-
1
-
-
33745848469
-
Oxidative DNA damage: Mechanisms and significance in health and disease
-
Kasai H, Kawai K (2006) Oxidative DNA damage: Mechanisms and significance in health and disease. Antioxid Redox Signal 8:981-983.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 981-983
-
-
Kasai, H.1
Kawai, K.2
-
2
-
-
33845682863
-
Carcinogenesis and transcriptional regulation through Maf recognition elements
-
Motohashi H, Yamamoto M (2007) Carcinogenesis and transcriptional regulation through Maf recognition elements. Cancer Sci 98:135-139.
-
(2007)
Cancer Sci
, vol.98
, pp. 135-139
-
-
Motohashi, H.1
Yamamoto, M.2
-
3
-
-
34248585061
-
Role of Dietary Supplements/Nutraceuticals in Chemoprevention through Induction of Cytoprotective Enzymes
-
Fahey JW, Kensler TW (2007) Role of Dietary Supplements/Nutraceuticals in Chemoprevention through Induction of Cytoprotective Enzymes. Chem Res Toxicol 20:572-576.
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 572-576
-
-
Fahey, J.W.1
Kensler, T.W.2
-
4
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
5
-
-
0035853157
-
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
-
Ramos-Gomez M, et al. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98:3410-3415.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3410-3415
-
-
Ramos-Gomez, M.1
-
6
-
-
4644328941
-
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis
-
Iida K, et al. (2004) Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 64:6424-6431.
-
(2004)
Cancer Res
, vol.64
, pp. 6424-6431
-
-
Iida, K.1
-
7
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
Kobayashi A, et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24:7130-7139.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
-
8
-
-
33344469643
-
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
-
Kobayashi A, et al. (2006) Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 26:221-229.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 221-229
-
-
Kobayashi, A.1
-
9
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M (2004) Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24:10941-10953.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
10
-
-
18844454763
-
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype
-
Devling TW, Lindsay CD, McLellan LI, McMahon M, Hayes JD (2005) Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype. Proc Natl Acad Sci USA 102:7280-7285.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7280-7285
-
-
Devling, T.W.1
Lindsay, C.D.2
McLellan, L.I.3
McMahon, M.4
Hayes, J.D.5
-
11
-
-
34447258909
-
Disruption of the keap1-containing ubiquitination complex as an antioxidant therapy
-
Kern JT, Hannink M, Hess JF (2007) Disruption of the keap1-containing ubiquitination complex as an antioxidant therapy. Curr Top Med Chem 7:977-983.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 977-983
-
-
Kern, J.T.1
Hannink, M.2
Hess, J.F.3
-
12
-
-
0028299545
-
Jun and Fos regulation of NAD (P)H: Quinone oxidoreductase gene expression
-
Jaiswal AK (1994) Jun and Fos regulation of NAD (P)H: Quinone oxidoreductase gene expression. Pharmacogenetics 4:1-10.
-
(1994)
Pharmacogenetics
, vol.4
, pp. 1-10
-
-
Jaiswal, A.K.1
-
13
-
-
33751252276
-
Cancer metastasis: Building a framework
-
Gupta GP, Massague J (2006) Cancer metastasis: Building a framework. Cell 127:679-695.
-
(2006)
Cell
, vol.127
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
14
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
Padmanabhan B, et al. (2006) Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell 21:689-700.
-
(2006)
Mol Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
-
15
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
Singh A, et al. (2006) Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med 3:e420.
-
(2006)
PLoS Med
, vol.3
-
-
Singh, A.1
-
16
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
Ohta T, et al. (2008) Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res 68:1303-1309.
-
(2008)
Cancer Res
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
-
17
-
-
7444251509
-
Identification of polymorphisms in the promoter region of the human NRF2 gene
-
Yamamoto T, et al. (2004) Identification of polymorphisms in the promoter region of the human NRF2 gene. Biochem Biophys Res Commun 321:72-79.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 72-79
-
-
Yamamoto, T.1
-
18
-
-
34347392512
-
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
-
Marzec JM, et al. (2007) Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J 21:2237-2246.
-
(2007)
FASEB J
, vol.21
, pp. 2237-2246
-
-
Marzec, J.M.1
-
19
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh K, et al. (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76-86.
-
(1999)
Genes Dev
, vol.13
, pp. 76-86
-
-
Itoh, K.1
-
20
-
-
33344463325
-
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
-
Tong KI, et al. (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model. Mol Cell Biol 26:2887-2900.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2887-2900
-
-
Tong, K.I.1
-
21
-
-
35648970026
-
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
-
Tong KI, et al. (2007) Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol 21:7511-7521.
-
(2007)
Mol Cell Biol
, vol.21
, pp. 7511-7521
-
-
Tong, K.I.1
-
22
-
-
33747606306
-
Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling
-
Lo SC, Li X, Henzl MT, Beamer LJ, Hannink M (2006) Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J 25:3605-3617.
