Sjögren's syndrome-like autoimmune sialadenitis in MRL-Fas lpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand

Autoimmunity

Volumn 46, Issue 4, 2013, Pages 231-237

  Saito, Keiichi ^a   Mori, Shiro ^b   Date, Fumiko ^c   Ono, Masao ^c  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

BAFF; CD80; CD86; MRL Faslpr mice; OX40L

Indexed keywords

B CELL ACTIVATING FACTOR; B7 ANTIGEN; CD137 LIGAND; CD86 ANTIGEN; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; OX40 LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; EPITHELIUM CELL; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOLECULE; MOUSE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; SALIVARY GLAND; SIALOADENITIS; SJOEGREN SYNDROME; SUBMANDIBULAR GLAND;

4-1BB LIGAND; ANIMALS; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, CD95; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLUCOCORTICOID-INDUCED TNFR-RELATED PROTEIN; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED MRL LPR; MICE, KNOCKOUT; MUTATION; OX40 LIGAND; SIALADENITIS; SJOGREN'S SYNDROME;

EID: 84877759054     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.757307     Document Type: Article

References (54)

1. Jonsson, R., K. Moen, D. Vestrheim, et al. 2002. Current issues in Sjögren's syndrome. Oral Dis. 8: 130-140
2. Borchers, A. T., S. M. Naguwa, C. L. Keen, et al. 2003. Immunopathogenesis of Sjögren's syndrome. Clin. Rev. Allergy Immunol. 225: 89-104
3. Manganelli, P., and P. Fietta. 2003. Apoptosis and Sjögren's syndrome. Sem. Arthritis Rheum. 33: 49-65
4. Delaleu, N., D. N. Jonsson, and M. M. Koller. 2005. Sjögren's syndrome. Eur. J. Oral Sci. 113: 101-113
5. Keir, M. E., and A. H. Sharpe. 2005. The B7/CD28 costimulatory family in autoimmunity. Immunol Rev. 204: 128-143
6. Gough, M. J., and A. D.Weinberg. 2009. OX40 (CD134) and OX40L. Adv. Exp. Med. Biol. 647: 94-107
7. Redmond, W. L., C. E. Ruby, and A. D. Weinberg. 2009. The role of OX40-mediated co-stimulation in T-cell activation and survival. Crit. Rev. Immunol. 29: 187-201
8. Lee, S. W., and M. Croft. 2009. 4-1BB as a therapeutic target for human disease. Adv. Exp. Med. Biol. 647: 120-129
9. Nocentini, G., and C. Riccardi. 2009. GITR: A modulator of immune response and inflammation. Adv. Exp. Med. Biol. 647: 156-173
10. Felix, N. J., A. Suri, L. Salter-Cid, et al. 2010. Targeting lymphocyte co-stimulation: From bench to bedside. Autoimmunity 43: 514-525
11. Shulga-Morskaya, S., M. Dobles, M. E. Walsh, et al. 2004. B Cell-activating factor belonging to the TNF family acts through separete receptors to support B cell survival and T cell-independent antibody formation. J. Immunol. 173: 2331-2341
12. Groom, J. R., C. A. Fletcher, S. N.Walters, et al. 2007. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 204: 1959-1971
13. Ryan, M. C., and I. S. Grewal. 2009. Targeting of BAFF and APRIL for autoimmunity and oncology. Adv. Exp. Med. Biol. 647: 52-63
14. O'Neill, S. K., Y. Cao, K.M. Hamel, et al. 2007. Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J. Immunol. 179: 5109-5116
15. Bae, E., W. J. Kim, Y. M. Kang, et al. 2007. Glucocorticoidinduced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adshesion and cytokine expression in rheumatoid arthritis. Clin. Exp. Immunol. 148: 410-418
16. Croft, M. 2010. Control of immunity by the TNFR-related molecule OX40 (CD134). Ann. Rev. Immunol. 28: 57-78
17. Ishii, N., T. Takahashi, P. Soroosh, et al. 2010. OX40-OX40 ligand interraction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98
18. Patschan, S., S. Dolff, A. Kribben, et al. 2006. CD134 expression on CD4 + T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus. Clin. Exp. Immunol. 145: 235-242
19. Ding, D., H. Mehta, W. J. McCune, et al. 2006. Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. J. Immunol. 177: 5878-5889
20. Morimoto, S., S. Nakano, T. Watanabe, et al. 2007. Expression of B-cell activating factor of the tumor necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: The role of BAFF in T cell-dependent B cell pathogenic autoantibody production. Rheumatology 46: 1083-1086
21. Croft, M. 2009. The role of TNF superfamily members in Tcell function and diseases. Nat. Rev. Immunol. 9: 271-285
22. Routsias, J. G., and A. G. Tzioufas. 2010. Autoimmune response and target autoantigens in Sjogren's syndrome. Eur. J. Clin. Invest. 40: 1026-1036
23. Manoussakis, M. N., and E. K. Kapsogeorgou. 2010. The role of intrinsic epithelial activation in the pathogenesis of Sjogren's syndrome. J. Autoimmun. 35: 219-224
24. Watson, M. L., J. K. Rao, G. S. Gilkeson, et al. 1992. Genetic analysis of MRL-lpr mice: Relationship of Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176: 1645-1656
