiol. 2006, 72:5052-5060.
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 5052-5060
    • Mateos, L.1
  • 118
    • 84894048651 scopus 로고    scopus 로고
    • Production of lycopene in the non-carotenoid-producing yeast Yarrowia lipolytica
    • Matthäus F., et al. Production of lycopene in the non-carotenoid-producing yeast Yarrowia lipolytica. Appl. Environ. Microbiol. 2014, 80:1660-1669.
    • (2014) Appl. Environ. Microbiol. , vol.80 , pp. 1660-1669
    • Matthäus, F.1
  • 119
    • 0033526419 scopus 로고    scopus 로고
    • An expression system matures: a highly efficient and cost-effective process for phytase production by recombinant strains of Hansenula polymorpha
    • Mayer A.F., et al. An expression system matures: a highly efficient and cost-effective process for phytase production by recombinant strains of Hansenula polymorpha. Biotechnol. Bioeng. 1999, 63:373-381.
    • (1999) Biotechnol. Bioeng. , vol.63 , pp. 373-381
    • Mayer, A.F.1
  • 120
    • 84891862050 scopus 로고    scopus 로고
    • Enhanced production of erythritol by Yarrowia lipolytica on glycerol in repeated batch cultures
    • Mironczuk A.M., et al. Enhanced production of erythritol by Yarrowia lipolytica on glycerol in repeated batch cultures. J. Ind. Microbiol. Biotechnol. 2014, 41:57-64.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 57-64
    • Mironczuk, A.M.1
  • 121
    • 84872408012 scopus 로고    scopus 로고
    • Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast
    • Mischo H.E., Proudfoot N.J. Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast. Biochim. Biophys. Acta 2013, 1829:174-185.
    • (2013) Biochim. Biophys. Acta , vol.1829 , pp. 174-185
    • Mischo, H.E.1    Proudfoot, N.J.2
  • 122
    • 0031657285 scopus 로고    scopus 로고
    • Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Kluyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica
    • Muller S., et al. Comparison of expression systems in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha, Kluyveromyces lactis, Schizosaccharomyces pombe and Yarrowia lipolytica. Cloning of two novel promoters from Yarrowia lipolytica. Yeast 1998, 14:1267-1283.
    • (1998) Yeast , vol.14 , pp. 1267-1283
    • Muller, S.1
  • 123
    • 0028953840 scopus 로고
    • Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds
    • Mumberg D., et al. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 1995, 156:119-122.
    • (1995) Gene , vol.156 , pp. 119-122
    • Mumberg, D.1
  • 124
    • 84863090270 scopus 로고    scopus 로고
    • Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology
    • Näätsaari L., et al. Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology. PLoS ONE 2012, 7:e39720.
    • (2012) PLoS ONE , vol.7 , pp. e39720
    • Näätsaari, L.1
  • 125
    • 84960404670 scopus 로고    scopus 로고
    • K. lactis Protein Expression Kit
    • (accessed 21.08.15).
    • NEB, 2015. K. lactis Protein Expression Kit. <> (accessed 21.08.15). https://www.neb.com/products/e1000-k-lactis-protein-expression-kit.
    • (2015)
  • 126
    • 0344466719 scopus 로고    scopus 로고
    • Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris
    • Nett J.H., Gerngross T.U. Cloning and disruption of the PpURA5 gene and construction of a set of integration vectors for the stable genetic modification of Pichia pastoris. Yeast 2003, 20:1279-1290.
    • (2003) Yeast , vol.20 , pp. 1279-1290
    • Nett, J.H.1    Gerngross, T.U.2
  • 127
    • 33747376106 scopus 로고    scopus 로고
    • Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae
    • Nevoigt E., et al. Engineering of promoter replacement cassettes for fine-tuning of gene expression in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2006, 72:5266-5273.
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 5266-5273
    • Nevoigt, E.1
  • 128
    • 84878641167 scopus 로고    scopus 로고
    • Metabolic engineering of yeast for production of fuels and chemicals
    • Nielsen J., et al. Metabolic engineering of yeast for production of fuels and chemicals. Curr. Opin. Biotechnol. 2013, 24:398-404.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 398-404
    • Nielsen, J.1
  • 129
    • 0017351932 scopus 로고
    • Regulation of extracellular protease production in Candida lipolytica
    • Ogrydziak D.M., et al. Regulation of extracellular protease production in Candida lipolytica. Biochim. Biophys. Acta 1977, 497:525-538.
