-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391(6669):806-811.
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
-
2
-
-
11844278458
-
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
-
Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120(1):15-20.
-
(2005)
Cell
, vol.120
, Issue.1
, pp. 15-20
-
-
Lewis, B.P.1
Burge, C.B.2
Bartel, D.P.3
-
3
-
-
15244358503
-
Systematic discovery of regulatory motifs in human promoters and 3? UTRs by comparison of several mammals
-
Xie X, et al. (2005) Systematic discovery of regulatory motifs in human promoters and 3? UTRs by comparison of several mammals. Nature 434(7031):338-345.
-
(2005)
Nature
, vol.434
, Issue.7031
, pp. 338-345
-
-
Xie, X.1
-
4
-
-
0035966319
-
Micrornas: Tiny regulators with great potential
-
Ambros V (2001) microRNAs: Tiny regulators with great potential. Cell 107(7):823-826.
-
(2001)
Cell
, vol.107
, Issue.7
, pp. 823-826
-
-
Ambros, V.1
-
5
-
-
0037133225
-
Micrornas: Hidden in the genome
-
Moss EG (2002) MicroRNAs: Hidden in the genome. Curr Biol 12(4):R138-R140.
-
(2002)
Curr Biol
, vol.12
, Issue.4
-
-
Moss, E.G.1
-
6
-
-
34547927823
-
Life beyond cleavage: The case of Ago2 and hematopoiesis
-
Martinez J, Busslinger M (2007) Life beyond cleavage: The case of Ago2 and hematopoiesis. Genes Dev 21(16):1983-1988.
-
(2007)
Genes Dev
, vol.21
, Issue.16
, pp. 1983-1988
-
-
Martinez, J.1
Busslinger, M.2
-
7
-
-
34547955952
-
A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
-
O'Carroll D, et al. (2007) A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev 21(16):1999-2004.
-
(2007)
Genes Dev
, vol.21
, Issue.16
, pp. 1999-2004
-
-
O'carroll, D.1
-
8
-
-
33845755467
-
Illuminating the silence: Understanding the structure and function of small RNAs
-
Rana TM (2007) Illuminating the silence: Understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol 8(1):23-36.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.1
, pp. 23-36
-
-
Rana, T.M.1
-
9
-
-
39749110083
-
Small non-coding RNAs in animal development
-
Stefani G, Slack FJ (2008) Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 9(3):219-230.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.3
, pp. 219-230
-
-
Stefani, G.1
Slack, F.J.2
-
10
-
-
0035905766
-
Role for a bidentate ribonuclease in the initiation step of RNA interference
-
Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409(6818):363-366.
-
(2001)
Nature
, vol.409
, Issue.6818
, pp. 363-366
-
-
Bernstein, E.1
Caudy, A.A.2
Hammond, S.M.3
Hannon, G.J.4
-
11
-
-
0035863097
-
RNA interference is mediated by 21- and 22-nucleotide RNAs
-
Elbashir SM, Lendeckel W, Tuschl T (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15(2):188-200.
-
(2001)
Genes Dev
, vol.15
, Issue.2
, pp. 188-200
-
-
Elbashir, S.M.1
Lendeckel, W.2
Tuschl, T.3
-
12
-
-
34250643646
-
Structure of Dicer and mechanistic implications for RNAi
-
MacRae IJ, Li F, Zhou K, Cande WZ, Doudna JA (2006) Structure of Dicer and mechanistic implications for RNAi. Cold Spring Harb Symp Quant Biol 71:73-80.
-
(2006)
Cold Spring Harb Symp Quant Biol
, vol.71
, pp. 73-80
-
-
Macrae, I.J.1
Li, F.2
Zhou, K.3
Cande, W.Z.4
Doudna, J.A.5
-
13
-
-
29144431656
-
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
-
Maniataki E, Mourelatos Z (2005) A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev 19(24):2979-2990.
-
(2005)
Genes Dev
, vol.19
, Issue.24
, pp. 2979-2990
-
-
Maniataki, E.1
Mourelatos, Z.2
-
14
-
-
4444368187
-
Argonaute2 is the catalytic engine of mammalian RNAi
-
Liu J, et al. (2004) Argonaute2 is the catalytic engine of mammalian RNAi. Science 305(5689):1437-1441.
-
(2004)
Science
, vol.305
, Issue.5689
, pp. 1437-1441
-
-
Liu, J.1
-
15
-
-
37549014207
-
Argonaute proteins: Key players in RNA silencing
-
Hutvágner G, Simard MJ (2008) Argonaute proteins: Key players in RNA silencing. Nat Rev Mol Cell Biol 9(1):22-32.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, Issue.1
, pp. 22-32
-
-
Hutvágner, G.1
Simard, M.J.2
-
16
-
-
27744590896
-
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
-
Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD (2005) Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 123(4):607-620.
