Tight control of hypoxia-inducible factor-α transient dynamics is essential for cell survival in hypoxia

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 5549-5564

  Bagnall, James ^a   Leedale, Joseph ^b   Taylor, Sarah E ^a   Spiller, David G ^a,c   White, Michael R H ^a   Sharkey, Kieran J ^b   Bearon, Rachel N ^b   Sée, Violaine ^a,b  

^a Institute of Integrative Biology   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EXPERIMENTAL ANALYSIS; FUNCTIONAL REDUNDANCY; HYPOXIA-INDUCIBLE FACTORS; INTRACELLULAR SIGNALING; INTRACELLULAR SIGNALS; NEGATIVE FEEDBACK REGULATORS; PRO-APOPTOTIC GENES; TEMPORAL INFORMATION;

CELL DEATH; DISEASE CONTROL; DYNAMICS; ENCODING (SYMBOLS); MATHEMATICAL MODELS; PROTEINS; TRANSCRIPTION;

CELL SIGNALING;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN P53;

ARTICLE; BIOACCUMULATION; CELL DEATH; CELL FATE; CELL SURVIVAL; CONTROLLED STUDY; HYPOXIA; IMAGE ANALYSIS; INTRACELLULAR SIGNALING; MATHEMATICAL MODEL; MOLECULAR INTERACTION; NEGATIVE FEEDBACK; OXYGENATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SENSOR;

CELL DEATH; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR; IMAGING; MATHEMATICAL MODELING; NEGATIVE FEEDBACK LOOP; P53; PROLYL HYDROXYLASE;

APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL SURVIVAL; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896884555     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.500405     Document Type: Article

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