Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells

Stem Cells

Volumn 22, Issue 6, 2004, Pages 962-971

  Saretzki, Gabriele ^a   Armstrong, Lyle ^b   Leake, Alan ^a   Lako, Majlinda ^a   Von Zglinicki, Thomas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

Antioxidant defense; Differentiation; DNA repair; Embryonic stem cells; P glycoprotein; Peroxides DNA strand break

Indexed keywords

DNA; REACTIVE OXYGEN METABOLITE; VERAPAMIL;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIFFERENTIATION; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; DNA STRAND BREAKAGE; EMBRYO; GENE CONTROL; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STRESS;

ANIMALIA; MURINAE;

EID: 8644232705     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.22-6-962     Document Type: Article

References (43)

1. Aladjem MI, Spike BT, Rodewald LW et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol 1998;8:145-155.
2. Van Sloun PP, Jansen JG, Weeda G et al. The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. Nucleic Acids Res 1999;27:3276-3282.
3. Corbel SW, Clarke AR, Gledhill S et al. P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells. Oncogene 1999;18:1537-1544.
4. Lorenz M, Saretzki G, Sitte N et al. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med 2001;31:824-831.
5. Stark-Reed PE, Oliver CN. Protein oxidation and proteolysis during ageing and oxidative stress. Arch Biochem Biophys 1989;275:559-567.
6. Sitte N, Merker K, Grune T et al. Lipofuscin accumulation in proliferating fibroblasts in vitro: an indicator of oxidative stress. Exp Gerontol 2001;36:475-86.
7. Von Zglinicki T, Saretzki G, Docke W et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp Cell Res 1995;220:186-193.
8. Parrinello S, Samper E, Krtolica A et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol 2003;5:741-747.
9. Busuttil RA, Rubio M, Dolle ME et al. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2003;2:287-294.
10. Samper E, Nicholls DG, Melov S. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell 2003;2:277-285.
11. Niwa H. Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct Funct 2001;26:137-148.
12. Armstrong L, Lako M, Lincoln J et al. mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells. Mech Dev 2000;97:107-116.
13. Brabeck C, Pfeiffer R, Leake A et al. L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation. J Pharmacol Exp Ther 2003;306:973-979.
14. Birnboim HC, Jevcak JJ. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res 1981;41: 1889-1892.
15. Bunting KD. ABC transporters as phenotypic markers and functional regulators of stem cells. STEM CELLS 2002;20: 11-20.
16. Schafer FQ, Buettner G. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001;30: 1191-1212.
17. Sun QA, Kirnarsky L, Sherman S et al. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems Proc Natl Acad Sci U S A 2001;98:3673-3678.
18. DeHaan JB, Crack PJ, Flentjar N et al. An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse. Redox Rep 2003;8:69-79.
19. Yang Y, Sharma R, Zimniak P et al. Role of class glutathione S-transferases as antioxidant enzymes in rodent tissues. Toxicol Appl Pharmacol 2002;182:105-115.
20. Leiers B, Kampkötter A, Grevelding CG et al. A stress-responsive glutathione S transferase confers resistance to oxidative stress in Caenorhabditis elegans. Free Radic Biol Med 2003;34:1405-1415.
21. Kirby K, Hu J, Hilliker AJ et al. RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc Natl Acad Sci USA 2002;99:16162-16167.
22. Mongan PD, Karaian J, Van Der Schuur BM et al. Pyruvate prevents poly-ADP ribose polymerase (PARP) activation, oxidative damage, and pyruvate dehydrogenase deactivation during hemorrhagic shock in swine. J Surg Res 2003; 112:180-188.
23. Varma SD, Hegde K, Henein M et al. Oxidative damage to mouse lens in culture: protective effect of pyruvate. Biochim Biophys Acta 2003;1621:246-252.
24. Houghton FD, Thompson JG, Kennedy CJ et al. Oxygen consumption and energy metabolism of the early mouse embryo. Mol Reprod Dev 1996;44:476-485.
25. Heidbreder M, Frolich F, Johren O et al. Hypoxia rapidly activates HIF-3 mRNA expression. FASEB J 2003;17: 1541-1543.
26. Safran M, Kaelin WG. H1F hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 2003;111: 779-783.
27. Stromer T, Ehrnsperger M, Gaestel M et al. Analysis of the interaction of small heat shock proteins with unfolding proteins. J Biol Chem 2003;278:18015-18021.
28. Yi MJ, Park SH, Cho HN et al. Heat-shock protein 25 (Hspb1) regulates manganese superoxide dismutase through activation of Nfkb (NF-kappaB). Radiat Res 2002;158: 641-649.
29. Gurbuxani S, Schmitt E, Cande C et al. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 2003;22:6669-6678.
30. Bevilacqua A, Kinnunen LH, Bevilacqua S et al. Stage-specific regulation of murine Hsp68 gene promoter in preimplantation mouse embryos. Dev Biol 1995;170:467-78.
31. Kaul SC, Taira K, Pereira-Smith OM et al. Mortalin: present and prospective. Exp Gerontol 2002;37:1157-1164.
32. Carette J, Lehnert S, Chow TYK. Implication of PBP74/mortalin/GRP75 in the radio-adaptive response. Int J Radiat Biol 2002;78:183-190.
33. Kaul S, Reddel RR, Sugihara T et al. Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2. FEBS Lett 2000;474:159-164.
34. Xu J, Xiao HH, Sartorelli AC et al. Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70. Oncol Res 1999;11:429-435.
35. Wadwha R, Takano S, Robert M et al. Inactivation of tumor suppressor p53 by Mot-2, a hsp70 family member. J Biol Chem 1998;273:29586-29591.
36. Kaul S, Yaguchi T, Taira K et al. Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res 2002;286:96-101.
37. Park IK, Morrison SJ, Clarke MF. Bmi1, stem cells, and senescence regulation. J Clin Invest 2004;113:175-179.
38. Molofsky AV, Pardal R, Iwashita T et al. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 2003;25:962-967.
39. Shannon M, Lamerdin JE, Richardson L et al. Characterization of the Mouse Xpf DNA repair gene and differential expression during spermatogenesis. Genomics 1999;62: 427-435.
40. Essers J, van Steeg H, de Wit J et al. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J 2000;19:1703-1710.
41. Tian M, Shinkura R, Shinkura N et al. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol 2004;24:1200-1205.
42. Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 2001;11:173-186.
43. Kirkwood TB, Austad SN. Why do we age? Nature 2000; 408:233-238.