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Volumn 7, Issue 3, 2016, Pages 316-329

siRNA and RNAi optimization

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; MICRORNA; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; PIWI PROTEIN; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; BIOLOGICAL PRODUCT;

EID: 84959036971     PISSN: 17577004     EISSN: 17577012     Source Type: Journal    
DOI: 10.1002/wrna.1337     Document Type: Review
Times cited : (61)

References (127)
  • 4
    • 84863930127 scopus 로고    scopus 로고
    • Special issue on gene silencing and delivery
    • Meares CF, Yokoyama M . Special issue on gene silencing and delivery. Acc Chem Res 2012, 45:959-1171.
    • (2012) Acc Chem Res , vol.45 , pp. 959-1171
    • Meares, C.F.1    Yokoyama, M.2
  • 5
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: current progress and future prospects
    • Burnett JC, Rossi JJ . RNA-based therapeutics: current progress and future prospects. Chem Biol 2012, 19:60-71.
    • (2012) Chem Biol , vol.19 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2
  • 6
    • 33847767005 scopus 로고    scopus 로고
    • Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing
    • Chakraborty C . Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing. Curr Drug Targets 2007, 8:469-482.
    • (2007) Curr Drug Targets , vol.8 , pp. 469-482
    • Chakraborty, C.1
  • 7
    • 58749096360 scopus 로고    scopus 로고
    • On the road to reading the RNA-interference code
    • Siomi H, Siomi MC . On the road to reading the RNA-interference code. Nature 2009, 457:396-404.
    • (2009) Nature , vol.457 , pp. 396-404
    • Siomi, H.1    Siomi, M.C.2
  • 8
    • 77249096959 scopus 로고    scopus 로고
    • Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook
    • Shukla S, Sumaria CS, Pradeepkumar PI . Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook. ChemMedChem 2010, 5:328-349.
    • (2010) ChemMedChem , vol.5 , pp. 328-349
    • Shukla, S.1    Sumaria, C.S.2    Pradeepkumar, P.I.3
  • 9
    • 78649505850 scopus 로고    scopus 로고
    • Medicinal chemistry of siRNA delivery
    • Stanton MG, Colletti SL . Medicinal chemistry of siRNA delivery. J Med Chem 2010, 53:7887-7901.
    • (2010) J Med Chem , vol.53 , pp. 7887-7901
    • Stanton, M.G.1    Colletti, S.L.2
  • 10
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
    • Napoli C, Lemieux C, Jorgensen R . Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 1990, 2:279-289.
    • (1990) Plant Cell , vol.2 , pp. 279-289
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 11
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans . Nature 1998, 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 12
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond SM, Bernstein E, Beach D, Hannon GJ . An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 2000, 404:293-296.
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 14
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton AJ, Baulcombe DC . A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 1999, 286:950-952.
    • (1999) Science , vol.286 , pp. 950-952
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 15
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T . Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 17
    • 80052146843 scopus 로고    scopus 로고
    • Structural diversity repertoire of gene silencing small interfering RNAs
    • Chang CI, Kim HA, Dua P, Kim S, Li CJ, Lee DK . Structural diversity repertoire of gene silencing small interfering RNAs. Nucleic Acid Ther 2011, 21:125-131.
    • (2011) Nucleic Acid Ther , vol.21 , pp. 125-131
    • Chang, C.I.1    Kim, H.A.2    Dua, P.3    Kim, S.4    Li, C.J.5    Lee, D.K.6
  • 18
    • 84908520977 scopus 로고    scopus 로고
    • Bioinformatics of siRNA design
    • Tafer H . Bioinformatics of siRNA design. Methods Mol Biol 2014, 1097:477-490.
    • (2014) Methods Mol Biol , vol.1097 , pp. 477-490
    • Tafer, H.1
  • 20
    • 34447102459 scopus 로고    scopus 로고
    • Molecular basis for target RNA recognition and cleavage by human RISC
    • Ameres SL, Martinez J, Schroeder R . Molecular basis for target RNA recognition and cleavage by human RISC. Cell 2007, 130:101-112.