25. Nishihara, M., M. Terada, J. Kamogawa, et al. 1999. Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice. Arthritis Rheum. 42: 2616-2623
26. Soyfoo, M. S., S. Steinfeld, and C. Delporte. 2007. Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome. Oral Diseas. 13: 366-375
27. Tsunawaki, S., S. Nakamura, Y. Ohyama, et al. 2002. Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren's syndrome. J. Rheumatol. 29: 1884-1896
28. Matsumura, R., K. Umemiya, T. Goto, et al. 2001. Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. Ann. Rheum. Dis. 60: 473-482
29. Kinoshita, K., G. Tesch, A. Schwarting, et al. 2000. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Fas lpr Mice. J. Immunol. 164: 6046-6056
30. Hayashi, Y., N. Haneji, and H. Hamano. 1996. Cytokine gene expression and autoantibody production in Sjögren's syndrome of MRL/lpr mice. Autoimmunity 23: 269-277
31. Ndhlovu, L. C., I. Takeda, K. Suganuma, et al. 2004. Expanding role of T-cell costimulations in regulatory T-cell function: Recent advances in accessory molecules expressed on both regulatory and non regulatory T cells. Crit. Rev. Immunol. 24: 251-266
32. Kober, J., J. Leitner, C. Klauser, et al. 2008. The capacity of the TNF family members 4-1BBL, OX40L, GITRL, CD30L and LIGHT to costimulate human T cells. Eur. J. Immunol. 38: 2678-2688
33. Azuma, M. 2010. Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Crit. Rev. Immunol. 30: 547-557
34. Gramaglia, I., A. D. Weinberg, M. Lemon, et al. 1998. Ox-40 Ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 16: 6510-6517
35. Munks, M. W., D. V. Mourich, R. S. Mittler, et al. 2004. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 112: 559-566
36. Lee, S. J., L. Myers, G. Muralimohan, et al. 2004. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector funtion. J. Immunol. 173: 3002-3012
37. Habib-Agahi, M., T. T. Phan, and P. F. Searie. 2007. Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int. Immunol. 19: 1383-1394
38. Shimizu, J., S. Yamazaki, T. Takahashi, et al. 2002. Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142
39. Walker, L. S. K. 2009. Regulatory T cells overturned: The effectors fight back. Immunology 126: 466-474
40. Monk, C. R., M. Spachidou, F. Rovis, et al. 2005. MRL/ Mp CD4 + CD25- T cells show reduced sensitivity to nsuppression by CD4 +, CD25 + rergulatory T cells in vitro. Arthtitis Rheum. 52: 1180-1184
41. Parietti, V., F. Monneaux, M. Décossas, et al. 2008. Function of CD4 + CD25 + Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells. Arthritis Rheum. 58: 1751-1761
42. So, T., S.W. Lee, and M. Croft. 2008. Immune regulation and control of regulatory T cells by OX40 and 4-1BB. Cytokine Growth Factor Rev. 19: 253-262
43. Kitamura, N., S. Murata, T. Ueki, et al. 2009. OX40 costimulation can abrogate Foxp3 + regulatory Tcellmediated suppression of antitumor immunity. Int. J. Cancer 125: 630-638
44. Ji, H., G. Liao, W. A. Faubion, et al. 2004. The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J. Immunol. 172: 5823-5827
45. Joatham, A., H. Ohnishi, M. Okamoto, et al. 2012. Loss of regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. J. Biol. Chem. 287: 17100-17108
46. Nocentini, G., S. Ronchetti, M. G. Petrillo, et al. 2012. Pharmacological modulation of GITRL/GITR system: Therapeutic perspectives. Br. J. Pharmacol. 165: 2089-2099
47. Ye, Q., L. Wang, A. D. Wells, et al. 2004. BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur. J. Immunol. 34: 2750-2759
48. Mackay, F., and H. Leung. 2006. The role of the BAFF/ APRIL system on T cell function. Semin Immunol. 18: 284-289
49. Gross, J. A., J. Johnston, S. Mmudri, et al. 2000. TACI and BCMA are receptors for a TNF homologue implicated in Bcell autoimmune disease. Nature 404: 995-999
50. Pers, J. O., F. d'Arbonneau, V. Devauchelle-Pensec, et al. 2005. Is priodontal disease mediated by salivary BAFF in Sjögren's syndrome? Arthritis Rheum. 52: 2411-2414
51. Jonsson, M. V., P. Szodoray, S. Jellestad, et al. 2005. Association between circulating levels of novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome. J. Clin. Immunol. 25: 189-201
52. Candon, S., J. E. Gottenberg, L. Bengoufa, et al. 2009. Quantitative assessment of antibodies to ribonucleoproteins in primary Sjögren's syndrome: Correlation with B-cell biomarkers and disese activity. Ann. Rheum. Dis. 68: 1208-1212
53. Varin, M. M., L. L. Pottier, P. Youinou, et al. 2010. B-cell tolerance breakdown in Sjögren's syndrome: Focus on BAFF. Autoimmun. Rev. 9: 604-608
54. Buckner, J. H. 2010. Mechanisms of impaired regulation by CD4 + CD25 + FOXP3 + regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol. 10: 849-859