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Volumn 2016, Issue , 2016, Pages

Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; DISEASES; DRUG THERAPY; MAINTENANCE; TUMORS;

EID: 84949266511     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2016/2428153     Document Type: Review
Times cited : (108)

References (170)
  • 2
    • 79251548626 scopus 로고    scopus 로고
    • Forkhead homeobox type O transcription factors in the responses to oxidative stress
    • P. Storz, "Forkhead homeobox type O transcription factors in the responses to oxidative stress, " Antioxidants & Redox Signaling, vol. 14, no. 4, pp. 593-605, 2011.
    • (2011) Antioxidants & Redox Signaling , vol.14 , Issue.4 , pp. 593-605
    • Storz, P.1
  • 3
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • R. S. Balaban, S. Nemoto, and T. Finkel, "Mitochondria, oxidants, and aging, " Cell, vol. 120, no. 4, pp. 483-495, 2005.
    • (2005) Cell , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 4
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • L. A. Sena and N. S. Chandel, "Physiological roles of mitochondrial reactive oxygen species, " Molecular Cell, vol. 48, no. 2, pp. 158-167, 2012.
    • (2012) Molecular Cell , vol.48 , Issue.2 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 5
    • 33748165596 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer cells: Live by the sword, die by the sword
    • P. T. Schumacker, "Reactive oxygen species in cancer cells: live by the sword, die by the sword, " Cancer Cell, vol. 10, no. 3, pp. 175-176, 2006.
    • (2006) Cancer Cell , vol.10 , Issue.3 , pp. 175-176
    • Schumacker, P.T.1
  • 6
    • 0028900690 scopus 로고
    • Persistent oxidative stress in cancer
    • S. Toyokuni, K. Okamoto, J. Yodoi, and H. Hiai, "Persistent oxidative stress in cancer, " FEBS Letters, vol. 358, no. 1, pp. 1-3, 1995.
    • (1995) FEBS Letters , vol.358 , Issue.1 , pp. 1-3
    • Toyokuni, S.1    Okamoto, K.2    Yodoi, J.3    Hiai, H.4
  • 7
    • 0348049803 scopus 로고    scopus 로고
    • Reactive oxygen species in oncogenic transformation
    • L. Behrend, G. Henderson, and R. Zwacka, "Reactive oxygen species in oncogenic transformation, " Biochemical Society Transactions, vol. 31, no. 6, pp. 1441-1444, 2003.
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1441-1444
    • Behrend, L.1    Henderson, G.2    Zwacka, R.3
  • 8
    • 1442360000 scopus 로고    scopus 로고
    • Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity
    • E. O. Hileman, J. Liu, M. Albitar, M. J. Keating, and P. Huang, "Intrinsic oxidative stress in cancer cells: A biochemical basis for therapeutic selectivity, " Cancer Chemotherapy and Pharmacology, vol. 53, no. 3, pp. 209-219, 2004.
    • (2004) Cancer Chemotherapy and Pharmacology , vol.53 , Issue.3 , pp. 209-219
    • Hileman, E.O.1    Liu, J.2    Albitar, M.3    Keating, M.J.4    Huang, P.5
  • 9
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • H. Pelicano, D. Carney, and P. Huang, "ROS stress in cancer cells and therapeutic implications, " Drug Resistance Updates, vol. 7, no. 2, pp. 97-110, 2004.
    • (2004) Drug Resistance Updates , vol.7 , Issue.2 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 10
    • 50049127672 scopus 로고    scopus 로고
    • Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6
    • Y. Adachi, Y. Shibai, J. Mitsushita, W. H. Shang, K. Hirose, and T. Kamata, "Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6, " Oncogene, vol. 27, no. 36, pp. 4921-4932, 2008.
    • (2008) Oncogene , vol.27 , Issue.36 , pp. 4921-4932
    • Adachi, Y.1    Shibai, Y.2    Mitsushita, J.3    Shang, W.H.4    Hirose, K.5    Kamata, T.6
  • 11
    • 2442693092 scopus 로고    scopus 로고
    • The superoxidegenerating oxidase Nox1 is functionally required for Ras oncogene transformation
    • J. Mitsushita, J. D. Lambeth, and T. Kamata, "The superoxidegenerating oxidase Nox1 is functionally required for Ras oncogene transformation, " Cancer Research, vol. 64, no. 10, pp. 3580-3585, 2004.
    • (2004) Cancer Research , vol.64 , Issue.10 , pp. 3580-3585
    • Mitsushita, J.1    Lambeth, J.D.2    Kamata, T.3
  • 12
    • 0036285034 scopus 로고    scopus 로고
    • C-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • O. Vafa, M. Wade, S. Kern et al., "c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability, " Molecular Cell, vol. 9, no. 5, pp. 1031-1044, 2002.
    • (2002) Molecular Cell , vol.9 , Issue.5 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3
  • 13
    • 0031736203 scopus 로고    scopus 로고
    • Somatic mutations of the mitochondrial genome in human colorectal tumours
    • K. Polyak, Y. Li, H. Zhu et al., "Somatic mutations of the mitochondrial genome in human colorectal tumours, " Nature Genetics, vol. 20, no. 3, pp. 291-293, 1998.
    • (1998) Nature Genetics , vol.20 , Issue.3 , pp. 291-293
    • Polyak, K.1    Li, Y.2    Zhu, H.3
  • 14
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?
    • D. Trachootham, J. Alexandre, and P. Huang, "Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?" Nature Reviews Drug Discovery, vol. 8, no. 7, pp. 579-591, 2009.
    • (2009) Nature Reviews Drug Discovery , vol.8 , Issue.7 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 15
    • 84859829553 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer stem cells
    • X. Shi, Y. Zhang, J. Zheng, and J. Pan, "Reactive oxygen species in cancer stem cells, " Antioxidants&Redox Signaling, vol. 16, no. 11, pp. 1215-1228, 2012.
    • (2012) Antioxidants&Redox Signaling , vol.16 , Issue.11 , pp. 1215-1228
    • Shi, X.1    Zhang, Y.2    Zheng, J.3    Pan, J.4
  • 16
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • T. Reya, S. J. Morrison, M. F. Clarke et al., "Stem cells, cancer, and cancer stem cells, " Nature, vol. 414, no. 6859, pp. 105-111, 2001.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3
  • 18
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • D. Bonnet and J. E. Dick, "Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, " Nature Medicine, vol. 3, no. 7, pp. 730-737, 1997.
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 19
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • C. A. O'Brien, A. Pollett, S. Gallinger, and J. E. Dick, "A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, " Nature, vol. 445, no. 7123, pp. 106-110, 2006.
    • (2006) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 20
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • S. K. Singh, C. Hawkins, I. D. Clarke et al., "Identification of human brain tumour initiating cells, " Nature, vol. 432, no. 7015, pp. 396-401, 2004.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 22
    • 78650389774 scopus 로고    scopus 로고
    • Coexpression of Oct4 andNanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelialmesenchymal transdifferentiation
    • S.-H. Chiou, M.-L. Wang, Y.-T. Chou et al., "Coexpression of Oct4 andNanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelialmesenchymal transdifferentiation, " Cancer Research, vol. 70, no. 24, pp. 10433-10444, 2010.
    • (2010) Cancer Research , vol.70 , Issue.24 , pp. 10433-10444
    • Chiou, S.-H.1    Wang, M.-L.2    Chou, Y.-T.3
  • 23
    • 79955608022 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (KLF4) is required formaintenance of breast cancer stem cells and for cell migration and invasion
    • F. Yu, J. Li, H. Chen et al., "Kruppel-like factor 4 (KLF4) is required formaintenance of breast cancer stem cells and for cell migration and invasion, " Oncogene, vol. 30, no. 18, pp. 2161-2172, 2011.
    • (2011) Oncogene , vol.30 , Issue.18 , pp. 2161-2172
    • Yu, F.1    Li, J.2    Chen, H.3
  • 24
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • L. Vermeulen, E. M. Felipe De Sousa, M. van der Heijden et al., "Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, " Nature Cell Biology, vol. 12, no. 5, pp. 468-476, 2010.
    • (2010) Nature Cell Biology , vol.12 , Issue.5 , pp. 468-476
    • Vermeulen, L.1    Sousa De Felipe, E.M.2    Heijden Der M.Van3
  • 25
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • C. Zhao, A. Chen, C. H. Jamieson et al., "Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia, " Nature, vol. 458, no. 7239, pp. 776-779, 2009.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 26
    • 36248953716 scopus 로고    scopus 로고
    • Mammary stem cells and breast cancer-role of Notch signalling
    • G. Farnie and R. B. Clarke, "Mammary stem cells and breast cancer-role of Notch signalling, " Stem Cell Reviews, vol. 3, no. 2, pp. 169-175, 2007.
