Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands

Journal of Immunology

Volumn 182, Issue 8, 2009, Pages 4581-4589

  Klinger, Mark ^a   Kim, Joong Kyu ^a   Chmura, Stephen A ^a   Barczak, Andrea ^a   Erle, David J ^a   Killeen, Nigel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CRE RECOMBINASE; HERMES ANTIGEN; INTEGRASE; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; TNFSF4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL FRACTIONATION; CELL SUBPOPULATION; CONTROLLED STUDY; LYMPHOCYTE ACTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; THYMOCYTE; ANIMAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPH NODE; METABOLISM; MOUSE; REPORTER GENE; SIGNAL TRANSDUCTION; THYMUS; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD44; GENE EXPRESSION REGULATION; GENES, REPORTER; INTEGRASES; LIGANDS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; THYMUS GLAND; TUMOR NECROSIS FACTORS;

EID: 65249117082     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900010     Document Type: Article

References (59)

1. Starr, T. K., S. C. Jameson, and K. A. Hogquist. 2003. Positive and negative selection of T cells. Annu. Rev. Immunol. 21: 139-176.
2. Kadlecek, T. A., N. S. van Oers, L. Lefrancois, S. Olson, D. Finlay, D. H. Chu, K. Connolly, N. Killeen, and A. Weiss. 1998. Differential requirements for ZAP-70 in TCR signaling and T cell development. J. Immunol. 161: 4688-4694.
3. Negishi, I., N. Motoyama, K. Nakayama, S. Senju, S. Hatakeyama, Q. Zhang, A. C. Chan, and D. Y. Loh. 1995. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376: 435-438.
4. Alam, S. M., P. J. Travers, J. L. Wung, W. Nasholds, S. Redpath, S. C. Jameson, and N. R. Gascoigne. 1996. T-cell-receptor affinity and thymocyte positive selection. Nature 381: 616-620.
5. Naeher, D., M. A. Daniels, B. Hausmann, P. Guillaume, I. Luescher, and E. Palmer. 2007. A constant affinity threshold for T cell tolerance. J. Exp. Med. 204: 2553-2559. (Pubitemid 350044781)
6. Savage, P. A., and M. M. Davis. 2001. A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity 14: 243-252.
7. Williams, C. B., D. L. Engle, G. J. Kersh, J. Michael White, and P. M. Allen. 1999. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J. Exp. Med. 189: 1531-1544.
8. He, X., and D. J. Kappes. 2006. CD4/CD8 lineage commitment: light at the end of the tunnel? Curr. Opin. Immunol. 18: 135-142. (Pubitemid 43327294)
9. Rothenberg, E. V., and T. Taghon. 2005. Molecular genetics of T cell development. Annu. Rev. Immunol. 23: 601-649.
10. Itano, A., P. Salmon, D. Kioussis, M. Tolaini, P. Corbella, and E. Robey. 1996. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183: 731-741. (Pubitemid 26113945)
11. Campbell, K. S., A. Buder, and U. Deuschle. 1995. Interactions between the amino-terminal domain of p56lck and cytoplasmic domains of CD4 and CD8α in yeast. Eur. J. Immunol. 25: 2408-2412.
12. Erman, B., A. S. Alag, O. Dahle, F. van Laethem, S. D. Sarafova, T. I. Guinter, S. O. Sharrow, A. Grinberg, P. E. Love, and A. Singer. 2006. Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. J. Immunol. 177: 6613-6625. (Pubitemid 44715024)
13. Singer, A., S. Adoro, and J. H. Park. 2008. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat. Rev. Immunol. 8: 788-801.
14. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3: 756-763.
15. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2: 301-306.
16. + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J. Immunol. 168: 4399-4405.
17. Hsieh, C. S., Y. Zheng, Y. Liang, J. D. Fontenot, and A. Y. Rudensky. 2006. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat. Immunol. 7: 401-410.
18. + regulatory T cells. Immunity 27: 493-504.
19. Pennington, D. J., B. Silva-Santos, T. Silberzahn, M. Escorcio-Correia, M. J. Woodward, S. J. Roberts, A. L. Smith, P. J. Dyson, and A. C. Hayday. 2006. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444: 1073-1077.
20. Silva-Santos, B., D. J. Pennington, and A. C. Hayday. 2005. Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors. Science 307: 925-928. (Pubitemid 40229229)
21. Mallett, S., S. Fossum, and A. N. Barclay. 1990. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes: a molecule related to nerve growth factor receptor. EMBO J. 9: 1063-1068. (Pubitemid 20110569)
22. Takeda, I., S. Ine, N. Killeen, L. C. Ndhlovu, K. Murata, S. Satomi, K. Sugamura, and N. Ishii. 2004. Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells. J. Immunol. 172: 3580-3589. (Pubitemid 38337939)
23. Le, S. Y., and J. V. Maizel, Jr. 1998. Evolution of a common structural core in the internal ribosome entry sites of picornavirus. Virus Genes 16: 25-38.
24. Gu, H., Y. R. Zou, and K. Rajewsky. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through CreloxP-mediated gene targeting. Cell 73: 1155-1164. (Pubitemid 23180489)
25. Dymecki, S. M. 1996. Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93: 6191-6196.
26. Srinivas, S., T. Watanabe, C. S. Lin, C. M. William, Y. Tanabe, T. M. Jessell, and F. Costantini. 2001. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1: 4. (Pubitemid 38883775)
