Characterization of the expanded T-cell populations in patients with Wegener's granulomatosis

Journal of Internal Medicine

Volumn 260, Issue 3, 2006, Pages 224-230

  Giscombe, R ^a   Wang, X B ^a   Kakoulidou, M ^a   Lefvert, A K ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Lymphocytes; Phenotype; T cell receptor; Wegener's granulomatosis

Indexed keywords

CD134 ANTIGEN; CD137 ANTIGEN; CD28 ANTIGEN; CD30 ANTIGEN; CD40 ANTIGEN; CD57 ANTIGEN; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CCR5; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FLUOROCHROME; HLA DR ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHRONIC INFLAMMATION; CLINICAL ARTICLE; FEMALE; FLOW CYTOMETRY; GLOMERULONEPHRITIS; GRANULOMATOUS INFLAMMATION; HUMAN; MALE; PRIORITY JOURNAL; SWEDEN; SYSTEMIC VASCULITIS; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; WEGENER GRANULOMATOSIS;

ADULT; AGED; ANTIGENS, CD; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, CCR5; T-LYMPHOCYTE SUBSETS; WEGENER GRANULOMATOSIS;

EID: 33747383913     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2006.01688.x     Document Type: Article

References (34)

1. Walton EW. Giant-cell granuloma of the respiratory tract (Wegener's granulomatosis). Brit Med J 1958; 2: 265-70.
2. Specks U, DeRemee RA. Granulomatous vasculitis. Wegener's granulomatosis and Churg-Strauss syndrome. Rheum Dis Clin North Am 1990; 16: 377-97.
3. Fauci A, Haynes BF, Katz P. The spectrum of vasculitis. Ann Intern Med 1978; 89: 660-76.
4. Ronco P, Verroust P, Mignon F et al. Immunopathological studies of polyarteritis nodosa and Wegener's granulomatosis: a report of 43 patients with 51 renal biopsies. Q J Med 1983; 52: 212-23.
5. Kekow JA, Rautmann A, Ulmer M, Gross WL. Correlation of soluble interleukin 2 receptors (sIL-2R) levels with disease activity in Wegeners granulomatosis (WG). Am J Kidney Dis 1991; 18: 205.
6. Schmitt WH, Heesen C, Csernok E, Rautmann A, Gross WL. Elevated serum levels of soluble Interleukin-2 receptor in patients with Wegener's granulomatosis. Arthritis Rheum 1992; 35: 1088-96.
7. Wang G, Hansen H, Tatsis E, Csernok E, Lemke H, Gross WL. High plasma levels of the soluble form of CD30 activation molecule reflect disease activity in patients with Wegener's granulomatosis. Am J Med 1997; 102: 517-23.
8. Schlesier M, Kaspar T, Gutfleisch J, Peter HH. Activated CD4+ and CD8+ T cell subsets in Wegener's granulomatosis. Rheumatol Int 1995; 14: 213-9.
9. Lamprecht P, Moosig F, Csernok E et al. CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax 2001; 56: 751-7.
10. Komocsi A, Lamprecht P, Csernok E et al. Peripheral blood and granuloma CD4+CD28- T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis. Am J Pathol 2002; 160: 1717-24.
11. Giscombe R, Grunewald J, Nityanand S, Lefvert AK. T cell receptor (TCR) V gene usage in patients with systemic necrotizing vasculitis. Clin Exp Immunol 1995; 101: 213-9.
12. Grunewald J, Halapi E, Wahlström J et al. T-cell expansions with conserved T-cell receptor b chain motifs in the peripheral blood of HLA-DRB1*0401 positive patients with necrotizing vasculitis. Blood 1998; 92: 3737-44.
13. Giscombe R, Nityanand S, Lewin N, Grunewald J, Lefvert A. Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlates with disease activity. J Clin Immunol 1998; 18: 404-13.
14. Rao JK, Weinberger M, Oddone EZ, Allen NB, Landsman P, Feussner JR. The role of antineutrophil cytoplasmic antibodies (cANCA) testing in the diagnosis of Wegener granulomatosis. A literature review and meta-analysis. Ann Intern Med 1995; 123: 925-32.
15. Tervaert JWC, Huitema MG, Hene RJ et al. Prevention of relapses in Wegener's granulomatosis by treatment based on antineutrophil cytoplasmic antibody titre. Lancet 1990; 336: 709-11.
16. Salih HR, Kiener PA, Nussler V. 4-1 BB ligand-just another costimulating molecule? Int J Clin Pharmacol Ther 2002; 40: 348-53.
17. Bretscher PA. A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A 1999; 96: 185-90.
18. Alegre ML, Frauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 2001; 1: 220-8.
19. Walunas TL, Lenschow DJ, Bakker CY et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994; 1: 405-13.
20. Carreno BM, Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu Rev Immunol 2002; 20: 29-53.
21. Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995; 182: 459-65.
22. Brenchley JM, Karandikar NJ, Betts MR et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101: 2711-20.
23. Koike Y, Seki S, Ohkawa T et al. CD57+ t cells augment IFN-γ production in a one way mixed lymphocyte reaction and their expansion after stem cell transplantation in paediatric patients. Clin Exp Immunol 2002; 130: 162-8.
24. + T cell subsets in chronic lymphocytic leukemia. J Immunol 1997; 158: 1482-9.
25. Schwab R, Szabo P, Manavalan JS et al. Expanded CD4+ and CD8+ T cell clones in elderly humans. J Immunol 1997; 158: 4493-9.
26. Moosig F, Csernok E, Wang G, Gross WL. Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells in Wegener's granulomatosis. Clin Exp Immunol 1998; 114: 113-8.
27. Steiner K, Moosig F, Csernok E et al. Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. Clin Exp Immunol 2001; 126: 143-50.
28. Lamprecht P, Erdmann A, Mueller A et al. Heterogeneity of CD4+ an CD8+ memory T cells in localized and generalized Wegener's granulomatosis. Arthritis Res Ther 2003; 5: R25-31.
29. Lamprecht P, Bruhl H, Erdmann A et al. Differences inCCR5 expression on peripheral blood CD4+CD28- T cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clin Immunol 2003; 108: 1-7.
30. Cannons JL, Lau P, Ghumman B et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. Journal of Immunology 2001; 167: 1313-24.
31. Kwon B, Lee H, Kwon B. New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells. Trend Immunol 2002; 8: 378-80.
32. Broll K, Richter G, Pauly S, Hofstaederdter F, Schwarz H. CD137 expression in tumor vessel walls: high correlation with malignant tumors. Am J Clin Pathol 2001; 115: 543.
33. Lee H-W, Nam K-O, Seo S, Kim YH, Kang H, Kwon BS. 4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocyte. Cellular Immunology 2003; 223: 143-50.
34. Goronzy JJ, Weyand CM. T-cell senescence and contraction of T cell repertoire diversity-catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther 2003; 5: 225-34.