Novel genetic tools for Hansenula polymorpha

FEMS Yeast Research

Volumn 12, Issue 3, 2012, Pages 271-278

  Saraya, Ruchi ^a   Krikken, Arjen M ^a   Kiel, Jan A K W ^a   Baerends, Richard J S ^a   Veenhuis, Marten ^a   van der Klei, Ida J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Dominant markers; Gateway technology; Genetic tools; Methylotrophic yeast; Non homologous end joining

Indexed keywords

FUNGAL GENETICS; FUNGAL STRAIN; GENE DELETION; GENE TARGETING; NONHUMAN; PICHIA ANGUSTA; POLYMERASE CHAIN REACTION; SHORT SURVEY;

BIOTECHNOLOGY; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC VECTORS; PICHIA; PLASMIDS; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC;

PICHIA ANGUSTA;

EID: 84859622845     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2011.00772.x     Document Type: Short Survey

References (37)

1. Baerends RJ, Salomons FA, Faber KN, Kiel JA, van der Klei IJ & Veenhuis M (1997) Deviant Pex3p levels affect normal peroxisome formation in Hansenula polymorpha: high steady-state levels of the protein fully abolish matrix protein import. Yeast 13: 1437-1448.
2. Böer E, Steinborn G, Kunze G & Gellissen G (2007) Yeast expression platforms. Appl Microbiol Biotechnol 77: 513-523.
3. Cepinska MN, Veenhuis M, van der Klei IJ & Nagotu S (2011) Peroxisome fission is associated with reorganization of specific membrane proteins. Traffic 12: 925-937.
4. Faber KN, Swaving GJ, Faber F, AB G, Harder W, Veenhuis M & Haima P (1992) Chromosomal targeting of replicating plasmids in the yeast Hansenula polymorpha. J Gen Microbiol 138: 2405-2416.
5. Faber KN, Haima P, Harder W, Veenhuis M & AB G (1994) Highly-efficient electrotransformation of the yeast Hansenula polymorpha. Curr Genet 25: 305-310.
6. Faber KN, Kram AM, Ehrmann M & Veenhuis M (2001) A novel method to determine the topology of peroxisomal membrane proteins in vivo using the tobacco etch virus protease. J Biol Chem 276: 36501-36507.
7. Gellissen G (2002) Hansenula polymorpha: Biology and Applications. Wiley, Weinhein.
8. Gellissen G, Kunze G, Gaillardin C, Cregg JM, Berardi E, Veenhuis M & van der Klei I (2005) New yeast expression platforms based on methylotrophic Hansenula polymorpha and Pichia pastoris and on dimorphic Arxula adeninivorans and Yarrowia lipolytica - a comparison. FEMS Yeast Res 5: 1079-1096.
9. Gidijala L, van der Klei IJ, Veenhuis M & Kiel JA (2007) Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene. FEMS Yeast Res 7: 1160-1167.
10. Gidijala L, Kiel JA, Douma RD, Seifar RM, van Gulik WM, Bovenberg RA, Veenhuis M & van der Klei IJ (2009) An engineered yeast efficiently secreting penicillin. PLoS ONE 4: e8317.
11. Gietl C, Faber KN, van der Klei IJ & Veenhuis M (1994) Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha. P Natl Acad Sci USA 91: 3151-3155.
12. Haan GJ, Faber KN, Baerends RJ, Koek A, Krikken A, Kiel JA, van der Klei IJ & Veenhuis M (2002) Hansenula polymorpha Pex3p is a peripheral component of the peroxisomal membrane. J Biol Chem 277: 26609-26617.
13. Ito H, Fukuda Y, Murata K & Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168.
14. Kang HA & Gellissen G (2005) Production of recombinant proteins; novel microbial. Eukaryotic Expression Systems, pp. 111-142. Wiley-VCH Verlag, Weinheim.
15. Kiel JA, Keizer-Gunnink IK, Krause T, Komori M & Veenhuis M (1995) Heterologous complementation of peroxisome function in yeast: the Saccharomyces cerevisiae PAS3 gene restores peroxisome biogenesis in a Hansenula polymorpha per9 disruption mutant. FEBS Lett 377: 434-438.
16. Kiel JA, Otzen M, Veenhuis M & van der Klei IJ (2005) Obstruction of polyubiquitination affects PTS1 peroxisomal matrix protein import. Biochim Biophys Acta 1745: 176-186.
