-
1
-
-
41049100674
-
Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically
-
Agca, C., Fritz, J. J., Walker, L. C., Levey, A. I., Chan, A. W., Lah, J. J., et al. (2008). Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically. BMC Neurosci. 9:28. doi: 10.1186/1471-2202-9-28
-
(2008)
BMC Neurosci
, vol.9
, pp. 28
-
-
Agca, C.1
Fritz, J.J.2
Walker, L.C.3
Levey, A.I.4
Chan, A.W.5
Lah, J.J.6
-
2
-
-
0029103167
-
Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase
-
Aksenov, M., Aksenova, M. V., Harris, M. E., Hensley, K., Butterfield, D. A., and Carney, J. M. (1995). Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase. J. Neurochem. 65, 1899-1902. doi: 10.1046/j.1471-4159.1995.65041899.x
-
(1995)
J. Neurochem
, vol.65
, pp. 1899-1902
-
-
Aksenov, M.1
Aksenova, M.V.2
Harris, M.E.3
Hensley, K.4
Butterfield, D.A.5
Carney, J.M.6
-
3
-
-
84910005783
-
2014 Alzheimer's disease facts and figures
-
Alzheimer's, A. (2014). 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 10, e47-e92. doi: 10.1016/j.jalz.2014.02.001
-
(2014)
Alzheimers Dement
, vol.10
, pp. e47-e92
-
-
Alzheimer's, A.1
-
4
-
-
84925880097
-
2015 Alzheimer's disease facts and figures
-
Alzheimer's, A. (2015). 2015 Alzheimer's disease facts and figures. Alzheimers Dement. 11, 332-384. doi: 10.1016/j.jalz.2015.02.003
-
(2015)
Alzheimers Dement
, vol.11
, pp. 332-384
-
-
Alzheimer's, A.1
-
5
-
-
0037437192
-
Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells
-
Anandatheerthavarada, H. K., Biswas, G., Robin, M. A., and Avadhani, N. G. (2003). Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells. J. Cell Biol. 161, 41-54. doi: 10.1083/jcb.200207030
-
(2003)
J. Cell Biol
, vol.161
, pp. 41-54
-
-
Anandatheerthavarada, H.K.1
Biswas, G.2
Robin, M.A.3
Avadhani, N.G.4
-
6
-
-
77950901539
-
Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors
-
Arslanova, D., Yang, T., Xu, X., Wong, S. T., Augelli-Szafran, C. E., and Xia, W. (2010). Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors. BMC Biotechnol. 10:24. doi: 10.1186/1472-6750-10-24
-
(2010)
BMC Biotechnol
, vol.10
, pp. 24
-
-
Arslanova, D.1
Yang, T.2
Xu, X.3
Wong, S.T.4
Augelli-Szafran, C.E.5
Xia, W.6
-
7
-
-
84921830931
-
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease
-
Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., et al. (2015). Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr. Alzheimer Res. 12, 32-46. doi: 10.2174/1567205012666141218140953
-
(2015)
Curr. Alzheimer Res
, vol.12
, pp. 32-46
-
-
Baranello, R.J.1
Bharani, K.L.2
Padmaraju, V.3
Chopra, N.4
Lahiri, D.K.5
Greig, N.H.6
-
8
-
-
33748028841
-
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons
-
Barsoum, M. J., Yuan, H., Gerencser, A. A., Liot, G., Kushnareva, Y., Graber, S., et al. (2006). Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 25, 3900-3911. doi: 10.1038/sj.emboj.7601253
-
(2006)
EMBO J
, vol.25
, pp. 3900-3911
-
-
Barsoum, M.J.1
Yuan, H.2
Gerencser, A.A.3
Liot, G.4
Kushnareva, Y.5
Graber, S.6
-
9
-
-
84939490054
-
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology
-
Baruch, K., Rosenzweig, N., Kertser, A., Deczkowska, A., Sharif, A. M., Spinrad, A., et al. (2015). Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology. Nat. Commun. 6, 7967. doi: 10.1038/ncomms8967
-
(2015)
Nat. Commun
, vol.6
, pp. 7967
-
-
Baruch, K.1
Rosenzweig, N.2
Kertser, A.3
Deczkowska, A.4
Sharif, A.M.5
Spinrad, A.6
-
10
-
-
84856541323
-
Structural features of the KPI domain control APP dimerization, trafficking, and processing
-
Ben Khalifa, N., Tyteca, D., Marinangeli, C., Depuydt, M., Collet, J. F., Courtoy, P. J., et al. (2012). Structural features of the KPI domain control APP dimerization, trafficking, and processing. FASEB J. 26, 855-867. doi: 10.1096/fj.11-190207
-
(2012)
FASEB J
, vol.26
, pp. 855-867
-
-
Ben Khalifa, N.1
Tyteca, D.2
Marinangeli, C.3
Depuydt, M.4
Collet, J.F.5
Courtoy, P.J.6
-
11
-
-
84861230374
-
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport
-
Bhalla, A., Vetanovetz, C. P., Morel, E., Chamoun, Z., Di Paolo, G., and Small, S. A. (2012). The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol. Dis. 47, 126-134. doi: 10.1016/j.nbd.2012.03.030
-
(2012)
Neurobiol. Dis
, vol.47
, pp. 126-134
-
-
Bhalla, A.1
Vetanovetz, C.P.2
Morel, E.3
Chamoun, Z.4
Di Paolo, G.5
Small, S.A.6
-
12
-
-
78649417803
-
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production
-
Bordji, K., Becerril-Ortega, J., Nicole, O., and Buisson, A. (2010). Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ss production. J. Neurosci. 30, 15927-15942.
-
(2010)
J. Neurosci
, vol.30
, pp. 15927-15942
-
-
Bordji, K.1
Becerril-Ortega, J.2
Nicole, O.3
Buisson, A.4
-
13
-
-
0026595567
-
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs
-
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., et al. (1992). Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J. Biol. Chem. 267, 546-554.
