-
4
-
-
84863930127
-
Special issue on gene silencing and delivery
-
Meares CF, Yokoyama M . Special issue on gene silencing and delivery. Acc Chem Res 2012, 45:959-1171.
-
(2012)
Acc Chem Res
, vol.45
, pp. 959-1171
-
-
Meares, C.F.1
Yokoyama, M.2
-
5
-
-
84856389509
-
RNA-based therapeutics: current progress and future prospects
-
Burnett JC, Rossi JJ . RNA-based therapeutics: current progress and future prospects. Chem Biol 2012, 19:60-71.
-
(2012)
Chem Biol
, vol.19
, pp. 60-71
-
-
Burnett, J.C.1
Rossi, J.J.2
-
6
-
-
33847767005
-
Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing
-
Chakraborty C . Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing. Curr Drug Targets 2007, 8:469-482.
-
(2007)
Curr Drug Targets
, vol.8
, pp. 469-482
-
-
Chakraborty, C.1
-
7
-
-
58749096360
-
On the road to reading the RNA-interference code
-
Siomi H, Siomi MC . On the road to reading the RNA-interference code. Nature 2009, 457:396-404.
-
(2009)
Nature
, vol.457
, pp. 396-404
-
-
Siomi, H.1
Siomi, M.C.2
-
8
-
-
77249096959
-
Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook
-
Shukla S, Sumaria CS, Pradeepkumar PI . Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook. ChemMedChem 2010, 5:328-349.
-
(2010)
ChemMedChem
, vol.5
, pp. 328-349
-
-
Shukla, S.1
Sumaria, C.S.2
Pradeepkumar, P.I.3
-
9
-
-
78649505850
-
Medicinal chemistry of siRNA delivery
-
Stanton MG, Colletti SL . Medicinal chemistry of siRNA delivery. J Med Chem 2010, 53:7887-7901.
-
(2010)
J Med Chem
, vol.53
, pp. 7887-7901
-
-
Stanton, M.G.1
Colletti, S.L.2
-
10
-
-
0001359591
-
Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
-
Napoli C, Lemieux C, Jorgensen R . Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 1990, 2:279-289.
-
(1990)
Plant Cell
, vol.2
, pp. 279-289
-
-
Napoli, C.1
Lemieux, C.2
Jorgensen, R.3
-
11
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans . Nature 1998, 391:806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
12
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond SM, Bernstein E, Beach D, Hannon GJ . An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000, 404:293-296.
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.J.4
-
13
-
-
4444368187
-
Argonaute2 is the catalytic engine of mammalian RNAi
-
Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ . Argonaute2 is the catalytic engine of mammalian RNAi. Science 2004, 305:1437-1441.
-
(2004)
Science
, vol.305
, pp. 1437-1441
-
-
Liu, J.1
Carmell, M.A.2
Rivas, F.V.3
Marsden, C.G.4
Thomson, J.M.5
Song, J.J.6
Hammond, S.M.7
Joshua-Tor, L.8
Hannon, G.J.9
-
14
-
-
0033615491
-
A species of small antisense RNA in posttranscriptional gene silencing in plants
-
Hamilton AJ, Baulcombe DC . A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 1999, 286:950-952.
-
(1999)
Science
, vol.286
, pp. 950-952
-
-
Hamilton, A.J.1
Baulcombe, D.C.2
-
15
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T . Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
16
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS . Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003, 21:635-637.
-
(2003)
Nat Biotechnol
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
Kobayashi, S.V.4
Burchard, J.5
Mao, M.6
Li, B.7
Cavet, G.8
Linsley, P.S.9
-
17
-
-
80052146843
-
Structural diversity repertoire of gene silencing small interfering RNAs
-
Chang CI, Kim HA, Dua P, Kim S, Li CJ, Lee DK . Structural diversity repertoire of gene silencing small interfering RNAs. Nucleic Acid Ther 2011, 21:125-131.
-
(2011)
Nucleic Acid Ther
, vol.21
, pp. 125-131
-
-
Chang, C.I.1
Kim, H.A.2
Dua, P.3
Kim, S.4
Li, C.J.5
Lee, D.K.6
-
18
-
-
84908520977
-
Bioinformatics of siRNA design
-
Tafer H . Bioinformatics of siRNA design. Methods Mol Biol 2014, 1097:477-490.
-
(2014)
Methods Mol Biol
, vol.1097
, pp. 477-490
-
-
Tafer, H.1
-
19
-
-
43449124403
-
The impact of target site accessibility on the design of effective siRNAs
-
Tafer H, Ameres SL, Obernosterer G, Gebeshuber CA, Schroeder R, Martinez J, Hofacker IL . The impact of target site accessibility on the design of effective siRNAs. Nat Biotechnol 2008, 26:578-583.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 578-583
-
-
Tafer, H.1
Ameres, S.L.2
Obernosterer, G.3
Gebeshuber, C.A.4
Schroeder, R.5
Martinez, J.6
Hofacker, I.L.7
-
20
-
-
34447102459
-
Molecular basis for target RNA recognition and cleavage by human RISC
-
Ameres SL, Martinez J, Schroeder R . Molecular basis for target RNA recognition and cleavage by human RISC. Cell 2007, 130:101-112.
-
(2007)
Cell
, vol.130
, pp. 101-112
-
-
Ameres, S.L.1
Martinez, J.2
Schroeder, R.3
-
21
-
-
84865526525
-
Designing chemically modified oligonucleotides for targeted gene silencing
-
Deleavey GF, Damha MJ . Designing chemically modified oligonucleotides for targeted gene silencing. Chem Biol 2012, 19:937-954.
-
(2012)
Chem Biol
, vol.19
, pp. 937-954
-
-
Deleavey, G.F.1
Damha, M.J.2
-
22
-
-
84903184138
-
Oligonucleotide delivery: a patent review (2010-2013)
-
Grijalvo S, Avino A, Eritja R . Oligonucleotide delivery: a patent review (2010-2013). Expert Opin Ther Pat 2014, 24:801-819.
