메뉴 건너뛰기




Volumn 8, Issue 5, 2008, Pages 1019-1028

The mTOR target 4E-BP1 contributes to differential protein expression during normoxia and hypoxia through changes in mRNA translation efficiency

Author keywords

4E BP1; Hypoxia; Translation

Indexed keywords

ACTIN; CALVASCULIN; ENOLASE; GLYCEROPHOSPHOINOSITOL INOSITOLPHOSPHODIESTERASE; HEAT SHOCK PROTEIN 70; INITIATION FACTOR 4E BINDING PROTEIN 1; LACTATE DEHYDROGENASE; PEPTIDYLPROLYL ISOMERASE; SHORT HAIRPIN RNA; TRANSGELIN;

EID: 41149153346     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200700551     Document Type: Article
Times cited : (40)

References (37)
  • 1
    • 33751249607 scopus 로고    scopus 로고
    • Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies
    • Magagnin, M. G., Koritzinsky, M., Wouters, B. G., Patterns of tumor oxygenation and their influence on the cellular hypoxic response and hypoxia-directed therapies. Drug Resist. Updat. 2006, 9, 185-197.
    • (2006) Drug Resist. Updat , vol.9 , pp. 185-197
    • Magagnin, M.G.1    Koritzinsky, M.2    Wouters, B.G.3
  • 2
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L., Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3, 721-732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 3
    • 0029074864 scopus 로고
    • Regulation of protein synthesis in human cells exposed to extreme hypoxia
    • Kraggerud, S. M., Sandvik, J. A., Pettersen, E. O., Regulation of protein synthesis in human cells exposed to extreme hypoxia. Anticancer Res. 1995, 15, 683-686.
    • (1995) Anticancer Res , vol.15 , pp. 683-686
    • Kraggerud, S.M.1    Sandvik, J.A.2    Pettersen, E.O.3
  • 4
    • 0029796904 scopus 로고    scopus 로고
    • Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack
    • Hochachka, P. W., Buck, L. T., Doll, C. J., Land, S. C., Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl. Acad. Sci. USA 1996, 93, 9493-9498.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9493-9498
    • Hochachka, P.W.1    Buck, L.T.2    Doll, C.J.3    Land, S.C.4
  • 5
    • 33644852277 scopus 로고    scopus 로고
    • Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
    • Koritzinsky, M., Magagnin, M. G., van den Beucken, T., Seigneuric, R. et al., Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 2006, 25, 1114-1125.
    • (2006) EMBO J , vol.25 , pp. 1114-1125
    • Koritzinsky, M.1    Magagnin, M.G.2    van den Beucken, T.3    Seigneuric, R.4
  • 6
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha
    • Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S. et al., Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha. Mol. Cell. Biol. 2002, 22, 7405-7416.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4
  • 7
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause, A., Belsham, G. J., Gingras, A. C., Donze, O. et al., Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 1994, 371, 762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.C.3    Donze, O.4
  • 8
    • 0032577691 scopus 로고    scopus 로고
    • 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
    • Poulin, F., Gingras, A. C., Olsen, H., Chevalier, S., Sonenberg, N., 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 1998, 273, 14002-14007.
    • (1998) J. Biol. Chem , vol.273 , pp. 14002-14007
    • Poulin, F.1    Gingras, A.C.2    Olsen, H.3    Chevalier, S.4    Sonenberg, N.5
  • 9
    • 0042031047 scopus 로고    scopus 로고
    • A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets
    • Arsham, A. M., Howell, J. J., Simon, M. C., A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 2003, 278, 29655-29660.
    • (2003) J. Biol. Chem , vol.278 , pp. 29655-29660
    • Arsham, A.M.1    Howell, J.J.2    Simon, M.C.3
  • 10
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D. et al., Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004, 18, 2893-2904.
    • (2004) Genes Dev , vol.18 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3    Manning, B.D.4
  • 11
    • 32944456143 scopus 로고    scopus 로고
    • Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions
    • Kaper, F., Dornhoefer, N., Giaccia, A. J., Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res. 2006, 66, 1561-1569.
    • (2006) Cancer Res , vol.66 , pp. 1561-1569
    • Kaper, F.1    Dornhoefer, N.2    Giaccia, A.J.3
  • 12
    • 33646550165 scopus 로고    scopus 로고
    • Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells
    • Connolly, E., Braunstein, S., Formenti, S., Schneider, R. J., Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol. Cell. Biol. 2006, 26, 3955-3965.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 3955-3965
    • Connolly, E.1    Braunstein, S.2    Formenti, S.3    Schneider, R.J.4
  • 13
    • 34250205154 scopus 로고    scopus 로고
    • Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia
