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Volumn 36, Issue 12, 2008, Pages

Promoter library designed for fine-tuned gene expression in Pichia pastoris

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL OXIDASE; ALCOHOL OXIDASE 1; CIS ACTING ELEMENT; ALCOHOL DEHYDROGENASE; HYBRID PROTEIN; TRANSCRIPTION FACTOR;

EID: 47249115376     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn369     Document Type: Article
Times cited : (251)

References (63)
  • 1
    • 0033955337 scopus 로고    scopus 로고
    • Heterologous protein expression in the methylotrophic yeast Pichia pastoris
    • Lin-Cereghino,J. and Cregg,J.M. (2000) Heterologous protein expression in the methylotrophic yeast Pichia pastoris. FEMS Microbiol. Rev., 24, 45-66.
    • (2000) FEMS Microbiol. Rev , vol.24 , pp. 45-66
    • Lin-Cereghino, J.1    Cregg, J.M.2
  • 2
    • 0026778048 scopus 로고
    • Foreign gene expression in yeast: A review
    • Romanos,M.A., Scorer,C.A. and Clare,J.J. (1992) Foreign gene expression in yeast: A review. Yeast, 8, 423-488.
    • (1992) Yeast , vol.8 , pp. 423-488
    • Romanos, M.A.1    Scorer, C.A.2    Clare, J.J.3
  • 5
    • 0034610097 scopus 로고    scopus 로고
    • Modeling Pichia pastoris growth on methanol and optimizing the production of a recombinant protein, the heavy-chain fragment C of botulinum neurotoxin, serotype A
    • Zhang,W., Bevins,M.A., Plantz,B.A., Smith,L.A. and Meagher,M.M. (2000) Modeling Pichia pastoris growth on methanol and optimizing the production of a recombinant protein, the heavy-chain fragment C of botulinum neurotoxin, serotype A. Biotechnol. Bioeng., 70, 1-8.
    • (2000) Biotechnol. Bioeng , vol.70 , pp. 1-8
    • Zhang, W.1    Bevins, M.A.2    Plantz, B.A.3    Smith, L.A.4    Meagher, M.M.5
  • 6
    • 33749163829 scopus 로고    scopus 로고
    • High level expression of a synthetic gene encoding Peniophora lycii phytase in methylotrophic yeast Pichia pastoris
    • Xiong,A.S., Yao,Q.H., Peng,R.H., Zhang,Z., Xu,F., Liu,J.G., Han,P.L. and Chen,J.M. (2006) High level expression of a synthetic gene encoding Peniophora lycii phytase in methylotrophic yeast Pichia pastoris. Appl. Microbiol. Biotechnol., 72, 1039-1047.
    • (2006) Appl. Microbiol. Biotechnol , vol.72 , pp. 1039-1047
    • Xiong, A.S.1    Yao, Q.H.2    Peng, R.H.3    Zhang, Z.4    Xu, F.5    Liu, J.G.6    Han, P.L.7    Chen, J.M.8
  • 8
    • 0023650956 scopus 로고
    • Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris
    • Tschopp,J.F., Brust,P.F., Cregg,J.M., Stillman,C.A. and Gingeras,T.R. (1987) Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris. Nucleic Acids Res., 15, 3859-3876.
    • (1987) Nucleic Acids Res , vol.15 , pp. 3859-3876
    • Tschopp, J.F.1    Brust, P.F.2    Cregg, J.M.3    Stillman, C.A.4    Gingeras, T.R.5
  • 9
    • 0028292207 scopus 로고
    • The positive and negative cis-acting elements for methanol regulation in the Pichia pastoris AOX2 gene
    • Ohi,H., Miura,M., Hiramatsu,R. and Ohmura,T. (1994) The positive and negative cis-acting elements for methanol regulation in the Pichia pastoris AOX2 gene. Mol. Gen. Genet., 243, 489-499.
    • (1994) Mol. Gen. Genet , vol.243 , pp. 489-499
    • Ohi, H.1    Miura, M.2    Hiramatsu, R.3    Ohmura, T.4
  • 10
    • 0032541478 scopus 로고    scopus 로고
    • A strong nitrogen source-regulated promoter for controlled expression of foreign genes in the yeast Pichia pastoris
    • Shen,S., Sulter,G., Jeffries,T.W. and Cregg,J.M. (1998) A strong nitrogen source-regulated promoter for controlled expression of foreign genes in the yeast Pichia pastoris. Gene, 216, 93-102.