-
(2014)
Expert Opin Ther Pat
, vol.24
, pp. 801-819
-
-
Grijalvo, S.1
Avino, A.2
Eritja, R.3
-
23
-
-
84879414849
-
Argonaute proteins: functional insights and emerging roles
-
Meister G . Argonaute proteins: functional insights and emerging roles. Nat Rev Genet 2013, 14:447-459.
-
(2013)
Nat Rev Genet
, vol.14
, pp. 447-459
-
-
Meister, G.1
-
24
-
-
77953479619
-
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2
-
Frank F, Sonenberg N, Nagar B . Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 2010, 465:818-822.
-
(2010)
Nature
, vol.465
, pp. 818-822
-
-
Frank, F.1
Sonenberg, N.2
Nagar, B.3
-
25
-
-
70350783745
-
Structural insights into RNA processing by the human RISC-loading complex
-
Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA, Nogales E . Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol 2009, 16:1148-1153.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1148-1153
-
-
Wang, H.W.1
Noland, C.2
Siridechadilok, B.3
Taylor, D.W.4
Ma, E.5
Felderer, K.6
Doudna, J.A.7
Nogales, E.8
-
26
-
-
0345490960
-
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
-
Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L . The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol 2003, 10:1026-1032.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 1026-1032
-
-
Song, J.J.1
Liu, J.2
Tolia, N.H.3
Schneiderman, J.4
Smith, S.K.5
Martienssen, R.A.6
Hannon, G.J.7
Joshua-Tor, L.8
-
27
-
-
84856723932
-
The N domain of Argonaute drives duplex unwinding during RISC assembly
-
Kwak PB, Tomari Y . The N domain of Argonaute drives duplex unwinding during RISC assembly. Nat Struct Mol Biol 2012, 19:145-151.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 145-151
-
-
Kwak, P.B.1
Tomari, Y.2
-
28
-
-
58749113430
-
A three-dimensional view of the molecular machinery of RNA interference
-
Jinek M, Doudna JA . A three-dimensional view of the molecular machinery of RNA interference. Nature 2009, 457:405-412.
-
(2009)
Nature
, vol.457
, pp. 405-412
-
-
Jinek, M.1
Doudna, J.A.2
-
29
-
-
33845755467
-
Illuminating the silence: understanding the structure and function of small RNAs
-
Rana TM . Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 2007, 8:23-36.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 23-36
-
-
Rana, T.M.1
-
30
-
-
84870038812
-
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
-
Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD . Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell 2012, 151:1055-1067.
-
(2012)
Cell
, vol.151
, pp. 1055-1067
-
-
Wee, L.M.1
Flores-Jasso, C.F.2
Salomon, W.E.3
Zamore, P.D.4
-
32
-
-
70350005156
-
Binding and cleavage specificities of human Argonaute2
-
Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST . Binding and cleavage specificities of human Argonaute2. J Biol Chem 2009, 284:26017-26028.
-
(2009)
J Biol Chem
, vol.284
, pp. 26017-26028
-
-
Lima, W.F.1
Wu, H.2
Nichols, J.G.3
Sun, H.4
Murray, H.M.5
Crooke, S.T.6
-
33
-
-
70149116785
-
The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2
-
Felice KM, Salzman DW, Shubert-Coleman J, Jensen KP, Furneaux HM . The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2. Biochem J 2009, 422:329-341.
-
(2009)
Biochem J
, vol.422
, pp. 329-341
-
-
Felice, K.M.1
Salzman, D.W.2
Shubert-Coleman, J.3
Jensen, K.P.4
Furneaux, H.M.5
-
34
-
-
77954214431
-
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein
-
Boland A, Tritschler F, Heimstadt S, Izaurralde E, Weichenrieder O . Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 2010, 11:522-527.
-
(2010)
EMBO Rep
, vol.11
, pp. 522-527
-
-
Boland, A.1
Tritschler, F.2
Heimstadt, S.3
Izaurralde, E.4
Weichenrieder, O.5
-
35
-
-
84945896487
-
Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
-
Schirle NT, Sheu-Gruttadauria J, Chandradoss SD, Joo C, MacRae IJ . Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets. Elife 2015, 4:e07646.
-
(2015)
Elife
, vol.4
, pp. e07646
-
-
Schirle, N.T.1
Sheu-Gruttadauria, J.2
Chandradoss, S.D.3
Joo, C.4
MacRae, I.J.5
-
36
-
-
84887671758
-
Short interfering RNA guide strand modifiers from computational screening
-
Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA . Short interfering RNA guide strand modifiers from computational screening. J Am Chem Soc 2013, 135:17069-17077.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 17069-17077
-
-
Onizuka, K.1
Harrison, J.G.2
Ball-Jones, A.A.3
Ibarra-Soza, J.M.4
Zheng, Y.5
Ly, D.6
Lam, W.7
Mac, S.8
Tantillo, D.J.9
Beal, P.A.10
-
37
-
-
70349961432
-
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
-
Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, Patel DJ . Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 2009, 461:754-761.
-
(2009)
Nature
, vol.461
, pp. 754-761
-
-
Wang, Y.1
Juranek, S.2
Li, H.3
Sheng, G.4
Wardle, G.S.5
Tuschl, T.6
Patel, D.J.7
-
38
-
-
84900814334
-
Composition of seed sequence is a major determinant of microRNA targeting patterns
-
Wang X . Composition of seed sequence is a major determinant of microRNA targeting patterns. Bioinformatics 2014, 30:1377-1383.
-
(2014)
Bioinformatics
, vol.30
, pp. 1377-1383
-
-
Wang, X.1
-
39
-
-
33745612464
-
Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
-
Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS . Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 2006, 12:1179-1187.
-
(2006)
RNA
, vol.12
, pp. 1179-1187
-
-
Jackson, A.L.1
Burchard, J.2
Schelter, J.3
Chau, B.N.4
Cleary, M.5
Lim, L.6
Linsley, P.S.7
-
40
-
-
84883549528
-
Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
-
Ui-Tei K . Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics. Front Genet 2013, 4:107.