17. Krappmann S, Pries R, Gellissen G, Hiller M & Braus GH (2000) HARO7 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization. J Bacteriol 182: 4188-4197.
18. Kurbatova E, Otzen M & van der Klei IJ (2009) p24 proteins play a role in peroxisome proliferation in yeast. FEBS Lett 583: 3175-3180.
19. Manivasakam P, Weber SC, McElver J & Schiesti RH (1995) Micro-homology mediated PCR targeting in Saccharomyces cerevisiae. Nucleic Acids Res 14: 2799-2800.
20. Martín Y, González YV, Cabrera E, Rodríguez C & Siverio JM (2011) Npr1 Ser/Thr protein kinase links nitrogen source quality and carbon availability with the yeast nitrate transporter (Ynt1) levels. J Biol Chem 286: 27225-27235.
21. Nagotu S, Krikken AM, Otzen M, Kiel JA, Veenhuis M & van der Klei IJ (2008a) Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. Traffic 9: 1471-1484.
22. Nagotu S, Saraya R, Otzen M, Veenhuis M & van der Klei IJ (2008b) Peroxisome proliferation in Hansenula polymorpha requires Dnm1p which mediates fission but not de novo formation. Biochim Biophys Acta 1783: 760-769.
23. Pastwa E & Blasiak J (2003) Non-homologous DNA end joining. Acta Biochim Pol 50: 891-908.
24. Qian W, Song H, Liu Y, Zhang C, Niu Z, Wang H & Qiu B (2009) Improved gene disruption method and Cre-loxP mutant system for multiple gene disruptions in Hansenula polymorpha. J Microbiol Methods 79: 253-259.
25. Ramezani-Rad M, Hollenberg CP, Lauber J et al. (2003) The Hansenula polymorpha (strain CBS4732) genome sequencing and analysis. FEMS Yeast Res 4: 207-215.
26. Raschke WC, Neiditch BR, Hendricks M & Cregg JM (1996) Inducible expression of a heterologous protein in Hansenula polymorpha using the alcohol oxidase 1 promoter of Pichia pastoris. Gene 177: 163-167.
27. Sakai Y, Oku M, van der Klei IJ & Kiel JA (2006) Pexophagy: autophagic degradation of peroxisomes. Biochim Biophys Acta 1763: 1767-1775.
28. Salomons FA, Kiel JA, Faber KN, Veenhuis M & van der Klei IJ (2000) Overproduction of Pex5p stimulates import of alcohol oxidase and dihydroxyacetone synthase in a Hansenula polymorpha Pex14 null mutant. J Biol Chem 275: 12603-12611.
29. Saraya R, Krikken AM, Veenhuis M & van der Klei IJ (2011) Peroxisome reintroduction in Hansenula polymorpha requires Pex25 and Rho1. J Cell Biol 193: 885-900.
30. Siverio JM (2002) Assimilation of nitrate by yeasts. FEMS Microbiol Rev 26: 277-284.
31. Snoek IS, van der Krogt ZA, Touw H, Kerkman R, Pronk JT, Bovenberg RA, van den Berg MA & Daran JM (2009) Construction of an hdfA Penicillium chrysogenum strain impaired in non-homologous end-joining and analysis of its potential for functional analysis studies. Fungal Genet Biol 46: 418-426.
32. Stockmann C, Scheidle M, Dittrich B, Merckelbach A, Hehmann G, Melmer G, Klee D, Buchs J, Kang HA & Gellissen G (2009) Process development in Hansenula polymorpha and Arxula adeninivorans, a re-assessment. Microb Cell Fact 8: 22.
33. Sudbery PE, Gleeson MA, Veale RA, Ledeboer AM & Zoetmulder MC (1988) Hansenula polymorpha as a novel yeast system for the expression of heterologous genes. Biochem Soc Trans 16: 1081-1083.
34. van der Klei IJ & Veenhuis M (2006) Yeast and filamentous fungi as model organisms in microbody research. Biochim Biophys Acta 1763: 1364-1373.
35. van der Klei IJ, Yurimoto H, Sakai Y & Veenhuis M (2006) The significance of peroxisomes in methanol metabolism in methylotrophic yeast. Biochim Biophys Acta 1763: 1453-1462.
36. van Zutphen T, Baerends RJ, Susanna KA, de Jong A, Kuipers OP, Veenhuis M & van der Klei IJ (2010) Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis. BMC Genomics 11: 1.
37. Vieira J & Messing J (1991) New pUC-derived cloning vectors with different selectable markers and DNA replication origins. Gene 100: 189-194.