    • (1998) Gene , vol.216 , pp. 93-102
    • Shen, S.1    Sulter, G.2    Jeffries, T.W.3    Cregg, J.M.4
  • 11
    • 0028955340 scopus 로고
    • PER3 a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import
    • Liu,H., Tan,X., Russell,K.A., Veenhuis,M. and Cregg,J.M. (1995) PER3 a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import. J. Biol. Chem., 270, 10940-10951.
    • (1995) J. Biol. Chem , vol.270 , pp. 10940-10951
    • Liu, H.1    Tan, X.2    Russell, K.A.3    Veenhuis, M.4    Cregg, J.M.5
  • 12
    • 0032526934 scopus 로고    scopus 로고
    • A versatile set of vectors for constitutive and regulated gene expression in Pichia pastoris
    • Sears,I.B., O'Connor,J., Rossanese,O.W. and Glick,B.S. (1998) A versatile set of vectors for constitutive and regulated gene expression in Pichia pastoris. Yeast, 14, 783-790.
    • (1998) Yeast , vol.14 , pp. 783-790
    • Sears, I.B.1    O'Connor, J.2    Rossanese, O.W.3    Glick, B.S.4
  • 13
    • 0031579445 scopus 로고    scopus 로고
    • Isolation of the Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene and regulation and use of its promoter
    • Waterham,H.R., Digan,M.E., Koutz,P.J., Lair,S.V. and Cregg,J.M. (1997) Isolation of the Pichia pastoris glyceraldehyde-3-phosphate dehydrogenase gene and regulation and use of its promoter. Gene, 186, 37-44.
    • (1997) Gene , vol.186 , pp. 37-44
    • Waterham, H.R.1    Digan, M.E.2    Koutz, P.J.3    Lair, S.V.4    Cregg, J.M.5
  • 14
    • 33847133851 scopus 로고    scopus 로고
    • Translation elongation factor 1-α gene from Pichia pastoris molecular cloning, sequence, and use of its promoter
    • Ahn,J., Hong,J., Lee,H., Park,M., Lee,E., Kim,C., Choi,E. and Jung,J. (2007) Translation elongation factor 1-α gene from Pichia pastoris molecular cloning, sequence, and use of its promoter. Appl. Microbiol. Biotechnol., 74, 601-608.
    • (2007) Appl. Microbiol. Biotechnol , vol.74 , pp. 601-608
    • Ahn, J.1    Hong, J.2    Lee, H.3    Park, M.4    Lee, E.5    Kim, C.6    Choi, E.7    Jung, J.8
  • 15
    • 23844505624 scopus 로고    scopus 로고
    • Molecular characterization of the 3-phosphoglycerate kinase gene (PGK1) from the methylotrophic yeast Pichia pastoris
    • de Almeida,J.R., de Moraes,L.M. and Torres,F.A. (2005) Molecular characterization of the 3-phosphoglycerate kinase gene (PGK1) from the methylotrophic yeast Pichia pastoris. Yeast, 22, 725-737.
    • (2005) Yeast , vol.22 , pp. 725-737
    • de Almeida, J.R.1    de Moraes, L.M.2    Torres, F.A.3
  • 16
    • 0142155560 scopus 로고    scopus 로고
    • The ICL1 gene of Pichia pastoris, transcriptional regulation and use of its promoter
    • Menendez,J., Valdes,I. and Cabrera,N. (2003) The ICL1 gene of Pichia pastoris, transcriptional regulation and use of its promoter. Yeast, 20, 1097-1108.
    • (2003) Yeast , vol.20 , pp. 1097-1108
    • Menendez, J.1    Valdes, I.2    Cabrera, N.3
  • 17
    • 33846886702 scopus 로고    scopus 로고
    • Regulation of methanol utilisation pathway genes in yeasts
    • Hartner,F.S. and Glieder,A. (2006) Regulation of methanol utilisation pathway genes in yeasts. Microb. Cell. Fact., 5, 39.
    • (2006) Microb. Cell. Fact , vol.5 , pp. 39
    • Hartner, F.S.1    Glieder, A.2
  • 18
    • 33748915125 scopus 로고    scopus 로고
    • Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris: A review
    • Cos,O., Ramon,R., Montesinos,J.L. and Valero,F. (2006) Operational strategies, monitoring and control of heterologous protein production in the methylotrophic yeast Pichia pastoris: A review. Microb. Cell. Fact., 5, 17.