-
(1992)
J. Biol. Chem
, vol.267
, pp. 546-554
-
-
Burdick, D.1
Soreghan, B.2
Kwon, M.3
Kosmoski, J.4
Knauer, M.5
Henschen, A.6
-
14
-
-
14444272986
-
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor
-
Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., et al. (1998). Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273, 27765-27767. doi: 10.1074/jbc.273.43.27765
-
(1998)
J. Biol. Chem
, vol.273
, pp. 27765-27767
-
-
Buxbaum, J.D.1
Liu, K.N.2
Luo, Y.3
Slack, J.L.4
Stocking, K.L.5
Peschon, J.J.6
-
15
-
-
0035112647
-
BACE1 is the major beta-secretase for generation of Abeta peptides by neurons
-
Cai, H., Wang, Y., McCarthy, D., Wen, H., Borchelt, D. R., Price, D. L., et al. (2001). BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4, 233-234. doi: 10.1038/85064
-
(2001)
Nat. Neurosci
, vol.4
, pp. 233-234
-
-
Cai, H.1
Wang, Y.2
McCarthy, D.3
Wen, H.4
Borchelt, D.R.5
Price, D.L.6
-
16
-
-
34547136377
-
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein
-
Carey, R. M., Balcz, B. A., Lopez-Coviella, I., and Slack, B. E. (2005). Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol. 6:30. doi: 10.1186/1471-2121-6-30
-
(2005)
BMC Cell Biol
, vol.6
, pp. 30
-
-
Carey, R.M.1
Balcz, B.A.2
Lopez-Coviella, I.3
Slack, B.E.4
-
17
-
-
0031242669
-
A new brain metalloendopeptidase which degrades the Alzheimer beta-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects
-
Carvalho, K. M., Franca, M. S., Camarao, G. C., and Ruchon, A. F. (1997). A new brain metalloendopeptidase which degrades the Alzheimer beta-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects. Braz. J. Med. Biol. Res. 30, 1153-1156.
-
(1997)
Braz. J. Med. Biol. Res
, vol.30
, pp. 1153-1156
-
-
Carvalho, K.M.1
Franca, M.S.2
Camarao, G.C.3
Ruchon, A.F.4
-
18
-
-
84885106363
-
Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex
-
Caster, A. H., and Kahn, R. A. (2013). Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex. J. Biol. Chem. 288, 28567-28580. doi: 10.1074/jbc.M113.481101
-
(2013)
J. Biol. Chem
, vol.288
, pp. 28567-28580
-
-
Caster, A.H.1
Kahn, R.A.2
-
19
-
-
0026075602
-
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
-
Chartier-Harlin, M. C., Crawford, F., Houlden, H., Warren, A., Hughes, D., Fidani, L., et al. (1991). Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature 353, 844-846. doi: 10.1038/353844a0
-
(1991)
Nature
, vol.353
, pp. 844-846
-
-
Chartier-Harlin, M.C.1
Crawford, F.2
Houlden, H.3
Warren, A.4
Hughes, D.5
Fidani, L.6
-
20
-
-
29144487182
-
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
-
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., et al. (2005). Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron 48, 913-922. doi: 10.1016/j.neuron.2005.10.028
-
(2005)
Neuron
, vol.48
, pp. 913-922
-
-
Cirrito, J.R.1
Yamada, K.A.2
Finn, M.B.3
Sloviter, R.S.4
Bales, K.R.5
May, P.C.6
-
21
-
-
34848893886
-
Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats
-
Clarke, J., Thornell, A., Corbett, D., Soininen, H., Hiltunen, M., and Jolkkonen, J. (2007). Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats. Eur. J. Neurosci. 26, 1845-1852. doi: 10.1111/j.1460-9568.2007.05807.x
-
(2007)
Eur. J. Neurosci
, vol.26
, pp. 1845-1852
-
-
Clarke, J.1
Thornell, A.2
Corbett, D.3
Soininen, H.4
Hiltunen, M.5
Jolkkonen, J.6
-
22
-
-
15044339964
-
Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
-
Crowther, D. C., Kinghorn, K. J., Miranda, E., Page, R., Curry, J. A., Duthie, F. A., et al. (2005). Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 132, 123-135. doi: 10.1016/j.neuroscience.2004.12.025
-
(2005)
Neuroscience
, vol.132
, pp. 123-135
-
-
Crowther, D.C.1
Kinghorn, K.J.2
Miranda, E.3
Page, R.4
Curry, J.A.5
Duthie, F.A.6
-
23
-
-
77953500851
-
Mitochondrial dysfunction in neurodegenerative diseases and cancer
-
de Moura, M. B., dos Santos, L. S., and Van Houten, B. (2010). Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environ. Mol. Mutagen. 51, 391-405. doi: 10.1002/em.20575
-
(2010)
Environ. Mol. Mutagen
, vol.51
, pp. 391-405
-
-
de Moura, M.B.1
dos Santos, L.S.2
Van Houten, B.3
-
24
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
-
De Strooper, B. (2003). Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron 38, 9-12.
