The relationship between phenolic compounds from diet and microbiota: Impact on human health

Food and Function

Volumn 6, Issue 8, 2015, Pages 2424-2439

  Valdes L ^a   Cuervo, A ^b   Salazar, N ^a   Ruas Madiedo, P ^a   Gueimonde, M ^a   Gonzalez S ^b  

^a DEPARTMENT OF MICROBIOLOGY AND BIOCHEMISTRY OF DAIRY PRODUCTS   (Spain)

^b UNIVERSITY OF OVIEDO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; HEALTH; PHENOLS;

ANTI-MICROBIAL ACTIVITY; BIOACTIVE COMPOUNDS; EXTERNAL FACTORS; HUMAN GUT MICROBIOTA; INTESTINAL ABSORPTION; INTESTINAL TRACT; MICROBIAL COMMUNITIES; PHENOLIC COMPOUNDS;

MICROORGANISMS;

PHENOL DERIVATIVE;

DIET; GASTROINTESTINAL TRACT; HEALTH; HUMAN; INTESTINE FLORA; METABOLISM; MICROBIOLOGY;

DIET; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HEALTH; HUMANS; PHENOLS;

EID: 84938798342     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c5fo00322a     Document Type: Review

References (165)

1. C. M. Guinane P. D. Cotter Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ Ther. Adv. Gastroenterol. 2013 6 295 308
2. J. Qin R. Li J. Raes M. Arumugam K. S. Burgdorf C. Manichanh T. Nielsen N. Pons F. Levenez T. Yamada D. R. Mende J. Li J. Xu S. Li D. Li J. Cao B. Wang H. Liang H. Zheng Y. Xie J. Tap P. Lepage M. Bertalan J. M. Batto T. Hansen P. D. Le A. Linneberg H. B. Nielsen E. Pelletier P. Renault T. Sicheritz-Ponten K. Turner H. Zhu C. Yu S. Li M. Jian Y. Zhou Y. Li X. Zhang S. Li N. Qin H. Yang J. Wang S. Brunak J. Dore F. Guarner K. Kristiansen O. Pedersen J. Parkhill J. Weissenbach P. Bork S. D. Ehrlich J. Wang A human gut microbial gene catalogue established by metagenomic sequencing Nature 2010 464 59 65
3. H. J. Flint K. P. Scott P. Louis S. H. Duncan The role of the gut microbiota in nutrition and health Nat. Rev. Gastroenterol. Hepatol. 2012 9 577 589
4. F. Sommer F. Backhed The gut microbiota - masters of host development and physiology Nat. Rev. Microbiol. 2013 11 227 238
5. G. Corthier J. Dore A new era in gut research concerning interactions between microbiota and human health Gastroenterol. Clin. Biol. 2010 34 Suppl. 1 S1 S6
6. S. Arboleya A. Binetti N. Salazar N. Fernandez G. Solis A. Hernandez-Barranco A. Margolles C. G. de los Reyes-Gavilan M. Gueimonde Establishment and development of intestinal microbiota in preterm neonates FEMS Microbiol. Ecol. 2012 79 763 772
7. M. Olivares A. Neef G. Castillejo G. D. Palma V. Varea A. Capilla F. Palau E. Nova A. Marcos I. Polanco C. Ribes-Koninckx L. Ortigosa L. Izquierdo Y. Sanz The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease Gut 2015 64 406 417
8. S. Matamoros C. Gras-Leguen V. F. Le G. Potel M. F. de La Cochetiere Development of intestinal microbiota in infants and its impact on health Trends Microbiol. 2013 21 167 173
9. J. Penders C. Thijs C. Vink F. F. Stelma B. Snijders I. Kummeling P. A. van den Brandt E. E. Stobberingh Factors influencing the composition of the intestinal microbiota in early infancy Pediatrics 2006 118 511 521
10. K. Aagaard J. Ma K. M. Antony R. Ganu J. Petrosino J. Versalovic The placenta harbors a unique microbiome Sci. Transl. Med. 2014 6 237ra65
11. J. M. Rodriguez K. Murphy C. Stanton R. P. Ross O. I. Kober N. Juge E. Avershina K. Rudi A. Narbad M. C. Jenmalm J. R. Marchesi M. C. Collado The composition of the gut microbiota throughout life, with an emphasis on early life Microb. Ecol. Health Dis. 2015 26 26050
12. N. Salazar S. Arboleya L. Valdes C. Stanton P. Ross L. Ruiz M. Gueimonde C. G. de los Reyes-Gavilan The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations Front. Genet. 2014 5 406
13. J. E. Koenig A. Spor N. Scalfone A. D. Fricker J. Stombaugh R. Knight L. T. Angenent R. E. Ley Succession of microbial consortia in the developing infant gut microbiome Proc. Natl. Acad. Sci. U. S. A. 2011 108 Suppl. 1 4578 4585
14. T. Yatsunenko F. E. Rey M. J. Manary I. Trehan M. G. Dominguez-Bello M. Contreras M. Magris G. Hidalgo R. N. Baldassano A. P. Anokhin A. C. Heath B. Warner J. Reeder J. Kuczynski J. G. Caporaso C. A. Lozupone C. Lauber J. C. Clemente D. Knights R. Knight J. I. Gordon Human gut microbiome viewed across age and geography Nature 2012 486 222 227
