Modulation of the RNA interference activity using central mismatched siRNAs and acyclic threoninol nucleic acids (aTNA) units

Molecules

Volumn 20, Issue 5, 2015, Pages 7602-7619

  Alagia, Adele ^a   Terrazas, Montserrat ^a,b   Eritja, Ramon ^a  

^a INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

Ago2; Central mismatched siRNA; L threoninol; On off target effects; RISC; RNAi; Silencing asymmetry; Single stranded siRNA; siRNA; Wobble base pair

Indexed keywords

AMINOALCOHOL; ARGONAUTE PROTEIN; BUTANEDIOL; EIF2C2 PROTEIN, HUMAN; HETERODUPLEX; NUCLEIC ACID; SMALL INTERFERING RNA; THREONINOL;

ANIMAL; BASE MISPAIRING; BASE PAIRING; CELL LINE; CHEMISTRY; CONFORMATION; GENETICS; HELA CELL LINE; HUMAN; MOUSE; PHYSIOLOGY; RNA INTERFERENCE;

AMINO ALCOHOLS; ANIMALS; ARGONAUTE PROTEINS; BASE PAIR MISMATCH; BASE PAIRING; BUTYLENE GLYCOLS; CELL LINE; HELA CELLS; HUMANS; MICE; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HETERODUPLEXES; NUCLEIC ACIDS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84929207351     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules20057602     Document Type: Article

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