-
(2005)
Cell
, vol.123
, Issue.4
, pp. 607-620
-
-
Matranga, C.1
Tomari, Y.2
Shin, C.3
Bartel, D.P.4
Zamore, P.D.5
-
17
-
-
28444437427
-
Slicer function of Drosophila Argonautes and its involvement in RISC formation
-
Miyoshi K, Tsukumo H, Nagami T, Siomi H, Siomi MC (2005) Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev 19(23):2837-2848.
-
(2005)
Genes Dev
, vol.19
, Issue.23
, pp. 2837-2848
-
-
Miyoshi, K.1
Tsukumo, H.2
Nagami, T.3
Siomi, H.4
Siomi, M.C.5
-
18
-
-
27744506761
-
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
-
Rand TA, Petersen S, Du F, Wang X (2005) Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 123(4):621-629.
-
(2005)
Cell
, vol.123
, Issue.4
, pp. 621-629
-
-
Rand, T.A.1
Petersen, S.2
Du, F.3
Wang, X.4
-
19
-
-
33645763485
-
Cleavage of the siRNA passenger strand during RISC assembly in human cells
-
Leuschner PJF, Ameres SL, Kueng S, Martinez J (2006) Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep 7(3):314-320.
-
(2006)
EMBO Rep
, vol.7
, Issue.3
, pp. 314-320
-
-
Pjf, L.1
Ameres, S.L.2
Kueng, S.3
Martinez, J.4
-
20
-
-
33845890037
-
Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes
-
Kim K, Lee YS, Carthew RW (2007) Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA 13(1):22-29.
-
(2007)
RNA
, vol.13
, Issue.1
, pp. 22-29
-
-
Kim, K.1
Lee, Y.S.2
Carthew, R.W.3
-
21
-
-
58749096360
-
On the road to reading the RNA-interference code
-
Siomi H, Siomi MC (2009) On the road to reading the RNA-interference code. Nature 457(7228):396-404.
-
(2009)
Nature
, vol.457
, Issue.7228
, pp. 396-404
-
-
Siomi, H.1
Siomi, M.C.2
-
22
-
-
0037144546
-
A microRNA in a multiple-Turnover RNAi enzyme complex
-
Hutvágner G, Zamore PD (2002) A microRNA in a multiple-Turnover RNAi enzyme complex. Science 297(5589):2056-2060.
-
(2002)
Science
, vol.297
, Issue.5589
, pp. 2056-2060
-
-
Hutvágner, G.1
Zamore, P.D.2
-
23
-
-
3042602447
-
Kinetic analysis of the RNAi enzyme complex
-
Haley B, Zamore PD (2004) Kinetic analysis of the RNAi enzyme complex. Nat Struct Mol Biol 11(7):599-606.
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.7
, pp. 599-606
-
-
Haley, B.1
Zamore, P.D.2
-
24
-
-
18744407284
-
Purified Argonaute2 and an siRNA form recombinant human RISC
-
Rivas FV, et al. (2005) Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol 12(4):340-349.
-
(2005)
Nat Struct Mol Biol
, vol.12
, Issue.4
, pp. 340-349
-
-
Rivas, F.V.1
-
25
-
-
0345359925
-
Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain
-
Lingel A, Simon B, Izaurralde E, Sattler M (2003) Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature 426(6965):465-469.
-
(2003)
Nature
, vol.426
, Issue.6965
, pp. 465-469
-
-
Lingel, A.1
Simon, B.2
Izaurralde, E.3
Sattler, M.4
-
26
-
-
0345490960
-
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
-
Song J-J, et al. (2003) The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol 10(12):1026-1032.
-
(2003)
Nat Struct Biol
, vol.10
, Issue.12
, pp. 1026-1032
-
-
Song, J.-J.1
-
27
-
-
0642345790
-
Structure and conserved RNA binding of the PAZ domain
-
Yan KS, et al. (2003) Structure and conserved RNA binding of the PAZ domain. Nature 426(6965):468-474.
-
(2003)
Nature
, vol.426
, Issue.6965
, pp. 468-474
-
-
Yan, K.S.1
-
28
-
-
2542461104
-
Nucleic acid 3α-end recognition by the Argonaute2 PAZ domain
-
Lingel A, Simon B, Izaurralde E, SattlerM (2004) Nucleic acid 3α-end recognition by the Argonaute2 PAZ domain. Nat Struct Mol Biol 11(6):576-577.
-
(2004)
Nat Struct Mol Biol
, vol.11
, Issue.6
, pp. 576-577
-
-
Lingel, A.1
Simon, B.2
Sattlerm, I.E.3
-
29
-
-
2442679207
-
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
-
Ma J-B, Ye K, Patel DJ (2004) Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature 429(6989):318-322.