-
(2003)
Neuron
, vol.38
, pp. 9-12
-
-
De Strooper, B.1
-
25
-
-
33748283747
-
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
-
Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., and Anandatheerthavarada, H. K. (2006). Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J. Neurosci. 26, 9057-9068. doi: 10.1523/JNEUROSCI.1469-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 9057-9068
-
-
Devi, L.1
Prabhu, B.M.2
Galati, D.F.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
26
-
-
84886179076
-
Modeling Alzheimer's disease in transgenic rats
-
Do Carmo, S., and Cuello, A. C. (2013). Modeling Alzheimer's disease in transgenic rats. Mol. Neurodegener. 8, 37. doi: 10.1186/1750-1326-8-37
-
(2013)
Mol. Neurodegener
, vol.8
, pp. 37
-
-
Do Carmo, S.1
Cuello, A.C.2
-
27
-
-
84898752869
-
Phase 3 trials of solanezumab and bapineuzumab for Alzheimer's disease
-
Doody, R. S., Farlow, M., Aisen, P. S., Alzheimer's Disease Cooperative Study Data, A., and Publication, C. (2014a). Phase 3 trials of solanezumab and bapineuzumab for Alzheimer's disease. N. Engl. J. Med. 370, 1460. doi: 10.1056/NEJMoa1312889
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 1460
-
-
Doody, R.S.1
Farlow, M.2
Aisen, P.S.3
Alzheimer's Disease Cooperative Study Data, A.4
Publication, C.5
-
28
-
-
84892748542
-
Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
-
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., et al. (2014b). Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 311-321. doi: 10.1056/NEJMoa1312889
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 311-321
-
-
Doody, R.S.1
Thomas, R.G.2
Farlow, M.3
Iwatsubo, T.4
Vellas, B.5
Joffe, S.6
-
29
-
-
0028924547
-
The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein
-
Dugan, J. M., deWit, C., McConlogue, L., and Maltese, W. A. (1995). The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein. J. Biol. Chem. 270, 10982-10989. doi: 10.1074/jbc.270.18.10982
-
(1995)
J. Biol. Chem
, vol.270
, pp. 10982-10989
-
-
Dugan, J.M.1
deWit, C.2
McConlogue, L.3
Maltese, W.A.4
-
30
-
-
0037462769
-
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme
-
Eckman, E. A., Watson, M., Marlow, L., Sambamurti, K., and Eckman, C. B. (2003). Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J. Biol. Chem. 278, 2081-2084. doi: 10.1074/jbc.C200642200
-
(2003)
J. Biol. Chem
, vol.278
, pp. 2081-2084
-
-
Eckman, E.A.1
Watson, M.2
Marlow, L.3
Sambamurti, K.4
Eckman, C.B.5
-
31
-
-
75649108560
-
Transgenic mouse models of Alzheimer's disease
-
Elder, G. A., Gama Sosa, M. A., and De Gasperi, R. (2010). Transgenic mouse models of Alzheimer's disease. Mt. Sinai J. Med. N. Y. 77, 69-81. doi: 10.1002/msj.20159
-
(2010)
Mt. Sinai J. Med. N. Y
, vol.77
, pp. 69-81
-
-
Elder, G.A.1
Gama Sosa, M.A.2
De Gasperi, R.3
-
32
-
-
84961141394
-
A new perspective of lysosomal cation channel-dependent homeostasis in Alzheimer's disease
-
[Epub ahead of print]
-
Ezeani, M., and Omabe, M. (2015). A new perspective of lysosomal cation channel-dependent homeostasis in Alzheimer's disease. Mol. Neurobiol. doi: 10.1007/s12035-015-9108-3 [Epub ahead of print].
-
(2015)
Mol. Neurobiol
-
-
Ezeani, M.1
Omabe, M.2
-
33
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., et al. (2003). Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. U.S.A. 100, 4162-4167. doi: 10.1073/pnas.0230450100
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
-
34
-
-
3242809725
-
A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster
-
Finelli, A., Kelkar, A., Song, H. J., Yang, H., and Konsolaki, M. (2004). A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol. Cell. Neurosci. 26, 365-375. doi: 10.1016/j.mcn.2004.03.001
-
(2004)
Mol. Cell. Neurosci
, vol.26
, pp. 365-375
-
-
Finelli, A.1
Kelkar, A.2
Song, H.J.3
Yang, H.4
Konsolaki, M.5
-
35
-
-
0028201821
-
APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease
-
Gandy, S., Caporaso, G., Buxbaum, J., Frangione, B., and Greengard, P. (1994). APP processing, A beta-amyloidogenesis, and the pathogenesis of Alzheimer's disease. Neurobiol. Aging 15, 253-256.
-
(1994)
Neurobiol. Aging
, vol.15
, pp. 253-256
-
-
Gandy, S.1
Caporaso, G.2
Buxbaum, J.3
Frangione, B.4
Greengard, P.5
-
36
-
-
15944426127
-
Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta
-
Glabe, C. C. (2005). Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta. Subcell. Biochem. 38, 167-177. doi: 10.1007/0-387-23226-5_8
-
(2005)
Subcell. Biochem
, vol.38
, pp. 167-177
-
-
Glabe, C.C.1
-
37
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A., Chartier-Harlin, M. C., Mullan, M., Brown, J., Crawford, F., Fidani, L., et al. (1991). Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706. doi: 10.1038/349704a0
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
-
38
-
-
0026539090
-
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
-
Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J., and Younkin, S. G. (1992). Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255, 728-730. doi: 10.1126/science.1738847
-
(1992)
Science
, vol.255
, pp. 728-730
-
-
Golde, T.E.1
Estus, S.2
Younkin, L.H.3
Selkoe, D.J.4
Younkin, S.G.5
-
39
-
-
0028915895
-
Amyloid beta protein. (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
-
Gravina, S. A., Ho, L., Eckman, C. B., Long, K. E., Otvos, L. Jr., Younkin, L. H., et al. (1995). Amyloid beta protein. (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J. Biol. Chem. 270, 7013-7016.
-
(1995)
J. Biol. Chem
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos, L.5
Younkin, L.H.6
-
40
-
-
0033582159
-
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
-
Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., et al. (1999). Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides. Proc. Natl. Acad. Sci. U.S.A. 96, 742-747. doi: 10.1073/pnas.96.2.742
-
(1999)
Proc. Natl. Acad. Sci. U.S.A
, vol.96
, pp. 742-747
-
-
Greenfield, J.P.1
Tsai, J.2
Gouras, G.K.3
Hai, B.4
Thinakaran, G.5
Checler, F.6
-
41
-
-
2142645114
-
Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
-
Greeve, I., Kretzschmar, D., Tschape, J. A., Beyn, A., Brellinger, C., Schweizer, M., et al. (2004). Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J. Neurosci. 24, 3899-3906. doi: 10.1523/JNEUROSCI.0283-04.2004
-
(2004)
J. Neurosci
, vol.24
, pp. 3899-3906
-
-
Greeve, I.1
Kretzschmar, D.2
Tschape, J.A.3
Beyn, A.4
Brellinger, C.5
Schweizer, M.6
-
42
-
-
0030569293
-
Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein
-
Hamazaki, H. (1996). Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein. FEBS Lett. 396, 139-142. doi: 10.1016/0014-5793(96)01087-3
-
(1996)
FEBS Lett
, vol.396
, pp. 139-142
-
-
Hamazaki, H.1
-
43
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy, J., and Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. doi: 10.1126/science.1072994
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
44
-
-
17944380958
-
Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex
-
Harkany, T., O'Mahony, S., Keijser, J., Kelly, J. P., Konya, C., Borostyankoi, Z. A., et al. (2001). Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiol. Dis. 8, 667-678. doi: 10.1006/nbdi.2001.0398
-
(2001)
Neurobiol. Dis
, vol.8
, pp. 667-678
-
-
Harkany, T.1
O'Mahony, S.2
Keijser, J.3
Kelly, J.P.4
Konya, C.5
Borostyankoi, Z.A.6
-
45
-
-
34250794526
-
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease
-
Harold, D., Jehu, L., Turic, D., Hollingworth, P., Moore, P., Summerhayes, P., et al. (2007). Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. Am. J. Med. Genet. 144B, 448-452. doi: 10.1002/ajmg.b.30456
-
(2007)
Am. J. Med. Genet
, vol.144B
, pp. 448-452
-
-
Harold, D.1
Jehu, L.2
Turic, D.3
Hollingworth, P.4
Moore, P.5
Summerhayes, P.6
-
46
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
-
Hartmann, T., Bieger, S. C., Bruhl, B., Tienari, P. J., Ida, N., Allsop, D., et al. (1997). Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat. Med. 3, 1016-1020. doi: 10.1038/nm0997-1016
-
(1997)
Nat. Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
Allsop, D.6
-
47
-
-
77956303159
-
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease
-
He, G., Luo, W., Li, P., Remmers, C., Netzer, W. J., Hendrick, J., et al. (2010). Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature 467, 95-98. doi: 10.1038/nature09325
-
(2010)
Nature
, vol.467
, pp. 95-98
-
-
He, G.1
Luo, W.2
Li, P.3
Remmers, C.4
Netzer, W.J.5
Hendrick, J.6
-
48
-
-
27844534846
-
Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor
-
Hemming, M. L., and Selkoe, D. J. (2005). Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. J. Biol. Chem. 280, 37644-37650. doi: 10.1074/jbc.M508460200
-
(2005)
J. Biol. Chem
, vol.280
, pp. 37644-37650
-
-
Hemming, M.L.1
Selkoe, D.J.2
-
49
-
-
84923444904
-
Innate immunity in Alzheimer's disease
-
Heneka, M. T., Golenbock, D. T., and Latz, E. (2015). Innate immunity in Alzheimer's disease. Nat. Immunol. 16, 229-236. doi: 10.1038/ni.3102
-
(2015)
Nat. Immunol
, vol.16
, pp. 229-236
-
-
Heneka, M.T.1
Golenbock, D.T.2
Latz, E.3
-
50
-
-
0027517448
-
Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane
-
Huber, L. A., Pimplikar, S., Parton, R. G., Virta, H., Zerial, M., and Simons, K. (1993). Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J. Cell Biol. 123, 35-45. doi: 10.1083/jcb.123.1.35
-
(1993)
J. Cell Biol
, vol.123
, pp. 35-45
-
-
Huber, L.A.1
Pimplikar, S.2
Parton, R.G.3
Virta, H.4
Zerial, M.5
Simons, K.6
-
51
-
-
45949102576
-
Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila
-
Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., et al. (2008). Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLoS ONE 3:e1703. doi: 10.1371/journal.pone.0001703
-
(2008)
PLoS ONE
, vol.3
-
-
Iijima, K.1
Chiang, H.C.2
Hearn, S.A.3
Hakker, I.4
Gatt, A.5
Shenton, C.6
-
52
-
-
0035947207
-
Metabolic regulation of brain Abeta by neprilysin
-
Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N. P., et al. (2001). Metabolic regulation of brain Abeta by neprilysin. Science 292, 1550-1552. doi: 10.1126/science.1059946
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
-
53
-
-
0344672942
-
APP processing and synaptic function
-
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., et al. (2003). APP processing and synaptic function. Neuron 37, 925-937. doi: 10.1016/S0896-6273(03)00124-7
-
(2003)
Neuron
, vol.37
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
-
54
-
-
84901341240
-
The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease
-
Kanekiyo, T., and Bu, G. (2014). The low-density lipoprotein receptor-related protein 1 and amyloid-beta clearance in Alzheimer's disease. Front. Aging Neurosci. 6:93. doi: 10.3389/fnagi.2014.00093
-
(2014)
Front. Aging Neurosci
, vol.6
, pp. 93
-
-
Kanekiyo, T.1
Bu, G.2
-
55
-
-
79551565625
-
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake
-
Kanekiyo, T., Zhang, J., Liu, Q., Liu, C. C., Zhang, L., and Bu, G. (2011). Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J. Neurosci. 31, 1644-1651. doi: 10.1523/JNEUROSCI.5491-10.2011
-
(2011)
J. Neurosci
, vol.31
, pp. 1644-1651
-
-
Kanekiyo, T.1
Zhang, J.2
Liu, Q.3
Liu, C.C.4
Zhang, L.5
Bu, G.6
-
56
-
-
0025014702
-
Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: preA4(695) mRNA is predominantly produced in rat and human brain
-
Kang, J., and Muller-Hill, B. (1990). Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: preA4(695) mRNA is predominantly produced in rat and human brain. Biochem. Biophys. Res. Commun. 166, 1192-1200. doi: 10.1016/0006-291X(90)90992-V
-
(1990)
Biochem. Biophys. Res. Commun
, vol.166
, pp. 1192-1200
-
-
Kang, J.1
Muller-Hill, B.2
-
57
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
-
Karran, E., Mercken, M., and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. 10, 698-712. doi: 10.1038/nrd3505
-
(2011)
Nat. Rev
, vol.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
58
-
-
33846435323
-
Abeta40 inhibits amyloid deposition in vivo
-
