메뉴 건너뛰기




Volumn 50, Issue 3, 2016, Pages 312-332

OX40, OX40L and Autoimmunity: a Comprehensive Review

Author keywords

Animal models; Immunoregulation; T cells; T regulatory cells; TNF receptors

Indexed keywords

CD134 ANTIGEN; OX40 LIGAND; PROTEIN BINDING;

EID: 84937894061     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-015-8498-3     Document Type: Review
Times cited : (204)

References (173)
  • 1
    • 0035797568 scopus 로고    scopus 로고
    • Autoimmune diseases
    • COI: 1:CAS:528:DC%2BD3MXmtVGqs7c%3D, PID: 11484692
    • Davidson A, Diamond B (2001) Autoimmune diseases. N Engl J Med 345(5):340–350. doi:10.1056/NEJM200108023450506
    • (2001) N Engl J Med , vol.345 , Issue.5 , pp. 340-350
    • Davidson, A.1    Diamond, B.2
  • 2
    • 77649239391 scopus 로고    scopus 로고
    • Definition of human autoimmunity — autoantibodies versus autoimmune disease
    • COI: 1:CAS:528:DC%2BC3cXhtVyltrjI, PID: 19963079
    • Lleo A, Invernizzi P, Gao B, Podda M, Gershwin ME (2010) Definition of human autoimmunity — autoantibodies versus autoimmune disease. Autoimmun Rev 9(5):A259–A266. doi:10.1016/j.autrev.2009.12.002
    • (2010) Autoimmun Rev , vol.9 , Issue.5 , pp. A259-A266
    • Lleo, A.1    Invernizzi, P.2    Gao, B.3    Podda, M.4    Gershwin, M.E.5
  • 3
    • 0141819043 scopus 로고    scopus 로고
    • The epidemiology of autoimmune diseases
    • PID: 12848952
    • Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2(3):119–125
    • (2003) Autoimmun Rev , vol.2 , Issue.3 , pp. 119-125
    • Cooper, G.S.1    Stroehla, B.C.2
  • 4
    • 0023503073 scopus 로고
    • Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
    • COI: 1:CAS:528:DyaL1cXjs1Siuw%3D%3D, PID: 2828930
    • Paterson DJ, Jefferies WA, Green JR, Brandon MR, Corthesy P, Puklavec M, Williams AF (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol Immunol 24(12):1281–1290
    • (1987) Mol Immunol , vol.24 , Issue.12 , pp. 1281-1290
    • Paterson, D.J.1    Jefferies, W.A.2    Green, J.R.3    Brandon, M.R.4    Corthesy, P.5    Puklavec, M.6    Williams, A.F.7
  • 5
    • 0025320534 scopus 로고
    • Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor
    • COI: 1:CAS:528:DyaK3cXkslKjsLs%3D, PID: 2157591
    • Mallett S, Fossum S, Barclay AN (1990) Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor. EMBO J 9(4):1063–1068
    • (1990) EMBO J , vol.9 , Issue.4 , pp. 1063-1068
    • Mallett, S.1    Fossum, S.2    Barclay, A.N.3
  • 6
    • 0028227874 scopus 로고
    • Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
    • COI: 1:CAS:528:DyaK2cXlsFGjuro%3D, PID: 7913952
    • Godfrey WR, Fagnoni FF, Harara MA, Buck D, Engleman EG (1994) Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J Exp Med 180(2):757–762
    • (1994) J Exp Med , vol.180 , Issue.2 , pp. 757-762
    • Godfrey, W.R.1    Fagnoni, F.F.2    Harara, M.A.3    Buck, D.4    Engleman, E.G.5
  • 8
    • 65349112520 scopus 로고    scopus 로고
    • The significance of OX40 and OX40L to T-cell biology and immune disease
    • COI: 1:CAS:528:DC%2BD1MXhsFGls7nN, PID: 19426222
    • Croft M, So T, Duan W, Soroosh P (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 229(1):173–191. doi:10.1111/j.1600-065X.2009.00766.x
    • (2009) Immunol Rev , vol.229 , Issue.1 , pp. 173-191
    • Croft, M.1    So, T.2    Duan, W.3    Soroosh, P.4
  • 10
    • 1542514775 scopus 로고    scopus 로고
    • Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells
    • COI: 1:CAS:528:DC%2BD2cXhvVKjur8%3D, PID: 15004159
    • Takeda I, Ine S, Killeen N, Ndhlovu LC, Murata K, Satomi S, Sugamura K, Ishii N (2004) Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J Immunol 172(6):3580–3589
    • (2004) J Immunol , vol.172 , Issue.6 , pp. 3580-3589
    • Takeda, I.1    Ine, S.2    Killeen, N.3    Ndhlovu, L.C.4    Murata, K.5    Satomi, S.6    Sugamura, K.7    Ishii, N.8
  • 11
    • 44749089348 scopus 로고    scopus 로고
    • Immune regulation and control of regulatory T cells by OX40 and 4-1BB
    • COI: 1:CAS:528:DC%2BD1cXnt1aksrk%3D, PID: 18508403
    • So T, Lee SW, Croft M (2008) Immune regulation and control of regulatory T cells by OX40 and 4-1BB. Cytokine Growth Factor Rev 19(3–4):253–262. doi:10.1016/j.cytogfr.2008.04.003
    • (2008) Cytokine Growth Factor Rev , vol.19 , Issue.3-4 , pp. 253-262
    • So, T.1    Lee, S.W.2    Croft, M.3
  • 12
    • 0027383870 scopus 로고
    • Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions
    • COI: 1:CAS:528:DyaK2cXnsV2ksQ%3D%3D, PID: 8228223
    • Calderhead DM, Buhlmann JE, van den Eertwegh AJ, Claassen E, Noelle RJ, Fell HP (1993) Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J Immunol 151(10):5261–5271
    • (1993) J Immunol , vol.151 , Issue.10 , pp. 5261-5271
    • Calderhead, D.M.1    Buhlmann, J.E.2    van den Eertwegh, A.J.3    Claassen, E.4    Noelle, R.J.5    Fell, H.P.6
  • 13
    • 4043169040 scopus 로고    scopus 로고
    • 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine
    • COI: 1:CAS:528:DC%2BD2cXmslKgtbk%3D, PID: 15270726
    • Munks MW, Mourich DV, Mittler RS, Weinberg AD, Hill AB (2004) 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 112(4):559–566. doi:10.1111/j.1365-2567.2004.01917.x
    • (2004) Immunology , vol.112 , Issue.4 , pp. 559-566
    • Munks, M.W.1    Mourich, D.V.2    Mittler, R.S.3    Weinberg, A.D.4    Hill, A.B.5
  • 14
    • 65249117082 scopus 로고    scopus 로고
    • Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands
    • COI: 1:CAS:528:DC%2BD1MXjvFOjt7k%3D, PID: 19342632
    • Klinger M, Kim JK, Chmura SA, Barczak A, Erle DJ, Killeen N (2009) Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands. J Immunol 182(8):4581–4589. doi:10.4049/jimmunol.0900010
    • (2009) J Immunol , vol.182 , Issue.8 , pp. 4581-4589
    • Klinger, M.1    Kim, J.K.2    Chmura, S.A.3    Barczak, A.4    Erle, D.J.5    Killeen, N.6
  • 17
    • 4444381480 scopus 로고    scopus 로고
    • Functional expression of CD134 by neutrophils
    • COI: 1:CAS:528:DC%2BD2cXmslanu7k%3D, PID: 15259024
    • Baumann R, Yousefi S, Simon D, Russmann S, Mueller C, Simon HU (2004) Functional expression of CD134 by neutrophils. Eur J Immunol 34(8):2268–2275. doi:10.1002/eji.200424863
    • (2004) Eur J Immunol , vol.34 , Issue.8 , pp. 2268-2275
    • Baumann, R.1    Yousefi, S.2    Simon, D.3    Russmann, S.4    Mueller, C.5    Simon, H.U.6
  • 18
    • 0032753621 scopus 로고    scopus 로고
    • Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC Chemokine receptor 5-positive CD4 cells and germinal centers
    • COI: 1:CAS:528:DyaK1MXmslKis78%3D, PID: 10523609
    • Walker LS, Gulbranson-Judge A, Flynn S, Brocker T, Raykundalia C, Goodall M, Forster R, Lipp M, Lane P (1999) Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC Chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med 190(8):1115–1122
    • (1999) J Exp Med , vol.190 , Issue.8 , pp. 1115-1122
    • Walker, L.S.1    Gulbranson-Judge, A.2    Flynn, S.3    Brocker, T.4    Raykundalia, C.5    Goodall, M.6    Forster, R.7    Lipp, M.8    Lane, P.9
  • 19
    • 0034812971 scopus 로고    scopus 로고
    • OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    • COI: 1:CAS:528:DC%2BD3MXntlSntb8%3D, PID: 11567634
    • Rogers PR, Song J, Gramaglia I, Killeen N, Croft M (2001) OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15(3):445–455
    • (2001) Immunity , vol.15 , Issue.3 , pp. 445-455
    • Rogers, P.R.1    Song, J.2    Gramaglia, I.3    Killeen, N.4    Croft, M.5
  • 20
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • COI: 1:CAS:528:DC%2BC3cXlsVSmsrs%3D, PID: 20307208
    • Croft M (2010) Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol 28:57–78. doi:10.1146/annurev-immunol-030409-101243
    • (2010) Annu Rev Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 21
    • 84970981442 scopus 로고    scopus 로고
    • Novel regulation of CD8 T cell-specific OX40 expression via an IL-2 and JAK3-dependent mechanism
    • Redmond WL, Weinberg A (2008) Novel regulation of CD8 T cell-specific OX40 expression via an IL-2 and JAK3-dependent mechanism. FASEB J 22(1076):21
    • (2008) FASEB J , vol.22 , Issue.1076 , pp. 21
    • Redmond, W.L.1    Weinberg, A.2
  • 23
    • 0032534582 scopus 로고    scopus 로고
    • Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses
    • COI: 1:CAS:528:DyaK1cXotFWqsL0%3D, PID: 9862675
    • Gramaglia I, Weinberg AD, Lemon M, Croft M (1998) Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J Immunol 161(12):6510–6517