    • (2007) Stem Cell Reviews , vol.3 , Issue.2 , pp. 169-175
    • Farnie, G.1    Clarke, R.B.2
  • 27
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    • D. Ponti, "Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties, " Cancer Research, vol. 65, no. 13, pp. 5506-5511, 2005.
    • (2005) Cancer Research , vol.65 , Issue.13 , pp. 5506-5511
    • Ponti, D.1
  • 28
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • M. Dean, T. Fojo, and S. Bates, "Tumour stem cells and drug resistance, " Nature Reviews Cancer, vol. 5, no. 4, pp. 275-284, 2005.
    • (2005) Nature Reviews Cancer , vol.5 , Issue.4 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 29
    • 78650979504 scopus 로고    scopus 로고
    • DNA-damage response in tissue-specific and cancer stem cells
    • C. Blanpain, M. Mohrin, P. A. Sotiropoulou, and E. Passegué, "DNA-damage response in tissue-specific and cancer stem cells, " Cell Stem Cell, vol. 8, no. 1, pp. 16-29, 2011.
    • (2011) Cell Stem Cell , vol.8 , Issue.1 , pp. 16-29
    • Blanpain, C.1    Mohrin, M.2    Sotiropoulou, P.A.3    Passegué, E.4
  • 30
    • 79952256467 scopus 로고    scopus 로고
    • Role of oxidative stress in stem, cancer, and cancer stem cells
    • A. A. Dayem, H. Choi, J. Kim, and S. Cho, "Role of oxidative stress in stem, cancer, and cancer stem cells, " Cancers, vol. 2, no. 2, pp. 859-884, 2010.
    • (2010) Cancers , vol.2 , Issue.2 , pp. 859-884
    • Dayem, A.A.1    Choi, H.2    Kim, J.3    Cho, S.4
  • 31
    • 84875143073 scopus 로고    scopus 로고
    • BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
    • E. Lagadinou, A. Sach, K. Callahan et al., "BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells, " Cell Stem Cell, vol. 12, no. 3, pp. 329-341, 2013.
    • (2013) Cell Stem Cell , vol.12 , Issue.3 , pp. 329-341
    • Lagadinou, E.1    Sach, A.2    Callahan, K.3
  • 32
    • 84909606388 scopus 로고    scopus 로고
    • Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity
    • C. Chang, Y. Chen, S. Chou et al., "Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and chemosensitivity, " Cancer Research, vol. 74, no. 21, pp. 6291-6305, 2014.
    • (2014) Cancer Research , vol.74 , Issue.21 , pp. 6291-6305
    • Chang, C.1    Chen, Y.2    Chou, S.3
  • 33
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • M. M. Gottesman, T. Fojo, and S. E. Bates, "Multidrug resistance in cancer: role of ATP-dependent transporters, " Nature Reviews Cancer, vol. 2, no. 1, pp. 48-58, 2002.
    • (2002) Nature Reviews Cancer , vol.2 , Issue.1 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 34
    • 80054796744 scopus 로고    scopus 로고
    • Drug-induced senescence generates chemoresistant stemlike cellswith lowreactive oxygen species
    • S. Achuthan, T. R. Santhoshkumar, J. Prabhakar, S. A. Nair, and M. R. Pillai, "Drug-induced senescence generates chemoresistant stemlike cellswith lowreactive oxygen species, "TheJournal of Biological Chemistry, vol. 286, no. 43, pp. 37813-37829, 2011.
    • (2011) TheJournal of Biological Chemistry , vol.286 , Issue.43 , pp. 37813-37829
    • Achuthan, S.1    Santhoshkumar, T.R.2    Prabhakar, J.3    Nair, S.A.4    Pillai, M.R.5
  • 36
    • 33750302541 scopus 로고    scopus 로고
    • SP analysis may be used to identify cancer stem cell populations
    • A. Hadnagy, L. Gaboury, R. Beaulieu, and D. Balicki, "SP analysis may be used to identify cancer stem cell populations, " Experimental Cell Research, vol. 312, no. 19, pp. 3701-3710, 2006.
    • (2006) Experimental Cell Research , vol.312 , Issue.19 , pp. 3701-3710
    • Hadnagy, A.1    Gaboury, L.2    Beaulieu, R.3    Balicki, D.4
  • 37
    • 84908428915 scopus 로고    scopus 로고
    • Stem cells and the impact of ROS signaling
    • C. L. Bigarella, R. Liang, and S. Ghaffari, "Stem cells and the impact of ROS signaling, " Development, vol. 141, no. 22, pp. 4206-4218, 2014.
    • (2014) Development , vol.141 , Issue.22 , pp. 4206-4218
    • Bigarella, C.L.1    Liang, R.2    Ghaffari, S.3
  • 38
    • 84897101058 scopus 로고    scopus 로고
    • Roles of reactive oxygen species in the fate of stem cells
    • P. Chaudhari, Z. Ye, and Y. Y. Jang, "Roles of reactive oxygen species in the fate of stem cells, " Antioxidants&Redox Signaling, vol. 20, no. 12, pp. 1881-1890, 2014.
    • (2014) Antioxidants&Redox Signaling , vol.20 , Issue.12 , pp. 1881-1890
    • Chaudhari, P.1    Ye, Z.2    Jang, Y.Y.3
  • 39
    • 84874708595 scopus 로고    scopus 로고
    • Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate
    • V. A. Rafalski, E. Mancini, and A. Brunet, "Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate, " Journal of Cell Science, vol. 125, no. 23, pp. 5597-5608, 2012.
    • (2012) Journal of Cell Science , vol.125 , Issue.23 , pp. 5597-5608
    • Rafalski, V.A.1    Mancini, E.2    Brunet, A.3
  • 40
    • 84875902088 scopus 로고    scopus 로고
    • Redox homeostasis: The linchpin in stem cell self-renewal and differentiation
    • K. Wang, T. Zhang, Q. Dong, E. C. Nice, C. Huang, and Y. Wei, "Redox homeostasis: The linchpin in stem cell self-renewal and differentiation, " Cell Death and Disease, vol. 4, no. 3, p. e537, 2013.
    • (2013) Cell Death and Disease , vol.4 , Issue.3 , pp. e537
    • Wang, K.1    Zhang, T.2    Dong, Q.3    Nice, E.C.4    Huang, C.5    Wei, Y.6
  • 41
    • 8644232705 scopus 로고    scopus 로고
    • Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells
    • G. Saretzki, L. Armstrong, A. Leake, and et al, "Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells, " Stem Cells, vol. 22, no. 6, pp. 962-971, 2004.
    • (2004) Stem Cells , vol.22 , Issue.6 , pp. 962-971
    • Saretzki, G.1    Armstrong, L.2    Leake, A.3
  • 42
    • 35548936968 scopus 로고    scopus 로고
    • A lowlevel of reactive oxygen species selects for primitive hematopoietic stemcells that may reside in the low-oxygenic niche
    • Y. Y. Jang andS. J. Sharkis, "A lowlevel of reactive oxygen species selects for primitive hematopoietic stemcells that may reside in the low-oxygenic niche, " Blood, vol. 110, no. 8, pp. 3056-3063, 2007.
    • (2007) Blood , vol.110 , Issue.8 , pp. 3056-3063
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 43
    • 51349117161 scopus 로고    scopus 로고
    • Oxidative stress in the regulation of normal and neoplastic hematopoiesis
    • S. Ghaffari, "Oxidative stress in the regulation of normal and neoplastic hematopoiesis, " Antioxidants & Redox Signaling, vol. 10, no. 11, pp. 1923-1940, 2008.
    • (2008) Antioxidants & Redox Signaling , vol.10 , Issue.11 , pp. 1923-1940
    • Ghaffari, S.1
  • 44
    • 33845647995 scopus 로고    scopus 로고
    • Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation
    • M. Schmelter, B. Ateghang, S. Helmig, M. Wartenberg, and H. Sauer, "Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation, " The FASEB Journal, vol. 20, no. 8, pp. 1182-1184, 2006.
    • (2006) The FASEB Journal , vol.20 , Issue.8 , pp. 1182-1184
    • Schmelter, M.1    Ateghang, B.2    Helmig, S.3    Wartenberg, M.4    Sauer, H.5
  • 46
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • C. Cosentino, D. Grieco, and V. Costanzo, "ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair, " The EMBO Journal, vol. 30, no. 3, pp. 546-555, 2011.
    • (2011) The EMBO Journal , vol.30 , Issue.3 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 47
    • 7244250309 scopus 로고    scopus 로고
    • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    • K. Ito, A. Hirao, F. Arai et al., "Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells, " Nature, vol. 431, no. 7011, pp. 997-1002, 2004.
