Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Progress in Lipid Research

Volumn 59, Issue , 2015, Pages 38-53

  Escribá, Pablo V ^a   Busquets, Xavier ^a   Inokuchi, Jin Ichi ^b   Balogh, Gábor ^c   Török, Zsolt ^c   Horváth, Ibolya ^c   Harwood, John L ^d   Vígh, László ^c  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

G protein membrane interactions; Membrane cell signaling; Membrane lipid structure; Membrane lipid therapy drugs; Membrane protein interactions

Indexed keywords

ADENYLATE CYCLASE; ANTHRACYCLINE; ATORVASTATIN; BAPINEUZUMAB; CALCIUM ION; CALMODULIN; CHEMOKINE RECEPTOR CXCR4; CHOLESTEROL; DOCOSAHEXAENOIC ACID; G PROTEIN COUPLED RECEPTOR; GLYCOSPHINGOLIPID; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; HEAT SHOCK PROTEIN; MEMBRANE LIPID; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPASE C; PROPOFOL; PROTEIN KINASE C; RAC1 PROTEIN; RAS PROTEIN; RICINOLEIC ACID; SPHINGOMYELIN; SPHINGOMYELIN SYNTHASE; SYNTHETASE; TETRAHYDROLIPSTATIN; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CALCIUM TRANSPORT; CELL MEMBRANE; CELL PROLIFERATION; CELLULAR STRESS RESPONSE; CHEMICAL MODIFICATION; DEGENERATIVE DISEASE; DIABETES MELLITUS; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FAT INTAKE; FATTY ACID METABOLISM; FLUIDIZATION; GENE; GENE EXPRESSION REGULATION; GLIOMA; HSP GENE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTRACELLULAR SIGNALING; LIPID ANALYSIS; LIPID BILAYER; LIPID COMPOSITION; LIPID RAFT; MEMBRANE BINDING; MEMBRANE STRUCTURE; METABOLIC SYNDROME X; MOLECULAR PATHOLOGY; NEUROPATHOLOGY; NONHUMAN; OBESITY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SPINAL CORD INJURY; TRANSCRIPTION INITIATION; ANIMAL; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLIC DISEASES; METABOLISM; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE; DRUG DISCOVERY; HUMANS; MEMBRANE LIPIDS; METABOLIC DISEASES; MOLECULAR TARGETED THERAPY; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 84930959876     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2015.04.003     Document Type: Review

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