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Volumn 244, Issue 1, 2011, Pages 218-231

Science gone translational: The OX40 agonist story

Author keywords

Costimulation; Immunotherapies; T cells; Tumor immunity

Indexed keywords

CD134 ANTIGEN;

EID: 80054866734     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/j.1600-065X.2011.01069.x     Document Type: Review
Times cited : (124)

References (97)
  • 1
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002;298:850-854.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1
  • 2
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med 2011;365:725-733.
    • (2011) N Engl J Med , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 3
    • 0022871958 scopus 로고
    • Clinical effects and toxicity of interleukin-2 in patients with cancer
    • Lotze MT, et al. Clinical effects and toxicity of interleukin-2 in patients with cancer. Cancer 1986;58:2764-2772.
    • (1986) Cancer , vol.58 , pp. 2764-2772
    • Lotze, M.T.1
  • 4
    • 84944285022 scopus 로고
    • High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings
    • Lotze MT, Chang AE, Seipp CA, Simpson C, Vetto JT, Rosenberg SA. High-dose recombinant interleukin 2 in the treatment of patients with disseminated cancer. Responses, treatment-related morbidity, and histologic findings. JAMA 1986;256:3117-3124.
    • (1986) JAMA , vol.256 , pp. 3117-3124
    • Lotze, M.T.1    Chang, A.E.2    Seipp, C.A.3    Simpson, C.4    Vetto, J.T.5    Rosenberg, S.A.6
  • 5
    • 79959302198 scopus 로고    scopus 로고
    • Impact of tumour volume on the potential efficacy of therapeutic vaccines
    • Gulley JL, Madan RA, Schlom J. Impact of tumour volume on the potential efficacy of therapeutic vaccines. Curr Oncol 2011;18:e150-e157.
    • (2011) Curr Oncol , vol.18
    • Gulley, J.L.1    Madan, R.A.2    Schlom, J.3
  • 6
    • 80054848695 scopus 로고    scopus 로고
    • Immune effects of trastuzumab
    • Nuti M, et al. Immune effects of trastuzumab. J Cancer 2011;2:317-323.
    • (2011) J Cancer , vol.2 , pp. 317-323
    • Nuti, M.1
  • 8
    • 77953469710 scopus 로고    scopus 로고
    • Toll-like receptor agonists in cancer therapy
    • Adams S. Toll-like receptor agonists in cancer therapy. Immunotherapy 2009;1:949-964.
    • (2009) Immunotherapy , vol.1 , pp. 949-964
    • Adams, S.1
  • 9
  • 11
    • 0346098179 scopus 로고    scopus 로고
    • History of antibody therapy for non-Hodgkin's lymphoma
    • Forero A, Lobuglio AF. History of antibody therapy for non-Hodgkin's lymphoma. Semin Oncol 2003;30:1-5.
    • (2003) Semin Oncol , vol.30 , pp. 1-5
    • Forero, A.1    Lobuglio, A.F.2
  • 12
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-723.
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1
  • 13
    • 79952839892 scopus 로고    scopus 로고
    • Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists
    • Garcia JA. Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists. Ther Adv Med Oncol 2011;3:101-108.
    • (2011) Ther Adv Med Oncol , vol.3 , pp. 101-108
    • Garcia, J.A.1
  • 14
    • 0023503073 scopus 로고
    • Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts
    • Paterson DJ, et al. Antigens of activated rat T lymphocytes including a molecule of 50, 000 Mr detected only on CD4 positive T blasts. Mol Immunol 1987;24:1281-1290.
    • (1987) Mol Immunol , vol.24 , pp. 1281-1290
    • Paterson, D.J.1
  • 15
    • 0025728020 scopus 로고
    • A new superfamily of cell surface proteins related to the nerve growth factor receptor
    • Mallett S, Barclay AN. A new superfamily of cell surface proteins related to the nerve growth factor receptor. Immunol Today 1991;12:220-223.
    • (1991) Immunol Today , vol.12 , pp. 220-223
    • Mallett, S.1    Barclay, A.N.2
  • 16
    • 0025320534 scopus 로고
    • Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor
    • Mallett S, Fossum S, Barclay AN. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor. EMBO J 1990;9:1063-1068.
