Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

BMC Biotechnology

Volumn 10, Issue , 2010, Pages

  Arslanova, Dilyara ^a   Yang, Ting ^a   Xu, Xiaoyin ^a   Wong, Stephen T ^b   Augelli Szafran, Corinne E ^a   Xia, Weiming ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; APOPTOTIC PROCESS; CELL-BASED ASSAYS; CLINICAL TRIAL; DOSE-DEPENDENT MANNER; EFFECTIVE CONCENTRATION; EXPRESSION LEVELS; GLEEVEC; IMAGE COMPOSITION; IN-SITU HYBRIDIZATION; INTRACELLULAR DOMAIN; PATHOGENIC PROTEINS; PHENOTYPIC ANALYSIS; PHENYLGLYCINES; POST-FERTILIZATION; PROTEOLYTIC CLEAVAGE; SECRETASES; SIGNALING MOLECULES; T-BUTYL ESTER; TARGET GENES; WELL PLATES; ZEBRAFISH;

ESTERS; GENE EXPRESSION; GLYCOPROTEINS; IMAGE ANALYSIS; PUMPING PLANTS;

PROTEINS;

AD 115; AD 28; AD 94; AD 95; AMYLOID BETA PROTEIN; DIMETHYL SULFOXIDE; GAMMA SECRETASE INHIBITOR; IMATINIB; N [N (3,5 DIFLUOROPHENACETYLALANYL)] S PHENYLGLYCINE TERT BUTYL ESTER; PROTEIN HER6; UNCLASSIFIED DRUG; 1,2-DILINOLENOYL-3-(4-AMINOBUTYRYL)PROPANE-1,2,3-TRIOL; 3 (4 AMINOBUTYRYL) 1,2 DILINOLENOYLGLYCEROL; 4 AMINOBUTYRIC ACID; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DRUG DERIVATIVE; HER6 PROTEIN, ZEBRAFISH; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; SECRETASE; TRIACYLGLYCEROL; ZEBRAFISH PROTEIN;

ALGORITHM; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOMATION; CELL ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG STRUCTURE; EMBRYO; FERTILIZATION; GENE EXPRESSION; IMAGE ANALYSIS; IMAGE PROCESSING; IN SITU HYBRIDIZATION; MICROSCOPE; MORTALITY; NICK END LABELING; NONHUMAN; PHENOTYPE; PIGMENTATION; TAIL; TRUNK; VALIDATION STUDY; ZEBRA FISH; ANIMAL; ANIMAL EMBRYO; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HIGH THROUGHPUT SCREENING; METABOLISM;

DANIO RERIO;

ALGORITHMS; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; EMBRYO, NONMAMMALIAN; GAMMA-AMINOBUTYRIC ACID; HIGH-THROUGHPUT SCREENING ASSAYS; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; PHENOTYPE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; TRIGLYCERIDES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 77950901539     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-10-24     Document Type: Article

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