    • (2007) Cell , vol.130 , pp. 101-112
    • Ameres, S.L.1    Martinez, J.2    Schroeder, R.3
  • 21
    • 84865526525 scopus 로고    scopus 로고
    • Designing chemically modified oligonucleotides for targeted gene silencing
    • Deleavey GF, Damha MJ . Designing chemically modified oligonucleotides for targeted gene silencing. Chem Biol 2012, 19:937-954.
    • (2012) Chem Biol , vol.19 , pp. 937-954
    • Deleavey, G.F.1    Damha, M.J.2
  • 22
    • 84903184138 scopus 로고    scopus 로고
    • Oligonucleotide delivery: a patent review (2010-2013)
    • Grijalvo S, Avino A, Eritja R . Oligonucleotide delivery: a patent review (2010-2013). Expert Opin Ther Pat 2014, 24:801-819.
    • (2014) Expert Opin Ther Pat , vol.24 , pp. 801-819
    • Grijalvo, S.1    Avino, A.2    Eritja, R.3
  • 23
    • 84879414849 scopus 로고    scopus 로고
    • Argonaute proteins: functional insights and emerging roles
    • Meister G . Argonaute proteins: functional insights and emerging roles. Nat Rev Genet 2013, 14:447-459.
    • (2013) Nat Rev Genet , vol.14 , pp. 447-459
    • Meister, G.1
  • 24
    • 77953479619 scopus 로고    scopus 로고
    • Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2
    • Frank F, Sonenberg N, Nagar B . Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 2010, 465:818-822.
    • (2010) Nature , vol.465 , pp. 818-822
    • Frank, F.1    Sonenberg, N.2    Nagar, B.3
  • 27
    • 84856723932 scopus 로고    scopus 로고
    • The N domain of Argonaute drives duplex unwinding during RISC assembly
    • Kwak PB, Tomari Y . The N domain of Argonaute drives duplex unwinding during RISC assembly. Nat Struct Mol Biol 2012, 19:145-151.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 145-151
    • Kwak, P.B.1    Tomari, Y.2
  • 28
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek M, Doudna JA . A three-dimensional view of the molecular machinery of RNA interference. Nature 2009, 457:405-412.
    • (2009) Nature , vol.457 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 29
    • 33845755467 scopus 로고    scopus 로고
    • Illuminating the silence: understanding the structure and function of small RNAs
    • Rana TM . Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 2007, 8:23-36.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 23-36
    • Rana, T.M.1
  • 30
    • 84870038812 scopus 로고    scopus 로고
    • Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
    • Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD . Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell 2012, 151:1055-1067.
    • (2012) Cell , vol.151 , pp. 1055-1067
    • Wee, L.M.1    Flores-Jasso, C.F.2    Salomon, W.E.3    Zamore, P.D.4
  • 33
    • 70149116785 scopus 로고    scopus 로고
    • The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2
    • Felice KM, Salzman DW, Shubert-Coleman J, Jensen KP, Furneaux HM . The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2. Biochem J 2009, 422:329-341.
    • (2009) Biochem J , vol.422 , pp. 329-341
    • Felice, K.M.1    Salzman, D.W.2    Shubert-Coleman, J.3    Jensen, K.P.4    Furneaux, H.M.5
  • 34
    • 77954214431 scopus 로고    scopus 로고
    • Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein
    • Boland A, Tritschler F, Heimstadt S, Izaurralde E, Weichenrieder O . Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 2010, 11:522-527.
    • (2010) EMBO Rep , vol.11 , pp. 522-527
    • Boland, A.1    Tritschler, F.2    Heimstadt, S.3    Izaurralde, E.4    Weichenrieder, O.5
  • 35
  • 37
    • 70349961432 scopus 로고    scopus 로고
    • Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
    • Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, Patel DJ . Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 2009, 461:754-761.
    • (2009) Nature , vol.461 , pp. 754-761
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Wardle, G.S.5    Tuschl, T.6    Patel, D.J.7
  • 38
    • 84900814334 scopus 로고    scopus 로고
    • Composition of seed sequence is a major determinant of microRNA targeting patterns
    • Wang X . Composition of seed sequence is a major determinant of microRNA targeting patterns. Bioinformatics 2014, 30:1377-1383.