    • (2004) Nature , vol.431 , Issue.7011 , pp. 997-1002
    • Ito, K.1    Hirao, A.2    Arai, F.3
  • 48
    • 33845969499 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species by Atm is essential for proper response to DNA doublestrand breaks in lymphocytes
    • K. Ito, K. Takubo, F. Arai et al., "Regulation of reactive oxygen species by Atm is essential for proper response to DNA doublestrand breaks in lymphocytes, " The Journal of Immunology, vol. 178, no. 1, pp. 103-110, 2007.
    • (2007) The Journal of Immunology , vol.178 , Issue.1 , pp. 103-110
    • Ito, K.1    Takubo, K.2    Arai, F.3
  • 49
    • 84900034723 scopus 로고    scopus 로고
    • FOXO transcription factors: Their clinical significance and regulation
    • Y. Wang, Y. Zhou, and D. T. Graves, "FOXO transcription factors: Their clinical significance and regulation, " BioMed Research International, vol. 2014, Article ID 925350, 13 pages, 2014.
    • (2014) BioMed Research International , vol.2014
    • Wang, Y.1    Zhou, Y.2    Graves, D.T.3
  • 50
    • 33751296789 scopus 로고    scopus 로고
    • FOXO transcription factors: Key regulators of cell fate
    • E. Lam, R. Francis, and M. Petkovic, "FOXO transcription factors: key regulators of cell fate, " Biochemical Society Transactions, vol. 34, no. 5, pp. 722-726, 2006.
    • (2006) Biochemical Society Transactions , vol.34 , Issue.5 , pp. 722-726
    • Lam, E.1    Francis, R.2    Petkovic, M.3
  • 51
    • 34249882777 scopus 로고    scopus 로고
    • Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    • K. Miyamoto, K. Y. Araki, K. Naka et al., "Foxo3a is essential for maintenance of the hematopoietic stem cell pool, " Cell Stem Cell, vol. 1, no. 1, pp. 101-112, 2007.
    • (2007) Cell Stem Cell , vol.1 , Issue.1 , pp. 101-112
    • Miyamoto, K.1    Araki, K.Y.2    Naka, K.3
  • 52
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Z. Tothova, R. Kollipara, B. J. Huntly et al., "FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress, " Cell, vol. 128, no. 2, pp. 325-339, 2007.
    • (2007) Cell , vol.128 , Issue.2 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3
  • 53
    • 54449092731 scopus 로고    scopus 로고
    • Foxo3 is essential for the regulation of ataxia telangiectasiamutated and oxidative stressmediated homeostasis of hematopoietic stem cells
    • S. Yalcin, X. Zhang, J. P. Luciano et al., "Foxo3 is essential for the regulation of ataxia telangiectasiamutated and oxidative stressmediated homeostasis of hematopoietic stem cells, " The Journal of Biological Chemistry, vol. 283, no. 37, pp. 25692-25705, 2008.
    • (2008) The Journal of Biological Chemistry , vol.283 , Issue.37 , pp. 25692-25705
    • Yalcin, S.1    Zhang, X.2    Luciano, J.P.3
  • 54
    • 70350497348 scopus 로고    scopus 로고
    • FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    • J. Paik, Z. Ding, R. Narurkar et al., "FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis, " Cell Stem Cell, vol. 5, no. 5, pp. 540-553, 2009.
    • (2009) Cell Stem Cell , vol.5 , Issue.5 , pp. 540-553
    • Paik, J.1    Ding, Z.2    Narurkar, R.3
  • 55
    • 70350506802 scopus 로고    scopus 로고
    • FoxO3 regulates neural stem cell homeostasis
    • V. M. Renault, V. A. Rafalski, A. A. Morgan et al., "FoxO3 regulates neural stem cell homeostasis, " Cell Stem Cell, vol. 5, no. 5, pp. 527-539, 2009.
    • (2009) Cell Stem Cell , vol.5 , Issue.5 , pp. 527-539
    • Renault, V.M.1    Rafalski, V.A.2    Morgan, A.A.3
  • 56
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • A. Brunet, A. Bonni, M. J. Zigmond et al., "Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor, " Cell, vol. 96, no. 6, pp. 857-868, 1999.
    • (1999) Cell , vol.96 , Issue.6 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 57
    • 0037018148 scopus 로고    scopus 로고
    • 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
    • A. Brunet, F. Kanai, J. Stehn, and et al, "14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport, " Journal of Cell Biology, vol. 156, no. 5, pp. 817-828, 2002.
    • (2002) Journal of Cell Biology , vol.156 , Issue.5 , pp. 817-828
    • Brunet, A.1    Kanai, F.2    Stehn, J.3
  • 58
    • 77953283847 scopus 로고    scopus 로고
    • AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
    • M. M. Juntilla, V. D. Patil, M. Calamito, R. P. Joshi, M. J. Birnbaum, and G. A. Koretzky, "AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species, " Blood, vol. 115, no. 20, pp. 4030-4038, 2010.
    • (2010) Blood , vol.115 , Issue.20 , pp. 4030-4038
    • Juntilla, M.M.1    Patil, V.D.2    Calamito, M.3    Joshi, R.P.4    Birnbaum, M.J.5    Koretzky, G.A.6
  • 59
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells fromleukaemiainitiating cells
    • Ö. H. Yilmaz, R. Valdez, B. K. Theisen et al., "Pten dependence distinguishes haematopoietic stem cells fromleukaemiainitiating cells, " Nature, vol. 441, no. 7092, pp. 475-482, 2006.
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, H.O.1    Valdez, R.2    Theisen, B.K.3
  • 60
    • 84861845402 scopus 로고    scopus 로고
    • The updated biology of hypoxia-inducible factor
    • S. N. Greer, J. L. Metcalf, Y. Wang, and M. Ohh, "The updated biology of hypoxia-inducible factor, " The EMBO Journal, vol. 31, no. 11, pp. 2448-2460, 2012.
    • (2012) The EMBO Journal , vol.31 , Issue.11 , pp. 2448-2460
    • Greer, S.N.1    Metcalf, J.L.2    Wang, Y.3    Ohh, M.4
  • 61
    • 75149117810 scopus 로고    scopus 로고
    • Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
    • C. E. Forristal, K. L. Wright, N. A. Hanley, R. O. Oreffo, and F. D. Houghton, "Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions, " Reproduction, vol. 139, no. 1, pp. 85-97, 2009.
    • (2009) Reproduction , vol.139 , Issue.1 , pp. 85-97
    • Forristal, C.E.1    Wright, K.L.2    Hanley, N.A.3    Oreffo, R.O.4    Houghton, F.D.5
  • 62
    • 33644747418 scopus 로고    scopus 로고
    • HIF-2 regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
    • K. L. Covello, J. Kehler, H. Yu et al., "HIF-2 regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth, " Genes & Development, vol. 20, no. 5, pp. 557-570, 2006.
    • (2006) Genes & Development , vol.20 , Issue.5 , pp. 557-570
    • Covello, K.L.1    Kehler, J.2    Yu, H.3
  • 63
    • 77957584397 scopus 로고    scopus 로고
    • O2 regulates stem cells through Wnt/-catenin signalling
    • J. Mazumdar, W. T. O'Brien, R. S. Johnson et al., "O2 regulates stem cells through Wnt/-catenin signalling, " Nature Cell Biology, vol. 12, no. 10, pp. 1007-1013, 2010.
    • (2010) Nature Cell Biology , vol.12 , Issue.10 , pp. 1007-1013
    • Mazumdar, J.1    O'Brien, W.T.2    Johnson, R.S.3
  • 64
    • 77956217067 scopus 로고    scopus 로고
    • Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
    • K. Takubo, N. Goda, W. Yamada et al., "Regulation of the HIF-1alpha level is essential for hematopoietic stem cells, " Cell Stem Cell, vol. 7, no. 3, pp. 391-402, 2010.
    • (2010) Cell Stem Cell , vol.7 , Issue.3 , pp. 391-402
    • Takubo, K.1    Goda, N.2    Yamada, W.3
  • 65
    • 84871001227 scopus 로고    scopus 로고
    • Meis1 regulates themetabolic phenotype and oxidant defense of hematopoietic stem cells
    • F. Kocabas, J. Zheng, S. Thet et al., "Meis1 regulates themetabolic phenotype and oxidant defense of hematopoietic stem cells, " Blood, vol. 120, no. 25, pp. 4963-4972, 2012.
    • (2012) Blood , vol.120 , Issue.25 , pp. 4963-4972
    • Kocabas, F.1    Zheng, J.2    Thet, S.3
  • 66
    • 33845904383 scopus 로고    scopus 로고
    • The response of CD24?//CD44+ breast cancer-initiating cells to radiation
    • T. M. Phillips, W. H. McBride, and F. Pajonk, "The response of CD24?//CD44+ breast cancer-initiating cells to radiation, " JNCI Journal of the National Cancer Institute, vol. 98, no. 24, pp. 1777-1785, 2006.