-
(2013)
Front Genet
, vol.4
, pp. 107
-
-
Ui-Tei, K.1
-
41
-
-
58749086586
-
Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
-
Ui-Tei K, Naito Y, Nishi K, Juni A, Saigo K . Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect. Nucleic Acids Res 2008, 36:7100-7109.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 7100-7109
-
-
Ui-Tei, K.1
Naito, Y.2
Nishi, K.3
Juni, A.4
Saigo, K.5
-
42
-
-
77957241115
-
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects
-
Bramsen JB, Pakula MM, Hansen TB, Bus C, Langkjaer N, Odadzic D, Smicius R, Wengel SL, Chattopadhyaya J, Engels JW, et al. A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects. Nucleic Acids Res 2010, 38:5761-5773.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5761-5773
-
-
Bramsen, J.B.1
Pakula, M.M.2
Hansen, T.B.3
Bus, C.4
Langkjaer, N.5
Odadzic, D.6
Smicius, R.7
Wengel, S.L.8
Chattopadhyaya, J.9
Engels, J.W.10
-
43
-
-
84925283447
-
Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs
-
Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA . Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res 2014, 42:12169-12176.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 12169-12176
-
-
Gu, S.1
Zhang, Y.2
Jin, L.3
Huang, Y.4
Zhang, F.5
Bassik, M.C.6
Kampmann, M.7
Kay, M.A.8
-
44
-
-
79953144826
-
Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
-
Vaish N, Chen F, Seth S, Fosnaugh K, Liu Y, Adami R, Brown T, Chen Y, Harvie P, Johns R, et al. Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs. Nucleic Acids Res 2011, 39:1823-1832.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 1823-1832
-
-
Vaish, N.1
Chen, F.2
Seth, S.3
Fosnaugh, K.4
Liu, Y.5
Adami, R.6
Brown, T.7
Chen, Y.8
Harvie, P.9
Johns, R.10
-
45
-
-
33745614074
-
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
-
Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, Johnson JM, Lim L, Karpilow J, Nichols K, et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 2006, 12:1197-1205.
-
(2006)
RNA
, vol.12
, pp. 1197-1205
-
-
Jackson, A.L.1
Burchard, J.2
Leake, D.3
Reynolds, A.4
Schelter, J.5
Guo, J.6
Johnson, J.M.7
Lim, L.8
Karpilow, J.9
Nichols, K.10
-
46
-
-
42449091989
-
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
-
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K . Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res 2008, 36:2136-2151.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 2136-2151
-
-
Ui-Tei, K.1
Naito, Y.2
Zenno, S.3
Nishi, K.4
Yamato, K.5
Takahashi, F.6
Juni, A.7
Saigo, K.8
-
47
-
-
84861451595
-
The crystal structure of human Argonaute2
-
Schirle NT, MacRae IJ . The crystal structure of human Argonaute2. Science 2012, 336:1037-1040.
-
(2012)
Science
, vol.336
, pp. 1037-1040
-
-
Schirle, N.T.1
MacRae, I.J.2
-
48
-
-
84921463352
-
A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency
-
Kume H, Hino K, Galipon J, Ui-Tei K . A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency. Nucleic Acids Res 2014, 42:10050-10060.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 10050-10060
-
-
Kume, H.1
Hino, K.2
Galipon, J.3
Ui-Tei, K.4
-
49
-
-
34447507937
-
Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
-
Sipa K, Sochacka E, Kazmierczak-Baranska J, Maszewska M, Janicka M, Nowak G, Nawrot B . Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA 2007, 13:1301-1316.
-
(2007)
RNA
, vol.13
, pp. 1301-1316
-
-
Sipa, K.1
Sochacka, E.2
Kazmierczak-Baranska, J.3
Maszewska, M.4
Janicka, M.5
Nowak, G.6
Nawrot, B.7
-
50
-
-
84906262205
-
Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors
-
Chak LL, Okamura K . Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors. Front Genet 2014, 5:172.
-
(2014)
Front Genet
, vol.5
, pp. 172
-
-
Chak, L.L.1
Okamura, K.2
-
51
-
-
33645763485
-
Cleavage of the siRNA passenger strand during RISC assembly in human cells
-
Leuschner PJ, Ameres SL, Kueng S, Martinez J . Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep 2006, 7:314-320.
-
(2006)
EMBO Rep
, vol.7
, pp. 314-320
-
-
Leuschner, P.J.1
Ameres, S.L.2
Kueng, S.3
Martinez, J.4
-
52
-
-
84865266916
-
Slicing-independent RISC activation requires the argonaute PAZ domain
-
Gu S, Jin L, Huang Y, Zhang F, Kay MA . Slicing-independent RISC activation requires the argonaute PAZ domain. Curr Biol 2012, 22:1536-1542.
-
(2012)
Curr Biol
, vol.22
, pp. 1536-1542
-
-
Gu, S.1
Jin, L.2
Huang, Y.3
Zhang, F.4
Kay, M.A.5
-
53
-
-
84899888621
-
Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells
-
Takahashi T, Zenno S, Ishibashi O, Takizawa T, Saigo K, Ui-Tei K . Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells. Nucleic Acids Res 2014, 42:5256-5269.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 5256-5269
-
-
Takahashi, T.1
Zenno, S.2
Ishibashi, O.3
Takizawa, T.4
Saigo, K.5
Ui-Tei, K.6
-
54
-
-
84885147092
-
Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation
-
Zheng J, Zhang L, Zhang J, Wang X, Ye K, Xi Z, Du Q, Liang Z . Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation. FASEB J 2013, 27:4017-4026.
-
(2013)
FASEB J
, vol.27
, pp. 4017-4026
-
-
Zheng, J.1
Zhang, L.2
Zhang, J.3
Wang, X.4
Ye, K.5
Xi, Z.6
Du, Q.7
Liang, Z.8
-
55
-
-
21244497878
-
Positional effect of chemical modifications on short interference RNA activity in mammalian cells
-
Prakash TP, Allerson CR, Dande P, Vickers TA, Sioufi N, Jarres R, Baker BF, Swayze EE, Griffey RH, Bhat B . Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J Med Chem 2005, 48:4247-4253.
-
(2005)
J Med Chem
, vol.48
, pp. 4247-4253
-
-
Prakash, T.P.1
Allerson, C.R.2
Dande, P.3
Vickers, T.A.4
Sioufi, N.5
Jarres, R.6
Baker, B.F.7
Swayze, E.E.8
Griffey, R.H.9
Bhat, B.10
-
56
-
-
84929207351
-
Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units
-
Alagia A, Terrazas M, Eritja R . Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units. Molecules 2015, 20:7602-7619.
