OX40/OX40L in systemic lupus erythematosus: Association with disease activity and lupus nephritis

Annals of Saudi Medicine

Volumn 31, Issue 1, 2011, Pages 29-34

  Farres, Mohamed N ^a   Al Zifzaf, Dina S ^a   Aly, Alaa A ^a   Abd Raboh, Nermine M ^b  

^a AIN SHAMS UNIVERSITY   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CREATININE; DOUBLE STRANDED DNA ANTIBODY; OX40 LIGAND;

ADOLESCENT; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; EGYPT; FEMALE; FLOW CYTOMETRY; HUMAN; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; OUTPATIENT DEPARTMENT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SYSTEMIC LUPUS ERYTHEMATOSUS; UNIVERSITY HOSPITAL;

ADOLESCENT; ADULT; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; NEPHRITIS; OX40 LIGAND; RECEPTORS, OX40; ROC CURVE; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 79251612617     PISSN: 02564947     EISSN: 09754466     Source Type: Journal    
DOI: 10.4103/0256-4947.75775     Document Type: Article

References (20)

1. Weinberg AD. OX40: Targeted immunotherapy-implications for tempering autoimmunity and enhancing vaccines. Trends Immunol 2002;23:102-9.
2. Weinberg AD, Evans DE, Thalhofer C, Shi T, Prell RA. The generation of T cell memory: A review describing the molecular and cellular events following OX40 (CD134) engagement. J Leukoc Biol 2004;75:962-72.
3. Manku H, Graham DS, Vyse TJ. Association of the co-stimulator OX40L with systemic lupus erythematosus. J Mol Med 2009;87:229-34.
4. Cunninghame Graham DS, Graham RR, Manku H, Wong AK, Whittaker JC, Gaffney PM, et al. Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus. Nat Genet 2008;40:83-9.
5. Tucci M, Calvani N, Richards HB, Quatraro C, Silvestris F. The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis. Ann N Y Acad Sci 2005;1051:421-32.
6. Odobasic D, Kitching AR, Tipping PG, Holdsworth SR. CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney Int 2005;68:584-94.
7. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.
8. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 1992;35:630-40.
9. Weening JJ, D'Agati VD, Schwartz MM, Seshan S V, Alpers CE, Appel GB, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 2004;65:521-30.
10. Anolik JH. B cell biology and dysfunction in SLE. Bull NYU Hosp Jt Dis 2007;65:182-6.
11. Zhu J, Liu X, Xie C, Yan M, Yu Y, Sobel ES, et al. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest 2005;115:1869-78.
12. Foell J, Mittler RS. Costimulatory molecules as immunotherapeutic targets in systemic lupus erythematosus. Springer Semin Immunopathol 2006;28:153-62.
13. Zhou YB, Ye RG, Li YJ, Xie CM, Wu YH. Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsD-NA antibody production in spleen cells from lupusprone BXSB mice. Autoimmunity 2008;41:395-404.
14. Patschan S, Dolff S, Kribben A, Dürig J, Patschan D, Wilde B, et al. CD134 expression on CD4+ T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus. Clin Exp Immunol 2006;145:235-42.
15. Li M, Yang Q, Zhang Y. Effects of CD134 monoclonal antibody on hemolysis activities and expression of perforin in peripheral blood mononuclear cells of systemic lupus erythematosus patients. Hybridoma (Larchmt) 2007;26:191-200.
16. Aten J, Roos A, Claessen N, Schilder-Tol EJ, Ten Berge IJ, Weening JJ. Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J Am Soc Nephrol 2000;11:1426-38.
17. Zhou YB, Ye RG, Li YJ, Xie CM. Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis. Rheumatol Int 2009;29:417-25.
18. Putterman C. New approaches to the renal pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. Autoimmun Rev 2004;3:7-11.
19. Lathrop SK, Huddleston CA, Dullforce PA, Montfort MJ, Weinberg AD, Parker DC. A signal through OX40 (CD134) allows anergic, autoreactive T cells to acquire effector cell functions. J Immunol 2004;172:6735-43.
20. Schwartz N, Rubinstein T, Burkly LC, Collins CE, Blanco I, Su L, et al. Urinary TWEAK as a biomarker of lupus nephritis: A multicenter cohort study. Arthritis Res Ther 2009;11: R143.