Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers

Journal of Experimental Medicine

Volumn 190, Issue 8, 1999, Pages 1115-1122

  Walker, Lucy S K ^a   Gulbranson Judge, Adam ^a   Flynn, Sarah ^a   Brocker, Thomas ^b   Raykundalia, Chandra ^a   Goodall, Margaret ^a   Förster, Reinhold ^c   Lipp, Martin ^c   Lane, Peter ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

CD28; Chemokine; Germinal center; OX40 OX40 ligand; T cell migration

Indexed keywords

ALPHA CHEMOKINE; CD28 ANTIGEN; CD4 ANTIGEN;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; COMPLEMENT ACTIVATION; GENE DELETION; GENETIC LINKAGE; GERMINAL CENTER; IMMUNIZATION; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD27; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL MOVEMENT; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GERMINAL CENTER; HUMANS; IMMUNOCONJUGATES; INTEGRIN ALPHAXBETA2; L-SELECTIN; MICE; MICE, TRANSGENIC; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0032753621     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.8.1115     Document Type: Article

References (38)

1. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165-1176.
2. Liu, Y.J., J. Zhang, P.J. Lane, E.Y. Chan, and I.C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951-2962.
3. MacLennan, I.C.M., A. Gulbranson-Judge, K.M. Toellner, M. Casamayor-Palleja, E. Chan, D.M.Y. Sze, S.A. Luther, and H.A. Orbea. 1997. The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol. Rev. 156:53-66.
4. Gulbranson-Judge, A., and I. MacLennan. 1996. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome C. Eur. J. Immunol. 26: 1830-1837.
5. Han, S., K. Hathcock, B. Zheng, T.B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155:556-567.
6. Shahinian, A., K. Pfeffer, K.P. Lee, T.M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P.S. Ohashi, C.B. Thompson, and T.W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:609-612.
7. + T cells. J. Exp. Med. 179:819-830.
8. Lenschow, D.J., K.C. Herold, L. Rhee, B. Patel, A. Koons, H.-Y. Qin, E. Fuchs, B. Singh, C.B. Thompson, and J.A. Bluestone. 1996. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 5:285-293.
9. Manickasingham, S.P., S.M. Anderton, C. Burkhart, and D.C. Wraith. 1998. Qualitative and quantitative effects of CD28/B7-mediated costimulation on naive T cells in vitro. J. Immunol. 161:3827-3835.
10. + T cells into high IL-4-producing effectors. Blood. 92: 3338-3345.
11. Flynn, S., K.-M. Toellner, C. Raykundalia, M. Goodall, and P. Lane. 1998. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J. Exp. Med. 188:297-304.
12. Brocker, T., A. Gulbranson-Judge, S. Flynn, M. Riedinger, C. Raykundalia, and P. Lane. 1999. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells into B follicles. Eur. J. Immunol. 29:1610-1616.
13. Toellner, K., S. Luther, D.M.-Y. Sze, R.K.-W. Choy, D.R. Taylor, I.C.M. MacLennan, and H. Acha-Orbea. 1998. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 187: 1193-1204.
14. Svetic, A., F.D. Finkelman, Y.C. Jian, C.W. Dieffenbach, D.E. Scott, K.F. McCarthy, A.D. Steinberg, and W.C. Gause. 1991. Cytokine gene-expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391-2397.
15. Weibel, E.R. 1963. Principles and methods for the morphometric study of the lung and other organs. Lab. Invest. 12: 131-155.
16. Schmidt, K.N., C.W. Hsu, C.T. Griffin, C.C. Goodnow, and J.G. Cyster. 1998. Spontaneous follicular exclusion of SHP1-deficient B cells is conditional on the presence of competitor wild-type B cells. J. Exp. Med. 187:929-937.
17. Nossal, G.J., and M. Karvelas. 1990. Soluble antigen abrogates the appearance of anti-protein IgG1-forming cell precursors during primary immunization. Proc. Natl. Acad. Sci. USA. 87:1615-1619.
18. Gramaglia, I., A.D. Weinberg, M. Lemon, and M. Croft. 1998. Ox-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161:6510-6517.
19. Förster, R., T. Emrich, E. Kremmer, and M. Lipp. 1994. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood. 84:830-840.
20. Förster, R., A.E. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp. 1996. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 87:1037-1047.
21. Ferguson, S.E., S. Han, G. Kelsoe, and C.B. Thompson. 1996. CD28 is required for germinal center formation. J. Immunol. 156:4576-4581.
22. Ohshima, Y., Y. Tanaka, H. Tozawa, Y. Takahashi, C. Maliszewski, and G. Delespesse. 1997. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159: 3838-3848.
23. Stüber, E., M. Neurath, D. Calderhead, H.P. Fell, and W. Strober. 1995. Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity. 2:507-521.
24. Gravestein, L.A., B. Blom, L.A. Nolten, E. Devries, G. Vanderhorst, F. Ossendorp, J. Borst, and W.A.M. Loenen. 1993. Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur. J . Immunol. 23: 943-950.
25. Stüber, E., and W. Strober. 1996. The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response. J. Exp. Med. 183:979-989.
26. Lenschow, D.J., T.L. Walunas, and J.A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258.
27. Brown, D.R., J.M. Green, N.H. Moskowitz, M. Davis, C.B. Thompson, and S.L. Reiner. 1996. Limited role of CD28-mediated signals in T helper subset differentiation. J. Exp. Med. 184:803-810.
28. Zimmermann, C., P. Seiler, P. Lane, and R.M. Zinkernagel. 1997. Antiviral immune responses in CTLA4 transgenic mice. J. Virol. 71:1802-1807.
29. King, C.L., X.L. Jia, C.H. June, R. Abe, and K.P. Lee. 1996. CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection. Eur. J. Immunol. 26:2448-2455.
30. Sayegh, M.H., E. Akalin, W.W. Hancock, M.E. Russell, C.B. Carpenter, P.S. Linsley, and L.A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J. Exp. Med. 181:1869-1874.
31. + T cells and defective antibody production in vivo. J. Exp. Med. 179:809-817.
32. Lane, P., C. Haller, and F. McConnell. 1996. Evidence that induction of tolerance in vivo involves active signaling via a B7 ligand-dependent mechanism: CTLA4-Ig protects Vβ8+ T cells from tolerance induction by the superantigen staphylococcal enterotoxin B. Eur. J. Immunol. 26:858-862.
33. Lenschow, D.J., S.C. Ho, H. Sattar, L. Rhee, G. Gray, N. Nabavi, K.C. Herold, and J.A. Bluestone. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145-1155.
34. Kuchroo, V.K., M.P. Das, J.A. Brown, A.M. Ranger, S.S. Zamvil, R.A. Sobel, H.L. Weiner, N. Nabavi, and L.H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 80:707-718.
35. Weinberg, A.D., A.T. Vella, and M. Croft. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471-480.
36. Higgins, L.M., S.A. McDonald, N. Whittle, N. Crockett, J.G. Shields, and T.T. MacDonald. 1999. Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J. Immunol. 162:486-493.
37. Imura, A., T. Hori, K. Imada, T. Ishikawa, Y. Tanaka, M. Maeda, S. Imamura, and T. Uchiyama. 1996. The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells. J. Exp. Med. 183:2185-2191.
38. Cross, A.H., T.J. Girard, K.S. Giacoletto, R.J. Evans, R.M. Keeling, R.F. Lin, J.L. Trotter, and R.W. Karr. 1995. Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA4-Fc supports a key role for CD28 costimulation. J. Clin. Invest. 95:2783-2789.