-
1
-
-
77950193944
-
Animal models for medical countermeasures to radiation exposure
-
Williams JP, et al. Animal models for medical countermeasures to radiation exposure. Radiat Res. 2010; 173(4):557-578.
-
(2010)
Radiat Res.
, vol.173
, Issue.4
, pp. 557-578
-
-
Williams, J.P.1
-
2
-
-
77954997865
-
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
-
Johnson SM, et al. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J Clin Invest. 2010;120(7):2528-2536.
-
(2010)
J Clin Invest.
, vol.120
, Issue.7
, pp. 2528-2536
-
-
Johnson, S.M.1
-
3
-
-
0028903635
-
Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy
-
Mauch P, et al. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int J Radiat Oncol Biol Phys. 1995; 31(5):1319-1339.
-
(1995)
Int J Radiat Oncol Biol Phys.
, vol.31
, Issue.5
, pp. 1319-1339
-
-
Mauch, P.1
-
4
-
-
84863683494
-
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity
-
Geiger H, et al. Pharmacological targeting of the thrombomodulin- activated protein C pathway mitigates radiation toxicity. Nat Med. 2012; 18(7):1123-1129.
-
(2012)
Nat Med.
, vol.18
, Issue.7
, pp. 1123-1129
-
-
Geiger, H.1
-
5
-
-
81855183759
-
Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death
-
Guinan EC, et al. Bactericidal/permeability-increasing protein (rBPI21) and fluoroquinolone mitigate radiation-induced bone marrow aplasia and death. Sci Transl Med. 2011;3(110):110ra118.
-
(2011)
Sci Transl Med.
, vol.3
, Issue.110
-
-
Guinan, E.C.1
-
6
-
-
84866029138
-
A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management
-
Farese AM, et al. A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management. Health Phys. 2012; 103(4):367-382.
-
(2012)
Health Phys.
, vol.103
, Issue.4
, pp. 367-382
-
-
Farese, A.M.1
-
7
-
-
84866049328
-
Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome
-
Chua HL, et al. Long-term hematopoietic stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome. Health Phys. 2012;103(4):356-366.
-
(2012)
Health Phys.
, vol.103
, Issue.4
, pp. 356-366
-
-
Chua, H.L.1
-
8
-
-
2342440129
-
Medicine. Modulation of radiation injury
-
Coleman CN, Stone HB, Moulder JE, Pellmar TC. Medicine. Modulation of radiation injury. Science. 2004;304(5671):693-694.
-
(2004)
Science
, vol.304
, Issue.5671
, pp. 693-694
-
-
Coleman, C.N.1
Stone, H.B.2
Moulder, J.E.3
Pellmar, T.C.4
-
9
-
-
77952003449
-
Radiation combined injury: Overview of NIAID research
-
DiCarlo AL, Ramakrishnan N, Hatchett RJ. Radiation combined injury: overview of NIAID research. Health Phys. 2010;98(6):863-867.
-
(2010)
Health Phys.
, vol.98
, Issue.6
, pp. 863-867
-
-
Dicarlo, A.L.1
Ramakrishnan, N.2
Hatchett, R.J.3
-
10
-
-
9244246263
-
Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003
-
Stone HB, et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004; 162(6):711-728.
-
(2004)
Radiat Res.
, vol.162
, Issue.6
, pp. 711-728
-
-
Stone, H.B.1
-
11
-
-
84555189736
-
The bone marrow at the crossroads of blood and immunity
-
Mercier FE, Ragu C, Scadden DT. The bone marrow at the crossroads of blood and immunity. Nat Rev Immunol. 2012;12(1):49-60.
-
(2012)
Nat Rev Immunol.
, vol.12
, Issue.1
, pp. 49-60
-
-
Mercier, F.E.1
Ragu, C.2
Scadden, D.T.3
-
12
-
-
0035578258
-
Evidence of oxidative stress following the viral infection of two lepidopteran insect cell lines
-
Wang Y, Oberley LW, Murhammer DW. Evidence of oxidative stress following the viral infection of two lepidopteran insect cell lines. Free Radic Biol Med. 2001;31(11):1448-1455.
