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Volumn 12, Issue 5, 2012, Pages 611-622

Defining a healthy human gut microbiome: Current concepts, future directions, and clinical applications

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PREBIOTIC AGENT; PROBIOTIC AGENT;

EID: 84869188027     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.10.012     Document Type: Review
Times cited : (612)

References (87)
  • 1
    • 0026549865 scopus 로고
    • Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis
    • P. Andrews Chronic constipation reversed by restoration of bowel flora. A case and a hypothesis Eur. J. Gastroenterol. Hepatol. 4 1992 245 247
    • (1992) Eur. J. Gastroenterol. Hepatol. , vol.4 , pp. 245-247
    • Andrews, P.1
  • 4
  • 6
    • 29244489093 scopus 로고    scopus 로고
    • Towards a dynamic definition of health and disease
    • J. Bircher Towards a dynamic definition of health and disease Med. Health Care Philos. 8 2005 335 341
    • (2005) Med. Health Care Philos. , vol.8 , pp. 335-341
    • Bircher, J.1
  • 7
    • 70449703996 scopus 로고    scopus 로고
    • What are the consequences of the disappearing human microbiota?
    • M.J. Blaser, and S. Falkow What are the consequences of the disappearing human microbiota? Nat. Rev. Microbiol. 7 2009 887 894
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 887-894
    • Blaser, M.J.1    Falkow, S.2
  • 9
    • 84862093037 scopus 로고    scopus 로고
    • Prebiotics and the health benefits of fiber: Current regulatory status, future research, and goals
    • A.M. Brownawell, W. Caers, G.R. Gibson, C.W. Kendall, K.D. Lewis, Y. Ringel, and J.L. Slavin Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals J. Nutr. 142 2012 962 974
    • (2012) J. Nutr. , vol.142 , pp. 962-974
    • Brownawell, A.M.1    Caers, W.2    Gibson, G.R.3    Kendall, C.W.4    Lewis, K.D.5    Ringel, Y.6    Slavin, J.L.7
  • 10
    • 48249125862 scopus 로고    scopus 로고
    • Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
    • P.D. Cani, R. Bibiloni, C. Knauf, A. Waget, A.M. Neyrinck, N.M. Delzenne, and R. Burcelin Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 57 2008 1470 1481
    • (2008) Diabetes , vol.57 , pp. 1470-1481
    • Cani, P.D.1    Bibiloni, R.2    Knauf, C.3    Waget, A.4    Neyrinck, A.M.5    Delzenne, N.M.6    Burcelin, R.7
  • 12
    • 84861185968 scopus 로고    scopus 로고
    • Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome
    • e248
    • I.M. Carroll, T. Ringel-Kulka, J.P. Siddle, and Y. Ringel Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome Neurogastroenterol. Motil. 24 2012 521 530 e248
    • (2012) Neurogastroenterol. Motil. , vol.24 , pp. 521-530
    • Carroll, I.M.1    Ringel-Kulka, T.2    Siddle, J.P.3    Ringel, Y.4
  • 14
    • 72949091232 scopus 로고    scopus 로고
    • Bacterial community variation in human body habitats across space and time
    • E.K. Costello, C.L. Lauber, M. Hamady, N. Fierer, J.I. Gordon, and R. Knight Bacterial community variation in human body habitats across space and time Science 326 2009 1694 1697
    • (2009) Science , vol.326 , pp. 1694-1697
    • Costello, E.K.1    Lauber, C.L.2    Hamady, M.3    Fierer, N.4    Gordon, J.I.5    Knight, R.6
  • 16
    • 79952756960 scopus 로고    scopus 로고
    • Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
    • L. Dethlefsen, and D.A. Relman Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation Proc. Natl. Acad. Sci. USA 108 Suppl 1 2011 4554 4561
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , Issue.SUPPL. 1 , pp. 4554-4561
    • Dethlefsen, L.1    Relman, D.A.2
  • 18
    • 0001412472 scopus 로고
    • Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis
    • B. Eiseman, W. Silen, G.S. Bascom, and A.J. Kauvar Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis Surgery 44 1958 854 859
    • (1958) Surgery , vol.44 , pp. 854-859
    • Eiseman, B.1    Silen, W.2    Bascom, G.S.3    Kauvar, A.J.4
  • 21
    • 0031692488 scopus 로고    scopus 로고
    • Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes
    • A.H. Franks, H.J. Harmsen, G.C. Raangs, G.J. Jansen, F. Schut, and G.W. Welling Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes Appl. Environ. Microbiol. 64 1998 3336 3345
