Structure-based design of novel chemical modification of the 3′-overhang for optimization of short interfering RNA performance

Biochemistry

Volumn 54, Issue 5, 2015, Pages 1268-1277

  Xu, Lexing ^a   Wang, Xin ^a   He, Hongwei ^a   Zhou, Jinming ^a   Li, Xiaoyu ^a   Ma, Hongtao ^b   Li, Zelin ^b   Zeng, Yi ^b   Shao, Rongguang ^a   Cen, Shan ^a   Wang, Yucheng ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; MAMMALS; NUCLEIC ACIDS; NUCLEOTIDES; RNA; SURFACE PLASMON RESONANCE;

BIOCHEMICAL ASSAY; COMPUTER MODELING; COMPUTER MODELING PROGRAMS; MAMMALIAN CELLS; RATIONAL OPTIMIZATION; SHORT INTERFERING RNA; SIRNA DESIGN; STRUCTURE-BASED DESIGNS;

CHEMICAL MODIFICATION;

ARGONAUTE 2 PROTEIN; SMALL INTERFERING RNA; ARGONAUTE PROTEIN; EIF2C2 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ARTICLE; CHEMICAL MODIFICATION; COMPUTER MODEL; CONTROLLED STUDY; GENE EXPRESSION; GENETIC MANIPULATION; HUMAN; HUMAN CELL; MAMMAL CELL; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; RNA SYNTHESIS; SURFACE PLASMON RESONANCE; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; GENETICS; HEPG2 CELL LINE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MAMMALIA;

ARGONAUTE PROTEINS; HEP G2 CELLS; HUMANS; NUCLEIC ACID CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922608242     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500602z     Document Type: Article

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