Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion

Journal of Immunology

Volumn 164, Issue 1, 2000, Pages 107-112

  Maxwell, Joseph R ^a   Weinberg, Andrew ^b   Prell, Rodney A ^b   Vella, Anthony T ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b PROVIDENCE PORTLAND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CELL SURFACE RECEPTOR; LIPOPOLYSACCHARIDE; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL SURVIVAL; CELLULAR IMMUNITY; CONTROLLED STUDY; EFFECTOR CELL; HELPER CELL; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0033957423     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.1.107     Document Type: Article

References (51)

1. Jenkins, M. K., D. M. Pardoll, J. Mizuguchi, H. Quill, and R. H. Schwartz. 1987. T cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol. Rev. 95:113.
2. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsivenesss in vitro and in vivo. J. Exp. Med. 165:302.
3. Linsley, P. S., W. Brady, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 custimulates T cell proliferation and IL-2 mRNA accumulation. J. Exp. Med. 173:721.
4. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Hodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation [see comments]. Science 262:905.
5. Freeman, G. J., J. G. Gribben, V. A. Boussiotis, J. W. Ng, V. A. Restivo, L. A. Lombard, G. S. Gray, and L. M. Nadler. 1993. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell profliferation. Science 262:909.
6. Freeman, G. J., F. Borriello, R. Hodes, H. Reiser, K. S. Hathcock, G. Laszlo, A. J. McKnight, J. Kim, L. Du, D. B. Lombard, et al. 1993. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262:907.
7. Azuma, M., D. Ito, H. Hagita, K. Okumura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
8. Maxwell, J. R., J. D. Campbell, C. H. Kim, and A. T. Vella. 1999. CD40 activation boosts T cell immunity in vivo by enhancing T cell clonal expansion and delaying peripheral T cell deletion. J Immunol. 162:2024.
9. Gruerder, S., D. E. Picarella, P. S. Linsley, and R. A. Flavell. 1994. Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor α leads to autoimmunity in transgenic mice. Proc: Natl. Acad. Sci. USA 91:5138.
10. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kündig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
11. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991.
12. Janeway, C. A. J. 1989. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harbor Symp. Quant. Biol. 54:1.
13. Matzinger, P. 1998. An innate sense of danger. Semin. Immunol. 10:399.
14. Clark, I. A., and W. M. Clouston. 1980. Effects of endotoxin on the histology of intact and athymic mice infected with Plasmodium vinckei petteri. J. Pathol. 131:221.
15. Groeneveld, P. H., E. Claassen, C. F. Kuper, and N. Van Rooijen. 1988. The role of macrophages in LPS-induced lethality and tissue injury. Immunology 63:521.
16. Beutler, B., and A. Cerami. 1986. Cachectin/tumor necrosis factor: an endogenous mediator of shock and inflammation. Immunology 5:281.
17. Fong, Y., K. Tracey, L. L. Moldawer, D. G. Hesse, K. B. Manogue, J. S. Kenney, A. T. Lee, G. C. Kuo, A. C. Allison, S. F. Lowery, and A. Cerami. 1989. Antibodies to cachectin/tumor necrosis factor reduce IL-1β and IL-6 appearance during lethal bacteremia. J. Exp. Med. 170:1627.
18. Waage, A., P. Brandtzaeg, A. Halstensen, P. Kierulf, and T. Espevik. 1989. The complex pattern of cytokines in serum from patients with meningococcal septic shock. J. Exp. Med. 169:333.
19. Chiller, J. M., and W. O. Weigle. 1973. Termination of tolerance to human y globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J. Exp. Med. 137:740.
20. Vella, A. T., J. E. McCormack, P. S. Linsley, J. W. Kappler, and P. Marrack. 1995. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261.
21. Wang, J., and M. J. Lenardo. 1997. Molecules involved in cell death and peripheral tolerance. Curr. Opin. Immunol. 9:818.
22. Kaleeba, J. A., H. Offner, A. A. Vandenbark, A. Lublinski, and A. D. Weinberg. 1998. The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specilic CD4+ T cells. Int. Immunol. 10:453.
