Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo

Nucleic Acids Research

Volumn 38, Issue 2, 2009, Pages 660-671

  Kenski, Denise M ^a   Cooper, Abby J ^a   Li, Jenny J ^a   Willingham, Aarron T ^a   Haringsma, Henry J ^a   Young, Tracy A ^a   Kuklin, Nelly A ^a   Jones, Jeffrey J ^a   Cancilla, Mark T ^a   McMasters, Daniel R ^a   Mathur, Melina ^a   Sachs, Alan B ^a   Michael Flanagan, W ^a  

^a Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYCLIC NUCLEOSIDE; APOLIPOPROTEIN B; ARGONAUTE 2 PROTEIN; ENDOPEPTIDASE CLP; NUCLEIC ACID; PROTEIN CLP1; RIBOSE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CLP1 PROTEIN, HUMAN; GUIDE RNA; INITIATION FACTOR 2; NUCLEAR PROTEIN; NUCLEOSIDE; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RNA ANALYSIS; RNA PROCESSING; SENSITIVITY ANALYSIS; ANIMAL; C57BL MOUSE; CELL LINE; CHEMISTRY; GENETICS; MALE; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; THERMODYNAMICS;

ANIMALS; APOLIPOPROTEINS B; CELL LINE; EUKARYOTIC INITIATION FACTOR-2; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; NUCLEOSIDES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; RNA INTERFERENCE; RNA, GUIDE; RNA, SMALL INTERFERING; THERMODYNAMICS; TRANSCRIPTION FACTORS;

EID: 77449136824     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp913     Document Type: Article

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