    • (2006) Microb. Cell. Fact , vol.5 , pp. 17
    • Cos, O.1    Ramon, R.2    Montesinos, J.L.3    Valero, F.4
  • 21
    • 0026508262 scopus 로고
    • Control of peroxisome proliferation in Saccharomyces cerevisiae by ADR1, SNF1 (CAT1, CCR1) and SNF4 (CAT3)
    • Simon,M., Binder,M., Adam,G., Hartig,A. and Ruis,H. (1992) Control of peroxisome proliferation in Saccharomyces cerevisiae by ADR1, SNF1 (CAT1, CCR1) and SNF4 (CAT3). Yeast, 8, 303-309.
    • (1992) Yeast , vol.8 , pp. 303-309
    • Simon, M.1    Binder, M.2    Adam, G.3    Hartig, A.4    Ruis, H.5
  • 22
    • 0031810672 scopus 로고    scopus 로고
    • Yeast carbon catabolite repression
    • Gancedo,J.M. (1998) Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev., 62, 334-361.
    • (1998) Microbiol. Mol. Biol. Rev , vol.62 , pp. 334-361
    • Gancedo, J.M.1
  • 23
    • 0028207654 scopus 로고
    • Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha
    • Gödecke,S., Eckart,M., Janowicz,Z.A. and Hollenberg,C.P. (1994) Identification of sequences responsible for transcriptional regulation of the strongly expressed methanol oxidase-encoding gene in Hansenula polymorpha. Gene, 139, 35-42.
    • (1994) Gene , vol.139 , pp. 35-42
    • Gödecke, S.1    Eckart, M.2    Janowicz, Z.A.3    Hollenberg, C.P.4
  • 24
    • 0345548548 scopus 로고    scopus 로고
    • Cis acting elements sufficient for induction of FDH1 expression by formate in the methylotrophic yeast Candida boidinii
    • Komeda,T., Yurimoto,H., Kato,N., Sakai,Y. and Kondo,K. (2003) Cis acting elements sufficient for induction of FDH1 expression by formate in the methylotrophic yeast Candida boidinii. Mol. Genet. Genomics, 270, 273-280.
    • (2003) Mol. Genet. Genomics , vol.270 , pp. 273-280
    • Komeda, T.1    Yurimoto, H.2    Kato, N.3    Sakai, Y.4    Kondo, K.5
  • 25
    • 0030002498 scopus 로고    scopus 로고
    • Conserved regulation of the Hansenula polymorpha MOX promoter in Saccharomyces cerevisiae reveals insights in the transcriptional activation by Adr1p
    • Pereira,G.G. and Hollenberg,C.P. (1996) Conserved regulation of the Hansenula polymorpha MOX promoter in Saccharomyces cerevisiae reveals insights in the transcriptional activation by Adr1p. Eur. J. Biochem., 238, 181-191.
    • (1996) Eur. J. Biochem , vol.238 , pp. 181-191
    • Pereira, G.G.1    Hollenberg, C.P.2
  • 26
    • 0028971143 scopus 로고
    • MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
    • Quandt,K., Frech,K., Karas,H., Wingender,E. and Werner,T. (1995) MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res., 23, 4878-4884.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4878-4884
    • Quandt, K.1    Frech, K.2    Karas, H.3    Wingender, E.4    Werner, T.5
  • 28
    • 14744295450 scopus 로고
    • Conversion of starch to ethanol in a recombinant Saccharomyces cerevisiae strain expressing rice α-amylase from a novel Pichia pastoris alcohol oxidase promoter
    • Kumagai,M.H., Sverlow,G.G., della-Cioppa,G. and Grill,L.K. (1993) Conversion of starch to ethanol in a recombinant Saccharomyces cerevisiae strain expressing rice α-amylase from a novel Pichia pastoris alcohol oxidase promoter. Biotechnology, 11, 606-610.
    • (1993) Biotechnology , vol.11 , pp. 606-610
    • Kumagai, M.H.1    Sverlow, G.G.2    della-Cioppa, G.3    Grill, L.K.4
  • 29
    • 5444226007 scopus 로고    scopus 로고
    • Reliable high-throughput screening with Pichia pastoris by limiting yeast cell death phenomena
    • Weis,R., Luiten,R., Skranc,W., Schwab,H., Wubbolts,M. and Glieder,A. (2004) Reliable high-throughput screening with Pichia pastoris by limiting yeast cell death phenomena. FEMS Yeast Res., 5, 179-189.