    • (2014) Bioinformatics , vol.30 , pp. 1377-1383
    • Wang, X.1
  • 39
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity
    • Jackson AL, Burchard J, Schelter J, Chau BN, Cleary M, Lim L, Linsley PS . Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA 2006, 12:1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 40
    • 84883549528 scopus 로고    scopus 로고
    • Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
    • Ui-Tei K . Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics. Front Genet 2013, 4:107.
    • (2013) Front Genet , vol.4 , pp. 107
    • Ui-Tei, K.1
  • 41
    • 58749086586 scopus 로고    scopus 로고
    • Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect
    • Ui-Tei K, Naito Y, Nishi K, Juni A, Saigo K . Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect. Nucleic Acids Res 2008, 36:7100-7109.
    • (2008) Nucleic Acids Res , vol.36 , pp. 7100-7109
    • Ui-Tei, K.1    Naito, Y.2    Nishi, K.3    Juni, A.4    Saigo, K.5
  • 43
    • 84925283447 scopus 로고    scopus 로고
    • Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs
    • Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA . Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Res 2014, 42:12169-12176.
    • (2014) Nucleic Acids Res , vol.42 , pp. 12169-12176
    • Gu, S.1    Zhang, Y.2    Jin, L.3    Huang, Y.4    Zhang, F.5    Bassik, M.C.6    Kampmann, M.7    Kay, M.A.8
  • 46
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K . Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res 2008, 36:2136-2151.
    • (2008) Nucleic Acids Res , vol.36 , pp. 2136-2151
    • Ui-Tei, K.1    Naito, Y.2    Zenno, S.3    Nishi, K.4    Yamato, K.5    Takahashi, F.6    Juni, A.7    Saigo, K.8
  • 47
    • 84861451595 scopus 로고    scopus 로고
    • The crystal structure of human Argonaute2
    • Schirle NT, MacRae IJ . The crystal structure of human Argonaute2. Science 2012, 336:1037-1040.
    • (2012) Science , vol.336 , pp. 1037-1040
    • Schirle, N.T.1    MacRae, I.J.2
  • 48
    • 84921463352 scopus 로고    scopus 로고
    • A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency
    • Kume H, Hino K, Galipon J, Ui-Tei K . A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency. Nucleic Acids Res 2014, 42:10050-10060.
    • (2014) Nucleic Acids Res , vol.42 , pp. 10050-10060
    • Kume, H.1    Hino, K.2    Galipon, J.3    Ui-Tei, K.4
  • 49
    • 34447507937 scopus 로고    scopus 로고
    • Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
    • Sipa K, Sochacka E, Kazmierczak-Baranska J, Maszewska M, Janicka M, Nowak G, Nawrot B . Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. RNA 2007, 13:1301-1316.
    • (2007) RNA , vol.13 , pp. 1301-1316
    • Sipa, K.1    Sochacka, E.2    Kazmierczak-Baranska, J.3    Maszewska, M.4    Janicka, M.5    Nowak, G.6    Nawrot, B.7
  • 50
    • 84906262205 scopus 로고    scopus 로고
    • Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors
    • Chak LL, Okamura K . Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors. Front Genet 2014, 5:172.
    • (2014) Front Genet , vol.5 , pp. 172
    • Chak, L.L.1    Okamura, K.2
  • 51
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner PJ, Ameres SL, Kueng S, Martinez J . Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep 2006, 7:314-320.
    • (2006) EMBO Rep , vol.7 , pp. 314-320
    • Leuschner, P.J.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 52
    • 84865266916 scopus 로고    scopus 로고
    • Slicing-independent RISC activation requires the argonaute PAZ domain
    • Gu S, Jin L, Huang Y, Zhang F, Kay MA . Slicing-independent RISC activation requires the argonaute PAZ domain. Curr Biol 2012, 22:1536-1542.
    • (2012) Curr Biol , vol.22 , pp. 1536-1542
    • Gu, S.1    Jin, L.2    Huang, Y.3    Zhang, F.4    Kay, M.A.5
  • 53
    • 84899888621 scopus 로고    scopus 로고
    • Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells
    • Takahashi T, Zenno S, Ishibashi O, Takizawa T, Saigo K, Ui-Tei K . Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells. Nucleic Acids Res 2014, 42:5256-5269.