    • Koritzinsky, M., Rouschop, K. M., van den Beucken, T., Magagnin, M. G. et al., Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia. Radiother. Oncol. 2007, 83, 353-361.
    • (2007) Radiother. Oncol , vol.83 , pp. 353-361
    • Koritzinsky, M.1    Rouschop, K.M.2    van den Beucken, T.3    Magagnin, M.G.4
  • 14
    • 23944525416 scopus 로고    scopus 로고
    • 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
    • Teleman, A. A., Chen, Y. W., Cohen, S. M., 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 2005, 19, 1844-1848.
    • (2005) Genes Dev , vol.19 , pp. 1844-1848
    • Teleman, A.A.1    Chen, Y.W.2    Cohen, S.M.3
  • 15
    • 0034770191 scopus 로고    scopus 로고
    • Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
    • Tsukiyama-Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T. et al., Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 2001, 7, 1128-1132.
    • (2001) Nat. Med , vol.7 , pp. 1128-1132
    • Tsukiyama-Kohara, K.1    Poulin, F.2    Kohara, M.3    DeMaria, C.T.4
  • 16
    • 0025314596 scopus 로고
    • Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap
    • Lazaris-Karatzas, A., Montine, K. S., Sonenberg, N., Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 1990, 345, 544-547.
    • (1990) Nature , vol.345 , pp. 544-547
    • Lazaris-Karatzas, A.1    Montine, K.S.2    Sonenberg, N.3
  • 17
    • 0033044355 scopus 로고    scopus 로고
    • eIF4E expression in tumors: Its possible role in progression of malignancies
    • De Benedetti, A., Harris, A. L., eIF4E expression in tumors: Its possible role in progression of malignancies. Int. J. Biochem. Cell Biol. 1999, 31, 59-72.
    • (1999) Int. J. Biochem. Cell Biol , vol.31 , pp. 59-72
    • De Benedetti, A.1    Harris, A.L.2
  • 18
    • 0942298123 scopus 로고    scopus 로고
    • Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth
    • Lynch, M., Fitzgerald, C., Johnston, K. A., Wang, S., Schmidt, E. V., Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth. J. Biol. Chem. 2004, 279, 3327-3339.
    • (2004) J. Biol. Chem , vol.279 , pp. 3327-3339
    • Lynch, M.1    Fitzgerald, C.2    Johnston, K.A.3    Wang, S.4    Schmidt, E.V.5
  • 19
    • 2942515128 scopus 로고    scopus 로고
    • Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells
    • Jiang, H., Coleman, J., Miskimins, R., Miskimins, W. K., Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells. Cancer Cell Int. 2003, 3, 2.
    • (2003) Cancer Cell Int , vol.3 , pp. 2
    • Jiang, H.1    Coleman, J.2    Miskimins, R.3    Miskimins, W.K.4
  • 20
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp, T. R., Bernards, R., Agami, R., A system for stable expression of short interfering RNAs in mammalian cells. Science 2002, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 21
    • 28444495830 scopus 로고    scopus 로고
    • The hypoxic proteome is influenced by gene-specific changes in mRNA translation
    • Koritzinsky, M., Seigneuric, R., Magagnin, M. G., van den Beucken, T. et al., The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother. Oncol. 2005, 76, 177-186.
    • (2005) Radiother. Oncol , vol.76 , pp. 177-186
    • Koritzinsky, M.1    Seigneuric, R.2    Magagnin, M.G.3    van den Beucken, T.4
  • 22
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72, 248-254.
    • (1976) Anal. Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 23
    • 3242794395 scopus 로고    scopus 로고
    • Proteomic analysis of small heat shock protein isoforms in barley shoots
    • Sule, A., Vanrobaeys, F., Hajos, G., Van Beeumen, J., Devreese, B., Proteomic analysis of small heat shock protein isoforms in barley shoots. Phytochemistry 2004, 65, 1853-1863.
    • (2004) Phytochemistry , vol.65 , pp. 1853-1863
    • Sule, A.1    Vanrobaeys, F.2    Hajos, G.3    Van Beeumen, J.4    Devreese, B.5
  • 24
    • 24044454980 scopus 로고    scopus 로고
    • Overexpression of S100A4 is closely associated with progression of colorectal cancer
    • Cho, Y. G., Kim, C. J., Nam, S. W., Yoon, S. H. et al., Overexpression of S100A4 is closely associated with progression of colorectal cancer. World J. Gastroenterol. 2005, 11, 4852-4856.
    • (2005) World J. Gastroenterol , vol.11 , pp. 4852-4856
    • Cho, Y.G.1    Kim, C.J.2    Nam, S.W.3    Yoon, S.H.4
  • 25
    • 16244421976 scopus 로고    scopus 로고
    • Identification and analysis of tumour-associated antigens in hepatocellular carcinoma
    • Shi, Y. Y., Wang, H. C., Yin, Y. H., Sun, W. S. et al., Identification and analysis of tumour-associated antigens in hepatocellular carcinoma. Br. J. Cancer 2005, 92, 929-934.
    • (2005) Br. J. Cancer , vol.92 , pp. 929-934
    • Shi, Y.Y.1    Wang, H.C.2    Yin, Y.H.3    Sun, W.S.4
  • 26
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G. L., Jiang, B. H., Leung, S. W., Passantino, R. et al., Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 1996, 271, 32529-32537.