    • (1998) Appl. Environ. Microbiol. , vol.64 , pp. 3336-3345
    • Franks, A.H.1    Harmsen, H.J.2    Raangs, G.C.3    Jansen, G.J.4    Schut, F.5    Welling, G.W.6
  • 24
    • 12744273405 scopus 로고    scopus 로고
    • Dietary modulation of the human colonic microbiota: Updating the concept of prebiotics
    • G.R. Gibson, H.M. Probert, J.V. Loo, R.A. Rastall, and M.B. Roberfroid Dietary modulation of the human colonic microbiota: updating the concept of prebiotics Nutr. Res. Rev. 17 2004 259 275
    • (2004) Nutr. Res. Rev. , vol.17 , pp. 259-275
    • Gibson, G.R.1    Probert, H.M.2    Loo, J.V.3    Rastall, R.A.4    Roberfroid, M.B.5
  • 26
    • 80054736926 scopus 로고    scopus 로고
    • Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection
    • E. Gough, H. Shaikh, and A.R. Manges Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection Clin. Infect. Dis. 53 2011 994 1002
    • (2011) Clin. Infect. Dis. , vol.53 , pp. 994-1002
    • Gough, E.1    Shaikh, H.2    Manges, A.R.3
  • 31
    • 0002054228 scopus 로고
    • Resilience and stability of ecological systems
    • C.S. Holling Resilience and stability of ecological systems Annu. Rev. Ecol. Syst. 4 1973 1 23
    • (1973) Annu. Rev. Ecol. Syst. , vol.4 , pp. 1-23
    • Holling, C.S.1
  • 32
    • 84859389254 scopus 로고    scopus 로고
    • The microbiome in infectious disease and inflammation
    • K. Honda, and D.R. Littman The microbiome in infectious disease and inflammation Annu. Rev. Immunol. 30 2012 759 795
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 759-795
    • Honda, K.1    Littman, D.R.2
  • 33
    • 84862286169 scopus 로고    scopus 로고
    • A framework for human microbiome research
    • Human Microbiome Project Consortium
    • Human Microbiome Project Consortium A framework for human microbiome research Nature 486 2012 215 221
    • (2012) Nature , vol.486 , pp. 215-221
  • 34
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium
    • Human Microbiome Project Consortium Structure, function and diversity of the healthy human microbiome Nature 486 2012 207 214
    • (2012) Nature , vol.486 , pp. 207-214
  • 35
    • 78651252504 scopus 로고    scopus 로고
    • Antibiotic use and inflammatory bowel diseases in childhood
    • A. Hviid, H. Svanström, and M. Frisch Antibiotic use and inflammatory bowel diseases in childhood Gut 60 2011 49 54
    • (2011) Gut , vol.60 , pp. 49-54
    • Hviid, A.1    Svanström, H.2    Frisch, M.3
  • 36
    • 79960854386 scopus 로고    scopus 로고
    • Intestinal microbiota in healthy adults: Temporal analysis reveals individual and common core and relation to intestinal symptoms
    • J. Jalanka-Tuovinen, A. Salonen, J. Nikkilä, O. Immonen, R. Kekkonen, L. Lahti, A. Palva, and W.M. de Vos Intestinal microbiota in healthy adults: temporal analysis reveals individual and common core and relation to intestinal symptoms PLoS ONE 6 2011 e23035
    • (2011) PLoS ONE , vol.6 , pp. 23035
    • Jalanka-Tuovinen, J.1    Salonen, A.2    Nikkilä, J.3    Immonen, O.4    Kekkonen, R.5    Lahti, L.6    Palva, A.7    De Vos, W.M.8
  • 37
    • 34248152283 scopus 로고    scopus 로고
    • Long-term ecological impacts of antibiotic administration on the human intestinal microbiota
    • C. Jernberg, S. Löfmark, C. Edlund, and J.K. Jansson Long-term ecological impacts of antibiotic administration on the human intestinal microbiota ISME J. 1 2007 56 66
    • (2007) ISME J. , vol.1 , pp. 56-66
    • Jernberg, C.1    Löfmark, S.2    Edlund, C.3    Jansson, J.K.4
  • 38
    • 35448965272 scopus 로고    scopus 로고
    • Transfer of an ampicillin resistance gene between two Escherichia coli strains in the bowel microbiota of an infant treated with antibiotics
    • N. Karami, A. Martner, V.I. Enne, S. Swerkersson, I. Adlerberth, and A.E. Wold Transfer of an ampicillin resistance gene between two Escherichia coli strains in the bowel microbiota of an infant treated with antibiotics J. Antimicrob. Chemother. 60 2007 1142 1145
    • (2007) J. Antimicrob. Chemother. , vol.60 , pp. 1142-1145
    • Karami, N.1    Martner, A.2    Enne, V.I.3    Swerkersson, S.4    Adlerberth, I.5    Wold, A.E.6