    • (2006) JNCI Journal of the National Cancer Institute , vol.98 , Issue.24 , pp. 1777-1785
    • Phillips, T.M.1    McBride, W.H.2    Pajonk, F.3
  • 67
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • M. Diehn, R. W. Cho, N. A. Lobo et al., "Association of reactive oxygen species levels and radioresistance in cancer stem cells, " Nature, vol. 458, no. 7239, pp. 780-783, 2009.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 68
    • 84863811010 scopus 로고    scopus 로고
    • A role for GPx3 in activity of normal and leukemia stem cells
    • O. Herault, K. J. Hope, E. Deneault et al., "A role for GPx3 in activity of normal and leukemia stem cells, " The Journal of Experimental Medicine, vol. 209, no. 5, pp. 895-901, 2012.
    • (2012) The Journal of Experimental Medicine , vol.209 , Issue.5 , pp. 895-901
    • Herault, O.1    Hope, K.J.2    Deneault, E.3
  • 69
    • 84906324132 scopus 로고    scopus 로고
    • Detoxification of oxidative stress in glioma stem cells: Mechanism, clinical relevance, and therapeutic development
    • S. Kim, C. Kwon, and I. Nakano, "Detoxification of oxidative stress in glioma stem cells: mechanism, clinical relevance, and therapeutic development, " Journal ofNeuroscience Research, vol. 92, no. 11, pp. 1419-1424, 2014.
    • (2014) Journal OfNeuroscience Research , vol.92 , Issue.11 , pp. 1419-1424
    • Kim, S.1    Kwon, C.2    Nakano, I.3
  • 70
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • T. Ishimoto, O. Nagano, T. Yae et al., "CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth, " Cancer Cell, vol. 19, no. 3, pp. 387-400, 2011.
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3
  • 71
    • 84875454018 scopus 로고    scopus 로고
    • XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
    • M. Yoshikawa, K. Tsuchihashi, T. Ishimoto et al., "xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma, " Cancer Research, vol. 73, no. 6, pp. 1855-1866, 2013.
    • (2013) Cancer Research , vol.73 , Issue.6 , pp. 1855-1866
    • Yoshikawa, M.1    Tsuchihashi, K.2    Ishimoto, T.3
  • 72
    • 77956388547 scopus 로고    scopus 로고
    • CD13 is a therapeutic target in human liver cancer stem cells
    • N. Haraguchi, H. Ishii, K. Mimori et al., "CD13 is a therapeutic target in human liver cancer stem cells, " Journal of Clinical Investigation, vol. 120, no. 9, pp. 3326-3339, 2010.
    • (2010) Journal of Clinical Investigation , vol.120 , Issue.9 , pp. 3326-3339
    • Haraguchi, N.1    Ishii, H.2    Mimori, K.3
  • 73
    • 84864987692 scopus 로고    scopus 로고
    • Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon
    • H. M. Kim, N. Haraguchi, H. Ishii et al., "Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon, " Annals of Surgical Oncology, vol. 19, supplement 3, pp. S539-S548, 2012.
    • (2012) Annals of Surgical Oncology , vol.19 , pp. S539-S548
    • Kim, H.M.1    Haraguchi, N.2    Ishii, H.3
  • 74
    • 76249087423 scopus 로고    scopus 로고
    • TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
    • K. Naka, T. Hoshii, T. Muraguchi et al., "TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia, " Nature, vol. 463, no. 7281, pp. 676-680, 2010.
    • (2010) Nature , vol.463 , Issue.7281 , pp. 676-680
    • Naka, K.1    Hoshii, T.2    Muraguchi, T.3
  • 75
    • 36048963331 scopus 로고    scopus 로고
    • Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
    • J. Zhou, J. Wulfkuhle, H. Zhang et al., "Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance, " Proceedings of the National Academy of Sciences, vol. 104, no. 41, pp. 16158-16163, 2007.
    • (2007) Proceedings of the National Academy of Sciences , vol.104 , Issue.41 , pp. 16158-16163
    • Zhou, J.1    Wulfkuhle, J.2    Zhang, H.3
  • 77
    • 80052841288 scopus 로고    scopus 로고
    • The phenotypic radiation resistance of CS44+/CD24?or low breast cancer cells is mediated through the enhanced activation of ATM signaling
    • H. Yin and J. Glass, "The phenotypic radiation resistance of CS44+/CD24?or low breast cancer cells is mediated through the enhanced activation of ATM signaling, " PLoS ONE, vol. 6, no. 9, Article ID e24080, 2011.
    • (2011) PLoS ONE , vol.6 , Issue.9
    • Yin, H.1    Glass, J.2
  • 78
    • 0024997241 scopus 로고
    • Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants
    • T. H. Rushmore and C. Pickett, "Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants, " The Journal of Biological Chemistry, vol. 265, no. 24, pp. 14648-14653, 1990.
    • (1990) The Journal of Biological Chemistry , vol.265 , Issue.24 , pp. 14648-14653
    • Rushmore, T.H.1    Pickett, C.2
  • 79
    • 0026755187 scopus 로고
    • Regulation of humanNAD (P)H: Quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element
    • Y. Li and A. Jaiswal, "Regulation of humanNAD (P)H: quinone oxidoreductase gene. Role of AP1 binding site contained within human antioxidant response element, "The Journal of Biological Chemistry, vol. 267, no. 21, pp. 15097-15104, 1992.
    • (1992) The Journal of Biological Chemistry , vol.267 , Issue.21 , pp. 15097-15104
    • Li, Y.1    Jaiswal, A.2
  • 80
    • 0029411321 scopus 로고
    • Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: Regulation by upstreamantioxidantresponsive elements (ARE)
    • T. Prestera, P. Talalay, J. Alam et al., "Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstreamantioxidantresponsive elements (ARE), "MolecularMedicine, vol. 1, no. 7, p. 827, 1995.
    • (1995) MolecularMedicine , vol.1 , Issue.7 , pp. 827
    • Prestera, T.1    Talalay, P.2    Alam, J.3
  • 81
    • 0029043995 scopus 로고
    • Cloning andcharacterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • K. Itoh, K. Igarashi, N. Hayashi et al., "Cloning andcharacterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins, " Molecular and Cellular Biology, vol. 15, no. 8, pp. 4184-4193, 1995.
    • (1995) Molecular and Cellular Biology , vol.15 , Issue.8 , pp. 4184-4193
    • Itoh, K.1    Igarashi, K.2    Hayashi, N.3
  • 82
    • 0029906134 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene
    • R. Venugopal and A. K. Jaiswal, "Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene, " Proceedings of the National Academy of Sciences, vol. 93, no. 25, pp. 14960-14965, 1996.
    • (1996) Proceedings of the National Academy of Sciences , vol.93 , Issue.25 , pp. 14960-14965
    • Venugopal, R.1    Jaiswal, A.K.2
  • 83
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • K. Itoh, T. Chiba, S. Takahashi et al., "An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements, " Biochemical and Biophysical Research Communications, vol. 236, no. 2, pp. 313-322, 1997.
    • (1997) Biochemical and Biophysical Research Communications , vol.236 , Issue.2 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3
  • 84
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    • M. Ramos-Gomez, M.-K. Kwak, P. M. Dolan et al., "Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice, " Proceedings of the National Academy of Sciences, vol. 98, no. 6, pp. 3410-3415, 2001.
    • (2001) Proceedings of the National Academy of Sciences , vol.98 , Issue.6 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.-K.2    Dolan, P.M.3
  • 85
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • M.-K. Kwak, N. Wakabayashi, K. Itoh, H. Motohashi, M. Yamamoto, and T. W. Kensler, "Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival, "The Journal of Biological Chemistry, vol. 278, no. 10, pp. 8135-8145, 2003.
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.10 , pp. 8135-8145
    • Kwak, M.-K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 86
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (?/?) mice
    • R. Hu, C. Xu, G. Shen et al., "Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (?/?) mice, " Cancer Letters, vol. 243, no. 2, pp. 170-192, 2006.
    • (2006) Cancer Letters , vol.243 , Issue.2 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3
  • 87
    • 0037101768 scopus 로고    scopus 로고
    • Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice
    • S. Chanas, Q. Jiang, and M. McMahon, "Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice, " Biochemical Journal, vol. 365, no. 2, pp. 405-416, 2002.
    • (2002) Biochemical Journal , vol.365 , Issue.2 , pp. 405-416
    • Chanas, S.1    Jiang, Q.2    McMahon, M.3
  • 89
    • 33644853063 scopus 로고    scopus 로고
    • Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin
    • G. Shen, C. Xu, R. Hu et al., "Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin, " Molecular CancerTherapeutics, vol. 5, no. 1, pp. 39-51, 2006.
    • (2006) Molecular CancerTherapeutics , vol.5 , Issue.1 , pp. 39-51
    • Shen, G.1    Xu, C.2    Hu, R.3
  • 90
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • J. D. Hayes and A. T. Dinkova-Kostova, "The Nrf2 regulatory network provides an interface between redox and intermediary metabolism, " Trends in Biochemical Sciences, vol. 39, no. 4, pp. 199-218, 2014.
    • (2014) Trends in Biochemical Sciences , vol.39 , Issue.4 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 91
    • 0141534255 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is required for the constitutive and inducible expression ofmultidrug resistance-associated protein 1 in mouse embryo fibroblasts
    • A. Hayashi, H. Suzuki, K. Itoh, M. Yamamoto, and Y. Sugiyama, "Transcription factor Nrf2 is required for the constitutive and inducible expression ofmultidrug resistance-associated protein 1 in mouse embryo fibroblasts, " Biochemical and Biophysical Research Communications, vol. 310, no. 3, pp. 824-829, 2003.
    • (2003) Biochemical and Biophysical Research Communications , vol.310 , Issue.3 , pp. 824-829
    • Hayashi, A.1    Suzuki, H.2    Itoh, K.3    Yamamoto, M.4    Sugiyama, Y.5
  • 92
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
    • E. Jigorel, M. Le Vee, C. Boursier-Neyret, Y. Parmentier, and O. Fardel, "Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes, " Drug Metabolismand Disposition, vol. 34, no. 10, pp. 1756-1763, 2006.
    • (2006) Drug Metabolismand Disposition , vol.34 , Issue.10 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 93
    • 84902436456 scopus 로고    scopus 로고
    • Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers
    • X. Wang, C. R. Campos, J. C. Peart et al., "Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers, " Journal of Neuroscience, vol. 34, no. 25, pp. 8585-8593, 2014.
    • (2014) Journal of Neuroscience , vol.34 , Issue.25 , pp. 8585-8593
    • Wang, X.1    Campos, C.R.2    Peart, J.C.3
  • 94
    • 84927610137 scopus 로고    scopus 로고
    • Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells
    • H. Jeong, I. Ryoo, and M. Kwak, "Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells, " Toxicology in Vitro, vol. 29, no. 5, pp. 884-892, 2015.
    • (2015) Toxicology in Vitro , vol.29 , Issue.5 , pp. 884-892
    • Jeong, H.1    Ryoo, I.2    Kwak, M.3
  • 95
    • 84919608289 scopus 로고    scopus 로고
    • Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene
    • M. J. Canet, M. D. Merrell, B. G. Harder et al., "Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene, " Drug Metabolism and Disposition, vol. 43, no. 1, pp. 93-99, 2014.
    • (2014) Drug Metabolism and Disposition , vol.43 , Issue.1 , pp. 93-99
    • Canet, M.J.1    Merrell, M.D.2    Harder, B.G.3
  • 96
    • 77955488723 scopus 로고    scopus 로고
    • Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype
    • A. Singh, H. Wu, P. Zhang, C. Happel, J. Ma, and S. Biswal, "Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype, " Molecular Cancer Therapeutics, vol. 9, no. 8, pp. 2365-2376, 2010.
    • (2010) Molecular Cancer Therapeutics , vol.9 , Issue.8 , pp. 2365-2376
    • Singh, A.1    Wu, H.2    Zhang, P.3    Happel, C.4    Ma, J.5    Biswal, S.6
  • 97
    • 0242329881 scopus 로고    scopus 로고
    • Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    • N. Wakabayashi, K. Itoh, J. Wakabayashi et al., "Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation, " Nature Genetics, vol. 35, no. 3, pp. 238-245, 2003.
    • (2003) Nature Genetics , vol.35 , Issue.3 , pp. 238-245
    • Wakabayashi, N.1    Itoh, K.2    Wakabayashi, J.3
  • 98
    • 4544294365 scopus 로고    scopus 로고
    • The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
    • S. B. Cullinan, J. D. Gordan, J. Jin, J. W. Harper, and J. A. Diehl, "The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase, "Molecular and Cellular Biology, vol. 24, no. 19, pp. 8477-8486, 2004.
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.19 , pp. 8477-8486
    • Cullinan, S.B.1    Gordan, J.D.2    Jin, J.3    Harper, J.W.4    Diehl, J.A.5
  • 99
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in keap1 are required for keap1-dependent ubiquitination of nrf2 and for stabilization of nrf2 by chemopreventive agents and oxidative stress
    • D. D. Zhang and M. Hannink, "Distinct cysteine residues in keap1 are required for keap1-dependent ubiquitination of nrf2 and for stabilization of nrf2 by chemopreventive agents and oxidative stress, " Molecular and Cellular Biology, vol. 23, no. 22, pp. 8137-8151, 2003.
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 100
    • 0037183998 scopus 로고    scopus 로고
    • The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
    • L. M. Zipper and R. T. Mulcahy, "The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm, " The Journal of Biological Chemistry, vol. 277, no. 39, pp. 36544-36552, 2002.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.39 , pp. 36544-36552
    • Zipper, L.M.1    Mulcahy, R.T.2
  • 101
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • M. C. Jaramillo and D. D. Zhang, "The emerging role of the Nrf2-Keap1 signaling pathway in cancer, " Genes&Development, vol. 27, no. 20, pp. 2179-2191, 2013.
    • (2013) Genes&Development , vol.27 , Issue.20 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 102
    • 33344463325 scopus 로고    scopus 로고
    • Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
    • K. I. Tong, Y. Katoh, H. Kusunoki, K. Itoh, T. Tanaka, andM. Yamamoto, "Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model, " Molecular and Cellular Biology, vol. 26, no. 8, pp. 2887-2900, 2006.
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.8 , pp. 2887-2900
    • Tong, K.I.1    Katoh, Y.2    Kusunoki, H.3    Itoh, K.4    Tanaka, T.5    Yamamoto, M.6
  • 103
    • 33750613056 scopus 로고    scopus 로고
    • Twosite substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
    • K. I. Tong, A. Kobayashi, F. Katsuoka, andM. Yamamoto, "Twosite substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism, " Biological Chemistry, vol. 387, no. 10-11, pp. 1311-1320, 2006.
    • (2006) Biological Chemistry , vol.387 , Issue.10-11 , pp. 1311-1320
    • Tong, K.I.1    Kobayashi, A.2    Katsuoka, F.3    Yamamoto, M.4
  • 104
    • 35648970026 scopus 로고    scopus 로고
    • Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
    • K. I. Tong, B. Padmanabhan, A. Kobayashi et al., "Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response, " Molecular and Cellular Biology, vol. 27, no. 21, pp. 7511-7521, 2007.
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.21 , pp. 7511-7521
    • Tong, K.I.1    Padmanabhan, B.2    Kobayashi, A.3
  • 105
    • 58249117780 scopus 로고    scopus 로고
    • The antioxidant defense systemKeap1-Nrf2 comprises amultiple sensingmechanism for responding to a wide range of chemical compounds
    • M. Kobayashi, L. Li, N. Iwamoto et al., "The antioxidant defense systemKeap1-Nrf2 comprises amultiple sensingmechanism for responding to a wide range of chemical compounds, "Molecular and Cellular Biology, vol. 29, no. 2, pp. 493-502, 2009.
    • (2009) Molecular and Cellular Biology , vol.29 , Issue.2 , pp. 493-502
    • Kobayashi, M.1    Li, L.2    Iwamoto, N.3
  • 106
    • 42149196050 scopus 로고    scopus 로고
    • Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
    • T. Yamamoto, T. Suzuki, A. Kobayashi et al., "Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity, " Molecular and Cellular Biology, vol. 28, no. 8, pp. 2758-2770, 2008.
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.8 , pp. 2758-2770
    • Yamamoto, T.1    Suzuki, T.2    Kobayashi, A.3
  • 107
    • 0036240610 scopus 로고    scopus 로고
    • Enhanced expression of the transcription factorNrf2 by cancer chemopreventive agents: Role of antioxidant response elementlike sequences in the nrf2 promoter
    • M. K. Kwak, K. Itoh, M. Yamamoto, and T. W. Kensler, "Enhanced expression of the transcription factorNrf2 by cancer chemopreventive agents: role of antioxidant response elementlike sequences in the nrf2 promoter, " Molecular and Cellular Biology, vol. 22, no. 9, pp. 2883-2892, 2002.
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.9 , pp. 2883-2892
    • Kwak, M.K.1    Itoh, K.2    Yamamoto, M.3    Kensler, T.W.4
  • 108
    • 84878620505 scopus 로고    scopus 로고
    • Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels
    • T. Suzuki, T. Shibata, K. Takaya et al., "Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels, "Molecular and Cellular Biology, vol. 33, no. 12, pp. 2402-2412, 2013.