23. Gramaglia, I., A. D. Weinberg, M. Lemon, and M. Croft. 1998. OX-40 ligand: a potent coslimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161:6510.
24. Weinberg, A. D., J. J. Wallin, R. E. Jones, T. J. Sullivan, D. N. Bourdette. A. A. Vandenbark, and H. Offner. 1994. Target organ-specific up-regulation of the MRC OX-40 marker and selective production of Th 1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with experimental autoimmune encephalomyelitis. J. Immunol. 152:4712.
25. Vetto, J. T., S. Lum, A. Morris, M. Sicotte, J. Davis, M. Lemon, and A. Weinberg. 1997. Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers. Am. J. Surg. 174:258.
26. + spinal cord T cells of Lewis rats wilh EAE. J. Neurosci. Res. 44:562.
27. Weinberg, A. D., A. T. Vella, and M. Croft. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471.
28. t detected only on CD4 positive T blasts. Mol. Immunol. 24:1281.
29. Kearney, E. R., K. A. Pape, D. Y. Loh, and M. K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1:327.
30. + TCRIo thymocytes in vivo. Science 250: 1720.
31. Julius, M. H., E. Simpson, and L. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645.
32. Pullen, A. M., P. Marrack, and J. W. Kappler. 1988. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335:796.
33. al-Shamkhani, A., M. L. Birkeland, M. Puklavec, M. H. Brown, W. James, and A. N. Barclay. 1996. OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26:1695.
34. McCormack, J. E., J. E. Callahan, J. Kappler, and P. Marrack. 1993. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785.
35. Dutton, R. W., L. M. Bradley, and S. L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201.
36. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
37. Khoruts, A., A. Mondino, K. A. Pape, S. L. Reiner, and M. K. Jenkins. 1998. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent. interleukin (IL)-2-independent mechanism. J. Exp. Med. 187: 225.
38. Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature 377: 348.
39. Krammer, P. H. 1999. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv. Immunol. 71:163.
40. Alderson, M. R., R. J. Armitage, E. Maraskovsky, T. W. Tough, E. Roux, K. Schooley, F. Ramsdell, and D. H. Lynch. 1993. Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178:2231.
41. Vella, A., T. K. Teague, J. Ihle, J. Kappler, and P. Marrack. 1997. Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4. J. Exp. Med. 186:325.
42. Vella, A. T., S. Dow, T. A. Potter, J. Kappler, and P. Marrack. 1998. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc. Natl. Acad. Sci. USA 95:3810.
43. Tilg, H., C. A. Dinarello, and J. W. Mier. 1997. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol. Today 18:428.
44. Teague, T. K., J. W. Kappler, P. Marrack, and A. T. Vella. 1997. Interleukin-6 inhibits resting from apoptosis. J. Immunol. 158:5791.
45. Kopf, M., H. Baumann, G. Greer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Kšhler. 1994. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 368:339.
46. + T cells. J. Immunol. 159:591.
47. Vella, A. T., T. Mitchell, B. Groth, P. S. Linsley, J. M. Green, C. B. Thompson, J. W. Kappler, and P. Marrack. 1997. CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo. J. Immunol. 158:4714.
48. Van Parijs, L., V. L. Perez, A. Biuckians, R. G. Maki, C. A. London, and A. K. Abbas. 1997. Role of interleukin 12 and costimulators in T cell anergy in vivo. J. Exp. Med. 186:1119.
49. Flynn, S., K. M. Toellner, C. Raykundalia, M. Goodall, and P. Lane. 1998. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 188:297.
50. Weinberg, A. D., D. N. Bourdette, T. J. Sullivan, M. Lemon, J. J. Wallin, R. Maziarz, M. Davey, F. Palida, W. Godfrey, E. Engleman, et al. 1996. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 2:183.
51. Dal Canto, R. A., M. K. Shaw, G. P. Nolan, L. Steinman, and C. G. Fathman. 1999. Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis. Clin. Immunol. 90:10.