-
3
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends upon redox-induced changes
-
(1997)
J Biol Chem
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
7
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
10
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
Huso, D.L.4
Sun, X.5
McWilliams, R.6
Beaty, T.7
Sham, J.S.K.8
Wiener, C.M.9
Sylvester, J.T.10
Semenza, G.L.11
-
11
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation, and tumour angiogenesis
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.-M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
14
-
-
0033547805
-
Age-dependent impairment of angiogenesis
-
(1999)
Circulation
, vol.99
, pp. 111-120
-
-
Rivard, A.1
Fabre, J.E.2
Silver, M.3
Chen, D.4
Murohara, T.5
Kearney, M.6
Magner, M.7
Asahara, T.8
Isner, J.M.9
-
15
-
-
0034703017
-
Age-dependent defect in VEGF expression is associated with reduced HIF-1 activity
-
(2000)
J Biol Chem
, vol.275
, pp. 29643-29647
-
-
Rivard, A.1
Berthou-Soulie, L.2
Principe, N.3
Kearney, M.4
Curry, C.5
Branellec, D.6
Semenza, G.L.7
Isner, J.M.8
-
16
-
-
0034739533
-
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding a HIF-1α/VP-16 hybrid transcription factor
-
(2000)
Circulation
, vol.102
, pp. 2255-2261
-
-
Vincent, K.A.1
Shyu, K.-G.2
Luo, Y.3
Magner, M.4
Tio, R.A.5
Jiang, C.6
Goldberg, M.A.7
Akita, G.Y.8
Gregory, R.J.9
Isner, J.M.10
-
17
-
-
0032932138
-
Hypoxia-inducible factor 1α is increased in ischemic retina: Temporal and spatial correlation with VEGF expression
-
(1999)
Invest Ophthalmol Vis Sci
, vol.40
, pp. 182-189
-
-
Ozaki, H.1
Yu, A.Y.2
Della, N.3
Ozaki, K.4
Luna, J.D.5
Yamada, H.6
Hackett, S.F.7
Okamoto, N.8
Zack, D.J.9
Semenza, G.L.10
Campochiaro, P.A.11
-
20
-
-
0028786651
-
Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 10457-10461
-
-
Aiello, L.P.1
Pierce, E.A.2
Foley, E.D.3
Takagi, H.4
Chen, H.5
Riddle, L.6
Ferrara, N.7
King, G.L.8
Smith, L.E.9
-
23
-
-
0027136260
-
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA binding activity: Implications for models of hypoxia signal transduction
-
(1993)
Blood
, vol.82
, pp. 3610-3615
-
-
Wang, G.L.1
Semenza, G.L.2
-
31
-
-
0034213146
-
Expression of hypoxia-inducible factor 1α in human brain tumors: Association with angiogenesis, invasion, and progression
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
32
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
36
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
37
-
-
0034682783
-
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakkola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
38
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
40
-
-
0032544113
-
Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: A possible model for IGFBP-1 expression in fetal hypoxia
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10188-10193
-
-
Tazuke, S.I.1
Mazure, N.M.2
Sugawara, J.3
Carland, G.4
Faessen, G.H.5
Suen, L.-F.6
Irwin, J.C.7
Powell, D.R.8
Giaccia, A.J.9
Giudice, L.C.10
-
51
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
(1999)
Genes Dev
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
Arany, Z.P.4
Kung, A.L.5
Livingston, D.M.6
-
52
-
-
0032795850
-
Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes
-
(1999)
Blood
, vol.94
, pp. 4177-4185
-
-
Kietzmann, T.1
Roth, U.2
Jungermann, K.3
-
55
-
-
0000655498
-
Identification of a hypoxia response element in the transferrin receptor gene
-
(1999)
J Biol Chem
, vol.274
, pp. 24147-24152
-
-
Lok, C.N.1
Ponka, P.2
-
58
-
-
0034654174
-
Modulation of HIF-1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.-M.6
Simons, J.W.7
Semenza, G.L.8
-
59
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
Koong, A.4
Kaper, F.5
Chen, E.6
Gottschalk, A.R.7
Ryan, H.E.8
Johnson, R.S.9
Jefferson, A.B.10
Stokoe, D.11
Giaccia, A.J.12
-
60
-
-
0033981845
-
ERK activation upon hypoxia: Involvement in HIF-1 activation
-
(2000)
FEBS Lett
, vol.484
, pp. 53-58
-
-
Minet, E.1
Arnould, T.2
Michel, G.3
Roland, D.4
Mottet, D.5
Raes, M.6
Remacle, J.7
Michiels, C.8
-
62
-
-
0030869787
-
Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
-
(1997)
Blood
, vol.90
, pp. 3322-3331
-
-
Mazure, N.M.1
Chen, E.Y.2
Laderoute, K.R.3
Giaccia, A.J.4
-
64
-
-
0031754373
-
Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity
-
(1998)
Mol Pharmacol
, vol.54
, pp. 749-754
-
-
Agani, F.1
Semenza, G.L.2
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