-
(2004)
Nature
, vol.429
, Issue.6989
, pp. 318-322
-
-
Ma, J.-B.1
Ye, K.2
Patel, D.J.3
-
30
-
-
77953479619
-
Structural basis for 5α-nucleotide base-specific recognition of guide RNA by human AGO2
-
Frank F, Sonenberg N, Nagar B (2010) Structural basis for 5α-nucleotide base-specific recognition of guide RNA by human AGO2. Nature 465(7299):818-822.
-
(2010)
Nature
, vol.465
, Issue.7299
, pp. 818-822
-
-
Frank, F.1
Sonenberg, N.2
Nagar, B.3
-
31
-
-
77954214431
-
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein
-
Boland A, Tritschler F, Heimstädt S, Izaurralde E, Weichenrieder O (2010) Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. EMBO Rep 11(7):522-527.
-
(2010)
EMBO Rep
, vol.11
, Issue.7
, pp. 522-527
-
-
Boland, A.1
Tritschler, F.2
Heimstädt, S.3
Izaurralde, E.4
Weichenrieder, O.5
-
32
-
-
79960181762
-
Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein
-
Boland A, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O (2011) Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proc Natl Acad Sci USA 108(26):10466-10471.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.26
, pp. 10466-10471
-
-
Boland, A.1
Huntzinger, E.2
Schmidt, S.3
Izaurralde, E.4
Weichenrieder, O.5
-
33
-
-
79551690559
-
Recognition of 2α-O-methylated 3α-end of piRNA by the PAZ domain of a Piwi protein
-
Simon B, et al. (2011) Recognition of 2α-O-methylated 3α-end of piRNA by the PAZ domain of a Piwi protein. Structure 19(2):172-180.
-
(2011)
Structure
, vol.19
, Issue.2
, pp. 172-180
-
-
Simon, B.1
-
34
-
-
79551634514
-
Structural basis for piRNA 2α-O-methylated 3α-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains
-
Tian Y, Simanshu DK, Ma J-B, Patel DJ (2011) Structural basis for piRNA 2α-O-methylated 3α-end recognition by Piwi PAZ (Piwi/Argonaute/ Zwille) domains. Proc Natl Acad Sci USA 108(3):903-910.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.3
, pp. 903-910
-
-
Tian, Y.1
Simanshu, D.K.2
Ma, J.-B.3
Patel, D.J.4
-
35
-
-
4444302947
-
Crystal structure of Argonaute and its implications for RISC slicer activity
-
Song J-J, Smith SK, Hannon GJ, Joshua-Tor L (2004) Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305(5689):1434-1437.
-
(2004)
Science
, vol.305
, Issue.5689
, pp. 1434-1437
-
-
Song, J.-J.1
Smith, S.K.2
Hannon, G.J.3
Joshua Tor, L.4
-
36
-
-
23144438396
-
Crystal structure of A aeolicus argonaute, a site-specific DNAguided endoribonuclease, provides insights into RISC-mediated mRNA cleavage
-
Yuan Y-R, et al. (2005) Crystal structure of A. aeolicus argonaute, a site-specific DNAguided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell 19(3):405-419.
-
(2005)
Mol Cell
, vol.19
, Issue.3
, pp. 405-419
-
-
Yuan, Y.-R.1
-
37
-
-
56249145105
-
Structure of the guide-strandcontaining argonaute silencing complex
-
Wang Y, Sheng G, Juranek S, Tuschl T, Patel DJ (2008) Structure of the guide-strandcontaining argonaute silencing complex. Nature 456(7219):209-213.
-
(2008)
Nature
, vol.456
, Issue.7219
, pp. 209-213
-
-
Wang, Y.1
Sheng, G.2
Juranek, S.3
Tuschl, T.4
Patel, D.J.5
-
38
-
-
57749206034
-
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
-
Wang Y, et al. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 456(7224):921-926.
-
(2008)
Nature
, vol.456
, Issue.7224
, pp. 921-926
-
-
Wang, Y.1
-
39
-
-
70349961432
-
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
-
Wang Y, et al. (2009) Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature 461(7265):754-761.
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 754-761
-
-
Wang, Y.1
-
40
-
-
84861451595
-
The crystal structure of human Argonaute2
-
Schirle NT, MacRae IJ (2012) The crystal structure of human Argonaute2. Science 336(6084):1037-1040.
-
(2012)
Science
, vol.336
, Issue.6084
, pp. 1037-1040
-
-
Schirle, N.T.1
Macrae, I.J.2
-
41
-
-
84863624199
-
The structure of human argonaute-2 in complex with miR-20a
-
Elkayam E, et al. (2012) The structure of human argonaute-2 in complex with miR-20a. Cell 150(1):100-110.