    • (1998) J Immunol , vol.161 , Issue.12 , pp. 6510-6517
    • Gramaglia, I.1    Weinberg, A.D.2    Lemon, M.3    Croft, M.4
  • 24
    • 84906327425 scopus 로고    scopus 로고
    • Establishment of a healthy human range for the whole blood “OX40” assay for the detection of antigen-specific CD4+ T cells by flow cytometry
    • PID: 24827553
    • Sadler R, Bateman EA, Heath V, Patel SY, Schwingshackl PP, Cullinane AC, Ayers L, Ferry BL (2014) Establishment of a healthy human range for the whole blood “OX40” assay for the detection of antigen-specific CD4+ T cells by flow cytometry. Cytometry B Clin Cytom 86(5):350–361. doi:10.1002/cyto.b.21165
    • (2014) Cytometry B Clin Cytom , vol.86 , Issue.5 , pp. 350-361
    • Sadler, R.1    Bateman, E.A.2    Heath, V.3    Patel, S.Y.4    Schwingshackl, P.P.5    Cullinane, A.C.6    Ayers, L.7    Ferry, B.L.8
  • 25
    • 34548649774 scopus 로고    scopus 로고
    • OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites
    • COI: 1:CAS:528:DC%2BD2sXnvVynu78%3D, PID: 17641042
    • Tone Y, Kojima Y, Furuuchi K, Brady M, Yashiro-Ohtani Y, Tykocinski ML, Tone M (2007) OX40 gene expression is up-regulated by chromatin remodeling in its promoter region containing Sp1/Sp3, YY1, and NF-kappa B binding sites. J Immunol 179(3):1760–1767
    • (2007) J Immunol , vol.179 , Issue.3 , pp. 1760-1767
    • Tone, Y.1    Kojima, Y.2    Furuuchi, K.3    Brady, M.4    Yashiro-Ohtani, Y.5    Tykocinski, M.L.6    Tone, M.7
  • 26
    • 0034993132 scopus 로고    scopus 로고
    • T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen
    • COI: 1:STN:280:DC%2BD3MzksVaqug%3D%3D, PID: 11407087
    • Giacomelli R, Passacantando A, Perricone R, Parzanese I, Rascente M, Minisola G, Tonietti G (2001) T lymphocytes in the synovial fluid of patients with active rheumatoid arthritis display CD134-OX40 surface antigen. Clin Exp Rheumatol 19(3):317–320
    • (2001) Clin Exp Rheumatol , vol.19 , Issue.3 , pp. 317-320
    • Giacomelli, R.1    Passacantando, A.2    Perricone, R.3    Parzanese, I.4    Rascente, M.5    Minisola, G.6    Tonietti, G.7
  • 27
    • 0033923293 scopus 로고    scopus 로고
    • The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn’s disease, ulcerative colitis)
    • COI: 1:CAS:528:DC%2BD3cXlsF2jtbY%3D
    • Stuber E, Buschenfeld A, Luttges J, Von Freier A, Arendt T, Folsch UR (2000) The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn’s disease, ulcerative colitis). Eur J Clin Investig 30(7):594–599
    • (2000) Eur J Clin Investig , vol.30 , Issue.7 , pp. 594-599
    • Stuber, E.1    Buschenfeld, A.2    Luttges, J.3    Von Freier, A.4    Arendt, T.5    Folsch, U.R.6
  • 29
    • 84906079941 scopus 로고    scopus 로고
    • OX40 controls effector CD4(+) T-cell expansion, not follicular T helper cell generation in acute Listeria infection
    • COI: 1:CAS:528:DC%2BC2cXot1ymt74%3D, PID: 24771127
    • Marriott CL, Mackley EC, Ferreira C, Veldhoen M, Yagita H, Withers DR (2014) OX40 controls effector CD4(+) T-cell expansion, not follicular T helper cell generation in acute Listeria infection. Eur J Immunol 44(8):2437–2447. doi:10.1002/eji.201344211
    • (2014) Eur J Immunol , vol.44 , Issue.8 , pp. 2437-2447
    • Marriott, C.L.1    Mackley, E.C.2    Ferreira, C.3    Veldhoen, M.4    Yagita, H.5    Withers, D.R.6
  • 31
    • 0037388954 scopus 로고    scopus 로고
    • Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo
    • COI: 1:CAS:528:DC%2BD3sXivFaisb4%3D, PID: 12668647
    • Linton PJ, Bautista B, Biederman E, Bradley ES, Harbertson J, Kondrack RM, Padrick RC, Bradley LM (2003) Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J Exp Med 197(7):875–883. doi:10.1084/jem.20021290
    • (2003) J Exp Med , vol.197 , Issue.7 , pp. 875-883
    • Linton, P.J.1    Bautista, B.2    Biederman, E.3    Bradley, E.S.4    Harbertson, J.5    Kondrack, R.M.6    Padrick, R.C.7    Bradley, L.M.8
  • 32
    • 78049524659 scopus 로고    scopus 로고
    • OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis
    • COI: 1:CAS:528:DC%2BC3cXht1Ggu7fM, PID: 20844189
    • Karulf M, Kelly A, Weinberg AD, Gold JA (2010) OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol 185(8):4856–4862. doi:10.4049/jimmunol.1000404
    • (2010) J Immunol , vol.185 , Issue.8 , pp. 4856-4862
    • Karulf, M.1    Kelly, A.2    Weinberg, A.D.3    Gold, J.A.4
  • 33
    • 35748935554 scopus 로고    scopus 로고
    • Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo
    • COI: 1:CAS:528:DC%2BD2sXpvFKlsrw%3D, PID: 17785785
    • Jenkins SJ, Perona-Wright G, Worsley AG, Ishii N, MacDonald AS (2007) Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol 179(6):3515–3523
    • (2007) J Immunol , vol.179 , Issue.6 , pp. 3515-3523
    • Jenkins, S.J.1    Perona-Wright, G.2    Worsley, A.G.3    Ishii, N.4    MacDonald, A.S.5
  • 34
    • 6344254397 scopus 로고    scopus 로고
    • T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells
    • COI: 1:CAS:528:DC%2BD2cXotFGjs78%3D, PID: 15470070
    • Kashiwakura J, Yokoi H, Saito H, Okayama Y (2004) T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells: comparison of gene expression profiles between human tonsillar and lung-cultured mast cells. J Immunol 173(8):5247–5257
    • (2004) J Immunol , vol.173 , Issue.8 , pp. 5247-5257
    • Kashiwakura, J.1    Yokoi, H.2    Saito, H.3    Okayama, Y.4
  • 35
    • 32044471903 scopus 로고    scopus 로고
    • Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF
    • COI: 1:CAS:528:DC%2BD28XpvV2mtQ%3D%3D, PID: 16455980
    • Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, Galli SJ (2006) Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol 176(4):2238–2248
    • (2006) J Immunol , vol.176 , Issue.4 , pp. 2238-2248
    • Nakae, S.1    Suto, H.2    Iikura, M.3    Kakurai, M.4    Sedgwick, J.D.5    Tsai, M.6    Galli, S.J.7
  • 36
    • 66749112939 scopus 로고    scopus 로고
    • CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle
    • COI: 1:STN:280:DC%2BD1MrgsFyksw%3D%3D, PID: 19220210
    • Krimmer DI, Loseli M, Hughes JM, Oliver BG, Moir LM, Hunt NH, Black JL, Burgess JK (2009) CD40 and OX40 ligand are differentially regulated on asthmatic airway smooth muscle. Allergy 64(7):1074–1082. doi:10.1111/j.1398-9995.2009.01959.x
    • (2009) Allergy , vol.64 , Issue.7 , pp. 1074-1082
    • Krimmer, D.I.1    Loseli, M.2    Hughes, J.M.3    Oliver, B.G.4    Moir, L.M.5    Hunt, N.H.6    Black, J.L.7    Burgess, J.K.8
  • 38
    • 0029895222 scopus 로고    scopus 로고
    • The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells
    • COI: 1:CAS:528:DyaK28XjtF2ksrg%3D, PID: 8642328
    • Imura A, Hori T, Imada K, Ishikawa T, Tanaka Y, Maeda M, Imamura S, Uchiyama T (1996) The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J Exp Med 183(5):2185–2195
    • (1996) J Exp Med , vol.183 , Issue.5 , pp. 2185-2195
    • Imura, A.1    Hori, T.2    Imada, K.3    Ishikawa, T.4    Tanaka, Y.5    Maeda, M.6    Imamura, S.7    Uchiyama, T.8
  • 39
    • 0036857838 scopus 로고    scopus 로고
    • Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice
    • COI: 1:CAS:528:DC%2BD38XovF2qsLs%3D, PID: 12555678
    • Sato T, Ishii N, Murata K, Kikuchi K, Nakagawa S, Ndhlovu LC, Sugamura K (2002) Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Eur J Immunol 32(11):3326–3335. doi:10.1002/1521-4141(200211)32:11<3326::aid-immu3326>3.0.co;2[-‐]9
    • (2002) Eur J Immunol , vol.32 , Issue.11 , pp. 3326-3335
    • Sato, T.1    Ishii, N.2    Murata, K.3    Kikuchi, K.4    Nakagawa, S.5    Ndhlovu, L.C.6    Sugamura, K.7
  • 40
    • 33747755806 scopus 로고    scopus 로고
    • Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15)
    • COI: 1:CAS:528:DC%2BD28Xot1Cjsb4%3D, PID: 16920944
    • Kim MY, Toellner K-M, White A, McConnell FM, Gaspal FMC, Parnell SM, Jenkinson E, Anderson G, Lane PJL (2006) Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15). J Immunol 177(5):3074–3081
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 3074-3081
    • Kim, M.Y.1    Toellner, K.-M.2    White, A.3    McConnell, F.M.4    Gaspal, F.M.C.5    Parnell, S.M.6    Jenkinson, E.7    Anderson, G.8    Lane, P.J.L.9
  • 41
    • 33646474850 scopus 로고    scopus 로고
    • OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity
    • COI: 1:CAS:528:DC%2BD28XktVWgtb0%3D, PID: 16670306
    • Soroosh P, Ine S, Sugamura K, Ishii N (2006) OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity. J Immunol 176(10):5975–5987