15. P. B. Eckburg E. M. Bik C. N. Bernstein E. Purdom L. Dethlefsen M. Sargent S. R. Gill K. E. Nelson D. A. Relman Diversity of the human intestinal microbial flora Science 2005 308 1635 1638
16. F. Backhed C. M. Fraser Y. Ringel M. E. Sanders R. B. Sartor P. M. Sherman J. Versalovic V. Young B. B. Finlay Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications Cell Host Microbe 2012 12 611 622
17. N. Voreades A. Kozil T. L. Weir Diet and the development of the human intestinal microbiome Front. Microbiol. 2014 5 494
18. Human Microbiome Consortium A framework for human microbiome research Nature 2012 486 215 221
19. M. Arumugam J. Raes E. Pelletier P. D. Le T. Yamada D. R. Mende G. R. Fernandes J. Tap T. Bruls J. M. Batto M. Bertalan N. Borruel F. Casellas L. Fernandez L. Gautier T. Hansen M. Hattori T. Hayashi M. Kleerebezem K. Kurokawa M. Leclerc F. Levenez C. Manichanh H. B. Nielsen T. Nielsen N. Pons J. Poulain J. Qin T. Sicheritz-Ponten S. Tims D. Torrents E. Ugarte E. G. Zoetendal J. Wang F. Guarner O. Pedersen W. M. de Vos S. Brunak J. Dore M. Antolin F. Artiguenave H. M. Blottiere M. Almeida C. Brechot C. Cara C. Chervaux A. Cultrone C. Delorme G. Denariaz R. Dervyn K. U. Foerstner C. Friss M. van de Guchte E. Guedon F. Haimet W. Huber J. van Hylckama-Vlieg A. Jamet C. Juste G. Kaci J. Knol O. Lakhdari S. Layec R. K. Le E. Maguin A. Merieux M. R. Melo C. M'rini J. Muller R. Oozeer J. Parkhill P. Renault M. Rescigno N. Sanchez S. Sunagawa A. Torrejon K. Turner G. Vandemeulebrouck E. Varela Y. Winogradsky G. Zeller J. Weissenbach S. D. Ehrlich P. Bork Enterotypes of the human gut microbiome Nature 2011 473 174 180
20. G. D. Wu J. Chen C. Hoffmann K. Bittinger Y. Y. Chen S. A. Keilbaugh M. Bewtra D. Knights W. A. Walters R. Knight R. Sinha E. Gilroy K. Gupta R. Baldassano L. Nessel H. Li F. D. Bushman J. D. Lewis Linking long-term dietary patterns with gut microbial enterotypes Science 2011 334 105 108
21. L. A. David C. F. Maurice R. N. Carmody D. B. Gootenberg J. E. Button B. E. Wolfe A. V. Ling A. S. Devlin Y. Varma M. A. Fischbach S. B. Biddinger R. J. Dutton P. J. Turnbaugh Diet rapidly and reproducibly alters the human gut microbiome Nature 2014 505 559 563
22. H. M. Roager T. R. Licht S. K. Poulsen T. M. Larsen M. I. Bahl Microbial enterotypes, inferred by the prevotella-to-bacteroides ratio, remained stable during a 6-month randomized controlled diet intervention with the new Nordic diet Appl. Environ. Microbiol. 2014 80 1142 1149
23. S. M. Huse Y. Ye Y. Zhou A. A. Fodor A core human microbiome as viewed through 16S rRNA sequence clusters PLoS One 2012 7 e34242
24. O. Koren D. Knights A. Gonzalez L. Waldron N. Segata R. Knight C. Huttenhower R. E. Ley A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets PLoS Comput. Biol. 2013 9 e1002863
25. B. Lakshminarayanan C. Stanton P. W. O'Toole R. P. Ross Compositional dynamics of the human intestinal microbiota with aging: implications for health J. Nutr. Health Aging 2014 18 773 786
26. M. J. Claesson I. B. Jeffery S. Conde S. E. Power E. M. O'Connor S. Cusack H. M. Harris M. Coakley B. Lakshminarayanan O. O'Sullivan G. F. Fitzgerald J. Deane M. O'Connor N. Harnedy K. O'Connor D. O'Mahony S. D. van M. Wallace L. Brennan C. Stanton J. R. Marchesi A. P. Fitzgerald F. Shanahan C. Hill R. P. Ross P. W. O'Toole Gut microbiota composition correlates with diet and health in the elderly Nature 2012 488 178 184
27. E. Biagi M. Candela S. Fairweather-Tait C. Franceschi P. Brigidi Aging of the human metaorganism: the microbial counterpart Age 2012 34 247 267
28. S. Bartosch A. Fite G. T. Macfarlane M. E. McMurdo Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota Appl. Environ. Microbiol. 2004 70 3575 3581
29. J. M. Keller C. M. Surawicz Clostridium difficile infection in the elderly Clin. Geriatr. Med. 2014 30 79 93
30. J. Qin Y. Li Z. Cai S. Li J. Zhu F. Zhang S. Liang W. Zhang Y. Guan D. Shen Y. Peng D. Zhang Z. Jie W. Wu Y. Qin W. Xue J. Li L. Han D. Lu P. Wu Y. Dai X. Sun Z. Li A. Tang S. Zhong X. Li W. Chen R. Xu M. Wang Q. Feng M. Gong J. Yu Y. Zhang M. Zhang T. Hansen G. Sanchez J. Raes G. Falony S. Okuda M. Almeida E. LeChatelier P. Renault N. Pons J. M. Batto Z. Zhang H. Chen R. Yang W. Zheng S. Li H. Yang J. Wang S. D. Ehrlich R. Nielsen O. Pedersen K. Kristiansen J. Wang A metagenome-wide association study of gut microbiota in type 2 diabetes Nature 2012 490 55 60
