NF-κB plays a key role in hypoxia-inducible factor-1-regulated erythropoietin gene expression

Experimental Hematology

Volumn 30, Issue 12, 2002, Pages 1419-1427

  Figueroa, Yanira G ^a   Chan, Anna K ^a   Ibrahim, Rania ^a   Tang, Yan ^a   Burow, Matthew E ^a   Alam, Jawed ^a,b   Scandurro, Aline B ^a   Beckman, Barbara S ^a,c  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OCHSNER MEDICAL CENTER   (United States)

^c TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ENZYME INHIBITOR; ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR 1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PYRROLIDINE DITHIOCARBAMATE; AKT1 PROTEIN, HUMAN; DNA BINDING PROTEIN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; NUCLEAR PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOXIC CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANOXIA; BIOSYNTHESIS; CELL CULTURE; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANOXIA; DNA-BINDING PROTEINS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NF-KAPPA B; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036882343     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(02)00934-7     Document Type: Article

References (47)

1. Bunn H.F., Poyton R.O. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev. 76:1996;839.
2. Semenza G.L., Jiang B.H., Leung S.W.et al. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 12:1992;5447.
3. Maxwell P.H., Pugh C.W., Ratcliffe P.J. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines. evidence for a widespread oxygen-sensing mechanism Proc Natl Acad Sci U S A. 90:1993;2423.
4. 2 tension. Proc Natl Acad Sci U S A. 92:1995;5510.
5. Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 270:1995;1230.
6. 2-dependent degradation in domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A. 95:1998;7987.
7. Salceda S., Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. its stabilization by hypoxia depends upon redox- induced changes J Biol Chem. 272:1997;22642.
8. 2-regulated prolyl hydroxylation. Science. 292:2001;468.
9. 2 sensing Science. 292:2001;464.
10. Ohigashi T., Mallia C.S., McGary E.et al. Protein kinase C α protein expression is necessary for sustained erythropoietin production in human hepatocellular carcinoma (Hep3B) cells exposed to hypoxia. Biochem Biophys Acta. 1450:1999;109.
11. Richard D.E., Berra E., Gothie E., Roux D., Pouyssegur J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem. 274:1999;32631.
12. Tamura K., Sudo T., Senftleben U., Dadak A.M., Johnson R., Karin M. Requirement for p38α in erythropoietin expression. a role for stress kinases in erythropoiesis Cell. 102:2000;221.
13. Mazure N.M., Chen E.Y., Laderoute K.R., Giaccia A.J. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 90:1997;3322.
14. Jiang B.-H., Zheng J.Z., Aoki M., Vogt P.K. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A. 97:2000;1749.
15. Wang D., Su Huang H.-J., Kazlauskas A., Cavenee W.K. Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res. 59:1999;1464.
16. Zhong H., Chiles K., Feldser D.et al. Modulation of hypoxia- inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells. implications for tumor angiogenesis and therapeutics Cancer Res. 60:2000;1541.
17. Cantley L.C., Neel B.G. New insights into tumor suppression. PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway Proc Natl Acad Sci U S A. 96:1999;4240.
18. Burow M.E., Weldon C.B., Melnik L.I.et al. PI3-K/AKT regulation of NF-κB signaling events in suppression of TNF-induced apoptosis. Biochem Biophys Res Comm. 271:2000;342.
19. Burow M.E., Weldon C.B., Collins-Burow B.M.et al. Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions. J Biol Chem. 275:2000;9628.
20. Vanhaesebroeck B., Alessi D. The PI3K-PDK1 connection. more than just a road to PKB Biochem J. 346:2000;561.
21. McMenamin M.E., Soung P., Perera S., Kaplan I., Loda M., Sellers W.R. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res. 59:1999;4291.