-
(2001)
Free Radic Biol Med.
, vol.31
, Issue.11
, pp. 1448-1455
-
-
Wang, Y.1
Oberley, L.W.2
Murhammer, D.W.3
-
13
-
-
30144439380
-
Total body irradiation selectively induces murine hematopoietic stem cell senescence
-
Wang Y, Schulte BA, LaRue AC, Ogawa M, Zhou D. Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. 2006; 107(1):358-366.
-
(2006)
Blood
, vol.107
, Issue.1
, pp. 358-366
-
-
Wang, Y.1
Schulte, B.A.2
Larue, A.C.3
Ogawa, M.4
Zhou, D.5
-
14
-
-
42049095095
-
An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
-
Burdelya LG, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science. 2008;320(5873):226-230.
-
(2008)
Science
, vol.320
, Issue.5873
, pp. 226-230
-
-
Burdelya, L.G.1
-
15
-
-
84875504895
-
Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice
-
Kawakatsu M, et al. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023.
-
(2013)
PLoS One
, vol.8
, Issue.3
-
-
Kawakatsu, M.1
-
16
-
-
84879636711
-
Strategies for optimizing the response of cancer and normal tissues to radiation
-
Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov. 2013; 12(7):526-542.
-
(2013)
Nat Rev Drug Discov.
, vol.12
, Issue.7
, pp. 526-542
-
-
Moding, E.J.1
Kastan, M.B.2
Kirsch, D.G.3
-
17
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
Rangasamy T, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest. 2004;114(9):1248-1259.
-
(2004)
J Clin Invest.
, vol.114
, Issue.9
, pp. 1248-1259
-
-
Rangasamy, T.1
-
18
-
-
77953012548
-
Stress-activated cap'n'collar transcription factors in aging and human disease
-
Sykiotis GP, Bohmann D. Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal. 2010;3(112):re3.
-
(2010)
Sci Signal.
, vol.3
, Issue.112
-
-
Sykiotis, G.P.1
Bohmann, D.2
-
19
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007; 47:89-116.
-
(2007)
Annu Rev Pharmacol Toxicol.
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
20
-
-
84867917942
-
Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation
-
Kim SB, et al. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc Natl Acad Sci U S A. 2012;109(43):E2949-E2955.
-
(2012)
Proc Natl Acad Sci U S a
, vol.109
, Issue.43
-
-
Kim, S.B.1
-
21
-
-
77958129306
-
Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance
-
Singh A, Bodas M, Wakabayashi N, Bunz F, Biswal S. Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance. Antioxid Redox Signal. 2010;13(11):1627-1637.
-
(2010)
Antioxid Redox Signal
, vol.13
, Issue.11
, pp. 1627-1637
-
-
Singh, A.1
Bodas, M.2
Wakabayashi, N.3
Bunz, F.4
Biswal, S.5
-
22
-
-
80051782981
-
NRF2 deficiency reduces life span of mice administered thoracic irradiation
-
Travis EL, et al. NRF2 deficiency reduces life span of mice administered thoracic irradiation. Free Radic Biol Med. 2011;51(6):1175-1183.
-
(2011)
Free Radic Biol Med.
, vol.51
, Issue.6
, pp. 1175-1183
-
-
Travis, E.L.1
-
23
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002;62(18):5196-5203.
-
(2002)
Cancer Res.
, vol.62
, Issue.18
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
Mai, K.H.2
Srisuma, S.3
Kensler, T.W.4
Yamamoto, M.5
Biswal, S.6
-
24
-
-
84055177613
-
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels
-
Merchant AA, Singh A, Matsui W, Biswal S. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood. 2011;118(25):6572-6579.