31. C. E. Le T. Nielsen J. Qin E. Prifti F. Hildebrand G. Falony M. Almeida M. Arumugam J. M. Batto S. Kennedy P. Leonard J. Li K. Burgdorf N. Grarup T. Jorgensen I. Brandslund H. B. Nielsen A. S. Juncker M. Bertalan F. Levenez N. Pons S. Rasmussen S. Sunagawa J. Tap S. Tims E. G. Zoetendal S. Brunak K. Clement J. Dore M. Kleerebezem K. Kristiansen P. Renault T. Sicheritz-Ponten W. M. de Vos J. D. Zucker J. Raes T. Hansen P. Bork J. Wang S. D. Ehrlich O. Pedersen Richness of human gut microbiome correlates with metabolic markers Nature 2013 500 541 546
32. M. Kalliomaki P. Kirjavainen E. Eerola P. Kero S. Salminen E. Isolauri Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing J. Allergy Clin. Immunol. 2001 107 129 134
33. M. Kalliomaki M. C. Collado S. Salminen E. Isolauri Early differences in fecal microbiota composition in children may predict overweight Am. J. Clin. Nutr. 2008 87 534 538
34. A. G. Davis-Richardson A. N. Ardissone R. Dias V. Simell M. T. Leonard K. M. Kemppainen J. C. Drew D. Schatz M. A. Atkinson B. Kolaczkowski J. Ilonen M. Knip J. Toppari N. Nurminen H. Hyoty R. Veijola T. Simell J. Mykkanen O. Simell E. W. Triplett Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes Front. Microbiol. 2014 5 678
35. A. L. Morrow A. J. Lagomarcino K. R. Schibler D. H. Taft Z. Yu B. Wang M. Altaye M. Wagner D. Gevers D. V. Ward M. A. Kennedy C. Huttenhower D. S. Newburg Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants Microbiome. 2013 1 13
36. L. M. Cox S. Yamanishi J. Sohn A. V. Alekseyenko J. M. Leung I. Cho S. G. Kim H. Li Z. Gao D. Mahana J. G. Zarate Rodriguez A. B. Rogers N. Robine P. Loke M. J. Blaser Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences Cell 2014 158 705 721
37. J. Hansen A. Gulati R. B. Sartor The role of mucosal immunity and host genetics in defining intestinal commensal bacteria Curr. Opin. Gastroenterol. 2010 26 564 571
38. T. Olszak D. An S. Zeissig M. P. Vera J. Richter A. Franke J. N. Glickman R. Siebert R. M. Baron D. L. Kasper R. S. Blumberg Microbial exposure during early life has persistent effects on natural killer T cell function Science 2012 336 489 493
39. R. Tojo A. Suarez M. G. Clemente C. G. de los Reyes-Gavilan A. Margolles M. Gueimonde P. Ruas-Madiedo Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis World J. Gastroenterol. 2014 20 15163 15176
40. A. D. Kostic R. J. Xavier D. Gevers The microbiome in inflammatory bowel disease: current status and the future ahead Gastroenterology 2014 146 1489 1499
41. M. Joossens G. Huys M. Cnockaert P. V. De K. Verbeke P. Rutgeerts P. Vandamme S. Vermeire Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives Gut 2011 60 631 637
42. H. Sokol B. Pigneur L. Watterlot O. Lakhdari L. G. Bermudez-Humaran J. J. Gratadoux S. Blugeon C. Bridonneau J. P. Furet G. Corthier C. Grangette N. Vasquez P. Pochart G. Trugnan G. Thomas H. M. Blottiere J. Dore P. Marteau P. Seksik P. Langella Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients Proc. Natl. Acad. Sci. U. S. A. 2008 105 16731 16736
43. D. N. Frank A. L. St Amand R. A. Feldman E. C. Boedeker N. Harpaz N. R. Pace Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases Proc. Natl. Acad. Sci. U. S. A. 2007 104 13780 13785
44. D. Gevers S. Kugathasan L. A. Denson Y. Vazquez-Baeza T. W. Van B. Ren E. Schwager D. Knights S. J. Song M. Yassour X. C. Morgan A. D. Kostic C. Luo A. Gonzalez D. McDonald Y. Haberman T. Walters S. Baker J. Rosh M. Stephens M. Heyman J. Markowitz R. Baldassano A. Griffiths F. Sylvester D. Mack S. Kim W. Crandall J. Hyams C. Huttenhower R. Knight R. J. Xavier The treatment-naive microbiome in new-onset Crohn's disease Cell Host Microbe 2014 15 382 392
45. A. Salonen W. M. de Vos A. Palva Gastrointestinal microbiota in irritable bowel syndrome: present state and perspectives Microbiology 2010 156 3205 3215
46. P. G. De I. Nadal M. Medina E. Donat C. Ribes-Koninckx M. Calabuig Y. Sanz Intestinal dysbiosis and reduced immunoglobulin-coated bacteria associated with coeliac disease in children BMC Microbiol. 2010 10 63