    • (2006) J Immunol , vol.176 , Issue.10 , pp. 5975-5987
    • Soroosh, P.1    Ine, S.2    Sugamura, K.3    Ishii, N.4
  • 42
    • 33645074150 scopus 로고    scopus 로고
    • Activated T cells express the OX40 ligand: requirements for induction and costimulatory function
    • COI: 1:CAS:528:DC%2BD28Xit1Siurc%3D, PID: 16423055
    • Mendel I, Shevach EM (2006) Activated T cells express the OX40 ligand: requirements for induction and costimulatory function. Immunology 117(2):196–204. doi:10.1111/j.1365-2567.2005.02279.x
    • (2006) Immunology , vol.117 , Issue.2 , pp. 196-204
    • Mendel, I.1    Shevach, E.M.2
  • 43
    • 47249140746 scopus 로고    scopus 로고
    • Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro
    • COI: 1:CAS:528:DC%2BD1cXoslenur4%3D, PID: 18485335
    • Wang Y, Li M, Song M, Xu X, Xiong J, Yang X, Tan J, Bai Y (2008) Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro. Cell Immunol 251(2):86–92. doi:10.1016/j.cellimm.2008.04.002
    • (2008) Cell Immunol , vol.251 , Issue.2 , pp. 86-92
    • Wang, Y.1    Li, M.2    Song, M.3    Xu, X.4    Xiong, J.5    Yang, X.6    Tan, J.7    Bai, Y.8
  • 44
    • 84856013855 scopus 로고    scopus 로고
    • Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression
    • COI: 1:CAS:528:DC%2BC38XjvVCjsw%3D%3D, PID: 22156349
    • Kurche JS, Haluszczak C, McWilliams JA, Sanchez PJ, Kedl RM (2012) Type I IFN-dependent T cell activation is mediated by IFN-dependent dendritic cell OX40 ligand expression and is independent of T cell IFNR expression. J Immunol 188(2):585–593. doi:10.4049/jimmunol.1102550
    • (2012) J Immunol , vol.188 , Issue.2 , pp. 585-593
    • Kurche, J.S.1    Haluszczak, C.2    McWilliams, J.A.3    Sanchez, P.J.4    Kedl, R.M.5
  • 45
    • 64049097483 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells
    • COI: 1:CAS:528:DC%2BD1MXjsFKhu70%3D, PID: 19029446
    • Krause P, Bruckner M, Uermosi C, Singer E, Groettrup M, Legler DF (2009) Prostaglandin E2 enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. Blood 113(11):2451–2460. doi:10.1182/blood-2008-05-157123
    • (2009) Blood , vol.113 , Issue.11 , pp. 2451-2460
    • Krause, P.1    Bruckner, M.2    Uermosi, C.3    Singer, E.4    Groettrup, M.5    Legler, D.F.6
  • 46
    • 27744510433 scopus 로고    scopus 로고
    • TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    • COI: 1:CAS:528:DC%2BD2MXht1Sntr%2FI, PID: 16275760
    • Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N, Qin FX, Yao Z, Cao W, Liu YJ (2005) TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 202(9):1213–1223. doi:10.1084/jem.20051135
    • (2005) J Exp Med , vol.202 , Issue.9 , pp. 1213-1223
    • Ito, T.1    Wang, Y.H.2    Duramad, O.3    Hori, T.4    Delespesse, G.J.5    Watanabe, N.6    Qin, F.X.7    Yao, Z.8    Cao, W.9    Liu, Y.J.10
  • 47
    • 33745304780 scopus 로고    scopus 로고
    • IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway
    • COI: 1:CAS:528:DC%2BD28XlvV2nsb0%3D, PID: 16785519
    • Maxwell JR, Yadav R, Rossi RJ, Ruby CE, Weinberg AD, Aguila HL, Vella AT (2006) IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway. J Immunol 177(1):234–245
    • (2006) J Immunol , vol.177 , Issue.1 , pp. 234-245
    • Maxwell, J.R.1    Yadav, R.2    Rossi, R.J.3    Ruby, C.E.4    Weinberg, A.D.5    Aguila, H.L.6    Vella, A.T.7
  • 48
    • 33846005516 scopus 로고    scopus 로고
    • Development of a sandwich ELISA for evaluating soluble OX40L (CD252) in human sera of different ages or with Graves’ disease
    • PID: 17166734
    • Wang Q, Chen Y, Xie F, Ge Y, Chen L, Wu H, Qu Q, Wang X, Zhang X (2006) Development of a sandwich ELISA for evaluating soluble OX40L (CD252) in human sera of different ages or with Graves’ disease. Cytokine 36(1–2):23–28. doi:10.1016/j.cyto.2006.10.006
    • (2006) Cytokine , vol.36 , Issue.1-2 , pp. 23-28
    • Wang, Q.1    Chen, Y.2    Xie, F.3    Ge, Y.4    Chen, L.5    Wu, H.6    Qu, Q.7    Wang, X.8    Zhang, X.9
  • 49
    • 0034665502 scopus 로고    scopus 로고
    • The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
    • COI: 1:CAS:528:DC%2BD3cXmslynsLc%3D, PID: 10975814
    • Gramaglia I, Jember A, Pippig SD, Weinberg AD, Killeen N, Croft M (2000) The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J Immunol 165(6):3043–3050
    • (2000) J Immunol , vol.165 , Issue.6 , pp. 3043-3050
    • Gramaglia, I.1    Jember, A.2    Pippig, S.D.3    Weinberg, A.D.4    Killeen, N.5    Croft, M.6
  • 50
    • 0033957423 scopus 로고    scopus 로고
    • Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion
    • COI: 1:CAS:528:DC%2BD3cXisVOk, PID: 10605000
    • Maxwell JR, Weinberg A, Prell RA, Vella AT (2000) Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J Immunol 164(1):107–112
    • (2000) J Immunol , vol.164 , Issue.1 , pp. 107-112
    • Maxwell, J.R.1    Weinberg, A.2    Prell, R.A.3    Vella, A.T.4
  • 51
    • 0032923689 scopus 로고    scopus 로고
    • CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles
    • COI: 1:CAS:528:DyaK1MXjtVOktb8%3D, PID: 10359115
    • Brocker T, Gulbranson-Judge A, Flynn S, Riedinger M, Raykundalia C, Lane P (1999) CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur J Immunol 29(5):1610–1616. doi:10.1002/(sici)1521-4141(199905)29:05<1610::aid-immu1610>3.0.co;2[-‐]8
    • (1999) Eur J Immunol , vol.29 , Issue.5 , pp. 1610-1616
    • Brocker, T.1    Gulbranson-Judge, A.2    Flynn, S.3    Riedinger, M.4    Raykundalia, C.5    Lane, P.6
  • 52
    • 0037108529 scopus 로고    scopus 로고
    • Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases
    • COI: 1:CAS:528:DC%2BD38XnvFGmsL8%3D, PID: 12370402
    • Murata K, Nose M, Ndhlovu LC, Sato T, Sugamura K, Ishii N (2002) Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol 169(8):4628–4636
    • (2002) J Immunol , vol.169 , Issue.8 , pp. 4628-4636
    • Murata, K.1    Nose, M.2    Ndhlovu, L.C.3    Sato, T.4    Sugamura, K.5    Ishii, N.6
  • 53
    • 17044427679 scopus 로고    scopus 로고
    • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand
    • COI: 1:CAS:528:DC%2BD2MXjtlSmu7o%3D, PID: 15618466
    • Dannull J, Nair S, Su Z, Boczkowski D, DeBeck C, Yang B, Gilboa E, Vieweg J (2005) Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. Blood 105(8):3206–3213. doi:10.1182/blood-2004-10-3944
    • (2005) Blood , vol.105 , Issue.8 , pp. 3206-3213
    • Dannull, J.1    Nair, S.2    Su, Z.3    Boczkowski, D.4    DeBeck, C.5    Yang, B.6    Gilboa, E.7    Vieweg, J.8
  • 54
    • 26444547693 scopus 로고    scopus 로고
    • Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA
    • COI: 1:CAS:528:DC%2BD2MXlslyjsb4%3D, PID: 15908450
    • Mestas J, Crampton SP, Hori T, Hughes CC (2005) Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. Int Immunol 17(6):737–747. doi:10.1093/intimm/dxh255
    • (2005) Int Immunol , vol.17 , Issue.6 , pp. 737-747
    • Mestas, J.1    Crampton, S.P.2    Hori, T.3    Hughes, C.C.4
  • 56
    • 78650202203 scopus 로고    scopus 로고
    • Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis
    • COI: 1:CAS:528:DC%2BC3MXis1Gqsg%3D%3D, PID: 20952591
    • Zhang Z, Zhong W, Hinrichs D, Wu X, Weinberg A, Hall M, Spencer D, Wegmann K, Rosenbaum JT (2010) Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis. AM J Pathol 177(6):2912–2920. doi:10.2353/ajpath.2010.100353
    • (2010) AM J Pathol , vol.177 , Issue.6 , pp. 2912-2920
    • Zhang, Z.1    Zhong, W.2    Hinrichs, D.3    Wu, X.4    Weinberg, A.5    Hall, M.6    Spencer, D.7    Wegmann, K.8    Rosenbaum, J.T.9
  • 57
    • 0032213337 scopus 로고    scopus 로고
    • OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors
    • COI: 1:CAS:528:DyaK1cXntFCqtrY%3D, PID: 9787171
    • Ohshima Y, Yang LP, Uchiyama T, Tanaka Y, Baum P, Sergerie M, Hermann P, Delespesse G (1998) OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 92(9):3338–3345
    • (1998) Blood , vol.92 , Issue.9 , pp. 3338-3345
    • Ohshima, Y.1    Yang, L.P.2    Uchiyama, T.3    Tanaka, Y.4    Baum, P.5    Sergerie, M.6    Hermann, P.7    Delespesse, G.8
  • 58
    • 0034881390 scopus 로고    scopus 로고
    • Signaling through OX40 (CD134) breaks peripheral T-cell tolerance
    • COI: 1:CAS:528:DC%2BD3MXlvVOksr4%3D, PID: 11479622
    • Bansal-Pakala P, Jember AG, Croft M (2001) Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat Med 7(8):907–912. doi:10.1038/90942
    • (2001) Nat Med , vol.7 , Issue.8 , pp. 907-912
    • Bansal-Pakala, P.1    Jember, A.G.2    Croft, M.3