-
(2011)
Blood
, vol.118
, Issue.25
, pp. 6572-6579
-
-
Merchant, A.A.1
Singh, A.2
Matsui, W.3
Biswal, S.4
-
25
-
-
66149115277
-
IFNalpha activates dormant haematopoietic stem cells in vivo
-
Essers MA, et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature. 2009; 458(7240):904-908.
-
(2009)
Nature
, vol.458
, Issue.7240
, pp. 904-908
-
-
Essers, M.A.1
-
26
-
-
41149109622
-
Uncertainty in the niches that maintain haematopoietic stem cells
-
Kiel MJ, Morrison SJ. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008;8(4):290-301.
-
(2008)
Nat Rev Immunol.
, vol.8
, Issue.4
, pp. 290-301
-
-
Kiel, M.J.1
Morrison, S.J.2
-
27
-
-
39149144034
-
Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
-
Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell. 2008;132(4):598-611.
-
(2008)
Cell
, vol.132
, Issue.4
, pp. 598-611
-
-
Morrison, S.J.1
Spradling, A.C.2
-
28
-
-
79959429766
-
Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
-
Kumar V, et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. J Med Chem. 2011;54(12):4147-4159.
-
(2011)
J Med Chem.
, vol.54
, Issue.12
, pp. 4147-4159
-
-
Kumar, V.1
-
29
-
-
0013282861
-
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome
-
Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem. 2003; 278(7):4536-4541.
-
(2003)
J Biol Chem.
, vol.278
, Issue.7
, pp. 4536-4541
-
-
Nguyen, T.1
Sherratt, P.J.2
Huang, H.C.3
Yang, C.S.4
Pickett, C.B.5
-
30
-
-
51849129227
-
Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
-
Malhotra D, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med. 2008;178(6):592-604.
-
(2008)
Am J Respir Crit Care Med.
, vol.178
, Issue.6
, pp. 592-604
-
-
Malhotra, D.1
-
31
-
-
0037462651
-
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
-
Stewart D, Killeen E, Naquin R, Alam S, Alam J. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem. 2003;278(4):2396-2402.
-
(2003)
J Biol Chem.
, vol.278
, Issue.4
, pp. 2396-2402
-
-
Stewart, D.1
Killeen, E.2
Naquin, R.3
Alam, S.4
Alam, J.5
-
32
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon M, Itoh K, Yamamoto M, Hayes JD. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem. 2003; 278(24):21592-21600.
-
(2003)
J Biol Chem.
, vol.278
, Issue.24
, pp. 21592-21600
-
-
McMahon, M.1
Itoh, K.2
Yamamoto, M.3
Hayes, J.D.4
-
33
-
-
12444257799
-
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
-
Itoh K, Wakabayashi N, Katoh Y, Ishii T, O'Connor T, Yamamoto M. Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells. 2003; 8(4):379-391.
-
(2003)
Genes Cells
, vol.8
, Issue.4
, pp. 379-391
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
O'Connor, T.5
Yamamoto, M.6
-
34
-
-
35449002458
-
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils
-
Thimmulappa RK, et al. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxid Redox Signal. 2007;9(11):1963-1970.
-
(2007)
Antioxid Redox Signal.
, vol.9
, Issue.11
, pp. 1963-1970
-
-
Thimmulappa, R.K.1
-
35
-
-
20144383831
-
Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
-
Dinkova-Kostova AT, et al. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc Natl Acad Sci U S A. 2005; 102(12):4584-4589.
-
(2005)
Proc Natl Acad Sci U S a
, vol.102
, Issue.12
, pp. 4584-4589
-
-
Dinkova-Kostova, A.T.1
-
36
-
-
33846786713
-
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
-
Yates MS, et al. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol Cancer Ther. 2007;6(1):154-162.
-
(2007)
Mol Cancer Ther.
, vol.6
, Issue.1
, pp. 154-162
-
-
Yates, M.S.1
-
37
-
-
79960855656
-
Bardoxolone methyl and kidney function in CKD with type 2 diabetes
-
Pergola PE, et al. Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med. 2011; 365(4):327-336.
-
(2011)
N Engl J Med.
