Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells

Cancer Research

Volumn 72, Issue 4, 2012, Pages 949-957

  Doe, Megan R ^a   Ascano, Janice M ^a,b   Kaur, Mandeep ^a   Cole, Michael D ^a  

^a NORRIS COTTON CANCER CENTER   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYC PROTEIN; VON HIPPEL LINDAU PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER CELL; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; POSTTRANSCRIPTIONAL CONTROL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STABILITY; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GENES, MYC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANSFECTION;

EID: 84857213034     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-2371     Document Type: Article

References (44)

1. Liao DJ, Dickson RB. c-Myc in breast cancer. Endocr Relat Cancer 2000;7:143-64.
2. Deming SL, Nass SJ, Dickson RB, Trock BJ. C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance. Br J Cancer 2000;83:1688-95. (Pubitemid 32001715)
3. D'Cruz C, Gunther E, Boxer R, Hartman J, Sintasath L, Moody S, et al. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med 2001;7: 235-9. (Pubitemid 32148492)
4. Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. The c-Myc target gene network. Semin Cancer Biol 2006;16:253-64.
5. Dang CV. c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 1999;19:1-11. (Pubitemid 29018404)
6. Kim J, Zeller K, Wang Y, Jegga A, Aronow B, O'Donnell K, et al. Evaluation of myc E-box phlyogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol Cell Biol 2004;24:509-20.
7. Osthus R, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, et al. Deregulation of glucose transporter 1 and glycolytic gene expression by c- Myc. J Biol Chem 2000;275:21797-800. (Pubitemid 30621745)
8. Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
9. Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 2007;39:223-29. (Pubitemid 47619374)
10. Wang GL, Jiang B-H, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular 02 tension. Proc Natl Acad Sci 1995;92:5510-4.
11. Huang E, Arany Z, Livingston D, Bunn H. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit. J Biol Chem 1996;271:32253-9. (Pubitemid 26422262)
12. Kallio P, Pongratz I, Gradin K, McGuire J, Poellinger L. Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci 1997;94:5667-72. (Pubitemid 27241827)
13. Jaakkola P, Mole D, Tian Y, Wilson M, Gielbert J, Gaskell S, et al. Targeting of HIF-α to the von Hippel Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72. (Pubitemid 32335942)
14. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292:464-8. (Pubitemid 32335941)
15. Masson N, Willam C, Maxwell P, Pugh C, Ratcliffe P. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation. EMBO J 2001;20: 5197-206. (Pubitemid 32910914)
16. Kaelin WJ. Proline hydroxylation and gene expression. Annu Rev Biochem 2005;74:115-28.
17. Leung S, Ohh M. Playing Tag with HIF: The VHL story. J Biomed Biotechnol 2002;2:131-5. (Pubitemid 44204509)
18. Pugh C, Ratcliffe P. The von Hippel-Lindau tumor suppressor, hypoxia- inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Semin Cancer Biol 2003;13:83-9. (Pubitemid 36269184)
19. Sutter C, Laughner E, Semenza G. HIF-1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci 2000;97:4748-53. (Pubitemid 30238629)
20. Brahimi-Horn M, Pouyssegur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer 2006;93:73-80.
21. Denko N. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat Rev Cancer 2008;8:705-13.
22. Semenza G. Oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med 2010;2:336-61.
23. Kim J, Gao P, Liu Y, Semenza G, Dang C. HIF-1 and dysregulated c-Myc cooperatively induces VEGF and metabolic switches, HK2 and PDK1. Mol Cell Biol 2007;27:7381-93.
24. Kim J-W, Gao P, Liu Y-C, Semenza G, Dang C. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 2007;27:7381-93. (Pubitemid 350033646)
25. Dang C, Kim J-W, Gao P, Yustein J. The interplay between MYC and HIF in cancer. Nat Rev Cancer 2008;8:51-6.
26. Yeung S, Pan J, Lee M-H. Roles of p53, Myc and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci 2008;65: 3981-99.
27. DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, et al. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res 2002;62:89-98. (Pubitemid 34073991)
28. Cowling VH, D'Cruz CM, Chodosh LA, Cole MD. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol 2007;27:5135-46. (Pubitemid 47068288)
29. Knies-Bamforth U, Fox S, Poulsom R, Evan G, Harris A. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 2004; 64:6563-70. (Pubitemid 39297915)
30. Shchors K, Shchors E, Rostker F, Lawlor E, Brown-Swigart L, Evan G. The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev 2006;20:2527-38. (Pubitemid 44396838)
31. Moroz E, Carlin S, Dyomina K, Burke S, Thaler H, Blasberg R, et al. Real-time imaging of HIF-1alpha stabilization and degradation. PLoS One 2009;4:e5077.
32. Chua Y, Dufour E, Dassa E, Rustin P, Jacobs H, Taylor C, et al. Stabilization of hypoxia-inducible factor-1-alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production. J Biol Chem 2010;285:31277-84.
33. Gao P, Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, et al. HIFdependent antitumorigenic effect of antioxidants in vivo. Cancer Cell 2007;12:230-8. (Pubitemid 47333417)
34. Li J, Shi M, Cao Y, Yuan W, Pang T, Li B, et al. Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun 2006;342: 1341-51.
35. Méndez O, Zavadil J, Esencay M, Lukyanov Y, Santovasi D, Wang S, et al. Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Mol Cancer 2010;9:133.
36. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009;15:501-13.
37. Chen N, Chen X, Huang R, Zeng H, Gong J, Meng W, et al. BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem 2009;284:10004-12.
38. Koshiji M, To K, Hammer S, Kumamoto K, Harris A, Modrich P, et al. HIF-1a induces genetic instability by transcriptionally downregulating MutSa expression. Mol Cell 2005;17:793-803. (Pubitemid 40386941)
39. Kleine-Kohlbrecher D, Adhikary S, Eilers M. Mechanisms of transcriptional repression by Myc. Curr Top Microbiol Immunol 2006;302: 51-62. (Pubitemid 43268503)
40. Li F, Wang Y, Zeller K, Potter J, Wonsey D, O'Donnell K, et al. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 2005;25:6225-34. (Pubitemid 40946570)
41. Gordan J, Thompson C, Simon M. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 2007;12:108-13. (Pubitemid 47199124)
42. Sutphin P, Giaccia A, Chan D. Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Dev Cell 2007;12:845-6. (Pubitemid 46805925)
43. Dang C, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 2009;15: 6479-83.
44. Zhang J, Sattler M, Tonon G, Grabher C, Lababidi S, Zimmerhackl A, et al. Targeting angiogenesis via a c-Myc/hypoxia-inducible factor- 1alpha-dependent pathway in multiple myeloma. Cancer Res 2009;69: 5082-90.