Relationship between OX40/4-1 BB (CD134/CD137) costimulatory molecules expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease;Analiza zależności miȩdzy cza̧steczkami OX40/4-1 BB (CD134/CD137) obecnymi na powierzchni limfocytów T a autoprzeciwciałami stymuluja̧cymi i blokuja̧cymi receptor TSH u dzieci z choroba̧ Gravesa-basedowa

Endokrynologia, Diabetologia i Choroby Przemiany Materii Wieku Rozwojowego

Volumn 11, Issue 3, 2005, Pages 133-140

  Bossowski, Artur ^a   Stasiak Barmuta, Anna ^b   Urban, Miroslawa ^a   Rinderle, Cornelia ^c  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^b BRAHMS Diagnostica w Berlinie ^*  (Poland)

^c Laboratorium Badawcze   (Poland)

Author keywords

Antithyroid autoantibodies; Costimulatory molecules; Graves' disease; Lymphocytes; Non toxic nodular goiter

Indexed keywords

AUTOANTIBODY; CD134 ANTIGEN; CD137 ANTIGEN; CD137 LIGAND; THIAMAZOLE; THYROTROPIN RECEPTOR ANTIBODY; BLOCKING ANTIBODY; LEUKOCYTE ANTIGEN; NERVE GROWTH FACTOR RECEPTOR; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN RECEPTOR; TNFRSF4 PROTEIN, HUMAN; TNFRSF9 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR;

ADOLESCENT; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; MONOCYTE; NODULAR GOITER; RADIOIMMUNOASSAY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; BLOOD; CASE CONTROL STUDY; CHILD; GENE EXPRESSION; METABOLISM;