    • (1990) EMBO J , vol.9 , pp. 1063-1068
    • Mallett, S.1    Fossum, S.2    Barclay, A.N.3
  • 17
    • 0022379617 scopus 로고
    • A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I)
    • Tanaka Y, Inoi T, Tozawa H, Yamamoto N, Hinuma Y. A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I). In J Cancer 1985;36:549-555.
    • (1985) In J Cancer , vol.36 , pp. 549-555
    • Tanaka, Y.1    Inoi, T.2    Tozawa, H.3    Yamamoto, N.4    Hinuma, Y.5
  • 18
    • 0028227874 scopus 로고
    • Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor
    • Godfrey WR, Fagnoni FF, Harara MA, Buck D, Engleman EG. Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor. J Exp Med 1994;180:757-762.
    • (1994) J Exp Med , vol.180 , pp. 757-762
    • Godfrey, W.R.1    Fagnoni, F.F.2    Harara, M.A.3    Buck, D.4    Engleman, E.G.5
  • 19
    • 0028023305 scopus 로고
    • Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    • Baum PR, et al. Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34. EMBO J 1994;13:3992-4001.
    • (1994) EMBO J , vol.13 , pp. 3992-4001
    • Baum, P.R.1
  • 20
    • 33746849379 scopus 로고    scopus 로고
    • The crystal structure of the costimulatory OX40-OX40L complex
    • Compaan DM, Hymowitz SG. The crystal structure of the costimulatory OX40-OX40L complex. Structure 2006;14:1321-1330.
    • (2006) Structure , vol.14 , pp. 1321-1330
    • Compaan, D.M.1    Hymowitz, S.G.2
  • 21
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • Croft M. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol 2010;28:57-78.
    • (2010) Annu Rev Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 22
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
    • Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 2005;105:2845-2851.
    • (2005) Blood , vol.105 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5    Colombo, M.P.6
  • 23
    • 78049524659 scopus 로고    scopus 로고
    • OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis
    • Karulf M, Kelly A, Weinberg AD, Gold JA. OX40 ligand regulates inflammation and mortality in the innate immune response to sepsis. J Immunol 2010;185:4856-4862.
    • (2010) J Immunol , vol.185 , pp. 4856-4862
    • Karulf, M.1    Kelly, A.2    Weinberg, A.D.3    Gold, J.A.4
  • 25
    • 0033083303 scopus 로고    scopus 로고
    • Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis
    • Weinberg AD, Wegmann KW, Funatake C, Whitham RH. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J Immunol 1999;162:1818-1826.
    • (1999) J Immunol , vol.162 , pp. 1818-1826
    • Weinberg, A.D.1    Wegmann, K.W.2    Funatake, C.3    Whitham, R.H.4
  • 26
    • 0035253725 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells
    • Nohara C, et al. Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol 2001;166:2108-2115.
    • (2001) J Immunol , vol.166 , pp. 2108-2115
    • Nohara, C.1
  • 27
    • 0033427044 scopus 로고    scopus 로고
    • Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions
    • Chen AI, et al. Ox40-ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity 1999;11:689-698.
    • (1999) Immunity , vol.11 , pp. 689-698
    • Chen, A.I.1
  • 28
    • 0029045255 scopus 로고
    • Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
    • Stuber E, Neurath M, Calderhead D, Fell HP, Strober W. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity 1995;2:507-521.
    • (1995) Immunity , vol.2 , pp. 507-521
    • Stuber, E.1    Neurath, M.2    Calderhead, D.3    Fell, H.P.4    Strober, W.5
  • 30
    • 0031872028 scopus 로고    scopus 로고
    • CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
    • Flynn S, Toellner KM, Raykundalia C, Goodall M, Lane P. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med 1998;188:297-304.
    • (1998) J Exp Med , vol.188 , pp. 297-304
    • Flynn, S.1    Toellner, K.M.2    Raykundalia, C.3    Goodall, M.4    Lane, P.5
  • 31
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 2004;4:420-431.
    • (2004) Nat Rev Immunol , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 32
    • 0033785481 scopus 로고    scopus 로고
    • Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis
    • Yoshioka T, et al. Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis. Eur J Immunol 2000;30:2815-2823.
