Brain plasmin enhances APP α-cleavage and Aβ degradation and is reduced in Alzheimer's disease brains

EMBO Reports

Volumn 1, Issue 6, 2000, Pages 530-535

  Ledesma, Maria Dolores ^a   Da Silva, Jorge Santos ^a   Crassaerts, Katleen ^b   Delacourte, Andre ^c   De Strooper, Bart ^b   Dotti, Carlos G ^a,d  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c INSERM   (France)

^d UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CAVEOLIN; CAVEOLIN 1; GANGLIOSIDE GM1; PLASMIN; PLASMINOGEN; TISSUE PLASMINOGEN ACTIVATOR;

ADULT; AGE; AGED; ALZHEIMER DISEASE; ANIMAL; ARTICLE; BRAIN; CELL CULTURE; CELL LINE; CELL MEMBRANE; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; METABOLISM; MIDDLE AGED; NERVE CELL; RAT; TIME; WESTERN BLOTTING;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; BRAIN; CAVEOLIN 1; CAVEOLINS; CELL LINE; CELLS, CULTURED; G(M1) GANGLIOSIDE; HIPPOCAMPUS; HUMANS; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NEURONS; PLASMIN; PLASMINOGEN; RATS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TRANSFECTION;

EID: 0034573026     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd107     Document Type: Article

References (30)

1. Anderson, J.J., Holtz, G., Baskin, P.P., Wang, R., Mazzarelli, L., Wagner, S.L. and Menzaghi, F. (1999) Reduced cerebrospinal fluid levels of α-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits. Neuroscience, 93, 1409-1420.
2. Baranes, D., Lederfin, D., Huang, Y.Y., Chen, M., Bailey, C.H. and Kandel, E.R. (1998) Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron, 21, 813-825.
3. Buxbaum, J.D. et al. (1998) Evidence that tumor necrosis factor a converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem., 273, 27765-27767.
4. Chen, Z.L. and Strickland, S. (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell, 91, 917-925.
5. De Strooper, B., Simons, M., Multhaup, G., Van Leuven, F., Beyreuther, K. and Dotti, C.G. (1995) Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. EMBO J., 14, 4932-4938.
6. Goslin, K. and Banker, G. (1991) Culturing Nerve Cells. MIT Press, Cambridge, MA, pp. 251-281.
7. Haass, C., Koo, E.H., Mellon, A., Hung, A.Y. and Selkoe, D.J. (1992) Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature, 357, 500-503.
8. Ikezu, T., Trapp, B.D., Song, K.S., Schlegel, A., Lisanti, M.P. and Okamoto, T. (1998) Caveolae, plasma membrane microdomains for α-secretase-mediated processing of the amyloid precursor protein. J. Biol. Chem., 273, 10485-10495.
9. Kleiner, D.E., Jr and Stetler-Stevenson, W.G. (1993) Structural biochemistry and activation of matrix metalloproteases. Curr. Opin. Cell Biol., 5, 891-897.
10. Koike, H. et al. (1999) Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein. Biochem. J., 343, 371-375.
11. Krueger, S.R., Ghisu, O.P., Cinelli, P., Gschwend, T.P., Osterwalder, T., Wolfer, D.P. and Sonderegger, P. (1997) Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J. Neurosci., 17, 8984-8996.
12. Kwaan, H.C. (1992) The plasminogen-plasmin system in malignancy. Cancer Metastasis Rev., 11, 291-311.
13. Lammich, S. et al. (1999) Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proc. Natl Acad. Sci. USA, 96, 3922-3927.
14. Lee, S. J, Liyanage, U., Bickel, P.E., Xia, W., Lansbury, P.T., Jr and Kosik, K.S. (1998) A detergent-insoluble membrane compartment contains Aβ in vivo. Nature Med., 4, 730-734.
15. Miles, L.A., Dahlberg, C.M., Levin, E.G. and Plow, E.F. (1989) Gangliosides interact directly with plasminogen and urokinase and may mediate binding of these fibrinolytic components to the cells. Biochemistry, 28, 9337-9343.
16. Parvathy, S., Hussain, I., Karran, E.H., Turner, A.J. and Hooper, N.M. (1999) Cleavage of Alzheimer's amyloid precursor protein by α-secretase occurs at the surface of neuronal cells. Biochemistry, 38, 9728-9734.
17. Plow, E.F., Herren, T., Redlitz, A., Miles, L.A. and Hoover-Plow, J.L. (1995) The cell biology of the plasminogen system. FASEB J., 9, 939-945.
18. Selkoe, D.J. (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature, 399, A23-A31.
19. Sennvik, K., Fastbom, J., Blomberg, M., Wahlund, L.O., Winblad, B. and Benedikz, E. (2000) Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients. Neurosci. Lett., 278, 169-172.
20. Simons, K. and Ikonen, E. (1997) Functional rafts in cell membranes. Nature, 387, 569-572.
21. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C.G. and Simons, K. (1998) Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc. Natl Acad. Sci. USA., 95, 6460-6464.
22. Sinha, S. and Lieberburg, I. (1999) Cellular mechanisms of β-amyloid production and secretion. Proc. Natl Acad Sci. USA, 96, 11049-11053.
23. Thewke, D.P. and Seeds, N.W. (1999) The expression of mRNAs for hepatocyte growth factor/scatter factor, its receptor c-met and one of its activators tPA show a systematic relationship in the developing and adult cerebral cortex and hippocampus. Brain Res., 821, 356-367.
24. Tsirka, S.E., Bugge, T.H., Degen, J.L. and Strickland, S. (1997) Neuronal death in the central nervous system demonstrates a non fibrin substrate for plasmin. Proc. Natl Acad. Sci. USA, 94, 9779-9781.
25. Tucker, H.M. et al. (2000) The plasmin system is induced by and degrades Amyloid-β aggregates. J. Neurosci., 20, 3937-3946.
26. Van Nostrand, W.E. and Porter, M. (1999) Plasmin cleavage of the amyloid β-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity. Biochemistry, 38, 11570-11576.
27. Vassalli, J.D., Sappino, A.P. and Belin, D. (1991) The plasminogen activator/ plasmin system. J. Clin. Invest., 88, 1067-1072.
28. Weinstein, M.J. and Doolittle, R.F. (1972) Differential specificities of the thrombin, plasmin and trypsin with regard to synthetic and natural substrates and inhibitors. Biochim. Biophys. Acta., 258, 577-590.
29. Wnendt, S., Wetzels, I. and Gunzler, W.A. (1997) Amyloid β peptides stimulate tissue-type plasminogen activator but not recombinant prourokinase. Thromb. Res., 85, 217-224
30. Yanasigawa, K., Odaka, A., Suzuki, N. and Ihara, Y. (1995) GM1 ganglioside-bound amyloid β-protein (Aβ): a possible form of preamyloid in Alzheimer's disease. Nature Med., 1, 1062-1066.