ADOLESCENT; ANTIBODIES, BLOCKING; ANTIGENS, CD; ANTIGENS, CD137; CASE-CONTROL STUDIES; CHILD; GENE EXPRESSION; GOITER, NODULAR; GRAVES DISEASE; HUMANS; IMMUNOGLOBULINS, THYROID-STIMULATING; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, OX40; RECEPTORS, THYROTROPIN; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 25844500274     PISSN: 1234625X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Ajjan R.A., Kemp E.H., Waterman E.A. i wsp.: Detection of binding and blocking autoantibodies to the human sodium-iodine symporter in patients with autoimmune thyroid disease. J. Clin. Endocrinol. Metab., 2000, 85, 2020.
2. Akamizu T., Moriyama K., Miura M. i wsp.: Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: epitope and binding study of two stimulatory TSHRAbs. Endocrinology, 1999, 140, 1594.
3. Aust G.G., Lehmann Y., Heberling H.J.: Different immunophenotype and autoantibody production by peripheral blood and thyroid-derived lymphocytes in patients with Graves'disease. Exp. Clin. Endocrinol., 1996, 104, 50.
4. Bansal-Pakala P., Jember A.G.H., Croft M.: Signaling through OX40 (CD134) breaks peropheral T-cell tolerance. Nat. Med., 2001, 7, 907.
5. Battifora M., Pesce G., Paolieri F. i wsp.: B7.1 costimulatory molecule is expressed on thyroid follicular cells in Hashimoto's thyroiditis, but not in Graves' disease. J. Clin. Endocrinol. Metab., 1998, 83, 4130.
6. Damle N., Klussman K., Leytze G. i wsp.: Costimulation of T lymphocytes with intergrin ligands intercellular adhesion molecule-1 or vascular cell adhesion mo lecule-1 induces functional expression of CTLA-4, a second receptor for B7. J. Immunol., 1994, 152, 2686.
7. De Smedt T., Smith J., Baum P. i wsp.: Ox 40 costimulation enhances the development of T cell responses induced by dendritic cells in vivo. J. Immunol., 2002, 168, 661.
8. Evans D.E., Prell R.A., Thalhofer C.J. i wsp.: Engagement of OX40 enhances antigen-specific CD4+ T cell mobilization/memory development and humoral immunity: comparison pf alpha OX-40 with alpha CTLA-4. J. Immunol., 2001, 167, 6804.
9. Guo J., Rapoport B., McLachlan: Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro. Autoimmunity, 1999, 30, 1.
10. Kakinuma A., Morimoto I., Kuroda T. i wsp.: Comparison of recombinant human thyrotropin receptors versus porcine thyrotropin receptors in the thyrotropin binding inhibition assay for thyrotropin receptor autoantibodies. Thyroid, 1999, 9, 849.
11. Kuchroo V.K., Das M.P., Brown J.A.: B7.1 and B7.2 costimulatory molecules differentially activate the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell, 1995, 80, 707.
12. Kwon B., Lee H.W., Kwon B.: New insights into the role of 4-1 BB in immune responses: beyond CD8+ T cells. Trends Immunol., 2002, 23, 378.
13. Langstein J., Schwarz H.: Identification of CD 137 as a potent monocyte survival factor. J. Leukoc. Biol., 1999, 65, 829.
14. Marazuela M.: Lymphocyte traffic and homing in autoimmune thyroid disorders. Eur. J. Endocrinol., 1999, 140, 287.
15. Morgenthaler N.G., Pampel I., Aust G. i wsp.: Application of a Bioassay with CHO cells for the routine detection of stimulating and blocking autoantibodies to the TSH-receptor. Horm. Metab. Res., 1998, 30, 162.
16. Oosterwegel A.M., Greenwald R.J., Mandelbrot D.A. i wsp.: CTLA-4 and T cell activation. Curr. Opin. Imunol., 1999, 11, 294.
17. Petty J.K., He K., Corless C.L. i wsp.: Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecules OX-40 (CD134). Am. J. Surg., 2002, 183, 512.
18. Pozzilli P., Carotenuto P., Delitalia G.: Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity. Clin. Endocrinol., 1994, 41, 545.
19. Racke M.K., Stuart R.W.: Targeting T cell costimulation in autoimmune disease. Exp. Opin. Ther. Targets, 2002, 6, 275.
20. Rogers P.R., Croft M.: CD28, OX-40, LFA-1 and CD4 modulation of TH1/Th2 differentiation is directly dependent on the dose of antigen. J. Immunol., 2000, 164, 2955.
21. Roos A., Schilder-Tol E.J., Weening J.J., Aten J.: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J. Leukoc. Biol., 1998, 64, 503.
22. Salmaso C., Olive D., Pesce G., Bagnasco M.: Costimulatory molecules and autoimmune thyroid diseases. Autoimmunity, 2002, 35, 159.
23. Sansom D., Hall N.: B7/BB1, the ligand for CD28, is expressed on repeatedly activated human cells in vitro. Eur. J. Immunol., 1993, 23, 295.
24. Shah R., Banks K., Patel A.: Intense expression of the B7.2 antigen presentation coactivator is an unfavourable prognostic indicator for differentiated thyroid carcinoma of children and adolescents. J. Clin. Endocrinol. Metab., 2002, 87, 4391.
25. Shimizu J., Yamazaki S., Takahashi T. i wsp.: Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance. Nature Immunol., 2002, 3, 135.
26. Singh B., Read S., Asseman C. i wsp.: Control of intestinal inflammation by regulatory T cells. Immunol. Rev., 2001, 182, 190.
27. Takasawa N., Ishii N., Higashimura N. i wsp.: Expression of gp34 (OX40L) on human T cell clones. Jap. J. Can. Res., 2001, 92, 377.
28. Taraban V.Y., Rowley T.F., O'Brien L. i wsp.: Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1 BB), and their role in the generation of anti-tumor immune responses. Eur. J. Immunol., 2002, 32, 3617.
29. Taylor L., Schwarz H.: Identification of a soluble OX40 isoform: development of a specific and quantitative immunoassay. J. Immunol. Met., 2001, 255, 67.
30. Van der Heijden H.J., De Bruin T.W., Glaudamans K.A. i wsp.: Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves'disease. Clin. Exp. Immunol., 1999, 118, 205.
31. Vinay D.S., Kwon B.S.: Differential expression and costimulatory effect of 4-1 BB (CD137) and CD28 molecules on cytokine-induced murine CD8(+) Tc1 and Tc2 cells. Cell Immunol., 1999, 192, 63.
32. Watts T.H., DeBenedette M.A.: T cell co-stimulatory molecules other than CD28. Curr. Opin. Imunol., 1999, 11, 286.
33. Weetman A.P., McGregor A.M.: Autoimmune thyroid disease: further developments in our understanding. Endocr. Rev., 1994, 15, 788.
34. Weetman A.P., Tandon N., Morgan B.P.: Antithyroid drugs and release of inflammatory mediators by complement-atttacted thyroid cells. Lancet, 1992, 340, 633.
35. Weinberg A.D.: OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines. Trends Immunol., 202, 23, 102.
36. Wyss-Coray T., Mauri-Hellweg D., Baumann K. i wsp.: The B7 adhesion molecule is expressed on activated human T cells: functional involvment in T-T cell interactions. Eur. J. Immunol., 1993, 23, 2175.