-
(2015)
Molecules
, vol.20
, pp. 7602-7619
-
-
Alagia, A.1
Terrazas, M.2
Eritja, R.3
-
57
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
-
Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T . Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 2001, 20:6877-6888.
-
(2001)
EMBO J
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
58
-
-
84887045209
-
Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein
-
Deerberg A, Willkomm S, Restle T . Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein. Proc Natl Acad Sci USA 2013, 110:17850-17855.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 17850-17855
-
-
Deerberg, A.1
Willkomm, S.2
Restle, T.3
-
59
-
-
85011940616
-
Single-molecule FRET supports the two-state model of Argonaute action
-
Zander A, Holzmeister P, Klose D, Tinnefeld P, Grohmann D . Single-molecule FRET supports the two-state model of Argonaute action. RNA Biol 2014, 11:45-56.
-
(2014)
RNA Biol
, vol.11
, pp. 45-56
-
-
Zander, A.1
Holzmeister, P.2
Klose, D.3
Tinnefeld, P.4
Grohmann, D.5
-
60
-
-
84914162482
-
RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs
-
Alagia A, Terrazas M, Eritja R . RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs. Molecules 2014, 19:17872-17896.
-
(2014)
Molecules
, vol.19
, pp. 17872-17896
-
-
Alagia, A.1
Terrazas, M.2
Eritja, R.3
-
61
-
-
79955010399
-
Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification
-
Terrazas M, Ocampo SM, Perales JC, Marquez VE, Eritja R . Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification. Chembiochem 2011, 12:1056-1065.
-
(2011)
Chembiochem
, vol.12
, pp. 1056-1065
-
-
Terrazas, M.1
Ocampo, S.M.2
Perales, J.C.3
Marquez, V.E.4
Eritja, R.5
-
62
-
-
41649113305
-
RNA interference in mammalia cells by RNA-3'-PNA chimeras
-
Potenza N, Moggio L, Milano G, Salvatore V, Di Blasio B, Russo A, Messere A . RNA interference in mammalia cells by RNA-3'-PNA chimeras. Int J Mol Sci 2008, 9:299-315.
-
(2008)
Int J Mol Sci
, vol.9
, pp. 299-315
-
-
Potenza, N.1
Moggio, L.2
Milano, G.3
Salvatore, V.4
Di Blasio, B.5
Russo, A.6
Messere, A.7
-
63
-
-
84915749904
-
Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA)
-
Kamiya Y, Takai J, Ito H, Murayama K, Kashida H, Asanuma H . Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA). Chembiochem 2014, 15:2549-2555.
-
(2014)
Chembiochem
, vol.15
, pp. 2549-2555
-
-
Kamiya, Y.1
Takai, J.2
Ito, H.3
Murayama, K.4
Kashida, H.5
Asanuma, H.6
-
64
-
-
84874393130
-
Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides
-
Terrazas M, Alagia A, Faustino I, Orozco M, Eritja R . Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides. Chembiochem 2013, 14:510-520.
-
(2013)
Chembiochem
, vol.14
, pp. 510-520
-
-
Terrazas, M.1
Alagia, A.2
Faustino, I.3
Orozco, M.4
Eritja, R.5
-
65
-
-
84872293995
-
Tuning RNA interference by enhancing siRNA/PAZ recognition
-
Gaglione M, Potenza N, Di Fabio G, Romanucci V, Mosca N, Russo A, Novellino E, Cosconati S, Messere A . Tuning RNA interference by enhancing siRNA/PAZ recognition. ACS Med Chem Lett 2013, 4:75-78.
-
(2013)
ACS Med Chem Lett
, vol.4
, pp. 75-78
-
-
Gaglione, M.1
Potenza, N.2
Di Fabio, G.3
Romanucci, V.4
Mosca, N.5
Russo, A.6
Novellino, E.7
Cosconati, S.8
Messere, A.9
-
66
-
-
77953311852
-
Modified siRNAs for the study of the PAZ domain
-
Somoza A, Terrazas M, Eritja R . Modified siRNAs for the study of the PAZ domain. Chem Commun (Camb) 2010, 46:4270-4272.
-
(2010)
Chem Commun (Camb)
, vol.46
, pp. 4270-4272
-
-
Somoza, A.1
Terrazas, M.2
Eritja, R.3
-
67
-
-
84882259509
-
In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference
-
Kandeel M, Kitade Y . In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference. J Comput Aided Mol Des 2013, 27:605-614.
-
(2013)
J Comput Aided Mol Des
, vol.27
, pp. 605-614
-
-
Kandeel, M.1
Kitade, Y.2
-
68
-
-
84868350874
-
Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on dicing polarity, strand selectivity, and RNA editing of siRNAs
-
Zhou J, Song MS, Jacobi AM, Behlke MA, Wu X, Rossi JJ . Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on dicing polarity, strand selectivity, and RNA editing of siRNAs. Mol Ther Nucleic Acids 2012, 1:e17.
-
(2012)
Mol Ther Nucleic Acids
, vol.1
, pp. e17
-
-
Zhou, J.1
Song, M.S.2
Jacobi, A.M.3
Behlke, M.A.4
Wu, X.5
Rossi, J.J.6
-
69
-
-
84922608242
-
Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance
-
Xu L, Wang X, He H, Zhou J, Li X, Ma H, Li Z, Zeng Y, Shao R, Cen S, et al. Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance. Biochemistry 2015, 54:1268-1277.
-
(2015)
Biochemistry
, vol.54
, pp. 1268-1277
-
-
Xu, L.1
Wang, X.2
He, H.3
Zhou, J.4
Li, X.5
Ma, H.6
Li, Z.7
Zeng, Y.8
Shao, R.9
Cen, S.10
-
70
-
-
54549084606
-
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
-
Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S . Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res 2008, 36:5812-5821.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 5812-5821
-
-
Sano, M.1
Sierant, M.2
Miyagishi, M.3
Nakanishi, M.4
Takagi, Y.5
Sutou, S.6
-
71
-
-
79957755711
-
siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract
-
Hoerter JA, Krishnan V, Lionberger TA, Walter NG . siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. PLoS One 2011, 6:e20359.
