A role for GPx3 in activity of normal and leukemia stem cells

Journal of Experimental Medicine

Volumn 209, Issue 5, 2012, Pages 895-901

  Herault, Olivier ^a,b   Hope, Kristin J ^a   Deneault, Eric ^a   Mayotte, Nadine ^a   Chagraoui, Jalila ^a   Wilhelm, Brian T ^a   Cellot, Sonia ^a   Sauvageau, Martin ^a   Andrade Navarro, Miguel A ^c,d   Hébert, Josée ^e   Sauvageau, Guy ^a  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b UNIVERSITÉ DE TOURS   (France)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE PEROXIDASE 3; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR HOXA9; DNA BINDING PROTEIN; GLUTATHIONE PEROXIDASE; GPX3 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; HOXB4 PROTEIN, HUMAN; MYELOID ECOTROPIC VIRAL INTEGRATION SITE 1 PROTEIN; PRDM16 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOTRANSFORMATION; CANCER PROGNOSIS; CANCER STEM CELL; CELL POPULATION; CELL PROLIFERATION; CELL SUBPOPULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; GENE EXPRESSION PROFILING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; LEUKEMIA STEM CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; ANIMAL; CELL LINE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; DNA SEQUENCE; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; LEUKEMIA; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL;

ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CELL LINE; DNA-BINDING PROTEINS; FLOW CYTOMETRY; FLUORESCENCE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; GLUTATHIONE PEROXIDASE; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA; MICE; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84863811010     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20102386     Document Type: Article

References (30)