    • (2000) Eur J Immunol , vol.30 , pp. 2815-2823
    • Yoshioka, T.1
  • 33
    • 0037108529 scopus 로고    scopus 로고
    • Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases
    • Murata K, Nose M, Ndhlovu LC, Sato T, Sugamura K, Ishii N. Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases. J Immunol 2002;169:4628-4636.
    • (2002) J Immunol , vol.169 , pp. 4628-4636
    • Murata, K.1    Nose, M.2    Ndhlovu, L.C.3    Sato, T.4    Sugamura, K.5    Ishii, N.6
  • 34
    • 0037528710 scopus 로고    scopus 로고
    • Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients
    • Blazar BR, et al. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood 2003;101:3741-3748.
    • (2003) Blood , vol.101 , pp. 3741-3748
    • Blazar, B.R.1
  • 35
    • 0035337241 scopus 로고    scopus 로고
    • Cd134l expression on dendritic cells in the mesenteric lymph nodes drives colitis in t cell-restored scid mice
    • Malmstrom V, et al. Cd134l expression on dendritic cells in the mesenteric lymph nodes drives colitis in t cell-restored scid mice. J Immunol 2001;166:6972-6981.
    • (2001) J Immunol , vol.166 , pp. 6972-6981
    • Malmstrom, V.1
  • 36
    • 38049037266 scopus 로고    scopus 로고
    • Targeting OX40 and OX40L for the treatment of autoimmunity and cancer
    • Redmond WL, Weinberg AD. Targeting OX40 and OX40L for the treatment of autoimmunity and cancer. Crit Rev Immunol 2007;27:415-436.
    • (2007) Crit Rev Immunol , vol.27 , pp. 415-436
    • Redmond, W.L.1    Weinberg, A.D.2
  • 37
    • 0031595673 scopus 로고    scopus 로고
    • Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease
    • Stuber E, Von Freier A, Marinescu D, Folsch UR. Involvement of OX40-OX40L interactions in the intestinal manifestations of the murine acute graft-versus-host disease. Gastroenterology 1998;115:1205-1215.
    • (1998) Gastroenterology , vol.115 , pp. 1205-1215
    • Stuber, E.1    Von Freier, A.2    Marinescu, D.3    Folsch, U.R.4
  • 38
    • 34848849793 scopus 로고    scopus 로고
    • OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: a CD4-dependent mechanism
    • Humphreys IR, et al. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: a CD4-dependent mechanism. J Immunol 2007;179:2195-2202.
    • (2007) J Immunol , vol.179 , pp. 2195-2202
    • Humphreys, I.R.1
  • 39
    • 0034651736 scopus 로고    scopus 로고
    • Engagement of the OX-40 receptor in vivo enhances antitumor immunity
    • Weinberg AD, et al. Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J Immunol 2000;164:2160-2169.
    • (2000) J Immunol , vol.164 , pp. 2160-2169
    • Weinberg, A.D.1
  • 40
    • 0025276664 scopus 로고
    • Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells
    • Weinberg AD, English M, Swain SL. Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. J Immunol 1990;144:1800-1807.
    • (1990) J Immunol , vol.144 , pp. 1800-1807
    • Weinberg, A.D.1    English, M.2    Swain, S.L.3
  • 41
    • 0025222698 scopus 로고
    • IL-4 directs the development of Th2-like helper effectors
    • Swain SL, Weinberg AD, English M, Huston G. IL-4 directs the development of Th2-like helper effectors. J Immunol 1990;145:3796-3806.
    • (1990) J Immunol , vol.145 , pp. 3796-3806
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3    Huston, G.4
  • 42
    • 0025329959 scopus 로고
    • CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro
    • Swain SL, Weinberg AD, English M. CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro. J Immunol 1990;144:1788-1799.
    • (1990) J Immunol , vol.144 , pp. 1788-1799
    • Swain, S.L.1    Weinberg, A.D.2    English, M.3
  • 43
    • 0025951644 scopus 로고
    • Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype
    • Swain SL, Huston G, Tonkonogy S, Weinberg A. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype. J Immunol 1991;147:2991-3000.
    • (1991) J Immunol , vol.147 , pp. 2991-3000
    • Swain, S.L.1    Huston, G.2    Tonkonogy, S.3    Weinberg, A.4
  • 44
    • 0026697915 scopus 로고
    • Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma
    • Olsson T. Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma. J Neuroimmunol 1992;40:211-218.