    • (2014) Nucleic Acids Res , vol.42 , pp. 5256-5269
    • Takahashi, T.1    Zenno, S.2    Ishibashi, O.3    Takizawa, T.4    Saigo, K.5    Ui-Tei, K.6
  • 54
    • 84885147092 scopus 로고    scopus 로고
    • Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation
    • Zheng J, Zhang L, Zhang J, Wang X, Ye K, Xi Z, Du Q, Liang Z . Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation. FASEB J 2013, 27:4017-4026.
    • (2013) FASEB J , vol.27 , pp. 4017-4026
    • Zheng, J.1    Zhang, L.2    Zhang, J.3    Wang, X.4    Ye, K.5    Xi, Z.6    Du, Q.7    Liang, Z.8
  • 56
    • 84929207351 scopus 로고    scopus 로고
    • Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units
    • Alagia A, Terrazas M, Eritja R . Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units. Molecules 2015, 20:7602-7619.
    • (2015) Molecules , vol.20 , pp. 7602-7619
    • Alagia, A.1    Terrazas, M.2    Eritja, R.3
  • 57
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T . Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J 2001, 20:6877-6888.
    • (2001) EMBO J , vol.20 , pp. 6877-6888
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 58
    • 84887045209 scopus 로고    scopus 로고
    • Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein
    • Deerberg A, Willkomm S, Restle T . Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein. Proc Natl Acad Sci USA 2013, 110:17850-17855.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17850-17855
    • Deerberg, A.1    Willkomm, S.2    Restle, T.3
  • 59
    • 85011940616 scopus 로고    scopus 로고
    • Single-molecule FRET supports the two-state model of Argonaute action
    • Zander A, Holzmeister P, Klose D, Tinnefeld P, Grohmann D . Single-molecule FRET supports the two-state model of Argonaute action. RNA Biol 2014, 11:45-56.
    • (2014) RNA Biol , vol.11 , pp. 45-56
    • Zander, A.1    Holzmeister, P.2    Klose, D.3    Tinnefeld, P.4    Grohmann, D.5
  • 60
    • 84914162482 scopus 로고    scopus 로고
    • RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs
    • Alagia A, Terrazas M, Eritja R . RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs. Molecules 2014, 19:17872-17896.
    • (2014) Molecules , vol.19 , pp. 17872-17896
    • Alagia, A.1    Terrazas, M.2    Eritja, R.3
  • 61
    • 79955010399 scopus 로고    scopus 로고
    • Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification
    • Terrazas M, Ocampo SM, Perales JC, Marquez VE, Eritja R . Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification. Chembiochem 2011, 12:1056-1065.
    • (2011) Chembiochem , vol.12 , pp. 1056-1065
    • Terrazas, M.1    Ocampo, S.M.2    Perales, J.C.3    Marquez, V.E.4    Eritja, R.5
  • 63
    • 84915749904 scopus 로고    scopus 로고
    • Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA)
    • Kamiya Y, Takai J, Ito H, Murayama K, Kashida H, Asanuma H . Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA). Chembiochem 2014, 15:2549-2555.
    • (2014) Chembiochem , vol.15 , pp. 2549-2555
    • Kamiya, Y.1    Takai, J.2    Ito, H.3    Murayama, K.4    Kashida, H.5    Asanuma, H.6
  • 64
    • 84874393130 scopus 로고    scopus 로고
    • Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides
    • Terrazas M, Alagia A, Faustino I, Orozco M, Eritja R . Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides. Chembiochem 2013, 14:510-520.
    • (2013) Chembiochem , vol.14 , pp. 510-520
    • Terrazas, M.1    Alagia, A.2    Faustino, I.3    Orozco, M.4    Eritja, R.5
  • 66
    • 77953311852 scopus 로고    scopus 로고
    • Modified siRNAs for the study of the PAZ domain
    • Somoza A, Terrazas M, Eritja R . Modified siRNAs for the study of the PAZ domain. Chem Commun (Camb) 2010, 46:4270-4272.
