Structural flexibility and the positive charges are the key factors in bacterial cell selectivity and membrane penetration of peptoid-substituted analog of Piscidin 1

Biochimica et Biophysica Acta - Biomembranes

Volumn 1798, Issue 10, 2010, Pages 1913-1925

  Kim, Jin Kyoung ^a   Lee, Sung Ah ^a   Shin, Soyoung ^a   Lee, Jee Young ^a   Jeong, Ki Woong ^a   Nan, Yong Hai ^b   Park, Yong Sun ^a   Shin, Song Yub ^b   Kim, Yangmee ^a  

^a Konkuk University   (South Korea)

^b Chosun University College of Medicine   (South Korea)

Author keywords

Antimicrobial peptide; Cell selectivity; NMR; Peptoid residue; Piscidin 1; Structure

Indexed keywords

DODECYLPHOSPHORYLCHOLINE; LYSINE; PHENYLALANYLPHENYLALANYLHISTIDYLHISTIDYLISOLEUCYLPHENYLALANYLARGINYLPROLYLISOLEUCYLVALYLHISTIDYLVALYLGLYCYLLYSYLTHREONYLISOLEUCYLHISTIDYLARGINYLLEUCYLVALYLTHREONYLGLYCINE; PISCIDIN 1; PISCIDIN 1 DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; FISH PROTEIN; GLYCINE; MORONECIDIN PROTEIN, MORONE SAXATILIS; PROLINE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE PERMEABILITY; CELL STRAIN 3T3; CIRCULAR DICHROISM; CONFOCAL LASER MICROSCOPY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ERYTHROCYTE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; MICELLE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN TERTIARY STRUCTURE; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; SURFACE CHARGE; 3T3 CELL LINE; AMINO ACID SEQUENCE; ANIMAL; BACTERIA; BASS; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; MICROBIAL VIABILITY; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BASS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; FISH PROTEINS; GLYCINE; HEMOLYSIS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE POTENTIALS; MICE; MICROBIAL VIABILITY; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NIH 3T3 CELLS; PROLINE; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS;

BACTERIA (MICROORGANISMS); MAMMALIA; MORONE; STAPHYLOCOCCUS AUREUS;

EID: 77955658045     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2010.06.026     Document Type: Article

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