  • 40
    • 77951700268 scopus 로고    scopus 로고
    • Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea
    • A. Khoruts, J. Dicksved, J.K. Jansson, and M.J. Sadowsky Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea J. Clin. Gastroenterol. 44 2010 354 360
    • (2010) J. Clin. Gastroenterol. , vol.44 , pp. 354-360
    • Khoruts, A.1    Dicksved, J.2    Jansson, J.K.3    Sadowsky, M.J.4
  • 41
    • 84856866840 scopus 로고    scopus 로고
    • Stress and the gut: Pathophysiology, clinical consequences, diagnostic approach and treatment options
    • P.C. Konturek, T. Brzozowski, and S.J. Konturek Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options J. Physiol. Pharmacol. 62 2011 591 599
    • (2011) J. Physiol. Pharmacol. , vol.62 , pp. 591-599
    • Konturek, P.C.1    Brzozowski, T.2    Konturek, S.J.3
  • 45
    • 84861001724 scopus 로고    scopus 로고
    • Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition
    • E. Li, C.M. Hamm, A.S. Gulati, R.B. Sartor, H. Chen, X. Wu, T. Zhang, F.J. Rohlf, W. Zhu, and C. Gu Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition PLoS ONE 7 2012 e26284
    • (2012) PLoS ONE , vol.7 , pp. 26284
    • Li, E.1    Hamm, C.M.2    Gulati, A.S.3    Sartor, R.B.4    Chen, H.5    Wu, X.6    Zhang, T.7    Rohlf, F.J.8    Zhu, W.9    Gu, C.10
  • 52
    • 75349111165 scopus 로고    scopus 로고
    • Probiotic bacteria influence the composition and function of the intestinal microbiota
    • P.W. O'Toole, and J.C. Cooney Probiotic bacteria influence the composition and function of the intestinal microbiota Interdiscip. Perspect. Infect. Dis. 2008 2008 175285
    • (2008) Interdiscip. Perspect. Infect. Dis. , vol.2008 , pp. 175285
    • O'Toole, P.W.1    Cooney, J.C.2
  • 57
    • 84859161631 scopus 로고    scopus 로고
    • The potential for probiotic manipulation of the gastrointestinal microbiome
    • M. Rauch, and S.V. Lynch The potential for probiotic manipulation of the gastrointestinal microbiome Curr. Opin. Biotechnol. 23 2012 192 201
    • (2012) Curr. Opin. Biotechnol. , vol.23 , pp. 192-201
    • Rauch, M.1    Lynch, S.V.2
  • 58
    • 80051717743 scopus 로고    scopus 로고
    • The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection
    • A.E. Reeves, C.M. Theriot, I.L. Bergin, G.B. Huffnagle, P.D. Schloss, and V.B. Young The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection Gut Microbes 2 2011 145 158
    • (2011) Gut Microbes , vol.2 , pp. 145-158
    • Reeves, A.E.1    Theriot, C.M.2    Bergin, I.L.3    Huffnagle, G.B.4    Schloss, P.D.5    Young, V.B.6
  • 59
    • 68649111410 scopus 로고    scopus 로고
    • Alterations in the intestinal microbiota and functional bowel symptoms
    • vii
    • Y. Ringel, and I.M. Carroll Alterations in the intestinal microbiota and functional bowel symptoms Gastrointest. Endosc. Clin. N. Am. 19 2009 141 150 vii
    • (2009) Gastrointest. Endosc. Clin. N. Am. , vol.19 , pp. 141-150
    • Ringel, Y.1    Carroll, I.M.2
  • 60
    • 84869151098 scopus 로고    scopus 로고
    • Probiotics and Gastrointestinal Disorders
    • Y. Ringel, E. Quigley, and H. Lin Probiotics and Gastrointestinal Disorders Am. J. Gastroenterol. Suppl 1 2012 34 40
    • (2012) Am. J. Gastroenterol. , Issue.SUPPL. 1 , pp. 34-40
    • Ringel, Y.1    Quigley, E.2    Lin, H.3
  • 61
    • 78649693004 scopus 로고    scopus 로고
    • Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis
    • R.B. Sartor Genetics and environmental interactions shape the intestinal microbiome to promote inflammatory bowel disease versus mucosal homeostasis Gastroenterology 139 2010 1816 1819
    • (2010) Gastroenterology , vol.139 , pp. 1816-1819
    • Sartor, R.B.1
  • 62
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • R.B. Sartor Microbial influences in inflammatory bowel diseases Gastroenterology 134 2008 577 594
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 64
    • 80052628623 scopus 로고    scopus 로고
    • Toward an efficient method of identifying core genes for evolutionary and functional microbial phylogenies
    • N. Segata, and C. Huttenhower Toward an efficient method of identifying core genes for evolutionary and functional microbial phylogenies PLoS ONE 6 2011 e24704