    • (2010) Chem Commun (Camb) , vol.46 , pp. 4270-4272
    • Somoza, A.1    Terrazas, M.2    Eritja, R.3
  • 67
    • 84882259509 scopus 로고    scopus 로고
    • In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference
    • Kandeel M, Kitade Y . In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference. J Comput Aided Mol Des 2013, 27:605-614.
    • (2013) J Comput Aided Mol Des , vol.27 , pp. 605-614
    • Kandeel, M.1    Kitade, Y.2
  • 68
    • 84868350874 scopus 로고    scopus 로고
    • Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on dicing polarity, strand selectivity, and RNA editing of siRNAs
    • Zhou J, Song MS, Jacobi AM, Behlke MA, Wu X, Rossi JJ . Deep sequencing analyses of DsiRNAs reveal the influence of 3' terminal overhangs on dicing polarity, strand selectivity, and RNA editing of siRNAs. Mol Ther Nucleic Acids 2012, 1:e17.
    • (2012) Mol Ther Nucleic Acids , vol.1 , pp. e17
    • Zhou, J.1    Song, M.S.2    Jacobi, A.M.3    Behlke, M.A.4    Wu, X.5    Rossi, J.J.6
  • 69
    • 84922608242 scopus 로고    scopus 로고
    • Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance
    • Xu L, Wang X, He H, Zhou J, Li X, Ma H, Li Z, Zeng Y, Shao R, Cen S, et al. Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance. Biochemistry 2015, 54:1268-1277.
    • (2015) Biochemistry , vol.54 , pp. 1268-1277
    • Xu, L.1    Wang, X.2    He, H.3    Zhou, J.4    Li, X.5    Ma, H.6    Li, Z.7    Zeng, Y.8    Shao, R.9    Cen, S.10
  • 70
    • 54549084606 scopus 로고    scopus 로고
    • Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
    • Sano M, Sierant M, Miyagishi M, Nakanishi M, Takagi Y, Sutou S . Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection. Nucleic Acids Res 2008, 36:5812-5821.
    • (2008) Nucleic Acids Res , vol.36 , pp. 5812-5821
    • Sano, M.1    Sierant, M.2    Miyagishi, M.3    Nakanishi, M.4    Takagi, Y.5    Sutou, S.6
  • 71
    • 79957755711 scopus 로고    scopus 로고
    • siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract
    • Hoerter JA, Krishnan V, Lionberger TA, Walter NG . siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract. PLoS One 2011, 6:e20359.
    • (2011) PLoS One , vol.6 , pp. e20359
    • Hoerter, J.A.1    Krishnan, V.2    Lionberger, T.A.3    Walter, N.G.4
  • 72
    • 31544456413 scopus 로고    scopus 로고
    • Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging
    • Bartlett DW, Davis ME . Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging. Nucleic Acids Res 2006, 34:322-333.
    • (2006) Nucleic Acids Res , vol.34 , pp. 322-333
    • Bartlett, D.W.1    Davis, M.E.2
  • 73
    • 34447306000 scopus 로고    scopus 로고
    • Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
    • Bartlett DW, Davis ME . Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol Bioeng 2007, 97:909-921.
    • (2007) Biotechnol Bioeng , vol.97 , pp. 909-921
    • Bartlett, D.W.1    Davis, M.E.2
  • 74
    • 84875878783 scopus 로고    scopus 로고
    • Development of therapeutic-grade small interfering RNAs by chemical engineering
    • Bramsen JB, Kjems J . Development of therapeutic-grade small interfering RNAs by chemical engineering. Front Genet 2012, 3:154.
    • (2012) Front Genet , vol.3 , pp. 154
    • Bramsen, J.B.1    Kjems, J.2
  • 75
    • 84880213957 scopus 로고    scopus 로고
    • Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants
    • Snead NM, Wu X, Li A, Cui Q, Sakurai K, Burnett JC, Rossi JJ . Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants. Nucleic Acids Res 2013, 41:6209-6221.
