OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

European Journal of Immunology

Volumn 33, Issue 12, 2003, Pages 3265-3274

  Obermeier, Florian ^a   Schwarz, Herbert ^b   Dunger, Nadja ^a   Strauch, Ulrike G ^a   Grunwald, Nicole ^a   Schölmerich, Jürgen ^a   Falk, Werner ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b Cantab Pharmaceuticals Ltd   (United Kingdom)

Author keywords

CD134; CXCR5; Dextran sulfate sodium; Experimental colitis; OX40

Indexed keywords

CD134 ANTIGEN; CD134 LIGAND; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR5; DEXTRAN SULFATE; HYBRID PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 5; LIGAND; MESSENGER RNA; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CHRONIC DISEASE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENTERITIS; FEMALE; GERMINAL CENTER; HISTOPATHOLOGY; LYMPH FOLLICLE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SCORING SYSTEM; T LYMPHOCYTE;

EID: 0346752125     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324124     Document Type: Article

References (42)

1. Andus, T. and Gross, V., Etiology and pathophysiology of inflammatory bowel disease - environmental factors. Hepatogastroenterology 2000. 47: 29-43.
2. Sartor, R. B., Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases. Am. J. Gastroenterol. 1997. 92: 5S-11S.
3. Hara, J., Ohtani, H., Matsumoto, T., Nakamura, S., Kitano, A., Arakawa, T., Nagura, H. and Kobayashi, K., Expression of costimulatory molecules B7-1 and B7-2 in macrophages and granulomas of Crohn's disease: demonstration of cell-to-cell contact with T lymphocytes. Lab. Invest. 1997. 77: 175-184.
4. Cong, Y., Weaver, C. T., Lazenby, A. and Elson, C. O., Colitis induced by enteric bacterial antigen-specific CD4+ T cells requires CD40-CD40 ligand interactions for a sustained increase in mucosal IL-12. J. Immunol. 2000. 165: 2173-2182.
5. De Jong, Y. P., Comiskey, M., Kalled, S. L., Mizoguchi, E., Flavell, R. A., Bhan, A. K. and Terhorst, C., Chronic murine colitis is dependent on the CD154/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology 2000. 119: 715-723.
6. Stuber, E., Strober, W. and Neurath, M., Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J. Exp. Med. 1996. 183: 693-698.
7. Vuckovic, S., Florin, T. H., Khalil, D., Zhang, M. F., Patel, K., Hamilton, I. and Hart, D. N., CD40 and CD86 upregulation with divergent CMRF44 expression on blood dendritic cells in inflammatory bowel diseases. Am. J. Gastroenterol. 2001. 96: 2946-2956.
8. Nakazawa, A., Watanabe, M., Kanai, T., Yajima, T., Yamazaki, M., Ogata, H., Ishii, H., Azuma, M. and Hibi, T., Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa. Gastroenterology 1999. 117: 536-545.
9. Calderhead, D. M., Buhlmann, J. E., van den Eertwegh, A. J., Claassen, E., Noelle, R. J. and Fell, H. P., Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions. J. Immunol. 1993. 151: 5261-5271.
10. Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T. and Lane, P. J., Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol. Today 2000. 21: 333-337.
11. De Smedt, T., Smith, J., Baum, P., Fanslow, W., Butz, E. and Maliszewski, C., Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol. 2002. 168: 661-670.
12. Maxwell, J. R., Weinberg, A., Prell, R. A. and Vella, A. T., Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J. Immunol. 2000. 164: 107-112.
13. Gramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N. and Croft, M., The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 2000. 165: 3043-3050.
14. Rogers, P. R., Song, J., Gramaglia, I., Killeen, N. and Croft, M., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001. 15: 445-455.
15. Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T., Raykundalia, C., Goodall, M., Forster, R., Lipp, M. and Lane, P., Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J. Exp. Med. 1999. 190: 1115-1122.
16. Brocker, T., Gulbranson-Judge, A., Flynn, S., Riedinger, M., Raykundalia, C. and Lane, P., CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur. J. Immunol. 1999. 29: 1610-1616.
17. Bansal-Pakala, P., Jember, A. G. and Croft, M., Signaling through OX40 (CD134) breaks peripheral T-cell tolerance. Nat. Med. 2001. 7: 907-912.
18. Murata, K., Nose, M., Ndhlovu, L. C., Sato, T., Sugamura, K. and Ishii, N., Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J. Immunol. 2002. 169: 4628-4636.