    • (1992) J Neuroimmunol , vol.40 , pp. 211-218
    • Olsson, T.1
  • 46
    • 0023413923 scopus 로고
    • Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells
    • Wekerle H, Sun D, Oropeza-Wekerle RL, Meyermann R. Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells. J Exp Biol 1987;132:43-57.
    • (1987) J Exp Biol , vol.132 , pp. 43-57
    • Wekerle, H.1    Sun, D.2    Oropeza-Wekerle, R.L.3    Meyermann, R.4
  • 47
    • 0026607639 scopus 로고
    • Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis
    • Weinberg AD, et al. Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. J Immunol 1992;148:2109-2117.
    • (1992) J Immunol , vol.148 , pp. 2109-2117
    • Weinberg, A.D.1
  • 48
    • 0027373857 scopus 로고
    • Lymphokine mRNA expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis is associated with a host recruited CD45R hi/CD4+ population during recovery
    • Weinberg AD, et al. Lymphokine mRNA expression in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis is associated with a host recruited CD45R hi/CD4+ population during recovery. J Neuroimmunol 1993;48:105-117.
    • (1993) J Neuroimmunol , vol.48 , pp. 105-117
    • Weinberg, A.D.1
  • 49
    • 0028211518 scopus 로고
    • Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune enciphalomyelitis
    • Weinberg AD, et al. Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune enciphalomyelitis. J Immunol 1994;152:4712-4721.
    • (1994) J Immunol , vol.152 , pp. 4712-4721
    • Weinberg, A.D.1
  • 50
    • 0027293755 scopus 로고
    • Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis
    • Offner H, et al. Where, when, and how to detect biased expression of disease-relevant V beta genes in rats with experimental autoimmune encephalomyelitis. J Immunol 1993;151:506-517.
    • (1993) J Immunol , vol.151 , pp. 506-517
    • Offner, H.1
  • 51
    • 0025721125 scopus 로고
    • Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3
    • Gold DP, Offner H, Sun D, Wiley S, Vandenbark AA, Wilson DB. Analysis of T cell receptor beta chains in Lewis rats with experimental allergic encephalomyelitis: conserved complementarity determining region 3. J Exp Med 1991;174:1467-1476.
    • (1991) J Exp Med , vol.174 , pp. 1467-1476
    • Gold, D.P.1    Offner, H.2    Sun, D.3    Wiley, S.4    Vandenbark, A.A.5    Wilson, D.B.6
  • 52
    • 0029904390 scopus 로고    scopus 로고
    • V beta CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE
    • Buenafe AC, Weinberg AD, Culbertson NE, Vandenbark AA, Offner H. V beta CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of Lewis rats with EAE. J Neurosci Res 1996;44:562-567.
    • (1996) J Neurosci Res , vol.44 , pp. 562-567
    • Buenafe, A.C.1    Weinberg, A.D.2    Culbertson, N.E.3    Vandenbark, A.A.4    Offner, H.5
  • 53
    • 13344283418 scopus 로고    scopus 로고
    • Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis
    • Weinberg AD, et al. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat Med 1996;2:183-189.
    • (1996) Nat Med , vol.2 , pp. 183-189
    • Weinberg, A.D.1
  • 55
    • 0036476664 scopus 로고    scopus 로고
    • OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines
    • Weinberg AD. OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines. Trends Immunol 2002;23:102-109.
    • (2002) Trends Immunol , vol.23 , pp. 102-109
    • Weinberg, A.D.1
  • 56
    • 0030778972 scopus 로고    scopus 로고
    • Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers
    • Vetto JT, et al. Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers. Am J Surg 1997;174:258-265.
    • (1997) Am J Surg , vol.174 , pp. 258-265
    • Vetto, J.T.1
  • 57
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997;3:682-685.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1
  • 58
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734-1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 59
    • 0028867835 scopus 로고
    • Manipulation of costimulatory signals to enhance antitumor T-cell responses
    • Allison JP, Hurwitz AA, Leach DR. Manipulation of costimulatory signals to enhance antitumor T-cell responses. Curr Opin Immunol 1995;7:682-686.