    • (1977) Biochim. Biophys. Acta , vol.497 , pp. 525-538
    • Ogrydziak, D.M.1
  • 130
    • 0000277434 scopus 로고
    • Yeast transformation: a model system for the study of recombination
    • Orr-Weaver T.L., et al. Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. U.S.A. 1981, 78:6354-6358.
    • (1981) Proc. Natl. Acad. Sci. U.S.A. , vol.78 , pp. 6354-6358
    • Orr-Weaver, T.L.1
  • 131
    • 79953879384 scopus 로고    scopus 로고
    • Sequential deletion of Pichia pastoris genes by a self-excisable cassette
    • Pan R., et al. Sequential deletion of Pichia pastoris genes by a self-excisable cassette. FEMS Yeast Res. 2011, 11:292-298.
    • (2011) FEMS Yeast Res. , vol.11 , pp. 292-298
    • Pan, R.1
  • 132
    • 54349112572 scopus 로고    scopus 로고
    • Expression of serotonin derivative synthetic genes on a single self-processing polypeptide and the production of serotonin derivatives in microbes
    • Park M., et al. Expression of serotonin derivative synthetic genes on a single self-processing polypeptide and the production of serotonin derivatives in microbes. Appl. Microbiol. Biotechnol. 2008, 81:43-49.
    • (2008) Appl. Microbiol. Biotechnol. , vol.81 , pp. 43-49
    • Park, M.1
  • 133
    • 84865142847 scopus 로고    scopus 로고
    • Microbial engineering for the production of advanced biofuels
    • Peralta-Yahya P.P., et al. Microbial engineering for the production of advanced biofuels. Nature 2012, 488:320-328.
    • (2012) Nature , vol.488 , pp. 320-328
    • Peralta-Yahya, P.P.1
  • 134
    • 66249088017 scopus 로고    scopus 로고
    • The second wave of synthetic biology: from modules to systems
    • Purnick P.E., Weiss R. The second wave of synthetic biology: from modules to systems. Nat. Rev. Mol. Cell Biol. 2009, 10:410-422.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 410-422
    • Purnick, P.E.1    Weiss, R.2
  • 135
    • 79958264719 scopus 로고    scopus 로고
    • GAP promoter library for fine-tuning of gene expression in Pichia pastoris
    • Qin X., et al. GAP promoter library for fine-tuning of gene expression in Pichia pastoris. Appl. Environ. Microbiol. 2011, 77:3600-3608.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 3600-3608
    • Qin, X.1
  • 136
    • 84949202418 scopus 로고    scopus 로고
    • Looking beyond Saccharomyces: the potential of non-conventional yeast species for desirable traits in bioethanol fermentation
    • Radecka D., et al. Looking beyond Saccharomyces: the potential of non-conventional yeast species for desirable traits in bioethanol fermentation. FEMS Yeast Res. 2015, 15.
    • (2015) FEMS Yeast Res. , pp. 15
    • Radecka, D.1
  • 137
    • 0242655049 scopus 로고    scopus 로고
    • The Hansenula polymorpha (strain CBS4732) genome sequencing and analysis
    • Ramezani-Rad M., et al. The Hansenula polymorpha (strain CBS4732) genome sequencing and analysis. FEMS Yeast Res. 2003, 4:207-215.
    • (2003) FEMS Yeast Res. , vol.4 , pp. 207-215
    • Ramezani-Rad, M.1
  • 138
    • 84937604735 scopus 로고    scopus 로고
    • The development and characterization of synthetic minimal yeast promoters
    • Redden H., Alper H.S. The development and characterization of synthetic minimal yeast promoters. Nat. Commun. 2015, 6:7810.
    • (2015) Nat. Commun. , vol.6 , pp. 7810
    • Redden, H.1    Alper, H.S.2
  • 139
    • 84877924494 scopus 로고    scopus 로고
    • Yeast on the milky way: genetics, physiology and biotechnology of Kluyveromyces lactis
    • Rodicio R., Heinisch J.J. Yeast on the milky way: genetics, physiology and biotechnology of Kluyveromyces lactis. Yeast 2013, 30:165-177.
    • (2013) Yeast , vol.30 , pp. 165-177
    • Rodicio, R.1    Heinisch, J.J.2
  • 140
    • 0022597545 scopus 로고
    • Transformation of the methylotrophic yeast Hansenula polymorpha by autonomous replication and integration vectors
    • Roggenkamp R., et al. Transformation of the methylotrophic yeast Hansenula polymorpha by autonomous replication and integration vectors. Mol. Gen. Genet. - MGG 1986, 202:302-308.
