The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

Neurobiology of Disease

Volumn 47, Issue 1, 2012, Pages 126-134

  Bhalla, Akhil ^a   Vetanovetz, Christopher P ^a   Morel, Etienne ^a   Chamoun, Zeina ^a   Di Paolo, Gilbert ^a   Small, Scott A ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Abeta; Alzheimer's disease; Amyloid precursor protein; Neurobiology; Retromer; Sorting; Trafficking; Vps26; Vps35

Indexed keywords

AMYLOID BETA PROTEIN; CARRIER PROTEIN; MEMBRANE PROTEIN; PROTEIN VPS35; RETROMER; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; ENDOSOME; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENE SILENCING; HIPPOCAMPUS; MOUSE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN TARGETING; PROTEIN TRANSPORT; TRANS GOLGI NETWORK; TRANSPORT KINETICS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CELLS, CULTURED; ENDOSOMES; HIPPOCAMPUS; HUMANS; NEURONS; PROTEIN TRANSPORT; TRANS-GOLGI NETWORK; VESICULAR TRANSPORT PROTEINS;

EID: 84861230374     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.03.030     Document Type: Article

References (31)

1. Andersen O.M., Reiche J., Schmidt V., Gotthardt M., Spoelgen R., Behlke J., von Arnim C.A., Breiderhoff T., Jansen P., Wu X., Bales K.R., Cappai R., Masters C.L., Gliemann J., Mufson E.J., Hyman B.T., Paul S.M., Nykjaer A., Willnow T.E. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:13461-13466.
2. Arighi C.N., Hartnell L.M., Aguilar R.C., Haft C.R., Bonifacino J.S. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J. Cell Biol. 2004, 165:123-133.
3. Belenkaya T.Y., Wu Y., Tang X., Zhou B., Cheng L., Sharma Y.V., Yan D., Selva E.M., Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 2008, 14:120-131.
4. Bonifacino J.S., Hurley J.H. Retromer. Curr. Opin. Cell Biol. 2008, 20:427-436.
5. Brunholz S., Sisodia S., Lorenzo A., Deyts C., Kins S., Morfini G. Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells. Exp. Brain Res. 2012, 217:353-364.
6. Cataldo A., Rebeck G.W., Ghetri B., Hulette C., Lippa C., Van Broeckhoven C., van Duijn C., Cras P., Bogdanovic N., Bird T., Peterhoff C., Nixon R. Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders. Ann. Neurol. 2001, 50:661-665.
7. Deinhardt K., Salinas S., Verastegui C., Watson R., Worth D., Hanrahan S., Bucci C., Schiavo G. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 2006, 52:293-305.
8. Dodson S.E., Gearing M., Lippa C.F., Montine T.J., Levey A.I., Lah J.J. LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease. J. Neuropathol. Exp. Neurol. 2006, 65:866-872.
9. Haft C.R., de la Luz Sierra M., Bafford R., Lesniak M.A., Barr V.A., Taylor S.I. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol. Biol. Cell 2000, 11:4105-4116.
10. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
11. Ikonen E., Parton R.G., Hunziker W., Simons K., Dotti C.G. Transcytosis of the polymeric immunoglobulin receptor in cultured hippocampal neurons. Curr. Biol. 1993, 3:635-644.
12. Israel M.A., Yuan S.H., Bardy C., Reyna S.M., Mu Y., Herrera C., Hefferan M.P., Van Gorp S., Nazor K.L., Boscolo F.S., Carson C.T., Laurent L.C., Marsala M., Gage F.H., Remes A.M., Koo E.H., Goldstein L.S. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 2012, 482:216-220.
13. Kaether C., Skehel P., Dotti C.G. Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol. Biol. Cell 2000, 11:1213-1224.
14. Kinoshita A., Fukumoto H., Shah T., Whelan C.M., Irizarry M.C., Hyman B.T. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J. Cell Sci. 2003, 116:3339-3346.
15. Koo E.H., Sisodia S.S., Archer D.R., Martin L.J., Weidemann A., Beyreuther K., Fischer P., Masters C.L., Price D.L. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:1561-1565.
16. Lane R.F., Raines S.M., Steele J.W., Ehrlich M.E., Lah J.A., Small S.A., Tanzi R.E., Attie A.D., Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J. Neurosci. 2010, 30:13110-13115.
17. Muhammad A., Flores I., Zhang H., Yu R., Staniszewski A., Planel E., Herman M., Ho L., Kreber R., Honig L.S., Ganetzky B., Duff K., Arancio O., Small S.A. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:7327-7332.
18. Nixon R.A. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol. Aging 2005, 26:373-382.
19. Qiang L., Fujita R., Yamashita T., Angulo S., Rhinn H., Rhee D., Doege C., Chau L., Aubry L., Vanti W.B., Moreno H., Abeliovich A. Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons. Cell 2011, 146:359-371.
20. Rajendran L., Honsho M., Zahn T.R., Keller P., Geiger K.D., Verkade P., Simons K. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:11172-11177.
21. Reitz C., Tokuhiro S., Clark L.N., Conrad C., Vonsattel J.P., Hazrati L.N., Palotas A., Lantigua R., Medrano M., Jiménez-Velázquez Ivonne Z., Vardarajan B., Simkin I., Haines J.L., Pericak-Vance M.A., Farrer L.A., Lee J.H., Rogaeva E., George-Hyslop P.S., Mayeux R. SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk. Ann. Neurol. 2011, 69:47-64.
22. Rogaeva E., Meng Y., Lee J.H., Gu Y., Kawarai T., Zou F., Katayama T., Baldwin C.T., Cheng R., Hasegawa H., et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat. Genet. 2007, 39:168-177.
23. Seaman M.N. Recycle your receptors with retromer. Trends Cell Biol. 2005, 15:68-75.
24. Small S.A. Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease. Arch. Neurol. 2008, 65:323-328.
25. Small S.A., Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006, 52:15-31.
26. Small S.A., Kent K., Pierce A., Leung C., Kang M.S., Okada H., Honig L., Vonsattel J.P., Kim T.W. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann. Neurol. 2005, 58:909-919.
27. Sullivan C.P., Jay A.G., Stack E.C., Pakaluk M., Wadlinger E., Fine R.E., Wells J.M., Morin P.J. Retromer disruption promotes amyloidogenic APP processing. Neurobiol. Dis. 2011, 43:338-345.
28. Verges M., Luton F., Gruber C., Tiemann F., Reinders L.G., Huang L., Burlingame A.L., Haft C.R., Mostov K.E. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat. Cell Biol. 2004, 6:763-769.
29. Vieira S.I., Rebelo S., Esselmann H., Wiltfang J., Lah J., Lane R., Small S.A., Gandy S., da Cruz E.S.E.F., da Cruz E.S.O.A. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol. Neurodegener. 2010, 5:40.
30. Vilarino-Guell C., Wider C., Ross O.A., Dachsel J.C., Kachergus J.M., Lincoln S.J., Soto-Ortolaza A.I., Cobb S.A., Wilhoite G.J., Bacon J.A., et al. VPS35 mutations in Parkinson disease. Am. J. Hum. Genet. 2011, 89:162-167.
31. Zimprich A., Benet-Pages A., Struhal W., Graf E., Eck S.H., Offman M.N., Haubenberger D., Spielberger S., Schulte E.C., Lichtner P., et al. A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am. J. Hum. Genet. 2011, 89:168-175.