    • (2013) Molecular and Cellular Biology , vol.33 , Issue.12 , pp. 2402-2412
    • Suzuki, T.1    Shibata, T.2    Takaya, K.3
  • 110
    • 59849113546 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2-mediated antioxidant response
    • W. Li and A. Kong, "Molecular mechanisms of Nrf2-mediated antioxidant response, " Molecular Carcinogenesis, vol. 48, no. 2, pp. 91-104, 2009.
    • (2009) Molecular Carcinogenesis , vol.48 , Issue.2 , pp. 91-104
    • Li, W.1    Kong, A.2
  • 111
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Y. J. Surh, "Cancer chemoprevention with dietary phytochemicals, " Nature Reviews Cancer, vol. 3, no. 10, pp. 768-780, 2003.
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 768-780
    • Surh, Y.J.1
  • 112
    • 33744950387 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
    • M. Salazar, A. I. Rojo, D. Velasco, R. M. de Sagarra, and A. Cuadrado, "Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2, " Journal of Biological Chemistry, vol. 281, no. 21, pp. 14841-14851, 2006.
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.21 , pp. 14841-14851
    • Salazar, M.1    Rojo, A.I.2    Velasco, D.3    De Sagarra, R.M.4    Cuadrado, A.5
  • 113
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • W. Chen, Z. Sun, X. J. Wang et al., "Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response, " Molecular Cell, vol. 34, no. 6, pp. 663-673, 2009.
    • (2009) Molecular Cell , vol.34 , Issue.6 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3
  • 114
    • 77649265091 scopus 로고    scopus 로고
    • The selective autophagy substrate p62 activates the stress responsive transcription factorNrf2 through inactivation of Keap1
    • M. Komatsu, H. Kurokawa, S. Waguri et al., "The selective autophagy substrate p62 activates the stress responsive transcription factorNrf2 through inactivation of Keap1, " Nature Cell Biology, vol. 12, no. 3, pp. 213-223, 2010.
    • (2010) Nature Cell Biology , vol.12 , Issue.3 , pp. 213-223
    • Komatsu, M.1    Kurokawa, H.2    Waguri, S.3
  • 115
    • 77958130983 scopus 로고    scopus 로고
    • Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    • J. D. Hayes, M. McMahon, S. Chowdhry, and A. T. Dinkova-Kostova, "Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway, " Antioxidants&Redox Signaling, vol. 13, no. 11, pp. 1713-1748, 2010.
    • (2010) Antioxidants&Redox Signaling , vol.13 , Issue.11 , pp. 1713-1748
    • Hayes, J.D.1    McMahon, M.2    Chowdhry, S.3    Dinkova-Kostova, A.T.4
  • 116
    • 77958114117 scopus 로고    scopus 로고
    • Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: Antioxidant coupled with antiinflammatory
    • R. Hu, C. L. Saw, R. Yu, and A. T. Kong, "Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: Antioxidant coupled with antiinflammatory, " Antioxidants & Redox Signaling, vol. 13, no. 11, pp. 1679-1698, 2010.
    • (2010) Antioxidants & Redox Signaling , vol.13 , Issue.11 , pp. 1679-1698
    • Hu, R.1    Saw, C.L.2    Yu, R.3    Kong, A.T.4
  • 117
    • 77649270763 scopus 로고    scopus 로고
    • Targeting NRF2 signaling for cancer chemoprevention
    • M. Kwak and T. W. Kensler, "Targeting NRF2 signaling for cancer chemoprevention, " Toxicology and Applied Pharmacology, vol. 244, no. 1, pp. 66-76, 2010.
    • (2010) Toxicology and Applied Pharmacology , vol.244 , Issue.1 , pp. 66-76
    • Kwak, M.1    Kensler, T.W.2
  • 118
    • 4644328941 scopus 로고    scopus 로고
    • Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
    • K. Iida, K. Itoh, Y. Kumagai et al., "Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis, " Cancer Research, vol. 64, no. 18, pp. 6424-6431, 2004.
    • (2004) Cancer Research , vol.64 , Issue.18 , pp. 6424-6431
    • Iida, K.1    Itoh, K.2    Kumagai, Y.3
  • 119
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • T. Jiang, N. Chen, F. Zhao et al., "High levels of Nrf2 determine chemoresistance in type II endometrial cancer, " Cancer Research, vol. 70, no. 13, pp. 5486-5496, 2010.
    • (2010) Cancer Research , vol.70 , Issue.13 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3
  • 120
    • 76749106638 scopus 로고    scopus 로고
    • Oncogenic NRF2mutations in squamous cell carcinomas of oesophagus and skin
    • Y. R. Kim, J. E. Oh, M. S. Kim et al., "Oncogenic NRF2mutations in squamous cell carcinomas of oesophagus and skin, " The Journal of Pathology, vol. 220, no. 4, pp. 446-451, 2010.
    • (2010) The Journal of Pathology , vol.220 , Issue.4 , pp. 446-451
    • Kim, Y.R.1    Oh, J.E.2    Kim, M.S.3
  • 121
    • 53049105119 scopus 로고    scopus 로고
    • Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    • T. Shibata, A. Kokubu, M. Gotoh et al., "Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer, " Gastroenterology, vol. 135, no. 4, pp. 1358. e4-1368. e4, 2008.
    • (2008) Gastroenterology , vol.135 , Issue.4 , pp. 1358e4-1368e4
    • Shibata, T.1    Kokubu, A.2    Gotoh, M.3
  • 122
  • 123
    • 33750885385 scopus 로고    scopus 로고
    • Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
    • A. Singh, V. Misra, R. K. Thimmulappa et al., "Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer, " PLoS Medicine, vol. 3, no. 10, article e420, 2006.
    • (2006) PLoS Medicine , vol.3 , Issue.10
    • Singh, A.1    Misra, V.2    Thimmulappa, R.K.3
  • 124
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • R. Wang, J. An, F. Ji, H. Jiao, H. Sun, and D. Zhou, "Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues, " Biochemical and Biophysical Research Communications, vol. 373, no. 1, pp. 151-154, 2008.
    • (2008) Biochemical and Biophysical Research Communications , vol.373 , Issue.1 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 125
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
    • P. Zhang, A. Singh, S. Yegnasubramanian et al., "Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth, "Molecular CancerTherapeutics, vol. 9, no. 2, pp. 336-346, 2010.
    • (2010) Molecular CancerTherapeutics , vol.9 , Issue.2 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3
  • 126
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • J. D. Hayes and M. McMahon, "NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer, " Trends in Biochemical Sciences, vol. 34, no. 4, pp. 176-188, 2009.
    • (2009) Trends in Biochemical Sciences , vol.34 , Issue.4 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 127
    • 33344456501 scopus 로고    scopus 로고
    • Structural basis for defects of Keap1 activity provoked by its pointmutations in lung cancer
    • B. Padmanabhan, K. I. Tong, T. Ohta et al., "Structural basis for defects of Keap1 activity provoked by its pointmutations in lung cancer, " Molecular Cell, vol. 21, no. 5, pp. 689-700, 2006.
    • (2006) Molecular Cell , vol.21 , Issue.5 , pp. 689-700
    • Padmanabhan, B.1    Tong, K.I.2    Ohta, T.3
  • 128
    • 79955492012 scopus 로고    scopus 로고
    • Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    • Y. Inami, S. Waguri, A. Sakamoto et al., "Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells, "TheJournal of Cell Biology, vol. 193, no. 2, pp. 275-284, 2011.
    • (2011) TheJournal of Cell Biology , vol.193 , Issue.2 , pp. 275-284
    • Inami, Y.1    Waguri, S.2    Sakamoto, A.3
  • 129
    • 79960060305 scopus 로고    scopus 로고
    • Oncogeneinduced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • G. M. DeNicola, F. A. Karreth, T. J. Humpton et al., "Oncogeneinduced Nrf2 transcription promotes ROS detoxification and tumorigenesis, " Nature, vol. 475, no. 7354, pp. 106-109, 2011.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3
  • 130
    • 77954695549 scopus 로고    scopus 로고
    • Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    • L. M. Solis, C. Behrens, W. Dong et al., "Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features, " Clinical Cancer Research, vol. 16, no. 14, pp. 3743-3753, 2010.
    • (2010) Clinical Cancer Research , vol.16 , Issue.14 , pp. 3743-3753
    • Solis, L.M.1    Behrens, C.2    Dong, W.3
  • 131
    • 34347222551 scopus 로고    scopus 로고
    • Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
    • N. M. Reddy, S. R. Kleeberger, H. Y. Cho et al., "Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants, " American Journal of Respiratory Cell and Molecular Biology, vol. 37, no. 1, pp. 3-8, 2007.