    • (2013) Nucleic Acids Res , vol.41 , pp. 6209-6221
    • Snead, N.M.1    Wu, X.2    Li, A.3    Cui, Q.4    Sakurai, K.5    Burnett, J.C.6    Rossi, J.J.7
  • 79
    • 57449107290 scopus 로고    scopus 로고
    • Asymmetric RNA duplexes mediate RNA interference in mammalian cells
    • Sun X, Rogoff HA, Li CJ . Asymmetric RNA duplexes mediate RNA interference in mammalian cells. Nat Biotechnol 2008, 26:1379-1382.
    • (2008) Nat Biotechnol , vol.26 , pp. 1379-1382
    • Sun, X.1    Rogoff, H.A.2    Li, C.J.3
  • 80
    • 84861690562 scopus 로고    scopus 로고
    • Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression
    • Yuan Z, Wu X, Liu C, Xu G, Wu Z . Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression. Hum Gene Ther 2012, 23:521-532.
    • (2012) Hum Gene Ther , vol.23 , pp. 521-532
    • Yuan, Z.1    Wu, X.2    Liu, C.3    Xu, G.4    Wu, Z.5
  • 83
    • 38649099969 scopus 로고    scopus 로고
    • Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
    • Chen PY, Weinmann L, Gaidatzis D, Pei Y, Zavolan M, Tuschl T, Meister G . Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA 2008, 14:263-274.
    • (2008) RNA , vol.14 , pp. 263-274
    • Chen, P.Y.1    Weinmann, L.2    Gaidatzis, D.3    Pei, Y.4    Zavolan, M.5    Tuschl, T.6    Meister, G.7
  • 86
    • 33747777302 scopus 로고    scopus 로고
    • Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs
    • Hossbach M, Gruber J, Osborn M, Weber K, Tuschl T . Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs. RNA Biol 2006, 3:82-89.
    • (2006) RNA Biol , vol.3 , pp. 82-89
    • Hossbach, M.1    Gruber, J.2    Osborn, M.3    Weber, K.4    Tuschl, T.5
  • 87
    • 84934438901 scopus 로고    scopus 로고
    • Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting
    • Saetrom P . Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting. Methods Mol Biol 2013, 942:169-177.
    • (2013) Methods Mol Biol , vol.942 , pp. 169-177
    • Saetrom, P.1
  • 89
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson AL, Linsley PS . Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov 2010, 9:57-67.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 91
    • 48549105152 scopus 로고    scopus 로고
    • Modifications in small interfering RNA that separate immunostimulation from RNA interference
    • Eberle F, Giessler K, Deck C, Heeg K, Peter M, Richert C, Dalpke AH . Modifications in small interfering RNA that separate immunostimulation from RNA interference. J Immunol 2008, 180:3229-3237.
    • (2008) J Immunol , vol.180 , pp. 3229-3237
    • Eberle, F.1    Giessler, K.2    Deck, C.3    Heeg, K.4    Peter, M.5    Richert, C.6    Dalpke, A.H.7
  • 94
    • 0036752955 scopus 로고    scopus 로고
    • Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    • Schwarz DS, Hutvagner G, Haley B, Zamore PD . Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell 2002, 10:537-548.
    • (2002) Mol Cell , vol.10 , pp. 537-548
    • Schwarz, D.S.1    Hutvagner, G.2    Haley, B.3    Zamore, P.D.4
  • 96
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen recognition
    • Kawai T, Akira S . The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009, 21:317-337.
    • (2009) Int Immunol , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 98
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler AJ, Williams BR . Interferon-inducible antiviral effectors. Nat Rev Immunol 2008, 8:559-568.
    • (2008) Nat Rev Immunol , vol.8 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 99
    • 34548129595 scopus 로고    scopus 로고
    • The response of mammalian cells to double-stranded RNA
    • Gantier MP, Williams BR . The response of mammalian cells to double-stranded RNA. Cytokine Growth Factor Rev 2007, 18:363-371.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 363-371
    • Gantier, M.P.1    Williams, B.R.2
  • 100
    • 66149114745 scopus 로고    scopus 로고
    • Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities
    • Uzri D, Gehrke L . Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol 2009, 83:4174-4184.
    • (2009) J Virol , vol.83 , pp. 4174-4184
    • Uzri, D.1    Gehrke, L.2
  • 105
    • 80051526424 scopus 로고    scopus 로고
    • 5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice
    • 706.e1-3.