Kim, J., Onstead, L., Randle, S., Price, R., Smithson, L., Zwizinski, C., et al. (2007). Abeta40 inhibits amyloid deposition in vivo. J. Neurosci. 27, 627-633. doi: 10.1523/JNEUROSCI.4849-06.2007
-
(2007)
J. Neurosci
, vol.27
, pp. 627-633
-
-
Kim, J.1
Onstead, L.2
Randle, S.3
Price, R.4
Smithson, L.5
Zwizinski, C.6
-
59
-
-
70349569016
-
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
-
Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., et al. (2009). Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum. Mol. Genet. 18, 3987-3996. doi: 10.1093/hmg/ddp323
-
(2009)
Hum. Mol. Genet
, vol.18
, pp. 3987-3996
-
-
Kim, M.1
Suh, J.2
Romano, D.3
Truong, M.H.4
Mullin, K.5
Hooli, B.6
-
60
-
-
84904187229
-
Molecular basis of substrate recognition and degradation by human presequence protease
-
King, J. V., Liang, W. G., Scherpelz, K. P., Schilling, A. B., Meredith, S. C., and Tang, W. J. (2014). Molecular basis of substrate recognition and degradation by human presequence protease. Structure 22, 996-1007. doi: 10.1016/j.str.2014.05.003
-
(2014)
Structure
, vol.22
, pp. 996-1007
-
-
King, J.V.1
Liang, W.G.2
Scherpelz, K.P.3
Schilling, A.B.4
Meredith, S.C.5
Tang, W.J.6
-
61
-
-
0033569653
-
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
-
Koike, H., Tomioka, S., Sorimachi, H., Saido, T. C., Maruyama, K., Okuyama, A., et al. (1999). Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein. Biochem. J. 343(Pt 2), 371-375. doi: 10.1042/0264-6021:3430371
-
(1999)
Biochem. J
, vol.343
, pp. 371-375
-
-
Koike, H.1
Tomioka, S.2
Sorimachi, H.3
Saido, T.C.4
Maruyama, K.5
Okuyama, A.6
-
62
-
-
0028276801
-
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
-
Koo, E. H., and Squazzo, S. L. (1994). Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J. Biol. Chem. 269, 17386-17389.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 17386-17389
-
-
Koo, E.H.1
Squazzo, S.L.2
-
63
-
-
0034573026
-
Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains
-
Ledesma, M. D., Da Silva, J. S., Crassaerts, K., Delacourte, A., De Strooper, B., and Dotti, C. G. (2000). Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. EMBO Rep. 1, 530-535. doi: 10.1093/embo-reports/kvd107
-
(2000)
EMBO Rep
, vol.1
, pp. 530-535
-
-
Ledesma, M.D.1
Da Silva, J.S.2
Crassaerts, K.3
Delacourte, A.4
De Strooper, B.5
Dotti, C.G.6
-
64
-
-
45549102847
-
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes
-
Lee, J., Retamal, C., Cuitino, L., Caruano-Yzermans, A., Shin, J. E., van Kerkhof, P., et al. (2008). Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J. Biol. Chem. 283, 11501-11508. doi: 10.1074/jbc.M800642200
-
(2008)
J. Biol. Chem
, vol.283
, pp. 11501-11508
-
-
Lee, J.1
Retamal, C.2
Cuitino, L.3
Caruano-Yzermans, A.4
Shin, J.E.5
van Kerkhof, P.6
-
65
-
-
77953020162
-
A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment
-
Leon, W. C., Canneva, F., Partridge, V., Allard, S., Ferretti, M. T., DeWilde, A., et al. (2010). A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. J. Alzheimers Dis. 0, 113-126. doi: 10.3233/JAD-2010-1349
-
(2010)
J. Alzheimers Dis
, pp. 113-126
-
-
Leon, W.C.1
Canneva, F.2
Partridge, V.3
Allard, S.4
Ferretti, M.T.5
DeWilde, A.6
-
66
-
-
84871749175
-
Differential regulation of amyloid-beta endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms
-
Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M. J., Xu, H., et al. (2012). Differential regulation of amyloid-beta endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. J. Biol. Chem. 287, 44593-44601. doi: 10.1074/jbc.M112.420224
-
(2012)
J. Biol. Chem
, vol.287
, pp. 44593-44601
-
-
Li, J.1
Kanekiyo, T.2
Shinohara, M.3
Zhang, Y.4
LaDu, M.J.5
Xu, H.6
-
67
-
-
0034595799
-
The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein
-
Li, Y., Marzolo, M. P., van Kerkhof, P., Strous, G. J., and Bu, G. (2000). The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. J. Biol. Chem. 275, 17187-17194. doi: 10.1074/jbc.M000490200
-
(2000)
J. Biol. Chem
, vol.275
, pp. 17187-17194
-
-
Li, Y.1
Marzolo, M.P.2
van Kerkhof, P.3
Strous, G.J.4
Bu, G.5
-
68
-
-
84938675573
-
Drosophila melanogaster as a model for studies on the early stages of Alzheimer's disease
-
Lim, J. Y., Ott, S., and Crowther, D. C. (2016). Drosophila melanogaster as a model for studies on the early stages of Alzheimer's disease. Methods Mol. Biol. 1303, 227-239. doi: 10.1007/978-1-4939-2627-5_13
-
(2016)
Methods Mol. Biol
, vol.1303
, pp. 227-239
-
-
Lim, J.Y.1
Ott, S.2
Crowther, D.C.3
-
69
-
-
33751397131
-
C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease
-
Link, C. D. (2006). C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp. Gerontol. 41, 1007-1013. doi: 10.1016/j.exger.2006.06.059
-
(2006)
Exp. Gerontol
, vol.41
, pp. 1007-1013
-
-
Link, C.D.1
-
70
-
-
84863011816
-
TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation
-
Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., et al. (2012). TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation. J. Immunol. 188, 1098-1107. doi: 10.4049/jimmunol.1101121
-
(2012)
J. Immunol
, vol.188
, pp. 1098-1107
-
-
Liu, S.1
Liu, Y.2
Hao, W.3
Wolf, L.4
Kiliaan, A.J.5
Penke, B.6
-
71
-
-
84875693819
-
Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for beta-amyloid peptide-induced toxicity
-
Lublin, A. L., and Link, C. D. (2013). Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for beta-amyloid peptide-induced toxicity. Drug Discov. Today Technol. 10, e115-e119. doi: 10.1016/j.ddtec.2012.02.002
-
(2013)
Drug Discov. Today Technol
, vol.10
, pp. e115-e119
-
-
Lublin, A.L.1
Link, C.D.2
-
72
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., et al. (2004). ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304, 448-452. doi: 10.1126/science.1091230
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
-
73
-
-
0028981159
-
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death
-
Mark, R. J., Hensley, K., Butterfield, D. A., and Mattson, M. P. (1995). Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. J. Neurosci. 15, 6239-6249.