    • (2004) FEMS Yeast Res , vol.5 , pp. 179-189
    • Weis, R.1    Luiten, R.2    Skranc, W.3    Schwab, H.4    Wubbolts, M.5    Glieder, A.6
  • 31
    • 0029670330 scopus 로고    scopus 로고
    • Improved green fluorescent protein by molecular evolution using DNA shuffling
    • Crameri,A., Whitehorn,E.A., Tate,E. and Stemmer,W.P. (1996) Improved green fluorescent protein by molecular evolution using DNA shuffling. Nat. Biotechnol., 14, 315-319.
    • (1996) Nat. Biotechnol , vol.14 , pp. 315-319
    • Crameri, A.1    Whitehorn, E.A.2    Tate, E.3    Stemmer, W.P.4
  • 32
    • 0032957639 scopus 로고    scopus 로고
    • Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange site-directed mutagenesis
    • Wang,W. and Malcolm,B.A. (1999) Two-stage PCR protocol allowing introduction of multiple mutations, deletions and insertions using QuikChange site-directed mutagenesis. Biotechniques, 26, 680-682.
    • (1999) Biotechniques , vol.26 , pp. 680-682
    • Wang, W.1    Malcolm, B.A.2
  • 33
    • 0034088553 scopus 로고    scopus 로고
    • Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris
    • Morawski,B., Lin,Z., Cirino,P., Joo,H., Bandara,G. and Arnold,F.H. (2000) Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris. Protein Eng., 13, 377-384.
    • (2000) Protein Eng , vol.13 , pp. 377-384
    • Morawski, B.1    Lin, Z.2    Cirino, P.3    Joo, H.4    Bandara, G.5    Arnold, F.H.6
  • 35
    • 0020739930 scopus 로고
    • Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site
    • Guarente,L. and Mason,T. (1983) Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site. Cell, 32, 1279-1286.
    • (1983) Cell , vol.32 , pp. 1279-1286
    • Guarente, L.1    Mason, T.2
  • 36
    • 0035941468 scopus 로고    scopus 로고
    • New selectable marker/auxotrophic host strain combinations for molecular genetic manipulation of Pichia pastoris
    • Lin-Cereghino,G.P., Lin-Cereghino,J., Sunga,A.J., Johnson,M.A., Lim,M., Gleeson,M.A. and Cregg,J.M. (2001) New selectable marker/auxotrophic host strain combinations for molecular genetic manipulation of Pichia pastoris. Gene, 263, 159-169.
    • (2001) Gene , vol.263 , pp. 159-169
    • Lin-Cereghino, G.P.1    Lin-Cereghino, J.2    Sunga, A.J.3    Johnson, M.A.4    Lim, M.5    Gleeson, M.A.6    Cregg, J.M.7
  • 37
    • 0020581632 scopus 로고
    • Fusion of the Saccharomyces cerevisiae leu2 gene to an Escherichia coli β-galactosidase gene
    • Martinez-Arias,A.E. and Casadaban,M.J. (1983) Fusion of the Saccharomyces cerevisiae leu2 gene to an Escherichia coli β-galactosidase gene. Mol. Cell. Biol., 3, 580-586.
    • (1983) Mol. Cell. Biol , vol.3 , pp. 580-586
    • Martinez-Arias, A.E.1    Casadaban, M.J.2
  • 38
    • 12344321400 scopus 로고    scopus 로고
    • Lin-Cereghino,J., Wong,W.W., Xiong,S., Giang,W., Luong,L.T., Vu,J., Johnson,S.D. and Lin-Cereghino,G.P. (2005) Condensed protocol for competent cell preparation and transformation of the methylotrophic yeast Pichia pastoris. Biotechniques, 38, 44, 46, 48.
    • Lin-Cereghino,J., Wong,W.W., Xiong,S., Giang,W., Luong,L.T., Vu,J., Johnson,S.D. and Lin-Cereghino,G.P. (2005) Condensed protocol for competent cell preparation and transformation of the methylotrophic yeast Pichia pastoris. Biotechniques, 38, 44, 46, 48.
  • 39
    • 0024636430 scopus 로고
    • Functional characterization of the two alcohol oxidase genes from the yeast Pichia pastoris
    • Cregg,J.M., Madden,K.R., Barringer,K.J., Thill,G.P. and Stillman,C.A. (1989) Functional characterization of the two alcohol oxidase genes from the yeast Pichia pastoris. Mol. Cell. Biol., 9, 1316-1323.