  • 60
    • 77949654340 scopus 로고    scopus 로고
    • Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right
    • COI: 1:CAS:528:DC%2BD1MXht1WhsLjO, PID: 19786544
    • Ruby CE, Yates MA, Hirschhorn-Cymerman D, Chlebeck P, Wolchok JD, Houghton AN, Offner H, Weinberg AD (2009) Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J Immunol 183(8):4853–4857. doi:10.4049/jimmunol.0901112
    • (2009) J Immunol , vol.183 , Issue.8 , pp. 4853-4857
    • Ruby, C.E.1    Yates, M.A.2    Hirschhorn-Cymerman, D.3    Chlebeck, P.4    Wolchok, J.D.5    Houghton, A.N.6    Offner, H.7    Weinberg, A.D.8
  • 61
    • 84862908662 scopus 로고    scopus 로고
    • New insights on OX40 in the control of T cell immunity and immune tolerance in vivo
    • COI: 1:CAS:528:DC%2BC38XjvVCgtg%3D%3D, PID: 22147766
    • Xiao X, Gong W, Demirci G, Liu W, Spoerl S, Chu X, Bishop DK, Turka LA, Li XC (2012) New insights on OX40 in the control of T cell immunity and immune tolerance in vivo. J Immunol 188(2):892–901. doi:10.4049/jimmunol.1101373
    • (2012) J Immunol , vol.188 , Issue.2 , pp. 892-901
    • Xiao, X.1    Gong, W.2    Demirci, G.3    Liu, W.4    Spoerl, S.5    Chu, X.6    Bishop, D.K.7    Turka, L.A.8    Li, X.C.9
  • 62
    • 34548646019 scopus 로고    scopus 로고
    • Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3+ T cells
    • COI: 1:CAS:528:DC%2BD2sXnvVyntro%3D, PID: 17641007
    • So T, Croft M (2007) Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3+ T cells. J Immunol 179(3):1427–1430
    • (2007) J Immunol , vol.179 , Issue.3 , pp. 1427-1430
    • So, T.1    Croft, M.2
  • 63
    • 84885121967 scopus 로고    scopus 로고
    • Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function
    • COI: 1:CAS:528:DC%2BC3sXhsV2nsLrM, PID: 24014877
    • Voo KS, Bover L, Harline ML, Vien LT, Facchinetti V, Arima K, Kwak LW, Liu YJ (2013) Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J Immunol 191(7):3641–3650. doi:10.4049/jimmunol.1202752
    • (2013) J Immunol , vol.191 , Issue.7 , pp. 3641-3650
    • Voo, K.S.1    Bover, L.2    Harline, M.L.3    Vien, L.T.4    Facchinetti, V.5    Arima, K.6    Kwak, L.W.7    Liu, Y.J.8
  • 64
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • COI: 1:CAS:528:DC%2BD1cXkvVyrsrg%3D, PID: 18362171
    • Piconese S, Valzasina B, Colombo MP (2008) OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 205(4):825–839. doi:10.1084/jem.20071341
    • (2008) J Exp Med , vol.205 , Issue.4 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 66
    • 77951060733 scopus 로고    scopus 로고
    • OX40 is required for regulatory T cell-mediated control of colitis
    • COI: 1:CAS:528:DC%2BC3cXkvFGrs78%3D, PID: 20368580
    • Griseri T, Asquith M, Thompson C, Powrie F (2010) OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med 207(4):699–709. doi:10.1084/jem.20091618
    • (2010) J Exp Med , vol.207 , Issue.4 , pp. 699-709
    • Griseri, T.1    Asquith, M.2    Thompson, C.3    Powrie, F.4
  • 67
  • 68
    • 0345447614 scopus 로고    scopus 로고
    • OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent
    • COI: 1:CAS:528:DC%2BD3sXptFOksLo%3D, PID: 14634111
    • Prell RA, Evans DE, Thalhofer C, Shi T, Funatake C, Weinberg AD (2003) OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent. J Immunol 171(11):5997–6005
    • (2003) J Immunol , vol.171 , Issue.11 , pp. 5997-6005
    • Prell, R.A.1    Evans, D.E.2    Thalhofer, C.3    Shi, T.4    Funatake, C.5    Weinberg, A.D.6
  • 69
    • 31144460031 scopus 로고    scopus 로고
    • Critical, but conditional, role of OX40 in memory T cell-mediated rejection
    • COI: 1:CAS:528:DC%2BD28XlsFyhsg%3D%3D, PID: 16424166
    • Vu MD, Clarkson MR, Yagita H, Turka LA, Sayegh MH, Li XC (2006) Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J Immunol 176(3):1394–1401
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1394-1401
    • Vu, M.D.1    Clarkson, M.R.2    Yagita, H.3    Turka, L.A.4    Sayegh, M.H.5    Li, X.C.6
  • 70
    • 38449090407 scopus 로고    scopus 로고
    • Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells
    • COI: 1:CAS:528:DC%2BD2sXhtFWitrrO, PID: 17911586
    • Soroosh P, Ine S, Sugamura K, Ishii N (2007) Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells. J Immunol 179(8):5014–5023
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 5014-5023
    • Soroosh, P.1    Ine, S.2    Sugamura, K.3    Ishii, N.4
  • 71
    • 0033427047 scopus 로고    scopus 로고
    • OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
    • COI: 1:CAS:528:DC%2BD3cXkt1SitQ%3D%3D, PID: 10626892
    • Kopf M, Ruedl C, Schmitz N, Gallimore A, Lefrang K, Ecabert B, Odermatt B, Bachmann MF (1999) OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection. Immunity 11(6):699–708
    • (1999) Immunity , vol.11 , Issue.6 , pp. 699-708
    • Kopf, M.1    Ruedl, C.2    Schmitz, N.3    Gallimore, A.4    Lefrang, K.5    Ecabert, B.6    Odermatt, B.7    Bachmann, M.F.8
  • 72
    • 1842581762 scopus 로고    scopus 로고
    • Costimulation of CD8 T cell responses by OX40
    • COI: 1:CAS:528:DC%2BD2cXivVShsrs%3D, PID: 15067059
    • Bansal-Pakala P, Halteman BS, Cheng MH, Croft M (2004) Costimulation of CD8 T cell responses by OX40. J Immunol 172(8):4821–4825
    • (2004) J Immunol , vol.172 , Issue.8 , pp. 4821-4825
    • Bansal-Pakala, P.1    Halteman, B.S.2    Cheng, M.H.3    Croft, M.4
  • 73
    • 71849120402 scopus 로고    scopus 로고
    • OX40 drives protective vaccinia virus-specific CD8 T cells
    • COI: 1:CAS:528:DC%2BD1cXhtl2gsLzJ, PID: 19017988
    • Salek-Ardakani S, Moutaftsi M, Crotty S, Sette A, Croft M (2008) OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol 181(11):7969–7976
    • (2008) J Immunol , vol.181 , Issue.11 , pp. 7969-7976
    • Salek-Ardakani, S.1    Moutaftsi, M.2    Crotty, S.3    Sette, A.4    Croft, M.5
  • 74
    • 78650852565 scopus 로고    scopus 로고
    • Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection
    • COI: 1:CAS:528:DC%2BC3cXhsFGrtr%2FE, PID: 21037534
    • Kinnear G, Wood KJ, Marshall D, Jones ND (2010) Anti-OX40 prevents effector T-cell accumulation and CD8+ T-cell mediated skin allograft rejection. Transplantation 90(12):1265–1271. doi:10.1097/TP.0b013e3181fe5396
    • (2010) Transplantation , vol.90 , Issue.12 , pp. 1265-1271
    • Kinnear, G.1    Wood, K.J.2    Marshall, D.3    Jones, N.D.4
  • 75
    • 84877059530 scopus 로고    scopus 로고
    • The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXisVyitb4%3D, PID: 23414607
    • Moran AE, Kovacsovics-Bankowski M, Weinberg AD (2013) The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr Opin Immunol 25(2):230–237. doi:10.1016/j.coi.2013.01.004
    • (2013) Curr Opin Immunol , vol.25 , Issue.2 , pp. 230-237
    • Moran, A.E.1    Kovacsovics-Bankowski, M.2    Weinberg, A.D.3
  • 77
    • 0346752125 scopus 로고    scopus 로고
    • OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice
    • COI: 1:CAS:528:DC%2BD3sXpvFCms74%3D, PID: 14635034
    • Obermeier F, Schwarz H, Dunger N, Strauch UG, Grunwald N, Scholmerich J, Falk W (2003) OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice. Eur J Immunol 33(12):3265–3274. doi:10.1002/eji.200324124
    • (2003) Eur J Immunol , vol.33 , Issue.12 , pp. 3265-3274
    • Obermeier, F.1    Schwarz, H.2    Dunger, N.3    Strauch, U.G.4    Grunwald, N.5    Scholmerich, J.6    Falk, W.7
  • 78
    • 0034661666 scopus 로고    scopus 로고
    • Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells
    • COI: 1:CAS:528:DC%2BD3cXkvFWis7k%3D, PID: 10878344
    • Jourdan P, Vendrell JP, Huguet MF, Segondy M, Bousquet J, Pene J, Yssel H (2000) Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells. J Immunol 165(2):716–724
    • (2000) J Immunol , vol.165 , Issue.2 , pp. 716-724
    • Jourdan, P.1    Vendrell, J.P.2    Huguet, M.F.3    Segondy, M.4    Bousquet, J.5    Pene, J.6    Yssel, H.7
  • 79
    • 0037152147 scopus 로고    scopus 로고
    • Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC Chemokine RANTES/CCL5
    • COI: 1:CAS:528:DC%2BD38XlvVeku70%3D, PID: 12161277
    • Kotani A, Hori T, Matsumura Y, Uchiyama T (2002) Signaling of gp34 (OX40 ligand) induces vascular endothelial cells to produce a CC Chemokine RANTES/CCL5. Immunol Lett 84(1):1–7
    • (2002) Immunol Lett , vol.84 , Issue.1 , pp. 1-7
    • Kotani, A.1    Hori, T.2    Matsumura, Y.3    Uchiyama, T.4
  • 80
    • 0032955192 scopus 로고    scopus 로고
    • Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