22. Suzuki H., Freije D., Nusskern D.R.et al. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res. 58:1998;204.
23. Wu X., Senechal K., Neshat M.S., Whang Y.E., Sawyers C.L. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase pathway. Proc Natl Acad Sci U S A. 95:1998;15587.
24. Allen R.G., Tresini M. Oxidative stress and gene regulation. Free Radical Biol Med. 28:2000;463.
25. Bowie A., O'Neill L.A. Oxidative stress and nuclear factor-κB activation. a reassessment of the evidence in the light of recent discoveries Biochem Pharm. 59:2000;13.
26. Piette J., Piret B., Bonizzi G.et al. Multiple redox regulation in NF-κB transcription factor activation. Biol Chem. 378:1997;1237.
27. D' Angio C.T., Finkelstein J.N. Oxygen regulation of gene expression. a study in opposites Mol Gen Metab. 71:2000;371.
28. Royds J.A., Dower S.K., Qwarnstrom E.E., Lewis C.E. Response of tumour cells to hypoxia. role of p53 and NFκB J Clin Pathol Mol Pathol. 51:1998;55.
29. Huang S., Robinson J.B., DeGuzman A., Bucana C.D., Fidler I.J. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res. 60:2000;5334.
30. Schrum L.W., Black D., Iimuro Y., Rippe R.A., Brenner D.A., Behrns K.E. C-jun does not mediate hepatocyte apoptosis following NFκB inhibition and partial hepatectomy. J Surg Res. 88:2000;142.
31. Taub R. Transcriptional control of liver regeneration. FASEB J. 10:1996;413.
32. Digicaylioglu M., Lipton S.A. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signaling cascades. Nature. 412:2001;641.
33. Craig R., Larkin A., Mingo A.M.et al. P38 MAPK and NF-κB collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system J Biol Chem. 275:2000;23814.
34. Jeon Y.J., Kim Y.K., Lee M., Park S.M., Han S.B., Kim H.M. Radicicol suppresses expression of inducible nitric-oxide synthase by blocking p38 kinase and nuclear factor-κB/Rel in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther. 294:2000;548.
35. Maulik N., Sato M., Price B.D., Das D.K. An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia. FEBS Lett. 429:1998;365.
36. Taher M.M., Oakley J.D., Hershey C., Valerie K. Activation of NF-κB and p38 MAP kinase is not sufficient for triggering efficient HIV gene expression in response to stress. Biochemistry. 39:2000;1709.
37. Janssen-Heininger Y.M.W., Poynter M.E., Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB. Free Radical Biol Med. 28:2000;1317.
38. Alam J., Cai J., Smith A. Isolation and characterization of the mouse heme oxygenase-1 gene. distal 5 sequences are required for induction of cadmium or heme J Biol Chem. 269:1994;1001.
39. Brockman J., Scherer D., McKinsey T.et al. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol Cell Biol. 15:1995;2809.
40. McGary E.C., Rondon I.J., Beckman B.S. Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin mRNA binding protein. J Biol Chem. 272(13):1997;8624.
41. Mason-Garcia M., Beckman B.S., Brookins J.W.et al. Development of a new radioimmunoassay for erythropoietin using recombinant erythropoietin. Kid Int. 38:1990;969.
42. Alvarez-Tejado M., Alfranca A., Aragones J.et al. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem. 277:2002;13508.
43. Bessho R., Matsubara K., Kubota M.et al. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes. Biochem Pharmacol. 48:1994;1883.
44. Laughner E., Taghari P., Chiles K.et al. HER2 (new) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis. novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol. 21:2001;3995.
45. Minet E., Ernest I., Michel G.et al. HIF-1α gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5′UTR. Biochem Biophys Res Commun. 261:1999;435.
46. Lee-Huang S., Lin J.-J., Kung H.-F.et al. The human erythropoietin-encoding gene contains a CAAT box, TATA boxes and other transcriptional regulatory elements in its 5′ flanking region. Gene. 128:1993;227.
47. Jacobs K., Shoemaker C., Rudersdorf R.et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 313:1985;806.