, vol.365
, Issue.4
, pp. 327-336
-
-
Pergola, P.E.1
-
38
-
-
79954582442
-
Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD
-
Pergola PE, et al. Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD. Am J Nephrol. 2011;33(5):469-476.
-
(2011)
Am J Nephrol.
, vol.33
, Issue.5
, pp. 469-476
-
-
Pergola, P.E.1
-
39
-
-
84879908171
-
Bardoxolone brings nrf2-based therapies to light
-
Zhang DD. Bardoxolone brings nrf2-based therapies to light. Antioxid Redox Signal. 2013;19(5):517-518.
-
(2013)
Antioxid Redox Signal.
, vol.19
, Issue.5
, pp. 517-518
-
-
Zhang, D.D.1
-
40
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
Malhotra D, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res. 2010;38(17):5718-5734.
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.17
, pp. 5718-5734
-
-
Malhotra, D.1
-
41
-
-
77956640097
-
Regulation of notch1 signaling by nrf2: Implications for tissue regeneration
-
Wakabayashi N, et al. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci Signal. 2010;3(130):ra52.
-
(2010)
Sci Signal.
, vol.3
, Issue.30
-
-
Wakabayashi, N.1
-
42
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
Malhotra D, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res. 2010;38(17):5718-5734.
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.17
, pp. 5718-5734
-
-
Malhotra, D.1
-
43
-
-
77950543499
-
Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells
-
Himburg HA, et al. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. Nat Med. 2010;16(4):475-482.
-
(2010)
Nat Med.
, vol.16
, Issue.4
, pp. 475-482
-
-
Himburg, H.A.1
-
44
-
-
58149336788
-
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
-
Real PJ, et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med. 2009;15(1):50-58.
-
(2009)
Nat Med.
, vol.15
, Issue.1
, pp. 50-58
-
-
Real, P.J.1
-
45
-
-
0036529989
-
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
-
Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002; 99(7):2369-2378.
-
(2002)
Blood
, vol.99
, Issue.7
, pp. 2369-2378
-
-
Stier, S.1
Cheng, T.2
Dombkowski, D.3
Carlesso, N.4
Scadden, D.T.5
-
46
-
-
30044444251
-
Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
-
Trowbridge JJ, Xenocostas A, Moon RT, Bhatia M. Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation. Nat Med. 2006; 12(1):89-98.
-
(2006)
Nat Med.
, vol.12
, Issue.1
, pp. 89-98
-
-
Trowbridge, J.J.1
Xenocostas, A.2
Moon, R.T.3
Bhatia, M.4
-
47
-
-
0033694305
-
Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
-
Varnum-Finney B, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000; 6(11):1278-1281.
-
(2000)
Nat Med.
, vol.6
, Issue.11
, pp. 1278-1281
-
-
Varnum-Finney, B.1
-
48
-
-
25844493155
-
Hematopoietic stem cell fate is established by the Notch-Runx pathway
-
Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005; 19(19):2331-2342.
-
(2005)
Genes Dev.
, vol.19
, Issue.19
, pp. 2331-2342
-
-
Burns, C.E.1
Traver, D.2
Mayhall, E.3
Shepard, J.L.4
Zon, L.I.5
-
49
-
-
20144370145
-
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
-
Duncan AW, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-322.
-
(2005)
Nat Immunol.
, vol.6
, Issue.3
, pp. 314-322
-
-
Duncan, A.W.1
-
50
-
-
0034613734
-
The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
-
Karanu FN, et al. The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells. J Exp Med. 2000;192(9):1365-1372.
-
(2000)
J Exp Med.
, vol.192
, Issue.9
, pp. 1365-1372
-
-
Karanu, F.N.1
-
51
-
-
0242268524
-
Osteoblastic cells regulate the haematopoietic stem cell niche
-
Calvi LM, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425(6960):841-846.