    • COI: 1:CAS:528:DyaK1MXjtlSqtQ%3D%3D, PID: 9886424
    • Higgins LM, McDonald SA, Whittle N, Crockett N, Shields JG, MacDonald TT (1999) Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol 162(1):486–493
    • (1999) J Immunol , vol.162 , Issue.1 , pp. 486-493
    • Higgins, L.M.1    McDonald, S.A.2    Whittle, N.3    Crockett, N.4    Shields, J.G.5    MacDonald, T.T.6
  • 81
    • 0035576394 scopus 로고    scopus 로고
    • Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction
    • COI: 1:CAS:528:DC%2BD3MXovVCis7o%3D, PID: 11714797
    • Shaikh RB, Santee S, Granger SW, Butrovich K, Cheung T, Kronenberg M, Cheroutre H, Ware CF (2001) Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J Immunol 167(11):6330–6337. doi:10.4049/jimmunol.167.11.6330
    • (2001) J Immunol , vol.167 , Issue.11 , pp. 6330-6337
    • Shaikh, R.B.1    Santee, S.2    Granger, S.W.3    Butrovich, K.4    Cheung, T.5    Kronenberg, M.6    Cheroutre, H.7    Ware, C.F.8
  • 82
    • 84865115346 scopus 로고    scopus 로고
    • The T-cell immune response against Kaposi’s sarcoma-associated herpesvirus
    • Robey RC, Mletzko S, Gotch FM (2010) The T-cell immune response against Kaposi’s sarcoma-associated herpesvirus. Adv Virol 2010(5):1–9. doi:10.1016/S1286-4579(99)80036-7
    • (2010) Adv Virol , vol.2010 , Issue.5 , pp. 1-9
    • Robey, R.C.1    Mletzko, S.2    Gotch, F.M.3
  • 83
    • 67349194081 scopus 로고    scopus 로고
    • Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-γ production
    • COI: 1:CAS:528:DC%2BD1MXmsFyitbk%3D
    • Castellano LR, Filho DC, Argiro L, Dessein H, Prata A, Dessein A, Rodrigues V (2009) Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-γ production. HIM J 70(6):383–390. doi:10.1016/j.humimm.2009.01.007
    • (2009) HIM J , vol.70 , Issue.6 , pp. 383-390
    • Castellano, L.R.1    Filho, D.C.2    Argiro, L.3    Dessein, H.4    Prata, A.5    Dessein, A.6    Rodrigues, V.7
  • 88
    • 84880875081 scopus 로고    scopus 로고
    • A replication study from Chinese supports association between lupus-risk allele in TNFSF4 and renal disorder
    • PID: 23936824
    • Zhou XJ, Cheng FJ, Qi YY, Zhao MH, Zhang H (2013) A replication study from Chinese supports association between lupus-risk allele in TNFSF4 and renal disorder. BioMed Res Int 2013:597921. doi:10.1155/2013/597921
    • (2013) BioMed Res Int , vol.2013 , pp. 597921
    • Zhou, X.J.1    Cheng, F.J.2    Qi, Y.Y.3    Zhao, M.H.4    Zhang, H.5
  • 89
    • 84866356404 scopus 로고    scopus 로고
    • Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis
    • COI: 1:CAS:528:DC%2BC38XhtF2rt7bL, PID: 22820624
    • Lee YH, Song GG (2012) Associations between TNFSF4 and TRAF1-C5 gene polymorphisms and systemic lupus erythematosus: a meta-analysis. Hum Immunol 73(10):1050–1054. doi:10.1016/j.humimm.2012.07.044
    • (2012) Hum Immunol , vol.73 , Issue.10 , pp. 1050-1054
    • Lee, Y.H.1    Song, G.G.2
  • 97
    • 0033929388 scopus 로고    scopus 로고
    • Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis
    • COI: 1:CAS:528:DC%2BD3cXlvVyhtro%3D
    • Aten J, Roos A, Claessen N, Schilder-Tol EJ, Ten Berge IJ, Weening JJ (2000) Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J American Soc Nephrol: JASN 11(8):1426–1438
    • (2000) J American Soc Nephrol: JASN , vol.11 , Issue.8 , pp. 1426-1438
    • Aten, J.1    Roos, A.2    Claessen, N.3    Schilder-Tol, E.J.4    Ten Berge, I.J.5    Weening, J.J.6
  • 98
    • 77951637688 scopus 로고    scopus 로고
    • Flowcytometric study of expression of perforin and CD134 in patients with systemic lupus erythematosus
    • Abo-Elenein A, Shaaban D, Gheith O (2008) Flowcytometric study of expression of perforin and CD134 in patients with systemic lupus erythematosus. Egypt J Immunol / Egypt Assoc Immunol 15(2):135–143
    • (2008) Egypt J Immunol / Egypt Assoc Immunol , vol.15 , Issue.2 , pp. 135-143
    • Abo-Elenein, A.1    Shaaban, D.2    Gheith, O.3
  • 99
    • 79251612617 scopus 로고    scopus 로고
    • OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis
    • PID: 21245596
    • Farres MN, Al-Zifzaf DS, Aly AA, Abd Raboh NM (2011) OX40/OX40L in systemic lupus erythematosus: association with disease activity and lupus nephritis. Ann Saudi med 31(1):29–34. doi:10.4103/0256-4947.75775
    • (2011) Ann Saudi med , vol.31 , Issue.1 , pp. 29-34
    • Farres, M.N.1    Al-Zifzaf, D.S.2    Aly, A.A.3    Abd Raboh, N.M.4
  • 100
    • 84886775821 scopus 로고    scopus 로고
    • Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression
    • COI: 1:CAS:528:DC%2BC3sXhslSqurbN, PID: 23896866
    • Kshirsagar S, Binder E, Riedl M, Wechselberger G, Steichen E, Edelbauer M (2013) Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. Arthritis Rheum 65(11):2996–3006. doi:10.1002/art.38089
    • (2013) Arthritis Rheum , vol.65 , Issue.11 , pp. 2996-3006
    • Kshirsagar, S.1    Binder, E.2    Riedl, M.3    Wechselberger, G.4    Steichen, E.5    Edelbauer, M.6
  • 102
    • 33745937715 scopus 로고    scopus 로고
    • CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus
    • COI: 1:CAS:528:DC%2BD28XptFWktL4%3D, PID: 16879242
    • Patschan S, Dolff S, Kribben A, Durig J, Patschan D, Wilde B, Specker C, Philipp T, Witzke O (2006) CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus. Clin Exp Immunol 145(2):235–242. doi:10.1111/j.1365-2249.2006.03141.x
    • (2006) Clin Exp Immunol , vol.145 , Issue.2 , pp. 235-242
    • Patschan, S.1    Dolff, S.2    Kribben, A.3    Durig, J.4    Patschan, D.5    Wilde, B.6    Specker, C.7    Philipp, T.8    Witzke, O.9
  • 103
    • 59449106441 scopus 로고    scopus 로고
    • Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis
    • COI: 1:CAS:528:DC%2BD1MXhsFWnur4%3D, PID: 18802705
    • Zhou YB, Ye RG, Li YJ, Xie CM (2009) Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis. Rheumatol Int 29(4):417–425. doi:10.1007/s00296-008-0697-2
    • (2009) Rheumatol Int , vol.29 , Issue.4 , pp. 417-425
    • Zhou, Y.B.1    Ye, R.G.2    Li, Y.J.3    Xie, C.M.4
  • 105
    • 33644819034 scopus 로고    scopus 로고
    • Expression of OX40 (CD134) on CD4+ T-cells from patients with myasthenia gravis
    • COI: 1:CAS:528:DC%2BD28XhtFWmurg%3D, PID: 16367941
    • Xiaoyan Z, Pirskanen R, Malmstrom V, Lefvert AK (2006) Expression of OX40 (CD134) on CD4+ T-cells from patients with myasthenia gravis. Clin Exp Immunol 143(1):110–116. doi:10.1111/j.1365-2249.2005.02955.x
    • (2006) Clin Exp Immunol , vol.143 , Issue.1 , pp. 110-116
    • Xiaoyan, Z.1    Pirskanen, R.2    Malmstrom, V.3    Lefvert, A.K.4
  • 106
    • 84907676969 scopus 로고    scopus 로고
    • High expression of OX40 (CD134) and 4-1BB (CD137) molecules on CD4(+)CD25(high) cells in children with type 1 diabetes
    • PID: 24797972
    • Szypowska A, Stelmaszczyk-Emmel A, Demkow U, Luczynski W (2014) High expression of OX40 (CD134) and 4-1BB (CD137) molecules on CD4(+)CD25(high) cells in children with type 1 diabetes. Adv Med Sci 59(1):39–43. doi:10.1016/j.advms.2013.07.003
    • (2014) Adv Med Sci , vol.59 , Issue.1 , pp. 39-43
    • Szypowska, A.1    Stelmaszczyk-Emmel, A.2    Demkow, U.3    Luczynski, W.4
  • 108
    • 84872185732 scopus 로고    scopus 로고
    • Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis
    • COI: 1:CAS:528:DC%2BC38Xhs1Ogt7jM
    • Rajabi P, Alaee M, Mousavizadeh K, Samadikuchaksaraei A et al (2012) Altered expression of TNFSF4 and TRAF2 mRNAs in peripheral blood mononuclear cells in patients with systemic lupus erythematosus: association with atherosclerotic symptoms and lupus nephritis. Inflamma Res: Off J EurHistamine Res Soc 61(12):1347–1354. doi:10.1007/s00011-012-0535-6
    • (2012) Inflamma Res: Off J EurHistamine Res Soc , vol.61 , Issue.12 , pp. 1347-1354
    • Rajabi, P.1    Alaee, M.2    Mousavizadeh, K.3    Samadikuchaksaraei, A.4
  • 111
    • 34548216282 scopus 로고    scopus 로고
    • Effects of CD134 monoclonal antibody on hemolysis activities and expression of perforin in peripheral blood mononuclear cells of systemic lupus erythematosus patients
    • COI: 1:CAS:528:DC%2BD2sXpsF2lt78%3D, PID: 17725380
    • Li M, Yang Q, Zhang Y (2007) Effects of CD134 monoclonal antibody on hemolysis activities and expression of perforin in peripheral blood mononuclear cells of systemic lupus erythematosus patients. Hybridoma 26(4):191–200. doi:10.1089/hyb.2007.010
    • (2007) Hybridoma , vol.26 , Issue.4 , pp. 191-200
    • Li, M.1    Yang, Q.2    Zhang, Y.3
  • 113