47. Q. Zhu R. Gao W. Wu H. Qin The role of gut microbiota in the pathogenesis of colorectal cancer Tumour Biol. 2013 34 1285 1300
48. S. Fuentes N. E. Van S. Tims J. I. Heikamp-de C. J. ter Braak J. J. Keller E. G. Zoetendal W. M. de Vos Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection ISME J. 2014 8 1621 1633
49. I. Nadal A. Santacruz A. Marcos J. Warnberg J. M. Garagorri L. A. Moreno M. Martin-Matillas C. Campoy A. Marti A. Moleres M. Delgado O. L. Veiga M. Garcia-Fuentes C. G. Redondo Y. Sanz Shifts in clostridia, bacteroides and immunoglobulin-coating fecal bacteria associated with weight loss in obese adolescents Int. J. Obes. (Lond) 2009 33 758 767
50. P. J. Turnbaugh M. Hamady T. Yatsunenko B. L. Cantarel A. Duncan R. E. Ley M. L. Sogin W. J. Jones B. A. Roe J. P. Affourtit M. Egholm B. Henrissat A. C. Heath R. Knight J. I. Gordon A core gut microbiome in obese and lean twins Nature 2009 457 480 484
51. N. M. Delzenne A. M. Neyrinck P. D. Cani Gut microbiota and metabolic disorders: How prebiotic can work? Br. J. Nutr. 2013 109 Suppl. 2 S81 S85
52. A. Everard C. Belzer L. Geurts J. P. Ouwerkerk C. Druart L. B. Bindels Y. Guiot M. Derrien G. G. Muccioli N. M. Delzenne W. M. de Vos P. D. Cani Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity Proc. Natl. Acad. Sci. U. S. A. 2013 110 9066 9071
53. A. Cotillard S. P. Kennedy L. C. Kong E. Prifti N. Pons C. E. Le M. Almeida B. Quinquis F. Levenez N. Galleron S. Gougis S. Rizkalla J. M. Batto P. Renault J. Dore J. D. Zucker K. Clement S. D. Ehrlich Dietary intervention impact on gut microbial gene richness Nature 2013 500 585 588
54. R. Jumpertz D. S. Le P. J. Turnbaugh C. Trinidad C. Bogardus J. I. Gordon J. Krakoff Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans Am. J. Clin. Nutr. 2011 94 58 65
55. P. D. Cani A. Everard T. Duparc Gut microbiota, enteroendocrine functions and metabolism Curr. Opin. Pharmacol. 2013 13 935 940
56. P. J. Pussinen A. S. Havulinna M. Lehto J. Sundvall V. Salomaa Endotoxemia is associated with an increased risk of incident diabetes Diabetes Care 2011 34 392 397
57. E. M. Quigley C. Stanton E. F. Murphy The gut microbiota and the liver. Pathophysiological and clinical implications J. Hepatol. 2013 58 1020 1027
58. Y. J. Huang H. A. Boushey The microbiome in asthma J. Allergy Clin. Immunol. 2015 135 25 30
59. A. Hevia C. Milani P. Lopez A. Cuervo S. Arboleya S. Duranti F. Turroni S. Gonzalez A. Suarez M. Gueimonde M. Ventura B. Sanchez A. Margolles Intestinal dysbiosis associated with systemic lupus erythematosus MBio. 2014 5 e01548 e01514
60. P. Bercik S. M. Collins E. F. Verdu Microbes and the gut-brain axis Neurogastroenterol. Motil. 2012 24 405 413
61. R. D. Del A. Rodriguez-Mateos J. P. Spencer M. Tognolini G. Borges A. Crozier Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases Antioxid. Redox Signal. 2013 18 1818 1892
62. USDA Database for the Flavonoid Content of Selected Foods, US Department of Agriculture, Beltsville, MD, 2007. US Department of Agriculture, 2015
63. USDA-Iowa State University Database on the Isoflavone Content of Foods, US Department of Agriculture, Beltsville, MD, 2007. US Department of Agriculture, 2015
64. USDA Database for the Proanthocyanidin Content of Selected Foods, US Department of Agriculture, Beltsville, MD, 2004. US Department of Agriculture, 2015
65. A. Crozier M. E. J. Lean M. S. McDonald C. Black Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuces, and celery J. Agric. Food Chem. 1997 45 590 595
66. V. Neveu J. Perez-Jimenez F. Vos V. Crespy C. L. du L. Mennen C. Knox R. Eisner J. Cruz D. Wishart A. Scalbert Phenol-Explorer: an online comprehensive database on polyphenol contents in foods Database 2010 2010 bap024
67. K. Karatzi K. Stamatelopoulos M. Lykka P. Mantzouratou S. Skalidi N. Zakopoulos C. Papamichael L. S. Sidossis Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men Eur. J. Prev. Cardiol. 2013 20 202 208
68. G. Lippi M. Franchini E. J. Favaloro G. Targher Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox" Semin. Thromb. Hemost. 2010 36 59 70
69. M. A. Rodríguez-Delgado G. González-Hernández J. E. Conde-González J. P. Pérez-Trujillo Principal component analysis of the polyphenol content in young red wines Food Chem. 2002 78 523 532
