The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 979-989

  Stüber, Eckhard ^a   Strober, Warren ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN M; OX40 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL INTERACTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; GERMINAL CENTER; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCING CELL; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIGENS, CD27; B-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MODELS, IMMUNOLOGICAL; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; SPLEEN; T-LYMPHOCYTES; TUMOR NECROSIS FACTORS;

EID: 0029938992     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.979     Document Type: Article

References (36)

1. Liu, Y.-L., J. Zhang, P.J.L. Lane, E.Y.-T. Chan, and I.C.M. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951-2962.
2. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165-1175.
3. Jacob, J., and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679-687.
4. Kelsoe, G., and B. Zengh. 1993. Sites of B-cell activation in vivo. Curr. Opin. Immunol. 5:418-422.
5. + T cells. J. Exp. Med. 179: 819-830.
6. Linsley, P., P.M. Wallace, J. Johnson, M.G. Gibson, J.L. Green, J.A. Ledbetter, C. Singh, and M.A. Tepper. 1992. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science (Wash. DC). 257:792-795.
7. + T cells and defective antibody production in vivo. J. Exp. Med. 179:809-817.
8. Foy, T.M., J.D. Laman, J.A. Ledbetter, A. Aruffo, E. Claassen, and R.J. Noelle. 1994. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180:157-163.
9. Fuleihan, R., N. Ramesh, and R.S. Geha. 1993. Role of CD40-CD40-ligand in Ig-isotype switching. Curr. Opin. Immunol. 5:963-967.
10. Linton, P.-J., D.J. Decker, and N.R. Klinman. 1989. Primary antibody forming cells and secondary B cells are generated from separate precursor cell populations. Cell. 59:1049-1059.
11. Paterson, D.J., W.A. Jefferies, J.R. Green, M.R. Brandon, P. Corthesy, M. Puklavec, and A.F. Williams. 1987. Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24:1281-1290.
12. Calderhead, D.M., J.E. Buhlmann, A.J.M. van der Eertwegh, E. Claassen, R.J. Noelle, and H.P. Fell. 1993. Cloning of mouse Ox40: a T cell activation marker that may mediate T-B interactions. J. Immunol. 151:5261-5271.
13. Sniber, E.R., M.F. Neurath, D. Calderhead, H.P. Fell, and W. Strober. 1995. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity. 2:307-521.
14. Bradford, M.M. 1976. A rapid sensitive method for the quanatation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
15. Claassen, E., N. Kors, and N. van Rooijen. 1986. Influence of carriers on the development and localization of anti-trinitrophenyl antibody-forming cells in the murine spleen. Eur. J. Immunol. 16:492-497.
16. Baum, P.R., R.B Gayle, F. Ramsdell, S. Srinivasan, R.A. Sorensen, M.L. Watson, M.F. Seldin, E. Baker, G.R. Sutherland, K.N. Clifford, et al. 1994. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1 regulated protein gp34. EMBO (Eur. Mol. Biol. Organ.) J. 13:3992-4001.
17. + T cells with homology to tumor necrosis factor. J. Exp. Med. 180:757-762.
18. Neurath, M.F., E.E. Max, and W. Strober. 1995. Pax5 regulates the murine immunoglobulin 3′α enhancer by affecting binding of NFαP, a protein that controls heavy chain transcription. Proc. Natl. Acad. Sci. USA. 92:5336-5340.
19. van Rooijen, N., W.E. Claassen, and P. Eikelenboom. 1986 Is there a single differentiation pathway for all antibody-forming cells in the spleen? Immunol. Today. 7:193-196.
20. Van den Eertwegh, A.J.M., R.J. Noelle, M. Roy, D.M. Shepherd, A. Aruffo, J.A. Ledbetter, W.J.A. Boersma, and E. Claassen. 1993. In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J. Exp. Med. 178:1555-1565.
21. + T cells. J. Immunol. 151:2497-2510.
22. Castle, B.E., K. Kishimoto, C. Stearns, M.L. Brown, and M.R. Kehry. 1993. Regulation of expression of the ligand for ligand on T helper lymphocytes. J. Immunol. 151:1777-1788.
23. Ling, N.R., I.C.M. MacLennan, and D.Y. Mason. 1987. B cell and plasma cell antigens: new and previously defined clusters. In Leukocyte Typing III. A.J. McMicael, editor. Oxford University Press, Oxford. 302-335.
24. van Kooten, C., C. Gaillard, J.P Gallizi, P. Hermann, F. Fossiez, J. Banchereau, and D. Blanchard. 1994. B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24:787-792.
25. Aruffo, A., M. Farrington, D. Hollenbaugh, X. Li, A. Milatovich, S. Nonoyama, J. Bajorath, L.S. Grosmeier, R. Stenkamp, And R. Neubauer. 1993. The CD40 ligand, gp39, is defective in activated T cells from patients with hyper-IgM syndrome. Cell. 72:291-300.
26. Allen, R.C., R.J. Armitage, M.E. Conley, H. Rosenblatt, N.A. Jenkins, N.G. Copeland, M.A. Bedell, S. Edelhoff, C.M. Disteche, and A. Simoneau. 1993. CD40 ligand gene defects responsible in X-linked hyper-IgM syndrome. Science (Wash. DC) 259:990-993.
27. DiSanto, J.P., J.Y. Bonnefoy, J.F. Gauchat, A. Fischer, and G. de Saint Basile. 1993. CD40-ligand mutations in x-linked immunodeficiency with hyper-IgM. Nature (Lond.). 361:541-543.
28. Korthauer, U., D. Graf, H.W. Mages, F. Briere, M. Padayachee, S Malcom, A.G. Ugazio, L.D. Notarangelo, R.J. Levinsky, and R.A. Kroczek. 1993. Defective expression of T-cell CD40 ligand causes x-linked immunodeficiencey with hyper-IgM. Nature (Lond.). 361:539-541.
29. MacLennan, I.C.M. 1994. Germinal centers. Annu. Rev. Immunol. 12:117-139.
30. Allman, D.M., S.E. Ferguson, V.M. Lentz, and M.P. Cancro. 1993. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immune developmental intermediate in the production of long lived marrow-derived B cells. J. Immunol. 151:4431-4444.
31. Pulendran, B., M. Karvelas, and G J.V. Nossal. 1994. A form of immunologic tolerance through impairment of germinal center development. Proc. Natl. Acad. Sci. USA. 91:2639-2643.
32. Weinstein, P.D., and J.J. Cebra. 1991. The preference for switching to IgA by Peyer's patch germinal center B cells is likely due to the intrinsic influence of their microenvironment. J. Immunol. 147:4126-4135.
33. DiSanto, J.P., G. de Saint Basile, A. Durandy, and A. Fischer. 1994. Hyper-IgM syndrome. Res. Immunol. 145:205-209.
34. Pecanha, L.M.T., H. Yamaguchi, A. Lees, R.J. Noelle, J. Mond, and C.M. Snapper. 1993. Dextran-conjugated anti-IgD antibodies inhibit T cell-mediated IgE production but augment the synthesis of IgM and IgG. J. Immunol. 150:2160-2168.
35. Ramsay, A.J., A.J. Husband, I.A. Ramshaw, S. Bao, K.I. Matthaei, G Koehler, and M. Kopf. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science (Wash. DC). 264:561-563.
36. Chen-Kian, S. 1995. Regulation of terminal differentiation of human B cells by IL-6. Curr. Top. Microbiol. Immunol. 194: 189-198.