    • 0031944922 scopus 로고    scopus 로고
    • The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells
    • COI: 1:CAS:528:DyaK1cXjtVOrtr0%3D, PID: 9620601
    • Kaleeba JA, Offner H, Vandenbark AA, Lublinski A, Weinberg AD (1998) The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells. Int Immunol 10(4):453–461
    • (1998) Int Immunol , vol.10 , Issue.4 , pp. 453-461
    • Kaleeba, J.A.1    Offner, H.2    Vandenbark, A.A.3    Lublinski, A.4    Weinberg, A.D.5
  • 114
    • 46749128189 scopus 로고    scopus 로고
    • The role of OX40 in CD4+ T cells cytokines production in ulcerative colitis
    • COI: 1:CAS:528:DC%2BD1MXislCnurg%3D, PID: 18346319
    • Wang XD, Wu TY (2008) The role of OX40 in CD4+ T cells cytokines production in ulcerative colitis. Zhonghua nei ke za zhi 47(1):15–18
    • (2008) Zhonghua nei ke za zhi , vol.47 , Issue.1 , pp. 15-18
    • Wang, X.D.1    Wu, T.Y.2
  • 116
    • 0035113959 scopus 로고    scopus 로고
    • Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice
    • COI: 1:STN:280:DC%2BD3Mzitlarsg%3D%3D, PID: 11221995
    • Yu S, Medling B, Yagita H, Braley-Mullen H (2001) Characteristics of inflammatory cells in spontaneous autoimmune thyroiditis of NOD.H-2h4 mice. J Autoimmun 16(1):37–46. doi:10.1006/jaut.2000.0458
    • (2001) J Autoimmun , vol.16 , Issue.1 , pp. 37-46
    • Yu, S.1    Medling, B.2    Yagita, H.3    Braley-Mullen, H.4
  • 117
    • 0036166344 scopus 로고    scopus 로고
    • Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells
    • COI: 1:CAS:528:DC%2BD38XhvF2qsrc%3D, PID: 11840457
    • Saijo S, Asano M, Horai R, Yamamoto H, Iwakura Y (2002) Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells. Arthritis Rheum 46(2):533–544
    • (2002) Arthritis Rheum , vol.46 , Issue.2 , pp. 533-544
    • Saijo, S.1    Asano, M.2    Horai, R.3    Yamamoto, H.4    Iwakura, Y.5
  • 118
    • 0038623916 scopus 로고    scopus 로고
    • IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
    • COI: 1:CAS:528:DC%2BD3sXjvFOlt70%3D, PID: 12721360
    • Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y (2003) IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci U S A 100(10):5986–5990. doi:10.1073/pnas.1035999100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.10 , pp. 5986-5990
    • Nakae, S.1    Saijo, S.2    Horai, R.3    Sudo, K.4    Mori, S.5    Iwakura, Y.6
  • 119
    • 9244243051 scopus 로고    scopus 로고
    • Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions
    • COI: 1:CAS:528:DC%2BD2cXhtVWisrfI, PID: 15368274
    • Pakala SV, Bansal-Pakala P, Halteman BS, Croft M (2004) Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions. Eur J Immunol 34(11):3039–3046. doi:10.1002/eji.200425141
    • (2004) Eur J Immunol , vol.34 , Issue.11 , pp. 3039-3046
    • Pakala, S.V.1    Bansal-Pakala, P.2    Halteman, B.S.3    Croft, M.4
  • 120
    • 34547408930 scopus 로고    scopus 로고
    • Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations
    • COI: 1:CAS:528:DC%2BD2sXovFSgur0%3D, PID: 17599765
    • Elmann A, Sharabi A, Dayan M, Zinger H, Ophir R, Mozes E (2007) Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations. Arthritis Rheum 56(7):2371–2381. doi:10.1002/art.22736
    • (2007) Arthritis Rheum , vol.56 , Issue.7 , pp. 2371-2381
    • Elmann, A.1    Sharabi, A.2    Dayan, M.3    Zinger, H.4    Ophir, R.5    Mozes, E.6
  • 121
    • 84878646429 scopus 로고    scopus 로고
    • Anti-CD40 Ab- or 8-oxo-dG-enhanced Treg cells reduce development of experimental autoimmune encephalomyelitis via down-regulating migration and activation of mast cells
    • COI: 1:CAS:528:DC%2BC3sXmsFCmt7g%3D, PID: 23622820
    • Hong GU, Kim NG, Jeoung D, Ro JY (2013) Anti-CD40 Ab- or 8-oxo-dG-enhanced Treg cells reduce development of experimental autoimmune encephalomyelitis via down-regulating migration and activation of mast cells. J Neuroimmunol 260(1–2):60–73. doi:10.1016/j.jneuroim.2013.04.002
    • (2013) J Neuroimmunol , vol.260 , Issue.1-2 , pp. 60-73
    • Hong, G.U.1    Kim, N.G.2    Jeoung, D.3    Ro, J.Y.4
  • 122
    • 0035337241 scopus 로고    scopus 로고
    • CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
    • COI: 1:CAS:528:DC%2BD3MXjvFaqs7c%3D, PID: 11359859
    • Malmstrom V, Shipton D, Singh B, Al-Shamkhani A, Puklavec MJ, Barclay AN, Powrie F (2001) CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol 166(11):6972–6981
    • (2001) J Immunol , vol.166 , Issue.11 , pp. 6972-6981
    • Malmstrom, V.1    Shipton, D.2    Singh, B.3    Al-Shamkhani, A.4    Puklavec, M.J.5    Barclay, A.N.6    Powrie, F.7
  • 123
    • 0033785481 scopus 로고    scopus 로고
    • Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD3cXnslKrsrw%3D, PID: 11069062
    • Yoshioka T, Nakajima A, Akiba H, Ishiwata T, Asano G, Yoshino S, Yagita H, Okumura K (2000) Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol 30(10):2815–2823. doi:10.1002/1521-4141(200010)30:10<2815::aid-immu2815>3.0.co;2-#
    • (2000) Eur J Immunol , vol.30 , Issue.10 , pp. 2815-2823
    • Yoshioka, T.1    Nakajima, A.2    Akiba, H.3    Ishiwata, T.4    Asano, G.5    Yoshino, S.6    Yagita, H.7    Okumura, K.8
  • 124
    • 84877759054 scopus 로고    scopus 로고
    • Sjogren’s syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand
    • COI: 1:CAS:528:DC%2BC3sXns1ahu7c%3D, PID: 23301790
    • Saito K, Mori S, Date F, Ono M (2013) Sjogren’s syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand. Autoimmunity 46(4):231–237. doi:10.3109/08916934.2012.757307
    • (2013) Autoimmunity , vol.46 , Issue.4 , pp. 231-237
    • Saito, K.1    Mori, S.2    Date, F.3    Ono, M.4
  • 127
  • 128
    • 9044251601 scopus 로고    scopus 로고
    • OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis
    • COI: 1:CAS:528:DyaK28Xos1KitQ%3D%3D, PID: 8838572
    • Weinberg AD, Lemon M, Jones AJ, Vainiene M, Celnik B, Buenafe AC, Culbertson N, Bakke A, Vandenbark AA, Offner H (1996) OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J Neurosci Res 43(1):42–49. doi:10.1002/jnr.490430105
    • (1996) J Neurosci Res , vol.43 , Issue.1 , pp. 42-49
    • Weinberg, A.D.1    Lemon, M.2    Jones, A.J.3    Vainiene, M.4    Celnik, B.5    Buenafe, A.C.6    Culbertson, N.7    Bakke, A.8    Vandenbark, A.A.9    Offner, H.10
  • 129
    • 26944446229 scopus 로고    scopus 로고
    • CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms
    • COI: 1:CAS:528:DC%2BD2MXpt1Wmsb0%3D, PID: 16014035
    • Odobasic D, Kitching AR, Tipping PG, Holdsworth SR (2005) CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney Int 68(2):584–594. doi:10.1111/j.1523-1755.2005.00436.x
    • (2005) Kidney Int , vol.68 , Issue.2 , pp. 584-594
    • Odobasic, D.1    Kitching, A.R.2    Tipping, P.G.3    Holdsworth, S.R.4
  • 131
    • 0035451519 scopus 로고    scopus 로고
    • Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD3MXmtlSju7k%3D, PID: 11509650
    • Ndhlovu LC, Ishii N, Murata K, Sato T, Sugamura K (2001) Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis. J Immunol 167(5):2991–2999
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2991-2999
    • Ndhlovu, L.C.1    Ishii, N.2    Murata, K.3    Sato, T.4    Sugamura, K.5
  • 132
    • 0035253725 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells
    • COI: 1:CAS:528:DC%2BD3MXhtVSisbk%3D, PID: 11160262
    • Nohara C, Akiba H, Nakajima A, Inoue A, Koh CS, Ohshima H, Yagita H, Mizuno Y, Okumura K (2001) Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol 166(3):2108–2115
    • (2001) J Immunol , vol.166 , Issue.3 , pp. 2108-2115
    • Nohara, C.1    Akiba, H.2    Nakajima, A.3    Inoue, A.4    Koh, C.S.5    Ohshima, H.6    Yagita, H.7    Mizuno, Y.8    Okumura, K.9
  • 134
    • 63149163677 scopus 로고    scopus 로고
    • The role of TNF superfamily members in T-cell function and diseases
    • COI: 1:CAS:528:DC%2BD1MXjsFCrsrk%3D, PID: 19319144
    • Croft M (2009) The role of TNF superfamily members in T-cell function and diseases. Nat Rev Immunol 9(4):271–285. doi:10.1038/nri2526
    • (2009) Nat Rev Immunol , vol.9 , Issue.4 , pp. 271-285
    • Croft, M.1
  • 137
    • 84899111478 scopus 로고    scopus 로고
    • Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals
    • COI: 1:CAS:528:DC%2BC3sXhsFeqtLjN, PID: 24075450
    • Mayer CT, Tian L, Hesse C, Kuhl AA, Swallow M, Kruse F, Thiele M, Gershwin ME, Liston A, Sparwasser T (2014) Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 50:23–32. doi:10.1016/j.jaut.2013.08.010