    • (1989) Mol. Cell. Biol , vol.9 , pp. 1316-1323
    • Cregg, J.M.1    Madden, K.R.2    Barringer, K.J.3    Thill, G.P.4    Stillman, C.A.5
  • 40
    • 33846798394 scopus 로고    scopus 로고
    • The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level
    • Barbara,K.E., Haley,T.M., Willis,K.A. and Santangelo,G.M. (2007) The transcription factor Gcr1 stimulates cell growth by participating in nutrient-responsive gene expression on a global level. Mol. Genet. Genomics, 277, 171-188.
    • (2007) Mol. Genet. Genomics , vol.277 , pp. 171-188
    • Barbara, K.E.1    Haley, T.M.2    Willis, K.A.3    Santangelo, G.M.4
  • 41
    • 0030876430 scopus 로고    scopus 로고
    • The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae
    • Uemura,H., Koshio,M., Inoue,Y., Lopez,M.C. and Baker,H.V. (1997) The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae. Genetics, 147, 521-532.
    • (1997) Genetics , vol.147 , pp. 521-532
    • Uemura, H.1    Koshio, M.2    Inoue, Y.3    Lopez, M.C.4    Baker, H.V.5
  • 42
    • 0023109408 scopus 로고
    • Expression of qa-1F activator protein: Identification of upstream binding sites in the qa gene cluster and localization of the DNA-binding domain
    • Baum,J.A., Geever,R. and Giles,N.H. (1987) Expression of qa-1F activator protein: Identification of upstream binding sites in the qa gene cluster and localization of the DNA-binding domain. Mol. Cell. Biol. 7, 1256-1266.
    • (1987) Mol. Cell. Biol , vol.7 , pp. 1256-1266
    • Baum, J.A.1    Geever, R.2    Giles, N.H.3
  • 43
    • 0028278743 scopus 로고
    • The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development
    • Andrianopoulos,A. and Timberlake,W.E. (1994) The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Mol. Cell. Biol., 14, 2503-2515.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 2503-2515
    • Andrianopoulos, A.1    Timberlake, W.E.2
  • 44
    • 0043269205 scopus 로고    scopus 로고
    • The RNA polymerase II core promoter
    • Smale,S.T. and Kadonaga,J.T. (2003) The RNA polymerase II core promoter. Annu. Rev. Biochem., 72, 449-479.
    • (2003) Annu. Rev. Biochem , vol.72 , pp. 449-479
    • Smale, S.T.1    Kadonaga, J.T.2
  • 46
    • 36749000446 scopus 로고    scopus 로고
    • An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice
    • Hartenbach,S., Baba,M.D., Weber,W. and Fussenegger,M. (2007) An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice. Nucleic Acids Res., 35, e136.
    • (2007) Nucleic Acids Res , vol.35
    • Hartenbach, S.1    Baba, M.D.2    Weber, W.3    Fussenegger, M.4
  • 47
    • 33747078696 scopus 로고    scopus 로고
    • Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes
    • Pfleger,B.F., Pitera,D.J., Smolke,C.D. and Keasling,J.D. (2006) Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes. Nat. Biotechnol., 24, 1027-1032.
    • (2006) Nat. Biotechnol , vol.24 , pp. 1027-1032
    • Pfleger, B.F.1    Pitera, D.J.2    Smolke, C.D.3    Keasling, J.D.4
  • 48
    • 35148890697 scopus 로고    scopus 로고
    • Shuffling of promoters for multiple genes to optimize xylose fermentation in an engineered Saccharomyces cerevisiae strain
    • Lu,C. and Jeffries,T. (2007) Shuffling of promoters for multiple genes to optimize xylose fermentation in an engineered Saccharomyces cerevisiae strain. Appl. Environ. Microbiol., 73, 6072-6077.
    • (2007) Appl. Environ. Microbiol , vol.73 , pp. 6072-6077
    • Lu, C.1    Jeffries, T.2
  • 49
    • 0032485843 scopus 로고    scopus 로고
    • Artificial promoters for metabolic optimization
    • Jensen,P.R. and Hammer,K. (1998) Artificial promoters for metabolic optimization. Biotechnol. Bioeng., 58, 191-195.
    • (1998) Biotechnol. Bioeng , vol.58 , pp. 191-195
    • Jensen, P.R.1    Hammer, K.2
  • 52
    • 36249017917 scopus 로고    scopus 로고
    • Programming gene expression with combinatorial promoters
    • Cox,R.S. III, Surette,M.G. and Elowitz,M.B. (2007) Programming gene expression with combinatorial promoters. Mol. Syst. Biol., 3 145.
