Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions

European Journal of Immunology

Volumn 34, Issue 11, 2004, Pages 3039-3046

  Pakala, Syamasundar V ^a   Bansal Pakala, Pratima ^a   Halteman, Beth S ^a   Croft, Michael ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Diabetes; NOD; OX40; OX40L

Indexed keywords

CD134 ANTIGEN; CD134 LIGAND; CD4 ANTIGEN; CD8 ANTIGEN; LYMPHOCYTE ANTIBODY; LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; DENDRITIC CELL; DEVELOPMENTAL STAGE; DIABETES MELLITUS; DISEASE COURSE; HISTOPATHOLOGY; IMMUNOTHERAPY; INSULITIS; LYMPHOID ORGAN; MOLECULAR INTERACTION; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNOHISTOCHEMISTRY; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; PANCREAS; SPLEEN; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTORS;

EID: 9244243051     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425141     Document Type: Article

References (30)

1. Tisch, R. and McDevitt, H., Insulin-dependent diabetes mellitus. Cell 1996. 85: 291-297.
2. + T cells. J. Exp. Med. 1987. 166: 823-832.
3. Bach, J. F. and Mathis, D., The NOD mouse. Res. Immunol. 1997. 148: 285-286.
4. Delovitch, T. L. and Singh, B., The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997. 7: 727-738.
5. Kurrer, M. O., Pakala, S. V., Hanson, H. L. and Katz, J. D., Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 1997. 94: 213-218.
6. Lenschow, D. J., Ho, S. C., Sattar, H., Rhea, L., Gray, G., Nabavi, N., Herold, K. C. and Bluestone, J. A., Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 1995. 181: 1145-1155.
7. Balasa, B., Krahl, T., Patstone, G., Lee, J., Tisch, R., McDevitt, H. O. and Sarvetnick, N., CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice. J. Immunol. 1997. 159: 4620-4627.
8. Croft, M., Co-stimulatory members of the TNFR family: Keys to effective T cell immunity? Nat. Rev. Immunol. 2003. 3: 609-620.
9. Gramaglia, I., Weinberg, A. D., Lemon, M. and Croft, M., Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 1998. 161: 6510-6517.
10. Rogers, P. R., Song, J., Gramaglia, I., Killeen, N. and Croft, M., OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 2001. 15: 445-455.
11. Salek-Ardakani, S., Song, J., Halteman, B. S., Jember, A. G., Akiba, H., Yagita, H. and Croft, M., OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J. Exp. Med. 2003. 198: 315-324.
12. Ohshima, Y., Tanaka, Y., Tozawa, H., Takahashi, Y., Maliszewski, C. and Delespesse, G., Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 1997. 159: 3838-3848.
13. Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T., Raykundalla, C., Goodall, M., Forster, R., Lipp, M. and Lane, P., Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J. Exp. Med. 1999. 190: 1115-1122.
14. Gramaglia, I., Jember, A., Pippig, S. D., Weinberg, A. D., Killeen, N. and Croft, M., The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 2000. 165: 3043-3050.
15. Bansal-Pakala, P., Gebre-Hiwot Jember, A. and Croft, M., Signaling through OX40 (CD134) breaks peripheral T cell tolerance. Nat. Med. 2001. 7: 907-912.
16. Baum, P. R., Gayle, R. B., Ramsdell, F., Srinivasan, S., Sorensen, R. A., Watson, M. L., Seldin, M. F., Baker, E., Sutherland, G. R., Clifford, K. N., Alderson, M. R., Goodwin, R. G. and Fanslow, W. C., Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J. 1994. 13: 3992-4001.
17. Al-Shamkhani, A., Birkeland, M. L., Puklavec, M., Brown, M. H., James, W. and Barclay, A. N., OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 1996. 26: 1695-1699.
18. Wang, H. C. and Klein, J. R., Multiple levels of activation of murine CD8(+) intraepithelial lymphocytes defined by OX40 (CD134) expression: effects on cell-mediated cytotoxicity, IFN-gamma, and IL-10 regulation. J. Immunol. 2001. 167: 6717-6723.
19. De Smedt, T., Smith, J., Baum, P., Fanslow, W., Butz, E. and Maliszewski, C., Ox40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol. 2002. 168: 661-670.
20. Yoshioka, T., Nakajima, A., Akiba, H., Ishiwata, T., Asano, G., Yoshino, S., Yagita, H. and Okumura, K., Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur. J. Immunol. 2000. 30: 2815-2823.
21. Martin-Orozco, N., Chen, Z., Poirot, L., Hyatt, E., Chen, A., Kanagawa, O., Sharpe, A., Mathis, D. and Benoist, C., Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. J. Immunol. 2003. 171: 6954-6960.
22. Croft, M., Costimulation of T cells by OX40, 4-1BB, and CD27. Cytokine Growth Factor Rev. 2003. 14: 265-273.
23. Weinberg, A. D., Wallin, J. J., Jones, R. E., Sullivan, T. J., Bourdette, D. N., Vandenbark, A. A. and Offner, H., Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J. Immunol. 1994. 152: 4712-4721.
24. Tittle, T. V., Weinberg, A. D., Steinkeler, C. N. and Maziarz, R. T., Expression of the T cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease. Blood 1997. 89: 4652-4658.
25. Stuber, E., Buschenfeld, A., Luttges, J., Von Freier, A., Arendt, T. and FoIsch, U. R., The expression of OX40 in immunologically mediated diseases of the gastrointestinal tract (celiac disease, Crohn's disease, ulcerative colitis). Eur. J. Clin. Invest. 2000. 30: 594-599.
26. Stuber, E., Neurath, M., Calderhead, D., Fell, H. P. and Strober, W., Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic; B cells. Immunity 1995. 2: 507-521.
27. Murata, K., Ishii, N., Takano, H., Miura, S., Ndhlovu, L. C., Nose, M., Node, T. and Sugamura, K., Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 2000. 191: 365-374.
28. Malmstrom, V., Shipton, D., Singh, B., Al-Shamkhani, A., Puklavec, M. J., Barclay, A. N. and Powrie, F., CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J. Immunol. 2001. 166: 6972-6981.
29. Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K. and Fathman, C. G., Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 1988. 240: 659-662.
30. Chatenoud, L., Thervet, E., Primo, J. and Bach, J. F., Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA 1994. 91: 123-127.