    • (1996) J. Biol. Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4
  • 27
    • 0033386596 scopus 로고    scopus 로고
    • Hypoxic repression of lactate dehydrogenase-B in retina
    • Buono, R. J., Lang, R. K., Hypoxic repression of lactate dehydrogenase-B in retina. Exp. Eye Res. 1999, 69, 685-693.
    • (1999) Exp. Eye Res , vol.69 , pp. 685-693
    • Buono, R.J.1    Lang, R.K.2
  • 28
    • 34248562291 scopus 로고    scopus 로고
    • Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death
    • Choi, K. J., Piao, Y. J., Lim, M. J., Kim, J. H. et al., Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia- and cisplatin-induced cell death. Cancer Res. 2007, 67, 3654-3662.
    • (2007) Cancer Res , vol.67 , pp. 3654-3662
    • Choi, K.J.1    Piao, Y.J.2    Lim, M.J.3    Kim, J.H.4
  • 29
    • 11144349225 scopus 로고    scopus 로고
    • Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival
    • Dundas, S. R., Lawrie, L. C., Rooney, P. H., Murray, G. I., Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J. Pathol. 2005, 205, 74-81.
    • (2005) J. Pathol , vol.205 , pp. 74-81
    • Dundas, S.R.1    Lawrie, L.C.2    Rooney, P.H.3    Murray, G.I.4
  • 30
    • 10344253805 scopus 로고    scopus 로고
    • Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: Identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma
    • Zou, M., Famulski, K. S., Parhar, R. S., Baitei, E. et al., Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: Identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma. J. Clin. Endocrinol. Metab. 2004, 89, 6146-6154.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 6146-6154
    • Zou, M.1    Famulski, K.S.2    Parhar, R.S.3    Baitei, E.4
  • 31
    • 0345569984 scopus 로고    scopus 로고
    • S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
    • Mathisen, B., Lindstad, R. I., Hansen, J., El-Gewely, S. A. et al., S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. Clin. Exp. Metastasis 2003, 20, 701-711.
    • (2003) Clin. Exp. Metastasis , vol.20 , pp. 701-711
    • Mathisen, B.1    Lindstad, R.I.2    Hansen, J.3    El-Gewely, S.A.4
  • 32
    • 33749516823 scopus 로고    scopus 로고
    • S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9
    • Saleem, M., Kweon, M. H., Johnson, J. J., Adhami, V. M. et al., S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc. Natl. Acad. Sci. USA 2006, 103, 14825-14830.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14825-14830
    • Saleem, M.1    Kweon, M.H.2    Johnson, J.J.3    Adhami, V.M.4
  • 33
    • 34250320950 scopus 로고    scopus 로고
    • Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress
    • Magagnin, M. G., Sergeant, K., van den Beucken, T., Rouschop, K. M. et al., Proteomic analysis of gene expression following hypoxia and reoxygenation reveals proteins involved in the recovery from endoplasmic reticulum and oxidative stress. Radiother. Oncol. 2007, 83, 340-345.
    • (2007) Radiother. Oncol , vol.83 , pp. 340-345
    • Magagnin, M.G.1    Sergeant, K.2    van den Beucken, T.3    Rouschop, K.M.4
  • 34
    • 31544442938 scopus 로고    scopus 로고
    • Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes
    • Lu, X., de la Pena, L., Barker, C., Camphausen, K., Tofilon, P. J., Radiation-induced changes in gene expression involve recruitment of existing messenger RNAs to and away from polysomes. Cancer Res. 2006, 66, 1052-1061.
    • (2006) Cancer Res , vol.66 , pp. 1052-1061
    • Lu, X.1    de la Pena, L.2    Barker, C.3    Camphausen, K.4    Tofilon, P.J.5
  • 35
    • 0242361561 scopus 로고    scopus 로고
    • Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes
    • Rajasekhar, V. K., Viale, A., Socci, N. D., Wiedmann, M. et al., Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes. Mol. Cell 2003, 12, 889-901.
    • (2003) Mol. Cell , vol.12 , pp. 889-901
    • Rajasekhar, V.K.1    Viale, A.2    Socci, N.D.3    Wiedmann, M.4
  • 36
    • 0342858949 scopus 로고    scopus 로고
    • 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers
    • Martin, M. E., Perez, M. I., Redondo, C., Alvarez, M. I. et al., 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers. Int. J. Biochem. Cell Biol. 2000, 32, 633-642.
    • (2000) Int. J. Biochem. Cell Biol , vol.32 , pp. 633-642
    • Martin, M.E.1    Perez, M.I.2    Redondo, C.3    Alvarez, M.I.4
  • 37
    • 33846276209 scopus 로고    scopus 로고
    • 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis
    • Rojo, F., Najera, L., Lirola, J., Jimenez, J. et al., 4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis. Clin. Cancer Res. 2007, 13, 81-89.
    • (2007) Clin. Cancer Res , vol.13 , pp. 81-89
    • Rojo, F.1    Najera, L.2    Lirola, J.3    Jimenez, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.