    • (2007) Mol. Syst. Biol , vol.3 , pp. 145
    • Cox III, R.S.1    Surette, M.G.2    Elowitz, M.B.3
  • 55
    • 33845329876 scopus 로고    scopus 로고
    • The significance of peroxisomes in methanol metabolism in methylotrophic yeast
    • van der Klei,I.J., Yurimoto,H., Sakai,Y. and Veenhuis,M. (2006) The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim. Biophys. Acta, 1763, 1453-1462.
    • (2006) Biochim. Biophys. Acta , vol.1763 , pp. 1453-1462
    • van der Klei, I.J.1    Yurimoto, H.2    Sakai, Y.3    Veenhuis, M.4
  • 56
    • 47249117123 scopus 로고    scopus 로고
    • Inan,M. (2000) Studies on the alcohol oxidase (AOX1) promoter of Pichia pastoris. Ph.D. thesis. Department of Food Science and Technology. University of Nebraska, Lincoln, NE.
    • Inan,M. (2000) Studies on the alcohol oxidase (AOX1) promoter of Pichia pastoris. Ph.D. thesis. Department of Food Science and Technology. University of Nebraska, Lincoln, NE.
  • 57
    • 47249129032 scopus 로고    scopus 로고
    • Inan,M., Meagher,M.M. and Benson,A.K. (2004) patent no. 6699691.
    • Inan,M., Meagher,M.M. and Benson,A.K. (2004) patent no. 6699691.
  • 58
    • 0033521072 scopus 로고    scopus 로고
    • Setting the standards: Quality control in the secretory pathway
    • Ellgaard,L., Molinari,M. and Helenius,A. (1999) Setting the standards: quality control in the secretory pathway. Science, 286, 1882-1888.
    • (1999) Science , vol.286 , pp. 1882-1888
    • Ellgaard, L.1    Molinari, M.2    Helenius, A.3
  • 59
    • 0141794536 scopus 로고    scopus 로고
    • A novel yeast expression system for the overproduction of quality-controlled membrane proteins
    • Griffith,D.A., Delipala,C., Leadsham,J., Jarvis,S.M. and Oesterhelt,D. (2003) A novel yeast expression system for the overproduction of quality-controlled membrane proteins. FEBS Lett., 553, 45-50.
    • (2003) FEBS Lett , vol.553 , pp. 45-50
    • Griffith, D.A.1    Delipala, C.2    Leadsham, J.3    Jarvis, S.M.4    Oesterhelt, D.5
  • 60
    • 13644258042 scopus 로고    scopus 로고
    • Differential gene expression in recombinant Pichia pastoris analysed by heterologous DNA microarray hybridisation
    • Sauer,M., Branduardi,P., Gasser,B., Valli,M., Maurer,M., Porro,D. and Mattanovich,D. (2004) Differential gene expression in recombinant Pichia pastoris analysed by heterologous DNA microarray hybridisation. Microb. Cell. Fact., 3, 17.
    • (2004) Microb. Cell. Fact , vol.3 , pp. 17
    • Sauer, M.1    Branduardi, P.2    Gasser, B.3    Valli, M.4    Maurer, M.5    Porro, D.6    Mattanovich, D.7
  • 61
    • 0442309687 scopus 로고    scopus 로고
    • Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris
    • Hohenblum,H., Gasser,B., Maurer,M., Borth,N. and Mattanovich,D. (2004) Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris. Biotechnol. Bioeng., 85 367-375.
    • (2004) Biotechnol. Bioeng , vol.85 , pp. 367-375
    • Hohenblum, H.1    Gasser, B.2    Maurer, M.3    Borth, N.4    Mattanovich, D.5
  • 62
    • 0031104672 scopus 로고    scopus 로고
    • Expression level tuning for optimal heterologous protein secretion in Saccharomyces cerevisiae
    • Parekh,R.N. and Wittrup,K.D. (1997) Expression level tuning for optimal heterologous protein secretion in Saccharomyces cerevisiae. Biotechnol. Prog., 13, 117-122.
    • (1997) Biotechnol. Prog , vol.13 , pp. 117-122
    • Parekh, R.N.1    Wittrup, K.D.2
  • 63
    • 0037450518 scopus 로고    scopus 로고
    • Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells
    • Higgins,M.K., Demir,M. and Tate,C.G. (2003) Calnexin co-expression and the use of weaker promoters increase the expression of correctly assembled Shaker potassium channel in insect cells. Biochim. Biophys. Acta, 1610, 124-132.
    • (2003) Biochim. Biophys. Acta , vol.1610 , pp. 124-132
    • Higgins, M.K.1    Demir, M.2    Tate, C.G.3


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