19. Nohara, C., Akiba, H., Nakajima, A., Inoue, A., Koh, C. S., Ohshima, H., Yagita, H., Mizuno, Y. and Okumura, K., Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J. Immunol. 2001. 166: 2108-2115.
20. Tsukada, N., Aklba, H., Kobata, T., Aizawa, Y., Yagita, H. and Okumura, K., Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation. Blood 2000. 95: 2434-2439.
21. Malmstrom, V., Shipton, D., Singh, B., Al Shamkhani, A., Puklavec, M. J., Barclay, A. N. and Powrie, F., CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 2001. 166: 6972-6981.
22. Higgins, L. M., McDonald, S. A., Whittle, N., Crockett, N., Shields, J. G. and MacDonald, T. T., Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 1999. 162: 486-493.
23. Souza, H. S., Elia, C. C., Spencer, J. and MacDonald, T. T., Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut 1999. 45: 856-863.
24. Wang, H. C. and Klein, J. R., Multiple levels of activation of murine CD8(+) intraepithelial lymphocytes defined by OX40 (CD134) expression: effects on cell-mediated cytotoxicity, IFN-gamma, and IL-10 regulation. J. Immunol. 2001. 167: 6717-6723.
25. Arestides, R. S., He, H., Westlake, R. M., Chen, A. I., Sharpe, A. H., Perkins, D. L. and Finn, P. W., Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. Eur. J. Immunol. 2002. 32: 2874-2880.
26. Kojouharoff, G., Hans, W., Obermeier, F., Männel, D. N., Andus, T., Schölmerich, J., Gross, V. and Falk, W., Neutralization of tumor necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate-induced colitis in mice. Clin. Exp. Immunol. 1997. 107: 353-358.
27. Obermeier, F., Kojouharoff, G., Schölmerich, J., Gross, V., and Falk, W., Mucosal damage in chronic DSS-colitis in mice is mediated by IL-12 and prevented by IL-10. Gastroenterology 1998. 114: A1053.
28. Obermeier, F., Kojouharoff, G., Hans, W., Schölmerich, J., Gross, V. and Falk, W., Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice. Clin. Exp. Immunol. 1999. 116: 238-245.
29. Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W. and Remaut, E., Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000. 289: 1352-1355.
30. Myers, K. J., Murthy, S., Flanigan, A., Witchell, D. R., Butler, M., Murray, S., Siwkowski, A., Goodfellow, D., Madsen, K and Baker, B., Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis. J. Pharmacol. Exp. Ther. 2003. 304: 411-424.
31. Grose, R. H., Howarth, G. S., Xian, C. J. and Hohmann, A. W., Expression of B7 costimulatory molecules by cells infiltrating the colon in experimental colitis induced by oral dextran sulfate sodium in the mouse. J. Gastroenterol. Hepatol. 2001. 16: 1228-1234.
32. Ohshima, Y., Yang, L. P., Uchiyama, T., Tanaka, Y., Baum, P., Sergerie, M., Hermann, P. and Delespesse, G., OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 1998. 92: 3338-3345.
33. Akiba, H., Miyahira, Y., Atsuta, M., Takeda, K., Nohara, C., Futagawa, T., Matsuda, H., Aoki, T., Yagita, H. and Okumura, K., Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 2000. 191: 375-380.
34. Jember, A. G., Zuberi, R., Liu, F. T. and Croft, M., Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40. J. Exp. Med. 2001. 193: 387-392.
35. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Noda, T. and Sugamura, K., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 2000. 191: 365-374.
36. Chen, A. I., McAdam, A. J., Buhimann, J. E., Scott, S., Lupher, M. L. Jr., Greenfield, E. A., Baum, P. R., Fanslow, W. C., Calderhead, D. M., Freeman, G. J. and Sharpe, A. H., Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity 1999. 11: 689-698.
37. Ohshima, Y., Tanaka, Y., Tozawa, H., Takahashi, Y., Maliszewski, C. and Delespesse, G., Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 1997. 159: 3838-3848.
38. Schaerli, P., Loetscher, P. and Moser, B., Cutting edge: induction of follicular homing precedes effector Th cell development. J. Immunol. 2001. 167: 6082-6086.
39. Moser, B., Schaerli, P. and Loetscher, P., CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol. 2002. 23: 250-254.
40. Moser, B. and Ebert, L., Lymphocyte traffic control by chemokines: follicular B helper T cells. Immunol. Lett. 2003. 85: 105-112.
41. Carlsen, H. S., Baekkevold, E. S., Johansen, F. E., Haraldsen, G. and Brandtzaeg, P., B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut 2002. 51: 364-371.
42. Kramer, D. R. and Cebra, J. J., Early appearance of "natural" mucosal IgA responses and germinal centers in suckling mice developing in the absence of maternal antibodies. J. Immunol. 1995. 154: 2051-2062.