-
(2011)
PLoS One
, vol.6
, pp. e20359
-
-
Hoerter, J.A.1
Krishnan, V.2
Lionberger, T.A.3
Walter, N.G.4
-
72
-
-
31544456413
-
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
-
Bartlett DW, Davis ME . Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res 2006, 34:322-333.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 322-333
-
-
Bartlett, D.W.1
Davis, M.E.2
-
73
-
-
34447306000
-
Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
-
Bartlett DW, Davis ME . Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol Bioeng 2007, 97:909-921.
-
(2007)
Biotechnol Bioeng
, vol.97
, pp. 909-921
-
-
Bartlett, D.W.1
Davis, M.E.2
-
74
-
-
84875878783
-
Development of therapeutic-grade small interfering RNAs by chemical engineering
-
Bramsen JB, Kjems J . Development of therapeutic-grade small interfering RNAs by chemical engineering. Front Genet 2012, 3:154.
-
(2012)
Front Genet
, vol.3
, pp. 154
-
-
Bramsen, J.B.1
Kjems, J.2
-
75
-
-
84880213957
-
Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants
-
Snead NM, Wu X, Li A, Cui Q, Sakurai K, Burnett JC, Rossi JJ . Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants. Nucleic Acids Res 2013, 41:6209-6221.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 6209-6221
-
-
Snead, N.M.1
Wu, X.2
Li, A.3
Cui, Q.4
Sakurai, K.5
Burnett, J.C.6
Rossi, J.J.7
-
76
-
-
80054810308
-
Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference
-
Abe N, Abe H, Nagai C, Harada M, Hatakeyama H, Harashima H, Ohshiro T, Nishihara M, Furukawa K, Maeda M, et al. Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference. Bioconjug Chem 2011, 22:2082-2092.
-
(2011)
Bioconjug Chem
, vol.22
, pp. 2082-2092
-
-
Abe, N.1
Abe, H.2
Nagai, C.3
Harada, M.4
Hatakeyama, H.5
Harashima, H.6
Ohshiro, T.7
Nishihara, M.8
Furukawa, K.9
Maeda, M.10
-
77
-
-
34848926634
-
Improved silencing properties using small internally segmented interfering RNAs
-
Bramsen JB, Laursen MB, Damgaard CK, Lena SW, Babu BR, Wengel J, Kjems J . Improved silencing properties using small internally segmented interfering RNAs. Nucleic Acids Res 2007, 35:5886-5897.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 5886-5897
-
-
Bramsen, J.B.1
Laursen, M.B.2
Damgaard, C.K.3
Lena, S.W.4
Babu, B.R.5
Wengel, J.6
Kjems, J.7
-
78
-
-
63949084982
-
Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects
-
Chang CI, Yoo JW, Hong SW, Lee SE, Kang HS, Sun X, Rogoff HA, Ban C, Kim S, Li CJ, et al. Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects. Mol Ther 2009, 17:725-732.
-
(2009)
Mol Ther
, vol.17
, pp. 725-732
-
-
Chang, C.I.1
Yoo, J.W.2
Hong, S.W.3
Lee, S.E.4
Kang, H.S.5
Sun, X.6
Rogoff, H.A.7
Ban, C.8
Kim, S.9
Li, C.J.10
-
79
-
-
57449107290
-
Asymmetric RNA duplexes mediate RNA interference in mammalian cells
-
Sun X, Rogoff HA, Li CJ . Asymmetric RNA duplexes mediate RNA interference in mammalian cells. Nat Biotechnol 2008, 26:1379-1382.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1379-1382
-
-
Sun, X.1
Rogoff, H.A.2
Li, C.J.3
-
80
-
-
84861690562
-
Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression
-
Yuan Z, Wu X, Liu C, Xu G, Wu Z . Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression. Hum Gene Ther 2012, 23:521-532.
-
(2012)
Hum Gene Ther
, vol.23
, pp. 521-532
-
-
Yuan, Z.1
Wu, X.2
Liu, C.3
Xu, G.4
Wu, Z.5
-
81
-
-
84865682650
-
Single-stranded siRNAs activate RNAi in animals
-
Lima WF, Prakash TP, Murray HM, Kinberger GA, Li W, Chappell AE, Li CS, Murray SF, Gaus H, Seth PP, et al. Single-stranded siRNAs activate RNAi in animals. Cell 2012, 150:883-894.
-
(2012)
Cell
, vol.150
, pp. 883-894
-
-
Lima, W.F.1
Prakash, T.P.2
Murray, H.M.3
Kinberger, G.A.4
Li, W.5
Chappell, A.E.6
Li, C.S.7
Murray, S.F.8
Gaus, H.9
Seth, P.P.10
-
82
-
-
77449136824
-
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo
-
Kenski DM, Cooper AJ, Li JJ, Willingham AT, Haringsma HJ, Young TA, Kuklin NA, Jones JJ, Cancilla MT, McMasters DR, et al. Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo. Nucleic Acids Res 2010, 38:660-671.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 660-671
-
-
Kenski, D.M.1
Cooper, A.J.2
Li, J.J.3
Willingham, A.T.4
Haringsma, H.J.5
Young, T.A.6
Kuklin, N.A.7
Jones, J.J.8
Cancilla, M.T.9
McMasters, D.R.10
-
83
-
-
38649099969
-
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
-
Chen PY, Weinmann L, Gaidatzis D, Pei Y, Zavolan M, Tuschl T, Meister G . Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 2008, 14:263-274.
-
(2008)
RNA
, vol.14
, pp. 263-274
-
-
Chen, P.Y.1
Weinmann, L.2
Gaidatzis, D.3
Pei, Y.4
Zavolan, M.5
Tuschl, T.6
Meister, G.7
-
84
-
-
84880110211
-
5' Unlocked nucleic acid modification improves siRNA targeting
-
Snead NM, Escamilla-Powers JR, Rossi JJ, McCaffrey AP . 5' Unlocked nucleic acid modification improves siRNA targeting. Mol Ther Nucleic Acids 2013, 2:e103.