    • (1995) Curr Opin Immunol , vol.7 , pp. 682-686
    • Allison, J.P.1    Hurwitz, A.A.2    Leach, D.R.3
  • 60
    • 0034306979 scopus 로고    scopus 로고
    • Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth
    • Kjaergaard J, Tanaka J, Kim JA, Rothchild K, Weinberg A, Shu S. Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth. Cancer Res 2000;60:5514-5521.
    • (2000) Cancer Res , vol.60 , pp. 5514-5521
    • Kjaergaard, J.1    Tanaka, J.2    Kim, J.A.3    Rothchild, K.4    Weinberg, A.5    Shu, S.6
  • 61
    • 0032394030 scopus 로고    scopus 로고
    • OX-40: life beyond the effector T cell stage
    • Weinberg AD, Vella AT, Croft M. OX-40: life beyond the effector T cell stage. Semin Immunol 1998;10:471-480.
    • (1998) Semin Immunol , vol.10 , pp. 471-480
    • Weinberg, A.D.1    Vella, A.T.2    Croft, M.3
  • 62
    • 0033957423 scopus 로고    scopus 로고
    • Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion
    • Maxwell JR, Weinberg A, Prell RA, Vella AT. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J Immunol 2000;164:107-112.
    • (2000) J Immunol , vol.164 , pp. 107-112
    • Maxwell, J.R.1    Weinberg, A.2    Prell, R.A.3    Vella, A.T.4
  • 63
    • 0035892897 scopus 로고    scopus 로고
    • Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4
    • Evans DE, Prell RA, Thalhofer CJ, Hurwitz AA, Weinberg AD. Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4. J Immunol 2001;167:6804-6811.
    • (2001) J Immunol , vol.167 , pp. 6804-6811
    • Evans, D.E.1    Prell, R.A.2    Thalhofer, C.J.3    Hurwitz, A.A.4    Weinberg, A.D.5
  • 64
    • 0345447614 scopus 로고    scopus 로고
    • OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent
    • Prell RA, Evans DE, Thalhofer C, Shi T, Funatake C, Weinberg AD. OX40-mediated memory T cell generation is TNF receptor-associated factor 2 dependent. J Immunol 2003;171:5997-6005.
    • (2003) J Immunol , vol.171 , pp. 5997-6005
    • Prell, R.A.1    Evans, D.E.2    Thalhofer, C.3    Shi, T.4    Funatake, C.5    Weinberg, A.D.6
  • 65
    • 33846399187 scopus 로고    scopus 로고
    • Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses
    • Ruby CE, Redmond WL, Haley D, Weinberg AD. Anti-OX40 stimulation in vivo enhances CD8(+) memory T cell survival and significantly increases recall responses. Eur J Immunol 2007;37:157-166.
    • (2007) Eur J Immunol , vol.37 , pp. 157-166
    • Ruby, C.E.1    Redmond, W.L.2    Haley, D.3    Weinberg, A.D.4
  • 67
    • 71849087411 scopus 로고    scopus 로고
    • Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation
    • Bandyopadhyay S, et al. Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation. J Immunol 2008;181:7728-7737.
    • (2008) J Immunol , vol.181 , pp. 7728-7737
    • Bandyopadhyay, S.1
  • 68
    • 58749086427 scopus 로고    scopus 로고
    • OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells
    • Mousavi SF, et al. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol 2008;181:5990-6001.
    • (2008) J Immunol , vol.181 , pp. 5990-6001
    • Mousavi, S.F.1
  • 69
    • 80052294659 scopus 로고    scopus 로고
    • Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection
    • Salek-Ardakani S, Moutaftsi M, Sette A, Croft M. Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection. J Virol 2011;85:9051-9059.
    • (2011) J Virol , vol.85 , pp. 9051-9059
    • Salek-Ardakani, S.1    Moutaftsi, M.2    Sette, A.3    Croft, M.4
  • 70
    • 78650939319 scopus 로고    scopus 로고
    • The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
    • Salek-Ardakani S, et al. The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice. J Clin Invest 2011;121:296-307.
    • (2011) J Clin Invest , vol.121 , pp. 296-307
    • Salek-Ardakani, S.1
  • 71
    • 70249141660 scopus 로고    scopus 로고
    • Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo
    • Redmond WL, Gough MJ, Weinberg AD. Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo. Eur J Immunol 2009;39:2184-2194.