    • (1986) Mol. Gen. Genet. - MGG , vol.202 , pp. 302-308
    • Roggenkamp, R.1
  • 141
    • 84879073792 scopus 로고    scopus 로고
    • Metabolic engineering of Kluyveromyces lactis for l-ascorbic acid (vitamin C) biosynthesis
    • Rosa J.C., et al. Metabolic engineering of Kluyveromyces lactis for l-ascorbic acid (vitamin C) biosynthesis. Microb. Cell Fact. 2013, 12:59.
    • (2013) Microb. Cell Fact. , vol.12 , pp. 59
    • Rosa, J.C.1
  • 142
    • 77958498881 scopus 로고    scopus 로고
    • Variable production windows for porcine trypsinogen employing synthetic inducible promoter variants in Pichia pastoris
    • Ruth C., et al. Variable production windows for porcine trypsinogen employing synthetic inducible promoter variants in Pichia pastoris. Syst. Synth. Biol. 2010, 4:181-191.
    • (2010) Syst. Synth. Biol. , vol.4 , pp. 181-191
    • Ruth, C.1
  • 143
    • 77955655316 scopus 로고    scopus 로고
    • Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes
    • Rymowicz W., et al. Citric acid production from glycerol-containing waste of biodiesel industry by Yarrowia lipolytica in batch, repeated batch, and cell recycle regimes. Appl. Microbiol. Biotechnol. 2010, 87:971-979.
    • (2010) Appl. Microbiol. Biotechnol. , vol.87 , pp. 971-979
    • Rymowicz, W.1
  • 144
    • 84859622845 scopus 로고    scopus 로고
    • Novel genetic tools for Hansenula polymorpha
    • Saraya R., et al. Novel genetic tools for Hansenula polymorpha. FEMS Yeast Res. 2012, 12:271-278.
    • (2012) FEMS Yeast Res. , vol.12 , pp. 271-278
    • Saraya, R.1
  • 145
    • 84921424809 scopus 로고    scopus 로고
    • Tools for genetic engineering of the yeast Hansenula polymorpha
    • Springer
    • Saraya R., et al. Tools for genetic engineering of the yeast Hansenula polymorpha. Yeast Metabolic Engineering 2014, 43-62. Springer.
    • (2014) Yeast Metabolic Engineering , pp. 43-62
    • Saraya, R.1
  • 146
    • 0023352241 scopus 로고
    • Functional expression of the Cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae
    • Sauer B. Functional expression of the Cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 1987, 7:2087-2096.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 2087-2096
    • Sauer, B.1
  • 147
    • 58149182731 scopus 로고    scopus 로고
    • Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes
    • Sherman D.J., et al. Génolevures: protein families and synteny among complete hemiascomycetous yeast proteomes and genomes. Nucleic Acids Res. 2009, 37:D550-D554.
    • (2009) Nucleic Acids Res. , vol.37 , pp. D550-D554
    • Sherman, D.J.1
  • 148
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski R.S., Hieter P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 1989, 122:19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorski, R.S.1    Hieter, P.2
  • 149
    • 84910110438 scopus 로고    scopus 로고
    • Scarless gene deletion in methylotrophic Hansenula polymorpha by using Mazf as counter-selectable marker
    • Song P., et al. Scarless gene deletion in methylotrophic Hansenula polymorpha by using Mazf as counter-selectable marker. Anal. Biochem. 2015, 468:66-74.
    • (2015) Anal. Biochem. , vol.468 , pp. 66-74
    • Song, P.1
  • 150
    • 0030997654 scopus 로고    scopus 로고
    • Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris
    • Sreekrishna K., et al. Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris. Eukary. Exp. Vector Syst.: Biol. Appl. 1997, 190:55-62.
    • (1997) Eukary. Exp. Vector Syst.: Biol. Appl. , vol.190 , pp. 55-62
    • Sreekrishna, K.1
  • 151
    • 0035209716 scopus 로고    scopus 로고
    • Riboflavin, overproduced during sporulation of Ashbya gossypii, protects its hyaline spores against ultraviolet light
    • Stahmann K.P., et al. Riboflavin, overproduced during sporulation of Ashbya gossypii, protects its hyaline spores against ultraviolet light. Environ. Microbiol. 2001, 3:545-550.
    • (2001) Environ. Microbiol. , vol.3 , pp. 545-550
    • Stahmann, K.P.1
  • 152
    • 0035970512 scopus 로고    scopus 로고
    • Plasmids with the Cre-recombinase and the dominant nat marker, suitable for use in prototrophic strains of Saccharomyces cerevisiae and Kluyveromyces lactis
    • Steensma H.Y., Ter Linde J.J. Plasmids with the Cre-recombinase and the dominant nat marker, suitable for use in prototrophic strains of Saccharomyces cerevisiae and Kluyveromyces lactis. Yeast 2001, 18:469-472.