-
(1995)
J. Neurosci
, vol.15
, pp. 6239-6249
-
-
Mark, R.J.1
Hensley, K.2
Butterfield, D.A.3
Mattson, M.P.4
-
74
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson, M. P. (2004). Pathways towards and away from Alzheimer's disease. Nature 430, 631-639. doi: 10.1038/nature02621
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
75
-
-
0030064136
-
Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein
-
McConlogue, L., Castellano, F., deWit, C., Schenk, D., and Maltese, W. A. (1996). Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J. Biol. Chem. 271, 1343-1348. doi: 10.1074/jbc.271.3.1343
-
(1996)
J. Biol. Chem
, vol.271
, pp. 1343-1348
-
-
McConlogue, L.1
Castellano, F.2
deWit, C.3
Schenk, D.4
Maltese, W.A.5
-
76
-
-
33646439410
-
APP processing and the APP-KPI domain involvement in the amyloid cascade
-
Menendez-Gonzalez, M., Perez-Pinera, P., Martinez-Rivera, M., Calatayud, M. T., and Blazquez Menes, B. (2005). APP processing and the APP-KPI domain involvement in the amyloid cascade. Neurodegener. Dis. 2, 277-283. doi: 10.1159/000092315
-
(2005)
Neurodegener. Dis
, vol.2
, pp. 277-283
-
-
Menendez-Gonzalez, M.1
Perez-Pinera, P.2
Martinez-Rivera, M.3
Calatayud, M.T.4
Blazquez Menes, B.5
-
77
-
-
33748524564
-
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease
-
Mueller-Steiner, S., Zhou, Y., Arai, H., Roberson, E. D., Sun, B., Chen, J., et al. (2006). Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 51, 703-714. doi: 10.1016/j.neuron.2006.07.027
-
(2006)
Neuron
, vol.51
, pp. 703-714
-
-
Mueller-Steiner, S.1
Zhou, Y.2
Arai, H.3
Roberson, E.D.4
Sun, B.5
Chen, J.6
-
78
-
-
77951931900
-
The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease
-
Muirhead, K. E., Borger, E., Aitken, L., Conway, S. J., and Gunn-Moore, F. J. (2010). The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease. Biochem. J. 426, 255-270. doi: 10.1042/BJ20091941
-
(2010)
Biochem. J
, vol.426
, pp. 255-270
-
-
Muirhead, K.E.1
Borger, E.2
Aitken, L.3
Conway, S.J.4
Gunn-Moore, F.J.5
-
79
-
-
84929938315
-
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
-
Musiek, E. S., and Holtzman, D. M. (2015). Three dimensions of the amyloid hypothesis: time, space and 'wingmen'. Nat. Neurosci. 18, 800-806. doi: 10.1038/nn.4018
-
(2015)
Nat. Neurosci
, vol.18
, pp. 800-806
-
-
Musiek, E.S.1
Holtzman, D.M.2
-
80
-
-
0033378754
-
Chronic intracerebroventricular infusion of beta-amyloid (1-40) results in a selective loss of neuropeptides in addition to a reduction in choline acetyltransferase activity in the cortical mantle and hippocampus in the rat
-
Nag, S., Yee, B. K., and Tang, F. (1999). Chronic intracerebroventricular infusion of beta-amyloid (1-40) results in a selective loss of neuropeptides in addition to a reduction in choline acetyltransferase activity in the cortical mantle and hippocampus in the rat. Ann. N. Y. Acad. Sci. 897, 420-422. doi: 10.1111/j.1749-6632.1999.tb07911.x
-
(1999)
Ann. N. Y. Acad. Sci
, vol.897
, pp. 420-422
-
-
Nag, S.1
Yee, B.K.2
Tang, F.3
-
81
-
-
0035823325
-
Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide
-
Nakamura, S., Murayama, N., Noshita, T., Annoura, H., and Ohno, T. (2001). Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide. Brain Res. 912, 128-136. doi: 10.1016/S0006-8993(01)02704-4
-
(2001)
Brain Res
, vol.912
, pp. 128-136
-
-
Nakamura, S.1
Murayama, N.2
Noshita, T.3
Annoura, H.4
Ohno, T.5
-
82
-
-
81155154302
-
Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia
-
Neniskyte, U., Neher, J. J., and Brown, G. C. (2011). Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia. J. Biol. Chem. 286, 39904-39913. doi: 10.1074/jbc.M111.267583
-
(2011)
J. Biol. Chem
, vol.286
, pp. 39904-39913
-
-
Neniskyte, U.1
Neher, J.J.2
Brown, G.C.3
-
83
-
-
38349046973
-
Autophagy, amyloidogenesis and Alzheimer disease
-
Nixon, R. A. (2007). Autophagy, amyloidogenesis and Alzheimer disease. J. Cell Sci. 120, 4081-4091. doi: 10.1242/jcs.019265
-
(2007)
J. Cell Sci
, vol.120
, pp. 4081-4091
-
-
Nixon, R.A.1
-
84
-
-
33749521100
-
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
-
Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., et al. (2006). Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 26, 10129-10140. doi: 10.1523/JNEUROSCI.1202-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 10129-10140
-
-
Oakley, H.1
Cole, S.L.2
Logan, S.3
Maus, E.4
Shao, P.5
Craft, J.6
-
85
-
-
0033516554
-
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42
-
Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., et al. (1999). Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. J. Biol. Chem. 274, 18851-18856. doi: 10.1074/jbc.274.27.18851
-
(1999)
J. Biol. Chem
, vol.274
, pp. 18851-18856
-
-
Perez, R.G.1
Soriano, S.2
Hayes, J.D.3
Ostaszewski, B.4
Xia, W.5
Selkoe, D.J.6
-
86
-
-
0009631131
-
Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes
-
Rohan de Silva, H. A., Jen, A., Wickenden, C., Jen, L. S., Wilkinson, S. L., and Patel, A. J. (1997). Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes. Brain Res. Mol. Brain Res. 47, 147-156. doi: 10.1016/S0169-328X(97)00045-4
-
(1997)
Brain Res. Mol. Brain Res
, vol.47
, pp. 147-156
-
-
Rohan de Silva, H.A.1
Jen, A.2
Wickenden, C.3
Jen, L.S.4
Wilkinson, S.L.5
Patel, A.J.6
-
87
-
-
84857145664
-
Exogenous seeding of cerebral beta-amyloid deposition in betaAPP-transgenic rats
-