70. F. Shahidi and M. Naczk, Wine, in Food phenolics: sources, chemistry, effects, applications, Technomic Publishing Co., Pennsylvania, 2013, pp. 136-148
71. M. Iriti Editorial: introduction to polyphenols, plant chemicals for human health Mini. Rev. Med. Chem. 2011 11 1183 1185
72. J. Kanner E. Frankel R. Granit B. German J. E. Kinsella Natural antioxidants in grapes and wine J. Agric. Food Chem. 1994 42 64 69
73. L. Liu Y. Wang K. S. Lam A. Xu Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications Endocr. Metab. Immune Disord. Drug Targets 2008 8 89 98
74. A. Y. Sun A. Simonyi G. Y. Sun The "French Paradox" and beyond: neuroprotective effects of polyphenols Free Radic. Biol. Med. 2002 32 314 318
75. F. Visioli A. Davalos Polyphenols and cardiovascular disease: a critical summary of the evidence Mini. Rev. Med. Chem. 2011 11 1186 1190
76. W. Yi J. Fischer C. C. Akoh Study of anticancer activities of muscadine grape phenolics in vitro J. Agric. Food Chem. 2005 53 8804 8812
77. M. L. Ovaskainen R. Torronen J. M. Koponen H. Sinkko J. Hellstrom H. Reinivuo P. Mattila Dietary intake and major food sources of polyphenols in Finnish adults J. Nutr. 2008 138 562 566
78. F. Saura-Calixto I. Goni Definition of the Mediterranean diet based on bioactive compounds Crit. Rev. Food Sci. Nutr. 2009 49 145 152
79. G. Grosso U. Stepaniak R. Topor-Madry K. Szafraniec A. Pajak Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study Nutrition 2014 30 1398 1403
80. R. A. Kemperman S. Bolca L. C. Roger E. E. Vaughan Novel approaches for analysing gut microbes and dietary polyphenols: challenges and opportunities Microbiology 2010 156 3224 3231
81. G. Williamson C. Manach Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies Am. J. Clin. Nutr. 2005 81 243S 255S
82. P. C. Hollman M. B. Katan Absorption, metabolism and health effects of dietary flavonoids in man Biomed. Pharmacother. 1997 51 305 310
83. C. Manach A. Scalbert C. Morand C. Remesy L. Jimenez Polyphenols: food sources and bioavailability Am. J. Clin. Nutr. 2004 79 727 747
84. P. Ader B. Grenacher P. Langguth E. Scharrer S. Wolffram Cinnamate uptake by rat small intestine: transport kinetics and transepithelial transfer Exp. Physiol. 1996 81 943 955
85. J. W. Lampe Interindividual differences in response to plant-based diets: implications for cancer risk Am. J. Clin. Nutr. 2009 89 1553S 1557S
86. J. H. Moon R. Nakata S. Oshima T. Inakuma J. Terao Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000 279 R461 R467
87. T. Koga M. Meydani Effect of plasma metabolites of (+)-catechin and quercetin on monocyte adhesion to human aortic endothelial cells Am. J. Clin. Nutr. 2001 73 941 948
88. A. Padayachee G. Netzel M. Netzel L. Day D. Zabaras D. Mikkelsen M. J. Gidley Binding of polyphenols to plant cell wall analogues-Part 2: Phenolic acids Food Chem. 2012 135 2287 2292
89. R. Baker R. Cameron Clouds of Citrus juice and juice drink Food Technol. 1999 53 64 69
90. A. Gil-Izquierdo M. I. Gil F. Ferreres F. A. Tomas-Barberan In vitro availability of flavonoids and other phenolics in orange juice J. Agric. Food Chem. 2001 49 1035 1041
91. G. Mandalaria A. Tomaino G. T. Rich R. Lo Curto T. Arcoraci M. Martorana C. Bisignano A. Saija M. L. Parker K. W. Waldron M. S. J. Wickham Polyphenol and nutrient release from skin of almonds during simulated human digestion Food Chem. 2010 122 1083 1088
92. N. Ortega J. Reguant M. P. Romero A. Macia M. J. Motilva Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model J. Agric. Food Chem. 2009 57 5743 5749
93. F. Saura-Calixto Dietary fiber as a carrier of dietary antioxidants: an essential physiological function J. Agric. Food Chem. 2011 59 43 49
94. I. C. Arts P. C. Hollman Polyphenols and disease risk in epidemiologic studies Am. J. Clin. Nutr. 2005 81 317S 325S
95. O. K. Chun S. J. Chung W. O. Song Estimated dietary flavonoid intake and major food sources of U. S. adults J. Nutr. 2007 137 1244 1252
96. J. W. Erdman Jr. D. Balentine L. Arab G. Beecher J. T. Dwyer J. Folts J. Harnly P. Hollman C. L. Keen G. Mazza M. Messina A. Scalbert J. Vita G. Williamson J. Burrowes Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC J. Nutr. 2007 137 718S 737S