    • (2001) Yeast , vol.18 , pp. 469-472
    • Steensma, H.Y.1    Ter Linde, J.J.2
  • 153
    • 0019888362 scopus 로고
    • Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
    • Sternberg N., Hamilton D. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J. Mol. Biol. 1981, 150:467-486.
    • (1981) J. Mol. Biol. , vol.150 , pp. 467-486
    • Sternberg, N.1    Hamilton, D.2
  • 154
    • 79954616114 scopus 로고    scopus 로고
    • Reconstitution of human RNA interference in budding yeast
    • Suk K., et al. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011, 39:e43.
    • (2011) Nucleic Acids Res. , vol.39 , pp. e43
    • Suk, K.1
  • 155
    • 77956231122 scopus 로고    scopus 로고
    • Characterization of alcohol dehydrogenase 1 of the thermotolerant methylotrophic yeast Hansenula polymorpha
    • Suwannarangsee S., et al. Characterization of alcohol dehydrogenase 1 of the thermotolerant methylotrophic yeast Hansenula polymorpha. Appl. Microbiol. Biotechnol. 2010, 88:497-507.
    • (2010) Appl. Microbiol. Biotechnol. , vol.88 , pp. 497-507
    • Suwannarangsee, S.1
  • 156
    • 0027860494 scopus 로고
    • The yeast Kluyveromyces lactis as an efficient host for heterologous gene expression
    • Swinkels B.W., et al. The yeast Kluyveromyces lactis as an efficient host for heterologous gene expression. Antonie Van Leeuwenhoek 1993, 64:187-201.
    • (1993) Antonie Van Leeuwenhoek , vol.64 , pp. 187-201
    • Swinkels, B.W.1
  • 157
    • 20344377636 scopus 로고    scopus 로고
    • Development of 2A peptide-based strategies in the design of multicistronic vectors
    • Szymczak A.L., Vignali D.A. Development of 2A peptide-based strategies in the design of multicistronic vectors. Exp. Opin. Biol. Ther. 2005, 5:627-638.
    • (2005) Exp. Opin. Biol. Ther. , vol.5 , pp. 627-638
    • Szymczak, A.L.1    Vignali, D.A.2
  • 158
    • 84870674137 scopus 로고    scopus 로고
    • Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
    • Tai M., Stephanopoulos G. Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production. Metab. Eng. 2013, 15:1-9.
    • (2013) Metab. Eng. , vol.15 , pp. 1-9
    • Tai, M.1    Stephanopoulos, G.2
  • 159
    • 84888055306 scopus 로고    scopus 로고
    • Development and characterization of AND-gate dynamic controllers with a modular synthetic GAL1 core promoter in Saccharomyces cerevisiae
    • Teo W.S., Chang M.W. Development and characterization of AND-gate dynamic controllers with a modular synthetic GAL1 core promoter in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2014, 111:144-151.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 144-151
    • Teo, W.S.1    Chang, M.W.2
  • 160
    • 0035818467 scopus 로고    scopus 로고
    • Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element
    • Thompson S.R., et al. Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:12972-12977.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 12972-12977
    • Thompson, S.R.1
  • 161
    • 0023650956 scopus 로고
    • Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris
    • Tschopp J.F., et al. Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris. Nucleic Acids Res. 1987, 15:3859-3876.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 3859-3876
    • Tschopp, J.F.1
  • 162
    • 84899632544 scopus 로고    scopus 로고
    • Synthetic biology tools for bioprospecting of natural products in eukaryotes
    • Unkles S.E., et al. Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem. Biol. 2014, 21:502-508.
    • (2014) Chem. Biol. , vol.21 , pp. 502-508
    • Unkles, S.E.1
  • 164
    • 0025096938 scopus 로고
    • Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin
    • Van den Berg J.A., et al. Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin. Nat. Biotechnol. 1990, 8:135-139.
    • (1990) Nat. Biotechnol. , vol.8 , pp. 135-139
    • Van den Berg, J.A.1
  • 165
    • 33645965276 scopus 로고    scopus 로고
    • Heterologous protein production in the yeast Kluyveromyces lactis
    • Van Ooyen A.J.J., et al. Heterologous protein production in the yeast Kluyveromyces lactis. FEMS Yeast Res. 2006, 6:381-392.