Rosen, R. F., Fritz, J. J., Dooyema, J., Cintron, A. F., Hamaguchi, T., Lah, J. J., et al. (2012). Exogenous seeding of cerebral beta-amyloid deposition in betaAPP-transgenic rats. J. Neurochem. 120, 660-666. doi: 10.1111/j.1471-4159.2011.07551.x
-
(2012)
J. Neurochem
, vol.120
, pp. 660-666
-
-
Rosen, R.F.1
Fritz, J.J.2
Dooyema, J.3
Cintron, A.F.4
Hamaguchi, T.5
Lah, J.J.6
-
88
-
-
34547977585
-
Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease
-
Sahlin, C., Pettersson, F. E., Nilsson, L. N., Lannfelt, L., and Johansson, A. S. (2007). Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease. Eur. J. Neurosci. 26, 882-889. doi: 10.1111/j.1460-9568.2007.05719.x
-
(2007)
Eur. J. Neurosci
, vol.26
, pp. 882-889
-
-
Sahlin, C.1
Pettersson, F.E.2
Nilsson, L.N.3
Lannfelt, L.4
Johansson, A.S.5
-
89
-
-
84892695519
-
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
-
Salloway, S., Sperling, R., Fox, N. C., Blennow, K., Klunk, W., Raskind, M., et al. (2014). Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N. Engl. J. Med. 370, 322-333. doi: 10.1056/NEJMoa1304839
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 322-333
-
-
Salloway, S.1
Sperling, R.2
Fox, N.C.3
Blennow, K.4
Klunk, W.5
Raskind, M.6
-
90
-
-
0028799897
-
Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid beta-protein
-
Saporito-Irwin, S. M., and Van Nostrand, W. E. (1995). Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid beta-protein. J. Biol. Chem. 270, 26265-26269. doi: 10.1074/jbc.270.44.26265
-
(1995)
J. Biol. Chem
, vol.270
, pp. 26265-26269
-
-
Saporito-Irwin, S.M.1
Van Nostrand, W.E.2
-
91
-
-
47249093676
-
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein
-
Schobel, S., Neumann, S., Hertweck, M., Dislich, B., Kuhn, P. H., Kremmer, E., et al. (2008). A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283, 14257-14268. doi: 10.1074/jbc.M801531200
-
(2008)
J. Biol. Chem
, vol.283
, pp. 14257-14268
-
-
Schobel, S.1
Neumann, S.2
Hertweck, M.3
Dislich, B.4
Kuhn, P.H.5
Kremmer, E.6
-
92
-
-
0026721943
-
Beta-amyloid precursor protein cleavage by a membrane-bound protease
-
Sisodia, S. S. (1992). Beta-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. U.S.A. 89, 6075-6079. doi: 10.1073/pnas.89.13.6075
-
(1992)
Proc. Natl. Acad. Sci. U.S.A
, vol.89
, pp. 6075-6079
-
-
Sisodia, S.S.1
-
93
-
-
0035433962
-
Alzheimer's disease and Abeta toxicity: from top to bottom
-
Small, D. H., Mok, S. S., and Bornstein, J. C. (2001). Alzheimer's disease and Abeta toxicity: from top to bottom. Nat. Rev. Neurosci. 2, 595-598. doi: 10.1038/35086072
-
(2001)
Nat. Rev. Neurosci
, vol.2
, pp. 595-598
-
-
Small, D.H.1
Mok, S.S.2
Bornstein, J.C.3
-
94
-
-
33751409639
-
ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells
-
Tanabe, C., Hotoda, N., Sasagawa, N., Sehara-Fujisawa, A., Maruyama, K., and Ishiura, S. (2007). ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells. Biochem. Biophys. Res. Commun. 352, 111-117. doi: 10.1016/j.bbrc.2006.10.181
-
(2007)
Biochem. Biophys. Res. Commun
, vol.352
, pp. 111-117
-
-
Tanabe, C.1
Hotoda, N.2
Sasagawa, N.3
Sehara-Fujisawa, A.4
Maruyama, K.5
Ishiura, S.6
-
95
-
-
33846953615
-
The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein
-
Taylor, D. R., and Hooper, N. M. (2007). The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein. Biochem. J. 402, 17-23. doi: 10.1042/BJ20061736
-
(2007)
Biochem. J
, vol.402
, pp. 17-23
-
-
Taylor, D.R.1
Hooper, N.M.2
-
96
-
-
60149093870
-
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons
-
Thathiah, A., Spittaels, K., Hoffmann, M., Staes, M., Cohen, A., Horre, K., et al. (2009). The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science 323, 946-951. doi: 10.1126/science.1160649
-
(2009)
Science
, vol.323
, pp. 946-951
-
-
Thathiah, A.1
Spittaels, K.2
Hoffmann, M.3
Staes, M.4
Cohen, A.5
Horre, K.6
-
97
-
-
84878502417
-
A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6
-
Thyrock, A., Ossendorf, E., Stehling, M., Kail, M., Kurtz, T., Pohlentz, G., et al. (2013). A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS ONE 8:e64149. doi: 10.1371/journal.pone.0064149
-
(2013)
PLoS ONE
, vol.8
-
-
Thyrock, A.1
Ossendorf, E.2
Stehling, M.3
Kail, M.4
Kurtz, T.5
Pohlentz, G.6
-
98
-
-
0037107974
-
Urokinase-type plasminogen activator inhibits amyloid-beta neurotoxicity and fibrillogenesis via plasminogen
-
Tucker, H. M., Kihiko-Ehmann, M., and Estus, S. (2002). Urokinase-type plasminogen activator inhibits amyloid-beta neurotoxicity and fibrillogenesis via plasminogen. J. Neurosci. Res. 70, 249-255. doi: 10.1002/jnr.10417
-
(2002)
J. Neurosci. Res
, vol.70
, pp. 249-255
-
-
Tucker, H.M.1
Kihiko-Ehmann, M.2
Estus, S.3
-
99
-
-
84890919877
-
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production
-
Udayar, V., Buggia-Prevot, V., Guerreiro, R. L., Siegel, G., Rambabu, N., Soohoo, A. L., et al. (2013). A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of beta-amyloid production. Cell Rep. 5, 1536-1551. doi: 10.1016/j.celrep.2013.12.005
-
(2013)
Cell Rep
, vol.5
, pp. 1536-1551
-
-
Udayar, V.1
Buggia-Prevot, V.2
Guerreiro, R.L.3
Siegel, G.4
Rambabu, N.5
Soohoo, A.L.6
-
100
-
-
0033860372
-
Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
-
Varadarajan, S., Yatin, S., Aksenova, M., and Butterfield, D. A. (2000). Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J. Struct. Biol. 130, 184-208. doi: 10.1006/jsbi.2000.4274
-
(2000)
J. Struct. Biol
, vol.130
, pp. 184-208
-
-
Varadarajan, S.1
Yatin, S.2