    • (2009) Eur J Immunol , vol.39 , pp. 2184-2194
    • Redmond, W.L.1    Gough, M.J.2    Weinberg, A.D.3
  • 72
    • 70249091483 scopus 로고    scopus 로고
    • Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge
    • Bekiaris V, et al. Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge. Eur J Immunol 2009;39:2120-2125.
    • (2009) Eur J Immunol , vol.39 , pp. 2120-2125
    • Bekiaris, V.1
  • 73
    • 69549111273 scopus 로고    scopus 로고
    • Pre-treatment with cyclophosphamide or OX40 (CD134) costimulation targeting regulatory T cell function enhances the anti-tumor immune effect of adoptively transferred CD8+ T cells from wild-type mice
    • Ueki T, Murata S, Kitamura N, Mekata E, Tani T. Pre-treatment with cyclophosphamide or OX40 (CD134) costimulation targeting regulatory T cell function enhances the anti-tumor immune effect of adoptively transferred CD8+ T cells from wild-type mice. Mol Med Report 2009;2:615-620.
    • (2009) Mol Med Report , vol.2 , pp. 615-620
    • Ueki, T.1    Murata, S.2    Kitamura, N.3    Mekata, E.4    Tani, T.5
  • 74
    • 48549099849 scopus 로고    scopus 로고
    • OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor
    • Gough MJ, Ruby CE, Redmond WL, Dhungel B, Brown A, Weinberg AD. OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor. Cancer Res 2008;68:5206-5215.
    • (2008) Cancer Res , vol.68 , pp. 5206-5215
    • Gough, M.J.1    Ruby, C.E.2    Redmond, W.L.3    Dhungel, B.4    Brown, A.5    Weinberg, A.D.6
  • 75
    • 38849164304 scopus 로고    scopus 로고
    • Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
    • Redmond WL, Gough MJ, Charbonneau B, Ratliff TL, Weinberg AD. Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist. J Immunol 2007;179:7244-7253.
    • (2007) J Immunol , vol.179 , pp. 7244-7253
    • Redmond, W.L.1    Gough, M.J.2    Charbonneau, B.3    Ratliff, T.L.4    Weinberg, A.D.5
  • 76
    • 0035576267 scopus 로고    scopus 로고
    • Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor
    • Kjaergaard J, Peng L, Cohen PA, Drazba JA, Weinberg AD, Shu S. Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J Immunol 2001;167:6669-6677.
    • (2001) J Immunol , vol.167 , pp. 6669-6677
    • Kjaergaard, J.1    Peng, L.2    Cohen, P.A.3    Drazba, J.A.4    Weinberg, A.D.5    Shu, S.6
  • 77
    • 33750546487 scopus 로고    scopus 로고
    • Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study
    • Weinberg AD, et al. Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study. J Immunother 2006;29:575-585.
    • (2006) J Immunother , vol.29 , pp. 575-585
    • Weinberg, A.D.1
  • 78
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010;363:411-422.
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1
  • 79
    • 42949139835 scopus 로고    scopus 로고
    • Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma
    • Thompson JA, et al. Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma. J Clin Oncol 2008;26:2034-2039.
    • (2008) J Clin Oncol , vol.26 , pp. 2034-2039
    • Thompson, J.A.1
  • 80
    • 37349089029 scopus 로고    scopus 로고
    • First-in-Man (FIM) clinical trials post-TeGenero: a review of the impact of the TeGenero trial on the design, conduct, and ethics of FIM trials
    • Nada A, Somberg J. First-in-Man (FIM) clinical trials post-TeGenero: a review of the impact of the TeGenero trial on the design, conduct, and ethics of FIM trials. Am J Ther 2007;14:594-604.
    • (2007) Am J Ther , vol.14 , pp. 594-604
    • Nada, A.1    Somberg, J.2
  • 81
    • 77951060733 scopus 로고    scopus 로고
    • OX40 is required for regulatory T cell-mediated control of colitis
    • Griseri T, Asquith M, Thompson C, Powrie F. OX40 is required for regulatory T cell-mediated control of colitis. J Exp Med 2010;207:699-709.
    • (2010) J Exp Med , vol.207 , pp. 699-709
    • Griseri, T.1    Asquith, M.2    Thompson, C.3    Powrie, F.4
  • 82
    • 66049113612 scopus 로고    scopus 로고
    • OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
    • Hirschhorn-Cymerman D, et al. OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. J Exp Med 2009;206:1103-1116.