-
(2013)
Mol Ther Nucleic Acids
, vol.2
, pp. e103
-
-
Snead, N.M.1
Escamilla-Powers, J.R.2
Rossi, J.J.3
McCaffrey, A.P.4
-
85
-
-
77952725116
-
Dual-targeting siRNAs
-
Tiemann K, Hohn B, Ehsani A, Forman SJ, Rossi JJ, Saetrom P . Dual-targeting siRNAs. RNA 2010, 16:1275-1284.
-
(2010)
RNA
, vol.16
, pp. 1275-1284
-
-
Tiemann, K.1
Hohn, B.2
Ehsani, A.3
Forman, S.J.4
Rossi, J.J.5
Saetrom, P.6
-
86
-
-
33747777302
-
Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs
-
Hossbach M, Gruber J, Osborn M, Weber K, Tuschl T . Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA Biol 2006, 3:82-89.
-
(2006)
RNA Biol
, vol.3
, pp. 82-89
-
-
Hossbach, M.1
Gruber, J.2
Osborn, M.3
Weber, K.4
Tuschl, T.5
-
87
-
-
84934438901
-
Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting
-
Saetrom P . Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting. Methods Mol Biol 2013, 942:169-177.
-
(2013)
Methods Mol Biol
, vol.942
, pp. 169-177
-
-
Saetrom, P.1
-
88
-
-
42449152837
-
Experimental validation of the importance of seed complement frequency to siRNA specificity
-
Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, Leake D, Fedorov Y, Karpilow J, Khvorova A . Experimental validation of the importance of seed complement frequency to siRNA specificity. RNA 2008, 14:853-861.
-
(2008)
RNA
, vol.14
, pp. 853-861
-
-
Anderson, E.M.1
Birmingham, A.2
Baskerville, S.3
Reynolds, A.4
Maksimova, E.5
Leake, D.6
Fedorov, Y.7
Karpilow, J.8
Khvorova, A.9
-
89
-
-
74049124186
-
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
-
Jackson AL, Linsley PS . Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 2010, 9:57-67.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 57-67
-
-
Jackson, A.L.1
Linsley, P.S.2
-
90
-
-
77950518550
-
Rational design of immunostimulatory siRNAs
-
Gantier MP, Tong S, Behlke MA, Irving AT, Lappas M, Nilsson UW, Latz E, McMillan NA, Williams BR . Rational design of immunostimulatory siRNAs. Mol Ther 2010, 18:785-795.
-
(2010)
Mol Ther
, vol.18
, pp. 785-795
-
-
Gantier, M.P.1
Tong, S.2
Behlke, M.A.3
Irving, A.T.4
Lappas, M.5
Nilsson, U.W.6
Latz, E.7
McMillan, N.A.8
Williams, B.R.9
-
91
-
-
48549105152
-
Modifications in small interfering RNA that separate immunostimulation from RNA interference
-
Eberle F, Giessler K, Deck C, Heeg K, Peter M, Richert C, Dalpke AH . Modifications in small interfering RNA that separate immunostimulation from RNA interference. J Immunol 2008, 180:3229-3237.
-
(2008)
J Immunol
, vol.180
, pp. 3229-3237
-
-
Eberle, F.1
Giessler, K.2
Deck, C.3
Heeg, K.4
Peter, M.5
Richert, C.6
Dalpke, A.H.7
-
92
-
-
79251538918
-
Modeling RNA interference in mammalian cells
-
Cuccato G, Polynikis A, Siciliano V, Graziano M, di Bernardo M, di Bernardo D . Modeling RNA interference in mammalian cells. BMC Syst Biol 2011, 5:19.
-
(2011)
BMC Syst Biol
, vol.5
, pp. 19
-
-
Cuccato, G.1
Polynikis, A.2
Siciliano, V.3
Graziano, M.4
di Bernardo, M.5
di Bernardo, D.6
-
93
-
-
65549130010
-
Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells
-
Wei JX, Yang J, Sun JF, Jia LT, Zhang Y, Zhang HZ, Li X, Meng YL, Yao LB, Yang AG . Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells. PLoS One 2009, 4:e5382.
-
(2009)
PLoS One
, vol.4
, pp. e5382
-
-
Wei, J.X.1
Yang, J.2
Sun, J.F.3
Jia, L.T.4
Zhang, Y.5
Zhang, H.Z.6
Li, X.7
Meng, Y.L.8
Yao, L.B.9
Yang, A.G.10
-
94
-
-
0036752955
-
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
-
Schwarz DS, Hutvagner G, Haley B, Zamore PD . Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell 2002, 10:537-548.
-
(2002)
Mol Cell
, vol.10
, pp. 537-548
-
-
Schwarz, D.S.1
Hutvagner, G.2
Haley, B.3
Zamore, P.D.4
-
95
-
-
84859515193
-
In vivo activity and duration of short interfering RNAs containing a synthetic 5'-phosphate
-
Kenski DM, Willingham AT, Haringsma HJ, Li JJ, Flanagan WM . In vivo activity and duration of short interfering RNAs containing a synthetic 5'-phosphate. Nucleic Acid Ther 2012, 22:90-95.
-
(2012)
Nucleic Acid Ther
, vol.22
, pp. 90-95
-
-
Kenski, D.M.1
Willingham, A.T.2
Haringsma, H.J.3
Li, J.J.4
Flanagan, W.M.5
-
96
-
-
63649108380
-
The roles of TLRs, RLRs and NLRs in pathogen recognition
-
Kawai T, Akira S . The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009, 21:317-337.
-
(2009)
Int Immunol
, vol.21
, pp. 317-337
-
-
Kawai, T.1
Akira, S.2
-
98
-
-
46249115827
-
Interferon-inducible antiviral effectors
-
Sadler AJ, Williams BR . Interferon-inducible antiviral effectors. Nat Rev Immunol 2008, 8:559-568.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 559-568
-
-
Sadler, A.J.1
Williams, B.R.2
-
99
-
-
34548129595
-
The response of mammalian cells to double-stranded RNA
-
Gantier MP, Williams BR . The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 2007, 18:363-371.