97. D. S. Malar K. P. Devi Dietary polyphenols for treatment of Alzheimer's disease-future research and development Curr. Pharm. Biotechnol. 2014 15 330 342
98. G. Williamson B. Holst Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction? Br. J. Nutr. 2008 99 Suppl. 3 S55 S58
99. V. Cheynier Polyphenols in foods are more complex than often thought Am. J. Clin. Nutr. 2005 81 223S 229S
100. A. Scalbert I. T. Johnson M. Saltmarsh Polyphenols: antioxidants and beyond Am. J. Clin. Nutr. 2005 81 215S 217S
101. U. Etxeberria A. Fernandez-Quintela F. I. Milagro L. Aguirre J. A. Martinez M. P. Portillo Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition J. Agric. Food Chem. 2013 61 9517 9533
102. A. Duda-Chodak T. Tarko P. Satora P. Sroka Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review Eur. J. Nutr. 2015 54 325 341
103. M. V. Selma J. C. Espin F. A. Tomas-Barberan Interaction between phenolics and gut microbiota: role in human health J. Agric. Food Chem. 2009 57 6485 6501
104. A. Matthies M. Blaut A. Braune Isolation of a human intestinal bacterium capable of daidzein and genistein conversion Appl. Environ. Microbiol. 2009 75 1740 1744
105. M. V. Selma D. Beltran R. Garcia-Villalba J. C. Espin F. A. Tomas-Barberan Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species Food Funct. 2014 5 1779 1784
106. A. Duda-Chodak The inhibitory effect of polyphenols on human gut microbiota J. Physiol. Pharmacol. 2012 63 497 503
107. J. S. Shin H. S. Chung Antibacterial activities of phenolic components from Camellia sinensis L. on pathogenic microorganisms J. Food Sci. Nutr. 2015 12 135 140
108. M. I. Queipo-Ortuno M. Boto-Ordonez M. Murri J. M. Gomez-Zumaquero M. Clemente-Postigo R. Estruch D. F. Cardona C. Andres-Lacueva F. J. Tinahones Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers Am. J. Clin. Nutr. 2012 95 1323 1334
109. H. C. Lee A. M. Jenner C. S. Low Y. K. Lee Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota Res. Microbiol. 2006 157 876 884
110. M. Massot-Cladera T. Perez-Berezo A. Franch M. Castell F. J. Perez-Cano Cocoa modulatory effect on rat faecal microbiota and colonic crosstalk Arch. Biochem. Biophys. 2012 527 105 112
111. S. Guglielmetti D. Fracassetti V. Taverniti B. C. Del S. Vendrame D. Klimis-Zacas S. Arioli P. Riso M. Porrini Differential modulation of human intestinal bifidobacterium populations after consumption of a wild blueberry (Vaccinium angustifolium) drink J. Agric. Food Chem. 2013 61 8134 8140
112. S. Vendrame S. Guglielmetti P. Riso S. Arioli D. Klimis-Zacas M. Porrini Six-week consumption of a wild blueberry powder drink increases bifidobacteria in the human gut J. Agric. Food Chem. 2011 59 12815 12820
113. C. Cueva F. Sanchez-Patan M. Monagas G. E. Walton G. R. Gibson P. J. Martin-Alvarez B. Bartolome M. V. Moreno-Arribas In vitro fermentation of grape seed flavan-3-ol fractions by human faecal microbiota: changes in microbial groups and phenolic metabolites FEMS Microbiol. Ecol. 2013 83 792 805
114. F. Sanchez-Patan C. Cueva M. Monagas G. E. Walton G. R. Gibson J. E. Quintanilla-Lopez R. Lebron-Aguilar P. J. Martin-Alvarez M. V. Moreno-Arribas B. Bartolome In vitro fermentation of a red wine extract by human gut microbiota: changes in microbial groups and formation of phenolic metabolites J. Agric. Food Chem. 2012 60 2136 2147
115. R. A. Kemperman G. Gross S. Mondot S. Possemiers M. Marzorati T. Van de Wiele J. Dore E. E. Vaughan Impact of polyphenols from black tea and red wine/grape juice on a gut model microbiome Food Res. Int. 2013 53 659 669
116. P. Dolara C. Luceri F. C. De A. P. Femia L. Giovannelli G. Caderni C. Cecchini S. Silvi C. Orpianesi A. Cresci Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats Mutat. Res. 2005 591 237 246
117. U. Etxeberria N. Arias N. Boque M. T. Macarulla M. P. Portillo J. A. Martinez F. I. Milagro Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats J. Nutr. Biochem. 2015 26 651 660
118. A. Cuervo C. G. Reyes-Gavilan P. Ruas-Madiedo P. Lopez A. Suarez M. Gueimonde S. Gonzalez Red Wine Consumption Is Associated with Fecal Microbiota and Malondialdehyde in a Human Population J. Am. Coll. Nutr. 2015 1 7