-
(2003)
Nature
, vol.425
, Issue.6960
, pp. 841-846
-
-
Calvi, L.M.1
-
52
-
-
84875228640
-
Epidermal growth factor regulates hematopoietic regeneration after radiation injury
-
Doan PL, et al. Epidermal growth factor regulates hematopoietic regeneration after radiation injury. Nat Med. 2013;19(3):295-304.
-
(2013)
Nat Med.
, vol.19
, Issue.3
, pp. 295-304
-
-
Doan, P.L.1
-
53
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature. 2004;431(7011):997-1002.
-
(2004)
Nature
, vol.431
, Issue.7011
, pp. 997-1002
-
-
Ito, K.1
-
54
-
-
84878572136
-
Toward clinical application of the Keap1-Nrf2 pathway
-
Suzuki T, Motohashi H, Yamamoto M. Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci. 2013;34(6):340-346.
-
(2013)
Trends Pharmacol Sci.
, vol.34
, Issue.6
, pp. 340-346
-
-
Suzuki, T.1
Motohashi, H.2
Yamamoto, M.3
-
55
-
-
84874655208
-
Nrf2 regulates haematopoietic stem cell function
-
Tsai JJ, et al. Nrf2 regulates haematopoietic stem cell function. Nat Cell Biol. 2013;15(3):309-316.
-
(2013)
Nat Cell Biol.
, vol.15
, Issue.3
, pp. 309-316
-
-
Tsai, J.J.1
-
56
-
-
0030044584
-
Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia
-
Farese AM, Herodin F, McKearn JP, Baum C, Burton E, MacVittie TJ. Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia. Blood. 1996;87(2):581-591.
-
(1996)
Blood
, vol.87
, Issue.2
, pp. 581-591
-
-
Farese, A.M.1
Herodin, F.2
McKearn, J.P.3
Baum, C.4
Burton, E.5
Macvittie, T.J.6
-
57
-
-
0034141809
-
Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression
-
MacVittie TJ, Farese AM, Smith WG, Baum CM, Burton E, McKearn JP. Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression. Blood. 2000;95(3):837-845.
-
(2000)
Blood
, vol.95
, Issue.3
, pp. 837-845
-
-
Macvittie, T.J.1
Farese, A.M.2
Smith, W.G.3
Baum, C.M.4
Burton, E.5
McKearn, J.P.6
-
58
-
-
78449270816
-
Ionizing radiation activates the Nrf2 antioxidant response
-
McDonald JT, et al. Ionizing radiation activates the Nrf2 antioxidant response. Cancer Res. 2010; 70(21):8886-8895.
-
(2010)
Cancer Res.
, vol.70
, Issue.21
, pp. 8886-8895
-
-
McDonald, J.T.1
-
59
-
-
84867917942
-
Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation
-
Kim SB, et al. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proc Natl Acad Sci U S A. 2012;109(43):E2949-2955.
-
(2012)
Proc Natl Acad Sci U S a
, vol.109
, Issue.43
-
-
Kim, S.B.1
-
60
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009;137(2):216-233.
-
(2009)
Cell
, vol.137
, Issue.2
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
61
-
-
79952217210
-
Notch2 governs the rate of generation of mouse long-and short-term repopulating stem cells
-
Varnum-Finney B, Halasz LM, Sun M, Gridley T, Radtke F, Bernstein ID. Notch2 governs the rate of generation of mouse long-and short-term repopulating stem cells. J Clin Invest. 2011;121(3):1207-1216.
-
(2011)
J Clin Invest.
, vol.121
, Issue.3
, pp. 1207-1216
-
-
Varnum-Finney, B.1
Halasz, L.M.2
Sun, M.3
Gridley, T.4
Radtke, F.5
Bernstein, I.D.6
-
62
-
-
77449121923
-
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
-
Butler JM, et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010; 6(3):251-264.
-
(2010)
Cell Stem Cell
, vol.6
, Issue.3
, pp. 251-264
-
-
Butler, J.M.1
-
63
-
-
15244346226
-
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
-
Mancini SJ, Mantei N, Dumortier A, Suter U, Mac-Donald HR, Radtke F. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005; 105(6):2340-2342.