    • Ebert G, Poeck H, Lucifora J, Baschuk N, Esser K, Esposito I, Hartmann G, Protzer U . 5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice. Gastroenterology 2011, 141:696-706, 706.e1-3.
    • (2011) Gastroenterology , vol.141 , pp. 696-706
    • Ebert, G.1    Poeck, H.2    Lucifora, J.3    Baschuk, N.4    Esser, K.5    Esposito, I.6    Hartmann, G.7    Protzer, U.8
  • 106
    • 80053330165 scopus 로고    scopus 로고
    • Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner
    • Han Q, Zhang C, Zhang J, Tian Z . Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner. Hepatology 2011, 54:1179-1189.
    • (2011) Hepatology , vol.54 , pp. 1179-1189
    • Han, Q.1    Zhang, C.2    Zhang, J.3    Tian, Z.4
  • 110
    • 84893772398 scopus 로고    scopus 로고
    • Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation
    • Meng G, Xia M, Xu C, Yuan D, Schnurr M, Wei J . Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation. Int J Cancer 2014, 134:1958-1971.
    • (2014) Int J Cancer , vol.134 , pp. 1958-1971
    • Meng, G.1    Xia, M.2    Xu, C.3    Yuan, D.4    Schnurr, M.5    Wei, J.6
  • 112
    • 84886943543 scopus 로고    scopus 로고
    • Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I
    • Schnurr M, Duewell P . Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I. Oncoimmunology 2013, 2:e24170.
    • (2013) Oncoimmunology , vol.2 , pp. e24170
    • Schnurr, M.1    Duewell, P.2
  • 113
    • 84934439207 scopus 로고    scopus 로고
    • Identifying siRNA-induced off-targets by microarray analysis
    • Anderson E, Boese Q, Khvorova A, Karpilow J . Identifying siRNA-induced off-targets by microarray analysis. Methods Mol Biol 2008, 442:45-63.
    • (2008) Methods Mol Biol , vol.442 , pp. 45-63
    • Anderson, E.1    Boese, Q.2    Khvorova, A.3    Karpilow, J.4
  • 114
    • 80052393683 scopus 로고    scopus 로고
    • Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing
    • Dua P, Yoo JW, Kim S, Lee DK . Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing. Mol Ther 2011, 19:1676-1687.
    • (2011) Mol Ther , vol.19 , pp. 1676-1687
    • Dua, P.1    Yoo, J.W.2    Kim, S.3    Lee, D.K.4
  • 115
    • 84858793517 scopus 로고    scopus 로고
    • Self-assembled RNA interference microsponges for efficient siRNA delivery
    • Lee JB, Hong J, Bonner DK, Poon Z, Hammond PT . Self-assembled RNA interference microsponges for efficient siRNA delivery. Nat Mater 2012, 11:316-322.
    • (2012) Nat Mater , vol.11 , pp. 316-322
    • Lee, J.B.1    Hong, J.2    Bonner, D.K.3    Poon, Z.4    Hammond, P.T.5
  • 118
    • 84902087150 scopus 로고    scopus 로고
    • Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis
    • Ding Y, Wang Y, Zhou J, Gu X, Wang W, Liu C, Bao X, Wang C, Li Y, Zhang Q . Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis. Biomaterials 2014, 35:7214-7227.
    • (2014) Biomaterials , vol.35 , pp. 7214-7227
    • Ding, Y.1    Wang, Y.2    Zhou, J.3    Gu, X.4    Wang, W.5    Liu, C.6    Bao, X.7    Wang, C.8    Li, Y.9    Zhang, Q.10
  • 123
    • 84861194242 scopus 로고    scopus 로고
    • Nanovector delivery of siRNA for cancer therapy
    • Shen H, Sun T, Ferrari M . Nanovector delivery of siRNA for cancer therapy. Cancer Gene Ther 2012, 19:367-373.
    • (2012) Cancer Gene Ther , vol.19 , pp. 367-373
    • Shen, H.1    Sun, T.2    Ferrari, M.3
  • 125
  • 126
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO . Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 127
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 2011, 13:423-433.
    • (2011) Nat Cell Biol , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3    Shamburek, R.D.4    Remaley, A.T.5


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