119. A. Cuervo A. Hevia P. Lopez A. Suarez B. Sanchez A. Margolles S. Gonzalez Association of polyphenols from oranges and apples with specific intestinal microorganisms in systemic lupus erythematosus patients Nutrients. 2015 7 1301 1317
120. A. Jimenez-Giron M. I. Queipo-Ortuno M. Boto-Ordonez I. Munoz-Gonzalez F. Sanchez-Patan M. Monagas P. J. Martin-Alvarez M. Murri F. J. Tinahones C. Andres-Lacueva B. Bartolome M. V. Moreno-Arribas Comparative study of microbial-derived phenolic metabolites in human feces after intake of gin, red wine, and dealcoholized red wine J. Agric. Food Chem. 2013 61 3909 3915
121. D. A. Camfield A. Scholey A. Pipingas R. Silberstein M. Kras K. Nolidin K. Wesnes M. Pase C. Stough Steady state visually evoked potential (SSVEP) topography changes associated with cocoa flavanol consumption Physiol. Behav. 2012 105 948 957
122. S. Baba N. Osakabe Y. Kato M. Natsume A. Yasuda T. Kido K. Fukuda Y. Muto K. Kondo Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans Am. J. Clin. Nutr. 2007 85 709 717
123. I. M. Petyaev P. Y. Dovgalevsky N. E. Chalyk V. Klochkov N. H. Kyle Reduction in blood pressure and serum lipids by lycosome formulation of dark chocolate and lycopene in prehypertension Food Sci. Nutr. 2014 2 744 750
124. K. Kondo R. Hirano A. Matsumoto O. Igarashi H. Itakura Inhibition of LDL oxidation by cocoa Lancet 1996 348 1514
125. D. Grassi S. Necozione C. Lippi G. Croce L. Valeri P. Pasqualetti G. Desideri J. B. Blumberg C. Ferri Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives Hypertension 2005 46 398 405
126. R. R. Holt S. A. Lazarus M. C. Sullards Q. Y. Zhu D. D. Schramm J. F. Hammerstone C. G. Fraga H. H. Schmitz C. L. Keen Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa Am. J. Clin. Nutr. 2002 76 798 804
127. H. Schroeter C. Heiss J. Balzer P. Kleinbongard C. L. Keen N. K. Hollenberg H. Sies C. Kwik-Uribe H. H. Schmitz M. Kelm (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans Proc. Natl. Acad. Sci. U. S. A. 2006 103 1024 1029
128. X. Tzounis A. Rodriguez-Mateos J. Vulevic G. R. Gibson C. Kwik-Uribe J. P. Spencer Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study Am. J. Clin. Nutr. 2011 93 62 72
129. I. R. Rowland A. K. Mallett A. Wise The effect of diet on the mammalian gut flora and its metabolic activities Crit. Rev. Toxicol. 1985 16 31 103
130. N. Hayek Chocolate, gut microbiota, and human health Front. Pharmacol. 2013 4 11
131. S. M. Chacko P. T. Thambi R. Kuttan I. Nishigaki Beneficial effects of green tea: a literature review Chin. Med. 2010 5 13
132. J. V. Higdon B. Frei Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions Crit. Rev. Food Sci. Nutr. 2003 43 89 143
133. M. N. Clifford J. J. van der Hooft A. Crozier Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols Am. J. Clin. Nutr. 2013 98 1619S 1630S
134. S. G. Parkar T. M. Trower D. E. Stevenson Fecal microbial metabolism of polyphenols and its effects on human gut microbiota Anaerobe 2013 23 12 19
135. J. S. Jin M. Touyama T. Hisada Y. Benno Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species Microbiol. Immunol. 2012 56 729 739
136. R. Rastmanesh High polyphenol, low probiotic diet for weight loss because of intestinal microbiota interaction Chem. Biol. Interact. 2011 189 1 8
137. T. Unno C. Osada Y. Motoo Y. Suzuki M. Kobayashi A. Nozawa Dietary tea catechins increase fecal energy in rats J. Nutr. Sci. Vitaminol. (Tokyo) 2009 55 447 451
138. L. Conterno F. Fava R. Viola K. M. Tuohy Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease? Genes Nutr. 2011 6 241 260
139. K. M. Tuohy L. Conterno M. Gasperotti R. Viola Up-regulating the human intestinal microbiome using whole plant foods, polyphenols, and/or fiber J. Agric. Food Chem. 2012 60 8776 8782
140. H. S. Oz T. Chen W. J. de Villiers Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models Front. Immunol. 2013 4 132
141. C. Duggan J. Gannon W. A. Walker Protective nutrients and functional foods for the gastrointestinal tract Am. J. Clin. Nutr. 2002 75 789 808
142. S. H. Ko S. W. Choi S. K. Ye B. L. Cho H. S. Kim M. H. Chung Comparison of the antioxidant activities of nine different fruits in human plasma J. Med. Food 2005 8 41 46