Aksenova, M.3
Butterfield, D.A.4
-
101
-
-
33845407472
-
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide
-
Wahle, T., Thal, D. R., Sastre, M., Rentmeister, A., Bogdanovic, N., Famulok, M., et al. (2006). GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide. J. Neurosci. 26, 12838-12846. doi: 10.1523/JNEUROSCI.1982-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 12838-12846
-
-
Wahle, T.1
Thal, D.R.2
Sastre, M.3
Rentmeister, A.4
Bogdanovic, N.5
Famulok, M.6
-
102
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., et al. (2002). Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539. doi: 10.1038/416535a
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
103
-
-
34248190279
-
A beta oligomers-a decade of discovery
-
Walsh, D. M., and Selkoe, D. J. (2007). A beta oligomers-a decade of discovery. J. Neurochem. 101, 1172-1184. doi: 10.1111/j.1471-4159.2006.04426.x
-
(2007)
J. Neurochem
, vol.101
, pp. 1172-1184
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
104
-
-
78449287185
-
Gamma-secretase gene mutations in familial acne inversa
-
Wang, B., Yang, W., Wen, W., Sun, J., Su, B., Liu, B., et al. (2010). Gamma-secretase gene mutations in familial acne inversa. Science 330, 1065. doi: 10.1126/science.1196284
-
(2010)
Science
, vol.330
, pp. 1065
-
-
Wang, B.1
Yang, W.2
Wen, W.3
Sun, J.4
Su, B.5
Liu, B.6
-
105
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
-
Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., et al. (2001). A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 414, 212-216. doi: 10.1038/35102591
-
(2001)
Nature
, vol.414
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
-
106
-
-
84862907635
-
VPS35 haploinsufficiency increases Alzheimer's disease neuropathology
-
Wen, L., Tang, F. L., Hong, Y., Luo, S. W., Wang, C. L., He, W., et al. (2011). VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J. Cell Biol. 195, 765-779. doi: 10.1083/jcb.201105109
-
(2011)
J. Cell Biol
, vol.195
, pp. 765-779
-
-
Wen, L.1
Tang, F.L.2
Hong, Y.3
Luo, S.W.4
Wang, C.L.5
He, W.6
-
107
-
-
33845613251
-
Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
-
Wu, Y., Wu, Z., Butko, P., Christen, Y., Lambert, M. P., Klein, W. L., et al. (2006). Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J. Neurosci. 26, 13102-13113. doi: 10.1523/JNEUROSCI.3448-06.2006
-
(2006)
J. Neurosci
, vol.26
, pp. 13102-13113
-
-
Wu, Y.1
Wu, Z.2
Butko, P.3
Christen, Y.4
Lambert, M.P.5
Klein, W.L.6
-
108
-
-
0030963605
-
Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
-
Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C., Sisodia, S. S., et al. (1997). Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc. Natl. Acad. Sci. U.S.A. 94, 3748-3752. doi: 10.1073/pnas.94.8.3748
-
(1997)
Proc. Natl. Acad. Sci. U.S.A
, vol.94
, pp. 3748-3752
-
-
Xu, H.1
Sweeney, D.2
Wang, R.3
Thinakaran, G.4
Lo, A.C.5
Sisodia, S.S.6
-
109
-
-
0028916146
-
Selective localization of gelatinase A, an enzyme degrading beta-amyloid protein, in white matter microglia and in Schwann cells
-
Yamada, T., Miyazaki, K., Koshikawa, N., Takahashi, M., Akatsu, H., and Yamamoto, T. (1995). Selective localization of gelatinase A, an enzyme degrading beta-amyloid protein, in white matter microglia and in Schwann cells. Acta Neuropathol. 89, 199-203. doi: 10.1007/BF00309334
-
(1995)
Acta Neuropathol
, vol.89
, pp. 199-203
-
-
Yamada, T.1
Miyazaki, K.2
Koshikawa, N.3
Takahashi, M.4
Akatsu, H.5
Yamamoto, T.6
-
110
-
-
0032936688
-
The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease
-
Yatin, S. M., Aksenov, M., and Butterfield, D. A. (1999). The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease. Neurochem. Res. 24, 427-435. doi: 10.1023/A:1020997903147
-
(1999)
Neurochem. Res
, vol.24
, pp. 427-435
-
-
Yatin, S.M.1
Aksenov, M.2
Butterfield, D.A.3
-
111
-
-
0033588991
-
Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster
-
Ye, Y., and Fortini, M. E. (1999). Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 146, 1351-1364. doi: 10.1083/jcb.146.6.1351
-
(1999)
J. Cell Biol
, vol.146
, pp. 1351-1364
-
-
Ye, Y.1
Fortini, M.E.2
-
112
-
-
4344689871
-
Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease
-
Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., et al. (2004). Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease. Int. J. Biochem. Cell Biol. 36, 2531-2540. doi: 10.1016/j.biocel.2004.05.010
-
(2004)
Int. J. Biochem. Cell Biol
, vol.36
, pp. 2531-2540
-
-
Yu, W.H.1
Kumar, A.2
Peterhoff, C.3
Shapiro Kulnane, L.4
Uchiyama, Y.5
Lamb, B.T.6
-
113
-
-
19644389648
-
CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production
-
Zhou, S., Zhou, H., Walian, P. J., and Jap, B. K. (2005). CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc. Natl. Acad. Sci. U.S.A. 102, 7499-7504. doi: 10.1073/pnas.0502768102
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 7499-7504
-
-
Zhou, S.1
Zhou, H.2
Walian, P.J.3
Jap, B.K.4
-
114
-
-
84938613456
-
Huperzine A protects neural stem cells against Abeta-induced apoptosis in a neural stem cells and microglia co-culture system
-
Zhu, N., Lin, J., Wang, K., Wei, M., Chen, Q., and Wang, Y. (2015). Huperzine A protects neural stem cells against Abeta-induced apoptosis in a neural stem cells and microglia co-culture system. Int. J. Clin. Exp. Pathol. 8, 6425-6433.
-
(2015)
Int. J. Clin. Exp. Pathol
, vol.8
, pp. 6425-6433
-
-
Zhu, N.1
Lin, J.2
Wang, K.3
Wei, M.4
Chen, Q.5
Wang, Y.6
|