1. Antonchuk, J., G. Sauvageau, and R.K. Humphries. 2001. HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation. Exp. Hematol. 29:1125-1134. http://dx.doi.org/10.1016/S0301-472X(01)00681-6
2. Deneault, E., S. Cellot, A. Faubert, J.P. Laverdure, M. Fréchette, J. Chagraoui, N. Mayotte, M. Sauvageau, S.B. Ting, and G. Sauvageau. 2009. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 137:369-379. http://dx.doi.org/10.1016/j.cell.2009.03.026
3. Diehn, M., R.W. Cho, N.A. Lobo, T. Kalisky, M.J. Dorie, A.N. Kulp, D. Qian, J.S. Lam, L.E. Ailles, M. Wong, et al. 2009. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 458:780-783. http://dx.doi.org/10.1038/nature07733
4. Finkel, T., and N.J. Holbrook. 2000. Oxidants, oxidative stress and the biology of ageing. Nature. 408:239-247. http://dx.doi.org/10.1038/35041687
5. Guzman, M.L., C.F. Swiderski, D.S. Howard, B.A. Grimes, R.M. Rossi, S.J. Szilvassy, and C.T. Jordan. 2002. Preferential induction of apoptosis for primary human leukemic stem cells. Proc. Natl. Acad. Sci. USA. 99:16220-16225. http://dx.doi.org/10.1073/pnas.252462599
6. Ito, K., A. Hirao, F. Arai, S. Matsuoka, K. Takubo, I. Hamaguchi, K. Nomiyama, K. Hosokawa, K. Sakurada, N. Nakagata, et al. 2004. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 431:997-1002. http://dx.doi.org/10.1038/nature02989
7. Ito, K., A. Hirao, F. Arai, K. Takubo, S. Matsuoka, K. Miyamoto, M. Ohmura, K. Naka, K. Hosokawa, Y. Ikeda, and T. Suda. 2006. Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat. Med. 12:446-451. http://dx.doi.org/10.1038/nm1388
8. Jang, Y.Y., and S.J. Sharkis. 2007. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood. 110:3056-3063. http://dx.doi.org/10.1182/blood-2007-05-087759
9. Konopleva, M.Y., and C.T. Jordan. 2011. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J. Clin. Oncol. 29:591- 599. http://dx.doi.org/10.1200/JCO.2010.31.0904
10. Kops, G.J., T.B. Dansen, P.E. Polderman, I. Saarloos, K.W. Wirtz, P.J. Coffer, T.T. Huang, J.L. Bos, R.H. Medema, and B.M. Burgering. 2002. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 419:316-321. http://dx.doi.org/10.1038/nature01036
11. Kroon, E., J. Krosl, U. Thorsteinsdottir, S. Baban, A.M. Buchberg, and G. Sauvageau. 1998. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 17:3714- 3725. http://dx.doi.org/10.1093/emboj/17.13.3714
12. Krosl, J., and G. Sauvageau. 2000. AP-1 complex is effector of Hox-induced cellular proliferation and transformation. Oncogene. 19:5134-5141. http://dx.doi.org/10.1038/sj.onc.1203897
13. Lapidot, T., C. Sirard, J. Vormoor, B. Murdoch, T. Hoang, J. Caceres-Cortes, M. Minden, B. Paterson, M.A. Caligiuri, and J.E. Dick. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 367:645-648. http://dx.doi.org/10.1038/367645a0
14. Lessard, J., and G. Sauvageau. 2003. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 423:255-260. http://dx.doi.org/10.1038/nature01572
15. Mrózek, K., G. Marcucci, P. Paschka, S.P. Whitman, and C.D. Bloomfield. 2007. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. 109:431- 448. http://dx.doi.org/10.1182/blood-2006-06-001149
16. Ohta, H., S. Sekulovic, S. Bakovic, C.J. Eaves, N. Pineault, M. Gasparetto, C. Smith, G. Sauvageau, and R.K. Humphries. 2007. Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions. Exp. Hematol. 35:817-830. http://dx.doi.org/10.1016/j.exphem.2007.02.012
17. Okada, S., H. Nakauchi, K. Nagayoshi, S. Nishikawa, Y. Miura, and T. Suda. 1992. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood. 80:3044-3050.
18. Owusu-Ansah, E., and U. Banerjee. 2009. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 461: 537-541. http://dx.doi.org/10.1038/nature08313
19. Owusu-Ansah, E., A. Yavari, S. Mandal, and U. Banerjee. 2008. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat. Genet. 40:356-361. http://dx.doi.org/10.1038/ng.2007.50
20. Rebel, V.I., C.L. Miller, C.J. Eaves, and P.M. Lansdorp. 1996. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts. Blood. 87:3500-3507.
21. Sattler, M., T. Winkler, S. Verma, C.H. Byrne, G. Shrikhande, R. Salgia, and J.D. Griffin. 1999. Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood. 93:2928-2935.
22. Sauvageau, G., U. Thorsteinsdottir, C.J. Eaves, H.J. Lawrence, C. Largman, P.M. Lansdorp, and R.K. Humphries. 1995. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev. 9:1753-1765. http://dx.doi.org/10.1101/gad.9.14.1753
23. Shao, L., H. Li, S.K. Pazhanisamy, A. Meng, Y. Wang, and D. Zhou. 2011. Reactive oxygen species and hematopoietic stem cell senescence. Int. J. Hematol. 94:24-32. http://dx.doi.org/10.1007/s12185-011-0872-1
24. Sundaresan, M., Z.X. Yu, V.J. Ferrans, K. Irani, and T. Finkel. 1995. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science. 270:296-299. http://dx.doi.org/10.1126/science.270.5234.296
25. Takeda, S., C. Gapper, H. Kaya, E. Bell, K. Kuchitsu, and L. Dolan. 2008. Local positive feedback regulation determines cell shape in root hair cells. Science. 319:1241-1244. http://dx.doi.org/10.1126/science.1152505
26. Thorsteinsdottir, U., G. Sauvageau, and R.K. Humphries. 1999. Enhanced in vivo regenerative potential of HOXB4-transduced hematopoietic stem cells with regulation of their pool size. Blood. 94:2605-2612.
27. Tothova, Z., R. Kollipara, B.J. Huntly, B.H. Lee, D.H. Castrillon, D.E. Cullen, E.P. McDowell, S. Lazo-Kallanian, I.R. Williams, C. Sears, et al. 2007. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 128:325-339. http://dx.doi.org/10.1016/j.cell.2007.01.003
28. van Rhenen, A., N. Feller, A. Kelder, A.H. Westra, E. Rombouts, S. Zweegman, M.A. van der Pol, Q. Waisfisz, G.J. Ossenkoppele, and G.J. Schuurhuis. 2005. High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. Clin. Cancer Res. 11:6520-6527. http://dx.doi.org/10.1158/1078-0432.CCR-05-0468
29. Wang, Y., A.V. Krivtsov, A.U. Sinha, T.E. North, W. Goessling, Z. Feng, L.I. Zon, and S.A. Armstrong. 2010. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 327:1650-1653. http://dx.doi.org/10.1126/science.1186624
30. Wilhelm, B.T., M. Briau, P. Austin, A. Faubert, G. Boucher, P. Chagnon, K. Hope, S. Girard, N. Mayotte, J.R. Landry, et al. 2011. RNA-seq analysis of 2 closely related leukemia clones that differ in their selfrenewal capacity. Blood. 117:e27-e38. http://dx.doi.org/10.1182/blood-2010-07-293332