    • (2006) FEMS Yeast Res. , vol.6 , pp. 381-392
    • Van Ooyen, A.J.J.1
  • 166
    • 84874802005 scopus 로고    scopus 로고
    • Efficient homologous recombination with short length flanking fragments in Ku70 deficient Yarrowia lipolytica strains
    • Verbeke J., et al. Efficient homologous recombination with short length flanking fragments in Ku70 deficient Yarrowia lipolytica strains. Biotechnol. Lett. 2013, 35:571-576.
    • (2013) Biotechnol. Lett. , vol.35 , pp. 571-576
    • Verbeke, J.1
  • 167
    • 84887626949 scopus 로고    scopus 로고
    • New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris
    • Vogl T., et al. New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris. Curr. Opin. Biotechnol. 2013, 24:1094-1101.
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 1094-1101
    • Vogl, T.1
  • 168
    • 84896951211 scopus 로고    scopus 로고
    • Synthetic core promoters for Pichia pastoris
    • Vogl T., et al. Synthetic core promoters for Pichia pastoris. ACS Synth. Biol. 2014, 3:188-191.
    • (2014) ACS Synth. Biol. , vol.3 , pp. 188-191
    • Vogl, T.1
  • 169
    • 84940726919 scopus 로고    scopus 로고
    • A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families
    • Vyas V.K., et al. A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families. Sci. Adv. 2015, 1:e1500248.
    • (2015) Sci. Adv. , vol.1 , pp. e1500248
    • Vyas, V.K.1
  • 170
    • 85006804320 scopus 로고    scopus 로고
    • A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris
    • Weninger A., et al. A toolbox of endogenous and heterologous nuclear localization sequences for the methylotrophic yeast Pichia pastoris. FEMS Yeast Res. 2015, 15.
    • (2015) FEMS Yeast Res. , pp. 15
    • Weninger, A.1
  • 171
    • 84856389651 scopus 로고    scopus 로고
    • Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
    • Westfall P.J., et al. Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E111-E118.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E111-E118
    • Westfall, P.J.1
  • 172
    • 0029591388 scopus 로고
    • High-level secretion of hirudin by Hansenula polymorpha-authentic processing of three different preprohirudins
    • Weydemann U., et al. High-level secretion of hirudin by Hansenula polymorpha-authentic processing of three different preprohirudins. Appl. Microbiol. Biotechnol. 1995, 44:377-385.
    • (1995) Appl. Microbiol. Biotechnol. , vol.44 , pp. 377-385
    • Weydemann, U.1
  • 173
    • 13444262282 scopus 로고    scopus 로고
    • The humanization of N-glycosylation pathways in yeast
    • Wildt S., Gerngross T.U. The humanization of N-glycosylation pathways in yeast. Nat. Rev. Microbiol. 2005, 3:119-128.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 119-128
    • Wildt, S.1    Gerngross, T.U.2
  • 175
    • 84883802093 scopus 로고    scopus 로고
    • Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica
    • Xue Z., et al. Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. Nat. Biotechnol. 2013, 31:734-740.
    • (2013) Nat. Biotechnol. , vol.31 , pp. 734-740
    • Xue, Z.1
  • 176
    • 84879762383 scopus 로고    scopus 로고
    • A genome-wide activity assessment of terminator regions in Saccharomyces cerevisiae provides a "terminatome" toolbox
    • Yamanishi M., et al. A genome-wide activity assessment of terminator regions in Saccharomyces cerevisiae provides a "terminatome" toolbox. ACS Synth. Biol. 2013, 2:337-347.
    • (2013) ACS Synth. Biol. , vol.2 , pp. 337-347
    • Yamanishi, M.1
  • 177
    • 65549168275 scopus 로고    scopus 로고
    • MazF as a counter-selectable marker for unmarked genetic modification of Pichia pastoris
    • Yang J., et al. MazF as a counter-selectable marker for unmarked genetic modification of Pichia pastoris. FEMS Yeast Res. 2009, 9:600-609.
    • (2009) FEMS Yeast Res. , vol.9 , pp. 600-609
    • Yang, J.1
  • 178
    • 84896722895 scopus 로고    scopus 로고
    • Engineering the alpha-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica
    • Yovkova V., et al. Engineering the alpha-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica. Appl. Microbiol. Biotechnol. 2014, 98:2003-2013.
    • (2014) Appl. Microbiol. Biotechnol. , vol.98 , pp. 2003-2013
    • Yovkova, V.1
  • 179
    • 84920992414 scopus 로고    scopus 로고
    • Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
    • Zalatan J.G., et al. Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds. Cell 2015, 160:339-350.
    • (2015) Cell , vol.160 , pp. 339-350
    • Zalatan, J.G.1


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