-
(2012)
Cell
, vol.150
, Issue.1
, pp. 100-110
-
-
Elkayam, E.1
-
42
-
-
58749113430
-
A three-dimensional view of the molecular machinery of RNA interference
-
Jinek M, Doudna JA (2009) A three-dimensional view of the molecular machinery of RNA interference. Nature 457(7228):405-412.
-
(2009)
Nature
, vol.457
, Issue.7228
, pp. 405-412
-
-
Jinek, M.1
Doudna, J.A.2
-
43
-
-
43549096196
-
The Argonaute protein family
-
Höck J, Meister G (2008) The Argonaute protein family. Genome Biol 9(2):210-218.
-
(2008)
Genome Biol
, vol.9
, Issue.2
, pp. 210-218
-
-
Höck, J.1
Meister, G.2
-
44
-
-
11244279683
-
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity
-
Parker JS, Roe SM, Barford D (2004) Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J 23(24):4727-4737.
-
(2004)
EMBO J
, vol.23
, Issue.24
, pp. 4727-4737
-
-
Parker, J.S.1
Roe, S.M.2
Barford, D.3
-
45
-
-
84862558196
-
Structure of yeast Argonaute with guide RNA
-
Nakanishi K, Weinberg DE, Bartel DP, Patel DJ (2012) Structure of yeast Argonaute with guide RNA. Nature 486(7403):368-374.
-
(2012)
Nature
, vol.486
, Issue.7403
, pp. 368-374
-
-
Nakanishi, K.1
Weinberg, D.E.2
Bartel, D.P.3
Patel, D.J.4
-
46
-
-
21244451435
-
Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
-
Nowotny M, Gaidamakov SA, Crouch RJ, Yang W (2005) Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis. Cell 121(7):1005-1016.
-
(2005)
Cell
, vol.121
, Issue.7
, pp. 1005-1016
-
-
Nowotny, M.1
Gaidamakov, S.A.2
Crouch, R.J.3
Yang, W.4
-
47
-
-
70350005156
-
Binding and cleavage specificities of human Argonaute2
-
Lima WF, et al. (2009) Binding and cleavage specificities of human Argonaute2. J Biol Chem 284(38):26017-26028.
-
(2009)
J Biol Chem
, vol.284
, Issue.38
, pp. 26017-26028
-
-
Lima, W.F.1
-
48
-
-
22144478256
-
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
-
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 7(7):719-723.
-
(2005)
Nat Cell Biol
, vol.7
, Issue.7
, pp. 719-723
-
-
Liu, J.1
Valencia-Sanchez, M.A.2
Hannon, G.J.3
Parker, R.4
-
49
-
-
34447102459
-
Molecular basis for target RNA recognition and cleavage by human RISC
-
Ameres SL, Martinez J, Schroeder R (2007) Molecular basis for target RNA recognition and cleavage by human RISC. Cell 130(1):101-112.
-
(2007)
Cell
, vol.130
, Issue.1
, pp. 101-112
-
-
Ameres, S.L.1
Martinez, J.2
Schroeder, R.3
-
50
-
-
0027092323
-
Mechanism and fidelity of HIV reverse transcriptase
-
Kati WM, Johnson KA, Jerva LF, Anderson KS (1992) Mechanism and fidelity of HIV reverse transcriptase. J Biol Chem 267(36):25988-25997.
-
(1992)
J Biol Chem
, vol.267
, Issue.36
, pp. 25988-25997
-
-
Kati, W.M.1
Johnson, K.A.2
Jerva, L.F.3
Anderson, K.S.4
-
51
-
-
84870038812
-
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
-
Wee LM, Flores-Jasso CF, Salomon WE, Zamore PD (2012) Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell 151(5):1055-1067.
-
(2012)
Cell
, vol.151
, Issue.5
, pp. 1055-1067
-
-
Wee, L.M.1
Flores-Jasso, C.F.2
Salomon, W.E.3
Zamore, P.D.4
-
52
-
-
14644393684
-
Perspective: Machines for RNAi
-
Tomari Y, Zamore PD (2005) Perspective: Machines for RNAi. Genes Dev 19(5):517-529.
-
(2005)
Genes Dev
, vol.19
, Issue.5
, pp. 517-529
-
-
Tomari, Y.1
Zamore, P.D.2
-
53
-
-
36849048778
-
Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
-
Diederichs S, Haber DA (2007) Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 131(6):1097-1108.
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1097-1108
-
-
Diederichs, S.1
Haber, D.A.2
-
54
-
-
81255176919
-
Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
-
Winter J, Diederichs S (2011) Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol 8(6):1149-1157.
-
(2011)
RNA Biol
, vol.8
, Issue.6
, pp. 1149-1157
-
-
Winter, J.1
Diederichs, S.2
|