Integrins Regulate Rac Targeting by Internalization of Membrane Domains

Science

Volumn 303, Issue 5659, 2004, Pages 839-842

  Del Pozo, Miguel A ^a,b   Alderson, Nazilla B ^a   Kiosses, William B ^a   Chiang, Hui Hsien ^a   Anderson, Richard G W ^c   Schwartz, Martin A ^a,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CHOLESTEROL; LIPIDS; PROTEINS;

PLASMA MEMBRANES;

CELL MEMBRANES;

GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; MEMBRANE LIPID; RAC PROTEIN;

MEMBRANE;

ARTICLE; BINDING KINETICS; BINDING SITE; CELL ADHESION; CELL MEMBRANE; EXTRACELLULAR MATRIX; GENE TRANSLOCATION; INTERNALIZATION; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TARGETING; REGULATORY MECHANISM;

ANIMALS; ANTIGENS, CD29; BINDING SITES; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CHOLERA TOXIN; CHOLESTEROL; G(M1) GANGLIOSIDE; GLYCOSYLPHOSPHATIDYLINOSITOLS; GUANOSINE TRIPHOSPHATE; HUMANS; INTEGRINS; LIPOSOMES; MEMBRANE MICRODOMAINS; MICE; NIH 3T3 CELLS; RAC1 GTP-BINDING PROTEIN; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0842331441     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092571     Document Type: Article

References (25)

1. M. A. Schwartz, M. H. Ginsberg, Nature Cell Biol. 4, E6S (2002).
2. E. Sahai, C. J. Marshall, Nature Rev. Cancer 2, 133 (2002).
3. M. A. del Pozo, L. S. Price, N. B. Alderson, X. D. Ren, M. A. Schwartz, EMBO J. 19, 2008 (2000).
4. M. A. del Pozo et al., Nature Cell Biol. 4, 232 (2002).
5. K. Simons, D. Toomre, Nature Rev. Mol. Cell Biol. 1, 31 (2000).
6. D. A. Brown, E. London, J. Biol. Chem. 275, 17221 (2000).
7. F. R. Maxfield, Curr. Opin. Cell Biol. 14, 483 (2002).
8. I. A. Prior, C. Muncke, R. G. Parton, J. F. Hancock, J. Cell Biol. 160, 165 (2003).
9. C. Dietrich, B. Yang, T. Fujiwara, A. Kusumi, K. Jacobson, Biophys. J. 82, 274 (2002)
10. M. Edidin, Annu. Rev. Biophys. Biomol. Struct. 32, 257 (2003).
11. C. Gómez-Mouton et al., Proc. Natl. Acad. Sci. U.S.A. 98, 9642 (2001).
12. R. G. Parton, J. Histochem. Cytochem. 42, 155 (1994).
13. R. G. Anderson, Proc. Natl. Acad. Sci. U.S.A. 90, 10909 (1993).
14. P. A. Michaely, C. Mineo, Y. S. Ying, R. G. Anderson, J. Biol. Chem. 274, 21430 (1999).
15. H. Kumanogoh, S. Miyata, Y. Sokawa, S. Maekawa, Neurosci. Res. 39, 189 (2001).
16. S. Grimmer, B. Van Deurs, K. Sandvig, J. Cell Sci. 11S, 2953 (2002).
17. Materials and methods are available as supporting material on Science Online.
18. A. Radhakrishnan, T. G. Anderson, H. M. McConnell, Proc. Natl. Acad. Sci. U.S.A. 97, 12422 (2000).
19. M. A. del Pozo, data not shown.
20. B. J. Nichols, Curr. Biol. 13, 686 (2003).
21. R. Montesano, J. Roth, A. Robert, L. Orci, Nature 296, 651 (1982).
22. N. Holtta-Vuori, K. Tanhuanpaa, W. Mobius, P. Somerharju, E. Ikonen, Mol. Biol. Cell 13, 3107 (2002).
23. S. Miyamoto, S. K. Akiyama, K. M. Yamada, Science 267, 883 (1995).
24. K. Simons, E. Ikonen, Science 290, 1721 (2000).
25. We thank P. Read and R. Nakamoto for the Rac1 and RhoGDI vectors I. S. Trowbridge for H68 antibody; and P. Liu, M. Zhu, S. Revak, and E. M. Moreno for advice and technical assistance. This work was supported by a Lady Tata Memorial Trust International Award for Research in Leukemia, a Special Fellow Award from the Leukemia and Lymphoma Society of America, and MCYT (Ministerio de Ciencia y Tecnología) grant SAF2002-02425 to M.A.d.P.; U.S. Public Health Service grant RO1 GM47214 to M.A.S.; and grants from NIH (HL 20948, GM52016) and the Perot Family Foundation to R.G.W.A. This is manuscript no. 15179-VB from The Scripps Research Institute.