    • (2009) J Exp Med , vol.206 , pp. 1103-1116
    • Hirschhorn-Cymerman, D.1
  • 83
    • 9244220630 scopus 로고    scopus 로고
    • Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection
    • Picker LJ, et al. Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 2004;200:1299-1314.
    • (2004) J Exp Med , vol.200 , pp. 1299-1314
    • Picker, L.J.1
  • 84
    • 33745202622 scopus 로고    scopus 로고
    • IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    • Picker LJ, et al. IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest 2006;116:1514-1524.
    • (2006) J Clin Invest , vol.116 , pp. 1514-1524
    • Picker, L.J.1
  • 85
    • 0036135578 scopus 로고    scopus 로고
    • Development and homeostasis of T cell memory in rhesus macaque
    • Pitcher CJ, et al. Development and homeostasis of T cell memory in rhesus macaque. J Immunol 2002;168:29-43.
    • (2002) J Immunol , vol.168 , pp. 29-43
    • Pitcher, C.J.1
  • 86
    • 77958047687 scopus 로고    scopus 로고
    • Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice
    • Gough MJ, et al. Adjuvant therapy with agonistic antibodies to CD134 (OX40) increases local control after surgical or radiation therapy of cancer in mice. J Immunother 2010;33:798-809.
    • (2010) J Immunother , vol.33 , pp. 798-809
    • Gough, M.J.1
  • 88
    • 34247183575 scopus 로고    scopus 로고
    • Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
    • Morris NP, et al. Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain. Mol Immunol 2007;44:3112-3121.
    • (2007) Mol Immunol , vol.44 , pp. 3112-3121
    • Morris, N.P.1
  • 89
    • 41149130863 scopus 로고    scopus 로고
    • Multiple roles for CD4+ T cells in anti-tumor immune responses
    • Kennedy R, Celis E. Multiple roles for CD4+ T cells in anti-tumor immune responses. Immunol Rev 2008;222:129-144.
    • (2008) Immunol Rev , vol.222 , pp. 129-144
    • Kennedy, R.1    Celis, E.2
  • 90
    • 77949654340 scopus 로고    scopus 로고
    • Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right
    • Ruby CE, et al. Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. J Immunol 2009;183:4853-4857.
    • (2009) J Immunol , vol.183 , pp. 4853-4857
    • Ruby, C.E.1
  • 91
    • 42149095015 scopus 로고    scopus 로고
    • IL-12 is required for anti-OX40-mediated CD4 T cell survival
    • Ruby CE, Montler R, Zheng R, Shu S, Weinberg AD. IL-12 is required for anti-OX40-mediated CD4 T cell survival. J Immunol 2008;180:2140-2148.
    • (2008) J Immunol , vol.180 , pp. 2140-2148
    • Ruby, C.E.1    Montler, R.2    Zheng, R.3    Shu, S.4    Weinberg, A.D.5
  • 92
    • 65349153756 scopus 로고    scopus 로고
    • T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
    • Houot R, Levy R. T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Blood 2009;113:3546-3552.
    • (2009) Blood , vol.113 , pp. 3546-3552
    • Houot, R.1    Levy, R.2
  • 93
    • 80051925716 scopus 로고    scopus 로고
    • 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection
    • Vezys V, et al. 4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection. J Immunol 2011;187:1634-1642.
    • (2011) J Immunol , vol.187 , pp. 1634-1642
    • Vezys, V.1
  • 94
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee SJ, et al. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J Immunol 2004;173:3002-3012.
    • (2004) J Immunol , vol.173 , pp. 3002-3012
    • Lee, S.J.1
  • 96
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-gamma-mediated antitumor immunity and suppresses established tumors. Cancer Res 2011;71:3540-3551.
    • (2011) Cancer Res , vol.71 , pp. 3540-3551
    • Ngiow, S.F.1    von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 97
    • 78449243489 scopus 로고    scopus 로고
    • Immune checkpoint proteins: a new therapeutic paradigm for cancer - preclinical background: CTLA-4 and PD-1 blockade
    • Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancer - preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol 2010;37:430-439.
    • (2010) Semin Oncol , vol.37 , pp. 430-439
    • Weber, J.1


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