-
(2006)
EMBO J
, vol.25
, pp. 3605-3617
-
-
Lo, S.C.1
Li, X.2
Henzl, M.T.3
Beamer, L.J.4
Hannink, M.5
-
23
-
-
0033873929
-
Comparative protein structure modeling of genes and genomes
-
Marti-Renom MA, et al. (2000) Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 29:291-325.
-
(2000)
Annu Rev Biophys Biomol Struct
, vol.29
, pp. 291-325
-
-
Marti-Renom, M.A.1
-
24
-
-
5644272705
-
Invasive potential induced under long-term oxidative stress in mammary epithelial cells
-
Mori K, Shibanuma M, Nose K (2004) Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res 64:7464-7672.
-
(2004)
Cancer Res
, vol.64
, pp. 7464-7672
-
-
Mori, K.1
Shibanuma, M.2
Nose, K.3
-
25
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
Petroski MD, Desharies RJ (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6:9 -15.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 9-15
-
-
Petroski, M.D.1
Desharies, R.J.2
-
26
-
-
33750613056
-
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
-
Tong KI, Kobayashi A, Katsuoka F, Yamamoto M (2006) Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism. Biol Chem 387:1311-1320.
-
(2006)
Biol Chem
, vol.387
, pp. 1311-1320
-
-
Tong, K.I.1
Kobayashi, A.2
Katsuoka, F.3
Yamamoto, M.4
-
27
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim WY, Kaelin WG (2004) Role of VHL gene mutation in human cancer. J Clin Oncol 22:4991-5004.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
28
-
-
23044506681
-
The ubiquitin-proteasome pathway and its role in cancer
-
Mani A, Gelmann EP (2005) The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 23:4776-4789.
-
(2005)
J Clin Oncol
, vol.23
, pp. 4776-4789
-
-
Mani, A.1
Gelmann, E.P.2
-
29
-
-
10544231876
-
Identification of a RING protein that can interact in vivo with the BRCA1 gene product
-
Wu LC, et al. (1996) Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat Genet 14:430-440.
-
(1996)
Nat Genet
, vol.14
, pp. 430-440
-
-
Wu, L.C.1
-
30
-
-
0030953635
-
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, amember of the Cdc53 family of proteins
-
Pause A, et al. (1997) The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, amember of the Cdc53 family of proteins. Proc Natl Acad Sci USA 94:2156-2161.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2156-2161
-
-
Pause, A.1
-
31
-
-
0033565672
-
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
-
Lisztwan J, Imbert G, Wirbelauer C, Gstaiger M, Krek W (1999) The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity. Genes Dev 13:1822-1833.
-
(1999)
Genes Dev
, vol.13
, pp. 1822-1833
-
-
Lisztwan, J.1
Imbert, G.2
Wirbelauer, C.3
Gstaiger, M.4
Krek, W.5
-
32
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O, Levy AP, Jiang C, Kaelin WG Jr., Goldberg MA (1996) Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA 93:10595-10599.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin Jr., W.G.4
Goldberg, M.A.5
-
33
-
-
33644684041
-
Substrates of the BRCA1-dependent ubiquitin ligase
-
Starita LM, Parvin JD (2006) Substrates of the BRCA1-dependent ubiquitin ligase. Cancer Biol Ther 5:137-141.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 137-141
-
-
Starita, L.M.1
Parvin, J.D.2
-
34
-
-
0242329881
-
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
-
Wakabayashi N, et al. (2003) Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-245.
-
(2003)
Nat Genet
, vol.35
, pp. 238-245
-
-
Wakabayashi, N.1
-
35
-
-
37449000924
-
Genetic dissection of the Nrf2-dependent redox signaling regulated transcriptional programs of cell proliferation and cytoprotection
-
Reddy NM, et al. (2007) Genetic dissection of the Nrf2-dependent redox signaling regulated transcriptional programs of cell proliferation and cytoprotection. Physiol Genomics 32:74-81.
-
(2007)
Physiol Genomics
, vol.32
, pp. 74-81
-
-
Reddy, N.M.1
-
36
-
-
10444287596
-
Genetic instability and the tumor microenvironment: Towards the concept of microenvironment-induced mutagenesis
-
Bindra RS, Glazer PM (2005) Genetic instability and the tumor microenvironment: Towards the concept of microenvironment-induced mutagenesis. Mutat Res 569:75-85.
-
(2005)
Mutat Res
, vol.569
, pp. 75-85
-
-
Bindra, R.S.1
Glazer, P.M.2
-
37
-
-
33846531356
-
The tumor microenvironment as a target for chemoprevention
-
Adriana A, Sporn MC (2007) The tumor microenvironment as a target for chemoprevention. Nat Rev Cancer 7:139-147.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 139-147
-
-
Adriana, A.1
Sporn, M.C.2
-
38
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3:721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
40
-
-
33846703755
-
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology
-
Kim YJ, et al. (2007) Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology. Cancer Res 67:546-554.
-
(2007)
Cancer Res
, vol.67
, pp. 546-554
-
-
Kim, Y.J.1
|