-
(2005)
Blood
, vol.105
, Issue.6
, pp. 2340-2342
-
-
Mancini, S.J.1
Mantei, N.2
Dumortier, A.3
Suter, U.4
Mac-Donald, H.R.5
Radtke, F.6
-
64
-
-
0032170451
-
Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells
-
Jones P, et al. Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells. Blood. 1998;92(5):1505-1511.
-
(1998)
Blood
, vol.92
, Issue.5
, pp. 1505-1511
-
-
Jones, P.1
-
65
-
-
80054713581
-
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis
-
Kong X, et al. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Am J Respir Crit Care Med. 2011; 184(8):928-938.
-
(2011)
Am J Respir Crit Care Med.
, vol.184
, Issue.8
, pp. 928-938
-
-
Kong, X.1
-
66
-
-
77951642473
-
Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation
-
Blake DJ, et al. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am J Respir Cell Mol Biol. 2010; 42(5):524-536.
-
(2010)
Am J Respir Cell Mol Biol.
, vol.42
, Issue.5
, pp. 524-536
-
-
Blake, D.J.1
-
67
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz OH, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441(7092):475-482.
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 475-482
-
-
Yilmaz, O.H.1
-
68
-
-
58549105575
-
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
-
Sussan TE, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc Natl Acad Sci U S A. 2009; 106(1):250-255.
-
(2009)
Proc Natl Acad Sci U S a
, vol.106
, Issue.1
, pp. 250-255
-
-
Sussan, T.E.1
-
69
-
-
84871647883
-
Flow cytometry analysis of murine hematopoietic stem cells
-
Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry A. 2013;83(1):27-37.
-
(2013)
Cytometry A.
, vol.83
, Issue.1
, pp. 27-37
-
-
Mayle, A.1
Luo, M.2
Jeong, M.3
Goodell, M.A.4
-
70
-
-
61449210913
-
A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow
-
Soleimani M, Nadri S. A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow. Nat Protoc. 2009;4(1):102-106.
-
(2009)
Nat Protoc.
, vol.4
, Issue.1
, pp. 102-106
-
-
Soleimani, M.1
Nadri, S.2
-
71
-
-
33750826092
-
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
-
Thimmulappa RK, et al. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun. 2006;351(4):883-889.
-
(2006)
Biochem Biophys Res Commun.
, vol.351
, Issue.4
, pp. 883-889
-
-
Thimmulappa, R.K.1
-
72
-
-
77956193657
-
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice
-
Kong X, Thimmulappa R, Kombairaju P, Biswal S. NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice. J Immunol. 2010;185(1):569-577.
-
(2010)
J Immunol.
, vol.185
, Issue.1
, pp. 569-577
-
-
Kong, X.1
Thimmulappa, R.2
Kombairaju, P.3
Biswal, S.4
-
73
-
-
80555124930
-
Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
-
Malhotra D, et al. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J Clin Invest. 2011;121(11):4289-4302.
-
(2011)
J Clin Invest.
, vol.121
, Issue.11
, pp. 4289-4302
-
-
Malhotra, D.1
-
74
-
-
0022445667
-
Effect of radiation dose on the recovery of aerobic and anaerobic bacteria from mice
-
Brook I, Walker RI, MacVittie TJ. Effect of radiation dose on the recovery of aerobic and anaerobic bacteria from mice. Can J Microbiol. 1986; 32(9):719-722.
-
(1986)
Can J Microbiol.
, vol.32
, Issue.9
, pp. 719-722
-
-
Brook, I.1
Walker, R.I.2
Macvittie, T.J.3
-
75
-
-
34147145299
-
Dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors
-
Abdallah BM, et al. dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors. J Biol Chem. 2007;282(10):7339- 7351.
-
(2007)
J Biol Chem.
, vol.282
, Issue.10
, pp. 7339-7351
-
-
Abdallah, B.M.1
|