-
(2007)
Cytokine Growth Factor Rev
, vol.18
, pp. 363-371
-
-
Gantier, M.P.1
Williams, B.R.2
-
100
-
-
66149114745
-
Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities
-
Uzri D, Gehrke L . Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol 2009, 83:4174-4184.
-
(2009)
J Virol
, vol.83
, pp. 4174-4184
-
-
Uzri, D.1
Gehrke, L.2
-
101
-
-
79959199054
-
Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA
-
Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA . Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc 2011, 133:9200-9203.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 9200-9203
-
-
Peacock, H.1
Fucini, R.V.2
Jayalath, P.3
Ibarra-Soza, J.M.4
Haringsma, H.J.5
Flanagan, W.M.6
Willingham, A.7
Beal, P.A.8
-
102
-
-
84862327400
-
Adenosine modification may be preferred for reducing siRNA immune stimulation
-
Fucini RV, Haringsma HJ, Deng P, Flanagan WM, Willingham AT . Adenosine modification may be preferred for reducing siRNA immune stimulation. Nucleic Acid Ther 2012, 22:205-210.
-
(2012)
Nucleic Acid Ther
, vol.22
, pp. 205-210
-
-
Fucini, R.V.1
Haringsma, H.J.2
Deng, P.3
Flanagan, W.M.4
Willingham, A.T.5
-
103
-
-
84920832411
-
Base modification strategies to modulate immune stimulation by an siRNA
-
Valenzuela RA, Suter SR, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Beal PA . Base modification strategies to modulate immune stimulation by an siRNA. Chembiochem 2015, 16:262-267.
-
(2015)
Chembiochem
, vol.16
, pp. 262-267
-
-
Valenzuela, R.A.1
Suter, S.R.2
Ball-Jones, A.A.3
Ibarra-Soza, J.M.4
Zheng, Y.5
Beal, P.A.6
-
104
-
-
55549114663
-
5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
-
Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Morskaya SS, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, et al. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nat Med 2008, 14:1256-1263.
-
(2008)
Nat Med
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
Besch, R.2
Maihoefer, C.3
Renn, M.4
Tormo, D.5
Morskaya, S.S.6
Kirschnek, S.7
Gaffal, E.8
Landsberg, J.9
Hellmuth, J.10
-
105
-
-
80051526424
-
5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice
-
706.e1-3.
-
Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, Protzer U . 5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. Gastroenterology 2011, 141:696-706, 706.e1-3.
-
(2011)
Gastroenterology
, vol.141
, pp. 696-706
-
-
Ebert, G.1
Poeck, H.2
Lucifora, J.3
Baschuk, N.4
Esser, K.5
Esposito, I.6
Hartmann, G.7
Protzer, U.8
-
106
-
-
80053330165
-
Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner
-
Han Q, Zhang C, Zhang J, Tian Z . Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner. Hepatology 2011, 54:1179-1189.
-
(2011)
Hepatology
, vol.54
, pp. 1179-1189
-
-
Han, Q.1
Zhang, C.2
Zhang, J.3
Tian, Z.4
-
107
-
-
34547123547
-
Inhibition of hepatitis C virus infection in cell culture by small interfering RNAs
-
Chevalier C, Saulnier A, Benureau Y, Flechet D, Delgrange D, Colbere-Garapin F, Wychowski C, Martin A . Inhibition of hepatitis C virus infection in cell culture by small interfering RNAs. Mol Ther 2007, 15:1452-1462.
-
(2007)
Mol Ther
, vol.15
, pp. 1452-1462
-
-
Chevalier, C.1
Saulnier, A.2
Benureau, Y.3
Flechet, D.4
Delgrange, D.5
Colbere-Garapin, F.6
Wychowski, C.7
Martin, A.8
-
108
-
-
70349971417
-
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
-
Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, Lee H, Scuto A, Liu Y, Yang C, et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nat Biotechnol 2009, 27:925-932.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 925-932
-
-
Kortylewski, M.1
Swiderski, P.2
Herrmann, A.3
Wang, L.4
Kowolik, C.5
Kujawski, M.6
Lee, H.7
Scuto, A.8
Liu, Y.9
Yang, C.10
-
109
-
-
84857033446
-
siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo
-
Khairuddin N, Gantier MP, Blake SJ, Wu SY, Behlke MA, Williams BR, McMillan NA . siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo. Immunol Cell Biol 2012, 90:187-196.
-
(2012)
Immunol Cell Biol
, vol.90
, pp. 187-196
-
-
Khairuddin, N.1
Gantier, M.P.2
Blake, S.J.3
Wu, S.Y.4
Behlke, M.A.5
Williams, B.R.6
McMillan, N.A.7
-
110
-
-
84893772398
-
Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation
-
Meng G, Xia M, Xu C, Yuan D, Schnurr M, Wei J . Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation. Int J Cancer 2014, 134:1958-1971.
-
(2014)
Int J Cancer
, vol.134
, pp. 1958-1971
-
-
Meng, G.1
Xia, M.2
Xu, C.3
Yuan, D.4
Schnurr, M.5
Wei, J.6
-
111
-
-
84875464528
-
Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer
-
Ellermeier J, Wei J, Duewell P, Hoves S, Stieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H, et al. Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer. Cancer Res 2013, 73:1709-1720.
-
(2013)
Cancer Res
, vol.73
, pp. 1709-1720
-
-
Ellermeier, J.1
Wei, J.2
Duewell, P.3
Hoves, S.4
Stieg, M.R.5
Adunka, T.6
Noerenberg, D.7
Anders, H.J.8
Mayr, D.9
Poeck, H.10
-
112
-
-
84886943543
-
Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I
-
Schnurr M, Duewell P . Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I. Oncoimmunology 2013, 2:e24170.
-
(2013)
Oncoimmunology
, vol.2
, pp. e24170
-
-
Schnurr, M.1
Duewell, P.2
-
113
-
-
84934439207
-
Identifying siRNA-induced off-targets by microarray analysis
-
Anderson E, Boese Q, Khvorova A, Karpilow J . Identifying siRNA-induced off-targets by microarray analysis. Methods Mol Biol 2008, 442:45-63.