143. F. Maffei A. Tarozzi F. Carbone A. Marchesi S. Hrelia C. Angeloni G. C. Forti P. Hrelia Relevance of apple consumption for protection against oxidative damage induced by hydrogen peroxide in human lymphocytes Br. J. Nutr. 2007 97 921 927
144. L. Yuan L. Meng W. Ma Z. Xiao X. Zhu J. F. Feng H. Yu R. Xiao Impact of apple and grape juice consumption on the antioxidant status in healthy subjects Int. J. Food Sci. Nutr. 2011 62 844 850
145. O. La-Ongkham M. Nakphaichit V. Leelavatcharamas S. Keawsompong S. Nitisinprasert Distinct gut microbiota of healthy children from two different geographic regions of Thailand Arch. Microbiol. 2015 197 561 573
146. J. Boyer R. H. Liu Apple phytochemicals and their health benefits Nutr. J. 2004 3 5
147. D. A. Hyson A comprehensive review of apples and apple components and their relationship to human health Adv. Nutr. 2011 2 408 420
148. K. Wolfe X. Wu R. H. Liu Antioxidant activity of apple peels J. Agric. Food Chem. 2003 51 609 614
149. C. Manach J. Hubert R. Llorach A. Scalbert The complex links between dietary phytochemicals and human health deciphered by metabolomics Mol. Nutr. Food Res. 2009 53 1303 1315
150. B. Romier Y. J. Schneider Y. Larondelle A. During Dietary polyphenols can modulate the intestinal inflammatory response Nutr. Rev. 2009 67 363 378
151. W. Russell G. Duthie Plant secondary metabolites and gut health: the case for phenolic acids Proc. Nutr. Soc. 2011 70 389 396
152. P. Konieczna C. A. Akdis E. M. Quigley F. Shanahan L. O'Mahony Portrait of an immunoregulatory Bifidobacterium Gut Microbes 2012 3 261 266
153. S. Sembries G. Dongowski K. Mehrlander F. Will H. Dietrich Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats J. Agric. Food Chem. 2006 54 10269 10280
154. K. Daly A. C. Darby N. Hall A. Nau D. Bravo S. P. Shirazi-Beechey Dietary supplementation with lactose or artificial sweetener enhances swine gut Lactobacillus population abundance Br. J. Nutr. 2014 111 Suppl. 1 S30 S35
155. A. Cuervo L. Valdes N. Salazar C. G. de los Reyes-Gavilan P. Ruas-Madiedo M. Gueimonde S. Gonzalez Pilot study of diet and microbiota: interactive associations of fibers and polyphenols with human intestinal bacteria J. Agric. Food Chem. 2014 62 5330 5336
156. P. Vitaglione I. Mennella R. Ferracane A. A. Rivellese R. Giacco D. Ercolini S. M. Gibbons S. A. La J. A. Gilbert S. Jonnalagadda F. Thielecke M. A. Gallo L. Scalfi V. Fogliano Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: role of polyphenols bound to cereal dietary fiber Am. J. Clin. Nutr. 2015 101 251 261
157. A. Cuervo S. Arboleya M. Gueimonde S. Gonzalez Microbiota modulation by diet in humans. Prebiotics, fibres and other compounds Agro Food Ind. Hi Tech. 2012 23 6 9
158. N. Salazar P. Lopez L. Valdes A. Margolles A. Suarez A. M. Patterson A. Cuervo C. G. de los Reyes-Gavilan P. Ruas-Madiedo S. Gonzalez M. Gueimonde Microbial targets for the development of functional foods accordingly with nutritional and immune parameters altered in the elderly J. Am. Coll. Nutr. 2013 32 399 406
159. M. L. McCullough J. J. Peterson R. Patel P. F. Jacques R. Shah J. T. Dwyer Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults Am. J. Clin. Nutr. 2012 95 454 464
160. K. D. Setchell C. Clerici Equol: history, chemistry, and formation J. Nutr. 2010 140 1355S 1362S
161. D. J. van E. E. Vaughan D. M. Jacobs R. A. Kemperman E. J. van Velzen G. Gross L. C. Roger S. Possemiers A. K. Smilde J. Dore J. A. Westerhuis T. Van de Wiele Metabolic fate of polyphenols in the human superorganism Proc. Natl. Acad. Sci. U. S. A. 2011 108 Suppl. 1 4531 4538
162. G. Galati P. J. O'Brien Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties Free Radic. Biol. Med. 2004 37 287 303
163. D. G. Bailey J. Malcolm O. Arnold J. D. Spence Grapefruit juice-drug interactions Br. J. Clin. Pharmacol. 1998 46 101 110
164. B. Cerda F. A. Tomas-Barberan J. C. Espin Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability J. Agric. Food Chem. 2005 53 227 235
165. G. Gross D. M. Jacobs S. Peters S. Possemiers D. J. van E. E. Vaughan T. Van de Wiele In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability J. Agric. Food Chem. 2010 58 10236 10246