    • (2007) American Journal of Respiratory Cell and Molecular Biology , vol.37 , Issue.1 , pp. 3-8
    • Reddy, N.M.1    Kleeberger, S.R.2    Cho, H.Y.3
  • 132
    • 37449000924 scopus 로고    scopus 로고
    • Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection
    • N. M. Reddy, S. R. Kleeberger, M. Yamamoto et al., "Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection, " Physiological Genomics, vol. 32, no. 1, pp. 74-81, 2007.
    • (2007) Physiological Genomics , vol.32 , Issue.1 , pp. 74-81
    • Reddy, N.M.1    Kleeberger, S.R.2    Yamamoto, M.3
  • 133
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Y. Mitsuishi, K. Taguchi, Y. Kawatani et al., "Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming, " Cancer Cell, vol. 22, no. 1, pp. 66-79, 2012.
    • (2012) Cancer Cell , vol.22 , Issue.1 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatani, Y.3
  • 134
    • 38149003106 scopus 로고    scopus 로고
    • Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
    • J. Cho, S. Manandhar, H. Lee, H. Park, and M. Kwak, "Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance, " Cancer Letters, vol. 260, no. 1-2, pp. 96-108, 2008.
    • (2008) Cancer Letters , vol.260 , Issue.1-2 , pp. 96-108
    • Cho, J.1    Manandhar, S.2    Lee, H.3    Park, H.4    Kwak, M.5
  • 135
    • 40449107193 scopus 로고    scopus 로고
    • Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    • T. Ohta, K. Iijima, M. Miyamoto et al., "Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth, " Cancer Research, vol. 68, no. 5, pp. 1303-1309, 2008.
    • (2008) Cancer Research , vol.68 , Issue.5 , pp. 1303-1309
    • Ohta, T.1    Iijima, K.2    Miyamoto, M.3
  • 136
    • 77958129306 scopus 로고    scopus 로고
    • Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
    • A. Singh, M. Bodas, N. Wakabayashi, F. Bunz, and S. Biswal, "Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance, "Antioxidants&Redox Signaling, vol. 13, no. 11, pp. 1627-1637, 2010.
    • (2010) Antioxidants&Redox Signaling , vol.13 , Issue.11 , pp. 1627-1637
    • Singh, A.1    Bodas, M.2    Wakabayashi, N.3    Bunz, F.4    Biswal, S.5
  • 137
    • 70350620150 scopus 로고    scopus 로고
    • Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
    • G.-S. Shim, S. Manandhar, D.-H. Shin, T. Kim, and M. Kwak, "Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway, " Free Radical Biology and Medicine, vol. 47, no. 11, pp. 1619-1631, 2009.
    • (2009) Free Radical Biology and Medicine , vol.47 , Issue.11 , pp. 1619-1631
    • Shim, G.-S.1    Manandhar, S.2    Shin, D.-H.3    Kim, T.4    Kwak, M.5
  • 138
    • 84859029752 scopus 로고    scopus 로고
    • NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity
    • S. Manandhar, B. Choi, K. Jung et al., "NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity, " Free Radical Biology and Medicine, vol. 52, no. 9, pp. 1773-1785, 2012.
    • (2012) Free Radical Biology and Medicine , vol.52 , Issue.9 , pp. 1773-1785
    • Manandhar, S.1    Choi, B.2    Jung, K.3
  • 139
    • 79952749190 scopus 로고    scopus 로고
    • NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation ofHIF-1
    • T. Kim, E.-g. Hur, S. J. Kang et al., "NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation ofHIF-1, " Cancer Research, vol. 71, no. 6, pp. 2260-2275, 2011.
    • (2011) Cancer Research , vol.71 , Issue.6 , pp. 2260-2275
    • Kim, T.1    Hur, E.-G.2    Kang, S.J.3
  • 140
    • 80054724249 scopus 로고    scopus 로고
    • Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FHdeficient papillary renal cell carcinoma type 2
    • L. Kinch, N. V. Grishin, and J. Brugarolas, "Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FHdeficient papillary renal cell carcinoma type 2, " Cancer Cell, vol. 20, no. 4, pp. 418-420, 2011.
    • (2011) Cancer Cell , vol.20 , Issue.4 , pp. 418-420
    • Kinch, L.1    Grishin, N.V.2    Brugarolas, J.3
  • 141
    • 84874655208 scopus 로고    scopus 로고
    • Nrf2 regulates haematopoietic stem cell function
    • J. J. Tsai, J. A. Dudakov, K. Takahashi et al., "Nrf2 regulates haematopoietic stem cell function, " Nature Cell Biology, vol. 15, no. 3, pp. 309-316, 2013.
    • (2013) Nature Cell Biology , vol.15 , Issue.3 , pp. 309-316
    • Tsai, J.J.1    Dudakov, J.A.2    Takahashi, K.3
  • 142
    • 84893836947 scopus 로고    scopus 로고
    • NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
    • J. H. Kim, R. K. Thimmulappa, V. Kumar et al., "NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation, " The Journal of Clinical Investigation, vol. 124, no. 2, pp. 730-741, 2014.
    • (2014) The Journal of Clinical Investigation , vol.124 , Issue.2 , pp. 730-741
    • Kim, J.H.1    Thimmulappa, R.K.2    Kumar, V.3
  • 143
    • 84896758124 scopus 로고    scopus 로고
    • NRF2 mitigates radiation-induced hematopoietic death
    • J. P. Chute, "NRF2 mitigates radiation-induced hematopoietic death, " The Journal of Clinical Investigation, vol. 124, no. 3, pp. 960-961, 2014.
    • (2014) The Journal of Clinical Investigation , vol.124 , Issue.3 , pp. 960-961
    • Chute, J.P.1
  • 144
    • 84908094625 scopus 로고    scopus 로고
    • Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells
    • J. Jang, Y. Wang, H. Kim, M. A. Lalli, and K. S. Kosik, "Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells, " Stem Cells, vol. 32, no. 10, pp. 2616-2625, 2014.
    • (2014) Stem Cells , vol.32 , Issue.10 , pp. 2616-2625
    • Jang, J.1    Wang, Y.2    Kim, H.3    Lalli, M.A.4    Kosik, K.S.5
  • 145
    • 84894462190 scopus 로고    scopus 로고
    • Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells
    • S. Murakami, R. Shimizu, P. Romeo, M. Yamamoto, and H. Motohashi, "Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells, " Genes to Cells, vol. 19, no. 3, pp. 239-253, 2014.
    • (2014) Genes to Cells , vol.19 , Issue.3 , pp. 239-253
    • Murakami, S.1    Shimizu, R.2    Romeo, P.3    Yamamoto, M.4    Motohashi, H.5
  • 146
    • 79551610653 scopus 로고    scopus 로고
    • Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila
    • C. E. Hochmuth, B. Biteau, D. Bohmann, andH. Jasper, "Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila, " Cell Stem Cell, vol. 8, no. 2, pp. 188-199, 2011.
    • (2011) Cell Stem Cell , vol.8 , Issue.2 , pp. 188-199
    • Hochmuth, C.E.1    Biteau, B.2    Bohmann, D.3    Jasper, H.4
  • 147
    • 84905905334 scopus 로고    scopus 로고
    • Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling
    • M. K. Paul, B. Bisht, D. O. Darmawan et al., "Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent notch signaling, " Cell Stem Cell, vol. 15, no. 2, pp. 199-214, 2014.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 199-214
    • Paul, M.K.1    Bisht, B.2    Darmawan, D.O.3
  • 148
    • 84904570079 scopus 로고    scopus 로고
    • Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependentmechanism
    • L. Gambari, G. Lisignoli, L. Cattini, C. Manferdini, A. Facchini, and F. Grassi, "Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependentmechanism, " Pharmacological Research, vol. 87, pp. 99-112, 2014.
    • (2014) Pharmacological Research , vol.87 , pp. 99-112
    • Gambari, L.1    Lisignoli, G.2    Cattini, L.3    Manferdini, C.4    Facchini, A.5    Grassi, F.6
  • 149
    • 13644268144 scopus 로고    scopus 로고
    • Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    • J. Li, D. Johnson, M. Calkins, L. Wright, C. Svendsen, and J. Johnson, "Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells, " Toxicological Sciences, vol. 83, no. 2, pp. 313-328, 2005.
    • (2005) Toxicological Sciences , vol.83 , Issue.2 , pp. 313-328
    • Li, J.1    Johnson, D.2    Calkins, M.3    Wright, L.4    Svendsen, C.5    Johnson, J.6
  • 150
    • 84055177613 scopus 로고    scopus 로고
    • The redoxsensitive transcription factorNrf2 regulatesmurine hematopoietic stem cell survival independently of ROS levels
    • A. A. Merchant, A. Singh, W. Matsui, and S. Biswal, "The redoxsensitive transcription factorNrf2 regulatesmurine hematopoietic stem cell survival independently of ROS levels, " Blood, vol. 118, no. 25, pp. 6572-6579, 2011.