    • (2014) J Autoimmun , vol.50 , pp. 23-32
    • Mayer, C.T.1    Tian, L.2    Hesse, C.3    Kuhl, A.A.4    Swallow, M.5    Kruse, F.6    Thiele, M.7    Gershwin, M.E.8    Liston, A.9    Sparwasser, T.10
  • 138
    • 82955247641 scopus 로고    scopus 로고
    • Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment
    • COI: 1:CAS:528:DC%2BC3MXhsV2rsLjP, PID: 22063316
    • Bresson D, Fousteri G, Manenkova Y, Croft M, von Herrath M (2011) Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment. J Autoimmun 37(4):342–351. doi:10.1016/j.jaut.2011.10.001
    • (2011) J Autoimmun , vol.37 , Issue.4 , pp. 342-351
    • Bresson, D.1    Fousteri, G.2    Manenkova, Y.3    Croft, M.4    von Herrath, M.5
  • 139
    • 84862833568 scopus 로고    scopus 로고
    • Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis
    • COI: 1:CAS:528:DC%2BC38XmsFSh, PID: 21948545
    • Wu X, Rosenbaum JT, Adamus G, Zhang GL, Duan J, Weinberg A, Zhang Z (2011) Activation of OX40 prolongs and exacerbates autoimmune experimental uveitis. Invest Ophthalmol Vis Sci 52(11):8520–8526. doi:10.1167/iovs.11-7664
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , Issue.11 , pp. 8520-8526
    • Wu, X.1    Rosenbaum, J.T.2    Adamus, G.3    Zhang, G.L.4    Duan, J.5    Weinberg, A.6    Zhang, Z.7
  • 140
    • 0035092850 scopus 로고    scopus 로고
    • CD28-independent induction of experimental autoimmune encephalomyelitis
    • COI: 1:CAS:528:DC%2BD3MXhs12ns7g%3D, PID: 11238558
    • Chitnis T, Najafian N, Abdallah KA, Dong V, Yagita H, Sayegh MH, Khoury SJ (2001) CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest 107(5):575–583. doi:10.1172/jci11220
    • (2001) J Clin Invest , vol.107 , Issue.5 , pp. 575-583
    • Chitnis, T.1    Najafian, N.2    Abdallah, K.A.3    Dong, V.4    Yagita, H.5    Sayegh, M.H.6    Khoury, S.J.7
  • 141
    • 0033083303 scopus 로고    scopus 로고
    • Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    • COI: 1:CAS:528:DyaK1MXhtVWms7w%3D, PID: 9973447
    • Weinberg AD, Wegmann KW, Funatake C, Whitham RH (1999) Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J Immunol 162(3):1818–1826
    • (1999) J Immunol , vol.162 , Issue.3 , pp. 1818-1826
    • Weinberg, A.D.1    Wegmann, K.W.2    Funatake, C.3    Whitham, R.H.4
  • 143
    • 47049086314 scopus 로고    scopus 로고
    • OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ Tregs
    • COI: 1:CAS:528:DC%2BD1cXntFWnsbY%3D, PID: 18551075
    • Chen M, Xiao X, Demirci G, Li XC (2008) OX40 controls islet allograft tolerance in CD154 deficient mice by regulating FOXP3+ Tregs. Transplantation 85(11):1659–1662. doi:10.1097/TP.0b013e3181726987
    • (2008) Transplantation , vol.85 , Issue.11 , pp. 1659-1662
    • Chen, M.1    Xiao, X.2    Demirci, G.3    Li, X.C.4
  • 144
    • 0030956579 scopus 로고    scopus 로고
    • OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration
    • COI: 1:CAS:528:DyaK2sXisFChuro%3D, PID: 9108415
    • Imura A, Hori T, Imada K, Kawamata S, Tanaka Y, Imamura S, Uchiyama T (1997) OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: implication for the possible involvement of OX40 in leukemic cell infiltration. Blood 89(8):2951–2958
    • (1997) Blood , vol.89 , Issue.8 , pp. 2951-2958
    • Imura, A.1    Hori, T.2    Imada, K.3    Kawamata, S.4    Tanaka, Y.5    Imamura, S.6    Uchiyama, T.7
  • 145
    • 34247183575 scopus 로고    scopus 로고
    • Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
    • COI: 1:CAS:528:DC%2BD2sXksVejurc%3D, PID: 17374396
    • Morris NP, Peters C, Montler R, Hu HM, Curti BD, Urba WJ, Weinberg AD (2007) Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain. Mol Immunol 44(12):3112–3121. doi:10.1016/j.molimm.2007.02.004
    • (2007) Mol Immunol , vol.44 , Issue.12 , pp. 3112-3121
    • Morris, N.P.1    Peters, C.2    Montler, R.3    Hu, H.M.4    Curti, B.D.5    Urba, W.J.6    Weinberg, A.D.7
  • 146
    • 84919360941 scopus 로고    scopus 로고
    • Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction
    • COI: 1:CAS:528:DC%2BC2cXhvVSjsLfO, PID: 24930776
    • Song Y, Margolles-Clark E, Bayer A, Buchwald P (2014) Small-molecule modulators of the OX40-OX40 ligand co-stimulatory protein-protein interaction. Br J Pharmacol 171(21):4955–4969. doi:10.1111/bph.12819
    • (2014) Br J Pharmacol , vol.171 , Issue.21 , pp. 4955-4969
    • Song, Y.1    Margolles-Clark, E.2    Bayer, A.3    Buchwald, P.4
  • 147
    • 84914810802 scopus 로고    scopus 로고
    • Ox40L–Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major
    • COI: 1:CAS:528:DC%2BC2cXhvFeju7%2FE, PID: 25447125
    • Tuladhar R, Oghumu S, Dong R, Peterson A, Sharpe AH, Satoskar AR (2015) Ox40L–Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major. Exp Parasitol 148(C):49–55. doi:10.1016/j.exppara.2014.11.002
    • (2015) Exp Parasitol , vol.148 , Issue.C , pp. 49-55
    • Tuladhar, R.1    Oghumu, S.2    Dong, R.3    Peterson, A.4    Sharpe, A.H.5    Satoskar, A.R.6
  • 148
    • 80054866734 scopus 로고    scopus 로고
    • Science gone translational: the OX40 agonist story
    • COI: 1:CAS:528:DC%2BC3MXhsFagsLzL, PID: 22017441
    • Weinberg AD, Morris NP, Kovacsovics-Bankowski M, Urba WJ, Curti BD (2011) Science gone translational: the OX40 agonist story. Immunol Rev 244(1):218–231. doi:10.1111/j.1600-065X.2011.01069.x
    • (2011) Immunol Rev , vol.244 , Issue.1 , pp. 218-231
    • Weinberg, A.D.1    Morris, N.P.2    Kovacsovics-Bankowski, M.3    Urba, W.J.4    Curti, B.D.5
  • 149
    • 33748428203 scopus 로고    scopus 로고
    • T-cell costimulation--biology, therapeutic potential, and challenges
    • COI: 1:CAS:528:DC%2BD28XpsFKmt7o%3D, PID: 16908487
    • Sharpe AH, Abbas AK (2006) T-cell costimulation--biology, therapeutic potential, and challenges. N Engl J Med 355(10):973–975. doi:10.1056/NEJMp068087
    • (2006) N Engl J Med , vol.355 , Issue.10 , pp. 973-975
    • Sharpe, A.H.1    Abbas, A.K.2
  • 150
    • 84888302854 scopus 로고    scopus 로고
    • Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis
    • COI: 1:CAS:528:DC%2BC3sXhslOmtrjE, PID: 24184937
    • Smeets E, Meiler S, Lutgens E (2013) Lymphocytic tumor necrosis factor receptor superfamily co-stimulatory molecules in the pathogenesis of atherosclerosis. Curr Opin Lipidol 24(6):518–524. doi:10.1097/mol.0000000000000025
    • (2013) Curr Opin Lipidol , vol.24 , Issue.6 , pp. 518-524
    • Smeets, E.1    Meiler, S.2    Lutgens, E.3
  • 151
    • 0032733508 scopus 로고    scopus 로고
    • Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD3cXhvV2jtg%3D%3D, PID: 10562584
    • Souza HS, Elia CC, Spencer J, MacDonald TT (1999) Expression of lymphocyte-endothelial receptor-ligand pairs, alpha4beta7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 45(6):856–863
    • (1999) Gut , vol.45 , Issue.6 , pp. 856-863
    • Souza, H.S.1    Elia, C.C.2    Spencer, J.3    MacDonald, T.T.4
  • 152
    • 84896066685 scopus 로고    scopus 로고
    • IL-15 controls T cell functions through its influence on CD30 and OX40 antigens in celiac disease
    • COI: 1:CAS:528:DC%2BC2cXltFajurg%3D, PID: 24680481
    • Periolo N, Guillén L, Arruvito ML, Alegre NS, Niveloni SI, Hwang JH, Bai JC, Cherñavsky AC (2014) IL-15 controls T cell functions through its influence on CD30 and OX40 antigens in celiac disease. Cytokine 67(1):44–51. doi:10.1016/j.cyto.2014.01.004
    • (2014) Cytokine , vol.67 , Issue.1 , pp. 44-51
    • Periolo, N.1    Guillén, L.2    Arruvito, M.L.3    Alegre, N.S.4    Niveloni, S.I.5    Hwang, J.H.6    Bai, J.C.7    Cherñavsky, A.C.8
  • 153
    • 0031853164 scopus 로고    scopus 로고
    • CD134/OX40 expression by synovial fluid CD4+ T lymphocytes in chronic synovitis
    • COI: 1:STN:280:DyaK1czhtlWitw%3D%3D, PID: 9651095
    • Brugnoni D, Bettinardi A, Malacarne F, Airo P, Cattaneo R (1998) CD134/OX40 expression by synovial fluid CD4+ T lymphocytes in chronic synovitis. Br J Rheumatol 37(5):584–585
    • (1998) Br J Rheumatol , vol.37 , Issue.5 , pp. 584-585
    • Brugnoni, D.1    Bettinardi, A.2    Malacarne, F.3    Airo, P.4    Cattaneo, R.5
  • 154
    • 33750082084 scopus 로고    scopus 로고
    • Synovial fluid OX40T lymphocytes of patients with rheumatoid arthritis display a Th2/Th0 polarization
    • COI: 1:CAS:528:DC%2BD28Xht1Shu7vE, PID: 17026834
    • Passacantando A, Parzanese I, Rascente M, Petrucci C, Minisola G, Tonietti G (2006) Synovial fluid OX40T lymphocytes of patients with rheumatoid arthritis display a Th2/Th0 polarization. Int J Immunopathol Pharmacol 19(3):499–505