    • (2011) PLoS ONE , vol.6 , pp. 24704
    • Segata, N.1    Huttenhower, C.2
  • 66
    • 34250375140 scopus 로고    scopus 로고
    • Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease
    • S. Sepehri, R. Kotlowski, C.N. Bernstein, and D.O. Krause Microbial diversity of inflamed and noninflamed gut biopsy tissues in inflammatory bowel disease Inflamm. Bowel Dis. 13 2007 675 683
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 675-683
    • Sepehri, S.1    Kotlowski, R.2    Bernstein, C.N.3    Krause, D.O.4
  • 67
    • 70449485061 scopus 로고    scopus 로고
    • Targeted therapies in inflammatory bowel disease
    • B. Siegmund Targeted therapies in inflammatory bowel disease Dig. Dis. 27 2009 465 469
    • (2009) Dig. Dis. , vol.27 , pp. 465-469
    • Siegmund, B.1
  • 69
    • 69549086653 scopus 로고    scopus 로고
    • Functional characterization of the antibiotic resistance reservoir in the human microflora
    • M.O.A. Sommer, G. Dantas, and G.M. Church Functional characterization of the antibiotic resistance reservoir in the human microflora Science 325 2009 1128 1131
    • (2009) Science , vol.325 , pp. 1128-1131
    • Sommer, M.O.A.1    Dantas, G.2    Church, G.M.3
  • 70
    • 77953901767 scopus 로고    scopus 로고
    • Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations
    • E.D. Sonnenburg, H. Zheng, P. Joglekar, S.K. Higginbottom, S.J. Firbank, D.N. Bolam, and J.L. Sonnenburg Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations Cell 141 2010 1241 1252
    • (2010) Cell , vol.141 , pp. 1241-1252
    • Sonnenburg, E.D.1    Zheng, H.2    Joglekar, P.3    Higginbottom, S.K.4    Firbank, S.J.5    Bolam, D.N.6    Sonnenburg, J.L.7
  • 71
    • 79952748287 scopus 로고    scopus 로고
    • Unravelling the effects of the environment and host genotype on the gut microbiome
    • A. Spor, O. Koren, and R. Ley Unravelling the effects of the environment and host genotype on the gut microbiome Nat. Rev. Microbiol. 9 2011 279 290
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 279-290
    • Spor, A.1    Koren, O.2    Ley, R.3
  • 73
    • 41849127118 scopus 로고    scopus 로고
    • Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome
    • P.J. Turnbaugh, F. Bäckhed, L. Fulton, and J.I. Gordon Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome Cell Host Microbe 3 2008 213 223
    • (2008) Cell Host Microbe , vol.3 , pp. 213-223
    • Turnbaugh, P.J.1    Bäckhed, F.2    Fulton, L.3    Gordon, J.I.4
  • 75
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 2006 1027 1031
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 76
    • 80053462850 scopus 로고    scopus 로고
    • Metagenomics and personalized medicine
    • H.W. Virgin, and J.A. Todd Metagenomics and personalized medicine Cell 147 2011 44 56
    • (2011) Cell , vol.147 , pp. 44-56
    • Virgin, H.W.1    Todd, J.A.2
  • 79
    • 79952768866 scopus 로고    scopus 로고
    • Shifting the balance: Antibiotic effects on host-microbiota mutualism
    • B.P. Willing, S.L. Russell, and B.B. Finlay Shifting the balance: antibiotic effects on host-microbiota mutualism Nat. Rev. Microbiol. 9 2011 233 243
    • (2011) Nat. Rev. Microbiol. , vol.9 , pp. 233-243
    • Willing, B.P.1    Russell, S.L.2    Finlay, B.B.3
  • 85
    • 84855269004 scopus 로고    scopus 로고
    • Studying the enteric microbiome in inflammatory bowel diseases: Getting through the growing pains and moving forward
    • V.B. Young, S.A. Kahn, T.M. Schmidt, and E.B. Chang Studying the enteric microbiome in inflammatory bowel diseases: getting through the growing pains and moving forward Front Microbiol. 2 2011 144
    • (2011) Front Microbiol. , vol.2 , pp. 144
    • Young, V.B.1    Kahn, S.A.2    Schmidt, T.M.3    Chang, E.B.4
  • 86
    • 0031684010 scopus 로고    scopus 로고
    • Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria
    • E.G. Zoetendal, A.D. Akkermans, and W.M. De Vos Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria Appl. Environ. Microbiol. 64 1998 3854 3859
    • (1998) Appl. Environ. Microbiol. , vol.64 , pp. 3854-3859
    • Zoetendal, E.G.1    Akkermans, A.D.2    De Vos, W.M.3


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