Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex

Biochemistry

Volumn 46, Issue 21, 2007, Pages 6277-6287

  Seifert, Franziska ^a   Ciszak, Ewa ^b   Korotchkina, Lioubov ^c   Golbik, Ralph ^a   Spinka, Michael ^a   Dominiak, Paulina ^b   Sidhu, Sukhdeep ^c   Brauer, Johanna ^a   Patel, Mulchand S ^c   Tittmann, Kai ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF ALABAMA IN HUNTSVILLE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCATALYSTS; CARBOXYLATION; GLYCOLS; PHOSPHORYLATION; SUBSTRATES; X RAY CRYSTALLOGRAPHY;

MICROSCOPIC STEPS; MOLECULAR MECHANISMS; PSEUDOPHOSPHORYLATION VARIANTS; PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX (PDH);

ENZYME ACTIVITY;

GLUTAMINE; GLYCINE; MULTIENZYME COMPLEX; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; SERINE;

ACETYLATION; ARTICLE; CATALYSIS; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ACETYLATION; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DECARBOXYLATION; HUMANS; KINETICS; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN CONFORMATION; PYRUVATE DEHYDROGENASE COMPLEX; SERINE; THERMODYNAMICS;

MAMMALIA;

EID: 34249702932     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700083z     Document Type: Article

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