    • (2006) Int J Immunopathol Pharmacol , vol.19 , Issue.3 , pp. 499-505
    • Passacantando, A.1    Parzanese, I.2    Rascente, M.3    Petrucci, C.4    Minisola, G.5    Tonietti, G.6
  • 155
    • 84944876983 scopus 로고    scopus 로고
    • Increased lymphocyte infiltration in rheumatoid arthritis is correlated with an increase in LTi-like cells in synovial fluid
    • PID: 24385942
    • Koo J, Kim S, Jung WJ, Lee YE, Song GG, Kim KS, Kim MY (2013) Increased lymphocyte infiltration in rheumatoid arthritis is correlated with an increase in LTi-like cells in synovial fluid. Immune Netw 13(6):240–248. doi:10.4110/in.2013.13.6.240
    • (2013) Immune Netw , vol.13 , Issue.6 , pp. 240-248
    • Koo, J.1    Kim, S.2    Jung, W.J.3    Lee, Y.E.4    Song, G.G.5    Kim, K.S.6    Kim, M.Y.7
  • 157
    • 0037082881 scopus 로고    scopus 로고
    • Expression of OX40 in muscles of polymyositis and granulomatous myopathy
    • COI: 1:CAS:528:DC%2BD38XmsFKjtw%3D%3D, PID: 11809163
    • Tateyama M, Fujihara K, Ishii N, Sugamura K, Onodera Y, Itoyama Y (2002) Expression of OX40 in muscles of polymyositis and granulomatous myopathy. J Neurol Sci 194(1):29–34
    • (2002) J Neurol Sci , vol.194 , Issue.1 , pp. 29-34
    • Tateyama, M.1    Fujihara, K.2    Ishii, N.3    Sugamura, K.4    Onodera, Y.5    Itoyama, Y.6
  • 158
    • 30944464613 scopus 로고    scopus 로고
    • Analysis of costimulatory molecules OX40/4-1BB (CD134/CD137) detection on chosen mononuclear cells in children and adolescents with Graves’ disease during methimazole therapy
    • COI: 1:CAS:528:DC%2BD28Xhtl2ltb8%3D, PID: 16459462
    • Bossowski A, Stasiak-Barmuta A, Urban M, Bossowska A (2005) Analysis of costimulatory molecules OX40/4-1BB (CD134/CD137) detection on chosen mononuclear cells in children and adolescents with Graves’ disease during methimazole therapy. J Pediatr Endocrinol Metab 18(12):1365–1372
    • (2005) J Pediatr Endocrinol Metab , vol.18 , Issue.12 , pp. 1365-1372
    • Bossowski, A.1    Stasiak-Barmuta, A.2    Urban, M.3    Bossowska, A.4
  • 160
    • 84887137091 scopus 로고    scopus 로고
    • Expressions and clinical significance of OX40 and OX40L in peripheral blood of patients with primary Sjogren’s syndrome
    • COI: 1:CAS:528:DC%2BC3sXhvVCru77I
    • Zhu R, Jiang J, Wang T, Xu T, Wu M, Liu C, Zhang X (2013) Expressions and clinical significance of OX40 and OX40L in peripheral blood of patients with primary Sjogren’s syndrome. Xi bao yu fen zi mian yi xue za zhi = Chin J Cell Mol immunol 29(8):862–865
    • (2013) Xi bao yu fen zi mian yi xue za zhi = Chin J Cell Mol immunol , vol.29 , Issue.8 , pp. 862-865
    • Zhu, R.1    Jiang, J.2    Wang, T.3    Xu, T.4    Wu, M.5    Liu, C.6    Zhang, X.7
  • 161
    • 0033807407 scopus 로고    scopus 로고
    • Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus
    • COI: 1:CAS:528:DC%2BD3cXntlSitrs%3D, PID: 11071109
    • Onodera J, Nagata T, Fujihara K, Ohuchi M, Ishii N, Sugamura K, Itoyama Y (2000) Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus. Acta Neurol Scand 102(4):236–243
    • (2000) Acta Neurol Scand , vol.102 , Issue.4 , pp. 236-243
    • Onodera, J.1    Nagata, T.2    Fujihara, K.3    Ohuchi, M.4    Ishii, N.5    Sugamura, K.6    Itoyama, Y.7
  • 162
    • 33747383913 scopus 로고    scopus 로고
    • Characterization of the expanded T-cell populations in patients with Wegener’s granulomatosis
    • COI: 1:CAS:528:DC%2BD28XhtVOgur3P, PID: 16918819
    • Giscombe R, Wang XB, Kakoulidou M, Lefvert AK (2006) Characterization of the expanded T-cell populations in patients with Wegener’s granulomatosis. J Intern Med 260(3):224–230. doi:10.1111/j.1365-2796.2006.01688.x
    • (2006) J Intern Med , vol.260 , Issue.3 , pp. 224-230
    • Giscombe, R.1    Wang, X.B.2    Kakoulidou, M.3    Lefvert, A.K.4
  • 164
    • 45949106830 scopus 로고    scopus 로고
    • Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsDNA antibody production in spleen cells from lupus-prone BXSB mice
    • COI: 1:CAS:528:DC%2BD1cXnsFehtr8%3D, PID: 18568645
    • Zhou YB, Ye RG, Li YJ, Xie CM, Wu YH (2008) Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsDNA antibody production in spleen cells from lupus-prone BXSB mice. Autoimmunity 41(5):395–404. doi:10.1080/08916930802002240
    • (2008) Autoimmunity , vol.41 , Issue.5 , pp. 395-404
    • Zhou, Y.B.1    Ye, R.G.2    Li, Y.J.3    Xie, C.M.4    Wu, Y.H.5
  • 166
    • 0347627710 scopus 로고    scopus 로고
    • Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand
    • COI: 1:CAS:528:DC%2BD3sXpsV2ru74%3D, PID: 14662903
    • Martin-Orozco N, Chen Z, Poirot L, Hyatt E, Chen A, Kanagawa O, Sharpe A, Mathis D, Benoist C (2003) Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J Immunol 171(12):6954–6960
    • (2003) J Immunol , vol.171 , Issue.12 , pp. 6954-6960
    • Martin-Orozco, N.1    Chen, Z.2    Poirot, L.3    Hyatt, E.4    Chen, A.5    Kanagawa, O.6    Sharpe, A.7    Mathis, D.8    Benoist, C.9
  • 167
    • 84883768106 scopus 로고    scopus 로고
    • Regulation of PI-3-kinase and Akt signaling in T lymphocytes and other cells by TNFR family molecules
    • COI: 1:CAS:528:DC%2BC3sXhtlGju7nP, PID: 23760533
    • So T, Croft M (2013) Regulation of PI-3-kinase and Akt signaling in T lymphocytes and other cells by TNFR family molecules. Front Immunol 4:139. doi:10.3389/fimmu.2013.00139
    • (2013) Front Immunol , vol.4 , pp. 139
    • So, T.1    Croft, M.2
  • 168
    • 0032489386 scopus 로고    scopus 로고
    • Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation
    • COI: 1:CAS:528:DyaK1cXhsleiur0%3D, PID: 9488716
    • Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T (1998) Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J Biol Chem 273(10):5808–5814
    • (1998) J Biol Chem , vol.273 , Issue.10 , pp. 5808-5814
    • Kawamata, S.1    Hori, T.2    Imura, A.3    Takaori-Kondo, A.4    Uchiyama, T.5
  • 169
    • 84887502545 scopus 로고    scopus 로고
    • Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1
    • COI: 1:CAS:528:DC%2BC3sXhslWls7fJ, PID: 24101548
    • Boettler T, Choi YS, Salek-Ardakani S, Cheng Y, Moeckel F, Croft M, Crotty S, von Herrath M (2013) Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. J Immunol 191(10):5026–5035. doi:10.4049/jimmunol.1300013
    • (2013) J Immunol , vol.191 , Issue.10 , pp. 5026-5035
    • Boettler, T.1    Choi, Y.S.2    Salek-Ardakani, S.3    Cheng, Y.4    Moeckel, F.5    Croft, M.6    Crotty, S.7    von Herrath, M.8
  • 170
    • 0031572569 scopus 로고    scopus 로고
    • Expression and function of OX40 ligand on human dendritic cells
    • COI: 1:CAS:528:DyaK2sXmvVSkur0%3D, PID: 9378971
    • Ohshima Y, Tanaka Y, Tozawa H, Takahashi Y, Maliszewski C, Delespesse G (1997) Expression and function of OX40 ligand on human dendritic cells. J Immunol 159(8):3838–3848
    • (1997) J Immunol , vol.159 , Issue.8 , pp. 3838-3848
    • Ohshima, Y.1    Tanaka, Y.2    Tozawa, H.3    Takahashi, Y.4    Maliszewski, C.5    Delespesse, G.6
  • 171
    • 0029938992 scopus 로고    scopus 로고
    • The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response
    • COI: 1:CAS:528:DyaK28XhvV2qsrg%3D, PID: 8642301
    • Stuber E, Strober W (1996) The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J Exp Med 183(3):979–989
    • (1996) J Exp Med , vol.183 , Issue.3 , pp. 979-989
    • Stuber, E.1    Strober, W.2
  • 172
    • 0029045255 scopus 로고
    • Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
    • COI: 1:CAS:528:DyaK2MXlvVWrsLY%3D, PID: 7749983
    • Stuber E, Neurath M, Calderhead D, Fell HP, Strober W (1995) Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 2(5):507–521
    • (1995) Immunity , vol.2 , Issue.5 , pp. 507-521
    • Stuber, E.1    Neurath, M.2    Calderhead, D.3    Fell, H.P.4    Strober, W.5
  • 173
    • 70350492339 scopus 로고    scopus 로고
    • Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation
    • COI: 1:CAS:528:DC%2BD1MXht1eit7vI, PID: 19643985
    • Piconese S, Gri G, Tripodo C, Musio S, Gorzanelli A, Frossi B, Pedotti R, Pucillo CE, Colombo MP (2009) Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation. Blood 114(13):2639–2648. doi:10.1182/blood-2009-05-220004
    • (2009) Blood , vol.114 , Issue.13 , pp. 2639-2648
    • Piconese, S.1    Gri, G.2    Tripodo, C.3    Musio, S.4    Gorzanelli, A.5    Frossi, B.6    Pedotti, R.7    Pucillo, C.E.8    Colombo, M.P.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.