    • (2011) Blood , vol.118 , Issue.25 , pp. 6572-6579
    • Merchant, A.A.1    Singh, A.2    Matsui, W.3    Biswal, S.4
  • 151
    • 78649346690 scopus 로고    scopus 로고
    • Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium
    • N. Gurusamy, D. Ray, I. Lekli, and D. K. Das, "Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium, " Journal of Cellular and Molecular Medicine, vol. 14, no. 9, pp. 2235-2239, 2010.
    • (2010) Journal of Cellular and Molecular Medicine , vol.14 , Issue.9 , pp. 2235-2239
    • Gurusamy, N.1    Ray, D.2    Lekli, I.3    Das, D.K.4
  • 153
    • 84866890498 scopus 로고    scopus 로고
    • The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release
    • C. Cai, L. Teng, D. Vu et al., "The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release, " The Journal of Biological Chemistry, vol. 287, no. 40, pp. 33720-33732, 2012.
    • (2012) The Journal of Biological Chemistry , vol.287 , Issue.40 , pp. 33720-33732
    • Cai, C.1    Teng, L.2    Vu, D.3
  • 154
    • 84924276073 scopus 로고    scopus 로고
    • The protective effect of melatonin on neural stem cell against LPS-induced inflammation
    • J. Song, S. M. Kang, K. M. Lee, and J. E. Lee, "The protective effect of melatonin on neural stem cell against LPS-induced inflammation, " BioMed Research International, vol. 2015, Article ID 854359, 13 pages, 2015.
    • (2015) BioMed Research International , vol.2015
    • Song, J.1    Kang, S.M.2    Lee, K.M.3    Lee, J.E.4
  • 155
    • 84902578456 scopus 로고    scopus 로고
    • Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity
    • V. Kärkkäinen, Y. Pomeshchik, E. Savchenko et al., "Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity, " STEM CELLS, vol. 32, no. 7, pp. 1904-1916, 2014.
    • (2014) STEM CELLS , vol.32 , Issue.7 , pp. 1904-1916
    • Kärkkäinen, V.1    Pomeshchik, Y.2    Savchenko, E.3
  • 156
    • 84865137387 scopus 로고    scopus 로고
    • Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity
    • M. Mohammadzadeh, R. Halabian, A. Gharehbaghian et al., "Nrf-2 overexpression in mesenchymal stem cells reduces oxidative stress-induced apoptosis and cytotoxicity, " Cell Stress and Chaperones, vol. 17, no. 5, pp. 553-565, 2012.
    • (2012) Cell Stress and Chaperones , vol.17 , Issue.5 , pp. 553-565
    • Mohammadzadeh, M.1    Halabian, R.2    Gharehbaghian, A.3
  • 157
    • 58149263824 scopus 로고    scopus 로고
    • Functional expression of 2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells
    • Y. Takahata, T. Takarada, M. Iemata et al., "Functional expression of 2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells, " Journal of Cellular Physiology, vol. 218, no. 2, pp. 268-275, 2009.
    • (2009) Journal of Cellular Physiology , vol.218 , Issue.2 , pp. 268-275
    • Takahata, Y.1    Takarada, T.2    Iemata, M.3
  • 158
    • 84923068541 scopus 로고    scopus 로고
    • Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells
    • J. Zhu, H. Wang, Y. Fan et al., "Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells, " Oncology Reports, vol. 32, no. 3, pp. 1170-1178, 2014.
    • (2014) Oncology Reports , vol.32 , Issue.3 , pp. 1170-1178
    • Zhu, J.1    Wang, H.2    Fan, Y.3
  • 159
    • 84881121768 scopus 로고    scopus 로고
    • Nrf2 is required to maintain the self-renewal of glioma stem cells
    • J. Zhu, H. Wang, Q. Sun et al., "Nrf2 is required to maintain the self-renewal of glioma stem cells, " BMC Cancer, vol. 13, no. 1, article 380, 2013.
    • (2013) BMC Cancer , vol.13 , Issue.1
    • Zhu, J.1    Wang, H.2    Sun, Q.3
  • 160
    • 84881485624 scopus 로고    scopus 로고
    • The secretome of colon cancer stem cells contains drug-metabolizing enzymes
    • B. L. Emmink, A. Verheem, W. J. Van Houdt et al., "The secretome of colon cancer stem cells contains drug-metabolizing enzymes, " Journal of Proteomics, vol. 91, pp. 84-96, 2013.
    • (2013) Journal of Proteomics , vol.91 , pp. 84-96
    • Emmink, B.L.1    Verheem, A.2    Van Houdt, W.J.3
  • 161
    • 84933279818 scopus 로고    scopus 로고
    • Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging systemin reactive oxygen species
    • T. Mizuno, N. Suzuki, H. Makino et al., "Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging systemin reactive oxygen species, " Gynecologic Oncology, vol. 137, no. 2, pp. 299-305, 2015.
    • (2015) Gynecologic Oncology , vol.137 , Issue.2 , pp. 299-305
    • Mizuno, T.1    Suzuki, N.2    Makino, H.3
  • 162
    • 84928381832 scopus 로고    scopus 로고
    • Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
    • I.-G. Ryoo, B.-H. Choi, and M.-K. Kwak, "Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells, " Oncotarget, vol. 6, no. 10, pp. 8167-8184, 2015.
    • (2015) Oncotarget , vol.6 , Issue.10 , pp. 8167-8184
    • Ryoo, I.-G.1    Choi, B.-H.2    Kwak, M.-K.3
  • 164
    • 84949259198 scopus 로고    scopus 로고
    • Elevated expression of Nrf-2 and ABCG2 involved in multi-drug resistance of lung cancer SP cells
    • B. Yang, Y. Ma, and Y. Liu, "Elevated expression of Nrf-2 and ABCG2 involved in multi-drug resistance of lung cancer SP cells, " Drug Research, 2015.
    • (2015) Drug Research
    • Yang, B.1    Ma, Y.2    Liu, Y.3
  • 165
    • 84865114153 scopus 로고    scopus 로고
    • Mithramycin represses basal and cigarette smoke-induced expression of abcg2 and inhibits stem cell signaling in lung and esophageal cancer cells
    • M. Zhang, A. Mathur, Y. Zhang et al., "Mithramycin represses basal and cigarette smoke-induced expression of abcg2 and inhibits stem cell signaling in lung and esophageal cancer cells, " Cancer Research, vol. 72, no. 16, pp. 4178-4192, 2012.
    • (2012) Cancer Research , vol.72 , Issue.16 , pp. 4178-4192
    • Zhang, M.1    Mathur, A.2    Zhang, Y.3
  • 166
    • 84920464700 scopus 로고    scopus 로고
    • De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling
    • C. A. Del Vecchio, Y. Feng, E. S. Sokol et al., "De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling, " PLoS Biology, vol. 12, no. 9, Article IDe1001945, 2014.
    • (2014) PLoS Biology , vol.12 , Issue.9
    • Del Vecchio, C.A.1    Feng, Y.2    Sokol, E.S.3
  • 168
    • 84885177241 scopus 로고    scopus 로고
    • Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
    • A. Arlt, S. Sebens, S. Krebs et al., "Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity, " Oncogene, vol. 32, no. 40, pp. 4825-4835, 2013.
    • (2013) Oncogene , vol.32 , Issue.40 , pp. 4825-4835
    • Arlt, A.1    Sebens, S.2    Krebs, S.3
  • 169
    • 84885960813 scopus 로고    scopus 로고
    • Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
    • A.-M. Gao, Z.-P. Ke, F. Shi, G. Sun, and H. Chen, "Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway, " Chemico-Biological Interactions, vol. 206, no. 1, pp. 100-108, 2013.
    • (2013) Chemico-Biological Interactions , vol.206 , Issue.1 , pp. 100-108
    • Gao, A.-M.1    Ke, Z.-P.2    Shi, F.3    Sun, G.4    Chen, H.5
  • 170
    • 84881525302 scopus 로고    scopus 로고
    • Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
    • A. M. Gao, Z. P. Ke, J. N. Wang, J. Yang, S. Chen, and H. Chen, "Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway, " Carcinogenesis, vol. 34, no. 8, pp. 1806-1814, 2013.
    • (2013) Carcinogenesis , vol.34 , Issue.8 , pp. 1806-1814
    • Gao, A.M.1    Ke, Z.P.2    Wang, J.N.3    Yang, J.4    Chen, S.5    Chen, H.6


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