-
(2008)
Methods Mol Biol
, vol.442
, pp. 45-63
-
-
Anderson, E.1
Boese, Q.2
Khvorova, A.3
Karpilow, J.4
-
114
-
-
80052393683
-
Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing
-
Dua P, Yoo JW, Kim S, Lee DK . Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing. Mol Ther 2011, 19:1676-1687.
-
(2011)
Mol Ther
, vol.19
, pp. 1676-1687
-
-
Dua, P.1
Yoo, J.W.2
Kim, S.3
Lee, D.K.4
-
115
-
-
84858793517
-
Self-assembled RNA interference microsponges for efficient siRNA delivery
-
Lee JB, Hong J, Bonner DK, Poon Z, Hammond PT . Self-assembled RNA interference microsponges for efficient siRNA delivery. Nat Mater 2012, 11:316-322.
-
(2012)
Nat Mater
, vol.11
, pp. 316-322
-
-
Lee, J.B.1
Hong, J.2
Bonner, D.K.3
Poon, Z.4
Hammond, P.T.5
-
116
-
-
84874978318
-
Exosomes as nucleic acid nanocarriers
-
van den Boorn JG, Dassler J, Coch C, Schlee M, Hartmann G . Exosomes as nucleic acid nanocarriers. Adv Drug Deliv Rev 2013, 65:331-335.
-
(2013)
Adv Drug Deliv Rev
, vol.65
, pp. 331-335
-
-
van den Boorn, J.G.1
Dassler, J.2
Coch, C.3
Schlee, M.4
Hartmann, G.5
-
117
-
-
84866760775
-
Exosome mimetics: a novel class of drug delivery systems
-
Kooijmans SA, Vader P, van Dommelen SM, van Solinge WW, Schiffelers RM . Exosome mimetics: a novel class of drug delivery systems. Int J Nanomedicine 2012, 7:1525-1541.
-
(2012)
Int J Nanomedicine
, vol.7
, pp. 1525-1541
-
-
Kooijmans, S.A.1
Vader, P.2
van Dommelen, S.M.3
van Solinge, W.W.4
Schiffelers, R.M.5
-
118
-
-
84902087150
-
Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis
-
Ding Y, Wang Y, Zhou J, Gu X, Wang W, Liu C, Bao X, Wang C, Li Y, Zhang Q . Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis. Biomaterials 2014, 35:7214-7227.
-
(2014)
Biomaterials
, vol.35
, pp. 7214-7227
-
-
Ding, Y.1
Wang, Y.2
Zhou, J.3
Gu, X.4
Wang, W.5
Liu, C.6
Bao, X.7
Wang, C.8
Li, Y.9
Zhang, Q.10
-
119
-
-
84864544432
-
Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles
-
Nakayama T, Butler JS, Sehgal A, Severgnini M, Racie T, Sharman J, Ding F, Morskaya SS, Brodsky J, Tchangov L, et al. Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles. Mol Ther 2012, 20:1582-1589.
-
(2012)
Mol Ther
, vol.20
, pp. 1582-1589
-
-
Nakayama, T.1
Butler, J.S.2
Sehgal, A.3
Severgnini, M.4
Racie, T.5
Sharman, J.6
Ding, F.7
Morskaya, S.S.8
Brodsky, J.9
Tchangov, L.10
-
121
-
-
84875274968
-
Drug delivery systems: an updated review
-
Tiwari G, Tiwari R, Sriwastawa B, Bhati L, Pandey S, Pandey P, Bannerjee SK . Drug delivery systems: an updated review. Int J Pharm Investig 2012, 2:2-11.
-
(2012)
Int J Pharm Investig
, vol.2
, pp. 2-11
-
-
Tiwari, G.1
Tiwari, R.2
Sriwastawa, B.3
Bhati, L.4
Pandey, S.5
Pandey, P.6
Bannerjee, S.K.7
-
122
-
-
84925271705
-
Shielding of lipid nanoparticles for siRNA delivery: impact on physicochemical properties, cytokine induction, and efficacy
-
Kumar V, Qin J, Jiang Y, Duncan RG, Brigham B, Fishman S, Nair JK, Akinc A, Barros SA, Kasperkovitz PV . Shielding of lipid nanoparticles for siRNA delivery: impact on physicochemical properties, cytokine induction, and efficacy. Mol Ther Nucleic Acids 2014, 3:e210.
-
(2014)
Mol Ther Nucleic Acids
, vol.3
, pp. e210
-
-
Kumar, V.1
Qin, J.2
Jiang, Y.3
Duncan, R.G.4
Brigham, B.5
Fishman, S.6
Nair, J.K.7
Akinc, A.8
Barros, S.A.9
Kasperkovitz, P.V.10
-
123
-
-
84861194242
-
Nanovector delivery of siRNA for cancer therapy
-
Shen H, Sun T, Ferrari M . Nanovector delivery of siRNA for cancer therapy. Cancer Gene Ther 2012, 19:367-373.
-
(2012)
Cancer Gene Ther
, vol.19
, pp. 367-373
-
-
Shen, H.1
Sun, T.2
Ferrari, M.3
-
124
-
-
84899110870
-
Advances in targeted delivery of small interfering RNA using simple bioconjugates
-
Nielsen C, Kjems J, Sorensen KR, Engelholm LH, Behrendt N . Advances in targeted delivery of small interfering RNA using simple bioconjugates. Expert Opin Drug Deliv 2014, 11:791-822.
-
(2014)
Expert Opin Drug Deliv
, vol.11
, pp. 791-822
-
-
Nielsen, C.1
Kjems, J.2
Sorensen, K.R.3
Engelholm, L.H.4
Behrendt, N.5
-
126
-
-
34249302620
-
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
-
Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 654-659
-
-
Valadi, H.1
Ekstrom, K.2
Bossios, A.3
Sjostrand, M.4
Lee, J.J.5
Lotvall, J.O.6
-
127
-
-
79953301730
-
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
-
Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011, 13:423-433.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 423-433
-
-
Vickers, K.C.1
Palmisano, B.T.2
Shoucri, B.M.3
Shamburek, R.D.4
Remaley, A.T.5
|