Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling

Journal of Molecular Medicine

Volumn 94, Issue 4, 2016, Pages 377-390

  Fábián, Zsolt ^a   Taylor, Cormac T ^a   Nguyen, Lan K ^a,b  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Hypoxia; Inflammation; Keywords; Mathematical model; Signal transduction

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; CARRIER PROTEIN; ISOENZYME; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN BINDING;

APOPTOSIS; FEEDBACK SYSTEM; HUMAN; HYPOXIA; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; ANIMAL; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGICAL FEEDBACK; PROCEDURES;

ANIMALS; CARRIER PROTEINS; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISOENZYMES; MAP KINASE SIGNALING SYSTEM; MICRORNAS; MODELS, BIOLOGICAL; NF-KAPPA B; PROLYL HYDROXYLASES; PROTEIN BINDING; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 84955566833     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1383-6     Document Type: Review

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