27. Wang, Q., L. Malherbe, D. Zhang, K. Zingler, N. Glaichenhaus, and N. Killeen. 2001. CD4 promotes breadth in the TCR repertoire. J. Immunol. 167: 4311-4320. (Pubitemid 32954306)
28. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z. E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268: 563-566.
29. Bolstad, B. M., R. A. Irizarry, M. Astrand, and T. P. Speed. 2003. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19: 185-193.
30. Lonnstedt, I., and T. P. Speed. 2002. Replicated microarray data. Stat. Sinica 2: 31-46.
31. Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 57: 289-300.
32. Holm, S. 1979. A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6: 65-70.
33. Gentleman, R. C., V. J. Carey, D. M. Bates, B. Bolstad, M. Dettling, S. Dudoit, B. Ellis, L. Gautier, Y. Ge, J. Gentry, et al. 2004. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5: R80.
34. Dennis, G., Jr., B. T. Sherman, D. A. Hosack, J. Yang, W. Gao, H. C. Lane, and R. A. Lempicki. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4: P3.
35. Edgar, R., M. Domrachev, and A. E. Lash. 2002. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30: 207-210. (Pubitemid 34679544)
36. Pippig, S. D., C. Pena-Rossi, J. Long, W. R. Godfrey, D. J. Fowell, S. L. Reiner, M. L. Birkeland, R. M. Locksley, A. N. Barclay, and N. Killeen. 1999. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J. Immunol. 163: 6520-6529.
37. Baum, P. R., R. B. Gayle, 3rd, F. Ramsdell, S. Srinivasan, R. A. Sorensen, M. L. Watson, M. F. Seldin, E. Baker, G. R. Sutherland, K. N. Clifford, et al. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 13: 3992-4001.
38. Douek, D. C., R. D. McFarland, P. H. Keiser, E. A. Gage, J. M. Massey, B. F. Haynes, M. A. Polis, A. T. Haase, M. B. Feinberg, J. L. Sullivan, et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396: 690-695.
39. Takeshita, S., M. Toda, and H. Yamagishi. 1989. Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus. EMBO J. 8: 3261-3270. (Pubitemid 19273552)
40. Vu, M. D., M. R. Clarkson, H. Yagita, L. A. Turka, M. H. Sayegh, and X. C. Li. 2006. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J. Immunol. 176: 1394-1401.
41. Lio, C. W., and C. S. Hsieh. 2008. A two-step process for thymic regulatory T cell development. Immunity 28: 100-111.
42. Zhang, D. J., Q. Wang, J. Wei, G. Baimukanova, F. Buchholz, A. F. Stewart, X. Mao, and N. Killeen. 2005. Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. J. Immunol. 174: 6725-6731.
43. + cells. Int. Immunol. 19: 455-463.
44. Gramaglia, I., A. D. Weinberg, M. Lemon, and M. Croft. 1998. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161: 6510-6517. (Pubitemid 28562188)
45. Lazarski, C. A., F. A. Chaves, S. A. Jenks, S. Wu, K. A. Richards, J. M. Weaver, and A. J. Sant. 2005. The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance. Immunity 23: 29-40. (Pubitemid 41019655)
46. van Oers, N. S., N. Killeen, and A. Weiss. 1996. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183: 1053-1062.
47. Alessi, D. R., M. T. Kozlowski, Q. P. Weng, N. Morrice, and J. Avruch. 1998. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr. Biol. 8: 69-81.
48. Pullen, N., P. B. Dennis, M. Andjelkovic, A. Dufner, S. C. Kozma, B. A. Hemmings, and G. Thomas. 1998. Phosphorylation and activation of p70s6k by PDK1. Science 279: 707-710.
49. Lee, K. Y., F. D'Acquisto, M. S. Hayden, J. H. Shim, and S. Ghosh. 2005. PDK1 nucleates T cell receptor-induced signaling complex for NF-κB activation. Science 308: 114-118.
50. Nirula, A., M. Ho, H. Phee, J. Roose, and A. Weiss. 2006. Phosphoinositidedependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J. Exp. Med. 203: 1733-1744. (Pubitemid 44036279)
51. Hinton, H. J., D. R. Alessi, and D. A. Cantrell. 2004. The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development. Nat. Immunol. 5: 539-545. (Pubitemid 38660467)
52. Huang, Y. H., D. Li, A. Winoto, and E. A. Robey. 2004. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. USA 101: 4936-4941.
53. + T cells to antigen stimulation in vivo. Nat. Immunol. 1: 47-53.
54. Walker, L. S., A. Gulbranson-Judge, S. Flynn, T. Brocker, C. Raykundalia, M. Goodall, R. Forster, M. Lipp, and P. Lane. 1999. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J. Exp. Med. 190: 1115-1122.
55. + T cells. Immunity 25: 249-259.
56. Lathrop, S. K., N. A. Santacruz, D. Pham, J. Luo, and C. S. Hsieh. 2008. Antigenspecific peripheral shaping of the natural regulatory T cell population. J. Exp. Med. 205: 3105-3117.
57. Burchill, M. A., J. Yang, K. B. Vang, J. J. Moon, H. H. Chu, C. W. Lio, A. L. Vegoe, C. S. Hsieh, M. K. Jenkins, and M. A. Farrar. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 28: 112-121.
58. McHeyzer-Williams, L. J., and M. G. McHeyzer-Williams. 2004. Developmentally distinct Th cells control plasma cell production in vivo. Immunity 20: 231-242.
59. + T cells by activating integrin-dependent adhesion pathways. Proc. Natl. Acad. Sci. USA 94: 6898-6903.