Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 167, Issue 5, 2001, Pages 2991-2999

  Ndhlovu, L C ^a   Ishii, N ^a   Murata, K ^a   Sato, T ^a   Sugamura, K ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC; LIGAND;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGENICITY; ARTICLE; CELL INTERACTION; CYTOKINE RELEASE; DENDRITIC CELL; DRUG RECEPTOR BINDING; GENE TARGETING; INFLAMMATORY CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0035451519     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.5.2991     Document Type: Article

References (49)

1. + T cells with homology to tumor necrosis factor
2. OX-40 ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses
3. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
4. Potential role of 4-1BB in T cell activation: Comparison with the costimulatory molecule CD28
5. Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation
6. TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
7. Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax
8. Crosslinking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
9. Expression and function of OX40 ligand on human dendritic cells
10. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand
11. CD4 T cell traffic control: In vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells into B follicles
12. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)
13. Cloning of mouse Ox40: A T cell activation marker that may mediate T-B interactions
14. Molecular characterization of murine and human OX-40/OX-40 ligand systems: Identification of a human OX-40 ligand as the HTLV-1-regulated protein gp34
15. Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I
16. Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: A critical role for OX40 ligand in migration, but not development, of pathogenic T cells
17. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
18. Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease
19. Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease
20. Strong and selective glomerular localization of CD134 ligand and TNF receptor-I in proliferative lupus nephritis
21. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
22. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection
23. Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40
24. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis
25. + T cells into high IL-4-producing effectors
26. CD4 T cell cytokine differentiation: The B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
27. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
28. CD134L engagement enhances human B cell Ig production: CD154/CD40, CD70/CD27, and CD134/CD134L interactions coordinately regulate T cell-dependent B cell responses
29. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein
30. OX40 expressed on fresh leukemic cells from adult T-cell leukemia patients mediates cell adhesion to vascular endothelial cells: Implication for the possible involvement of OX40 in leukemic cell infiltration
31. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
32. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5 positive CD4 cells and germinal centers
33. Engagement of the OX-40 receptor in vivo enhances antitumor immunity
34. Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40
35. Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation
36. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: A comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade
37. A critical role for lymphotoxin in experimental allergic encephalomyelitis
38. Differential T cell costimulatory requirements in CD28-deficient mice
39. Limited role of CD28-mediated signals in T helper subset differentiation
40. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
41. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encepha-lomyelitis
42. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
43. The T lymphocyte in experimental allergic encephalomyelitis
44. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
45. Failure to suppress the expansion of the activated CD4 T cell population in interferon γ-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
46. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
47. Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies
48. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular cells
49. CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells