Inositol-lipid binding motifs: Signal integrators through protein-lipid and protein-protein interactions

Journal of Cell Science

Volumn 118, Issue 10, 2005, Pages 2093-2104

  Balla, Tamas ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Inositol lipid kinase; Inositol lipid phosphatase; Intracellular signaling; Phosphoinositide; Phosphorylation; Pleckstrin homology domain

Indexed keywords

ADAPTOR PROTEIN; GLUCOSE REGULATED PROTEIN; INOSITOL; INSULIN RECEPTOR SUBSTRATE 1; MEMBRANE LIPID; MOESIN; PDZ PROTEIN; PHOSPHATIDYLINOSITIDE; PLECKSTRIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE B; PROTEIN SHC; RETINA S ANTIGEN; SPECTRIN; TALIN;

EUKARYOTIC CELL; GENETIC CONSERVATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; CELL MEMBRANE; INOSITOL; MEMBRANE LIPIDS; MODELS, MOLECULAR; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 21044443928     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02387     Document Type: Review

References (131)

1. Alberti, S. (1998). A phosphoinositide-binding sequence is shared by PH domain target molecules - A model for the binding of PH domains to proteins. Prot. Struct. Funct. Gen. 31, 1-9.
2. Balla, T. and Varnai, P. (2002). Visualizing cellular phosphoinositide pools with GFP-fused protein-modules. Sci. STKE 125, 1-16.
3. Balla, T., Bondeva, T. and Varnai, P. (2000). How accurately can we image inositol lipids in live cells? Trends Pharmacol. Sci. 21, 238-241.
4. Barr, A. J., Ali, H., Haribabu, B., Snyderman, R. and Smrcka, A. V. (2000). Identification of a region at the N-terminus of phospholipase C-beta 3 that interacts with G protein beta gamma subunits. Biochemistry 39, 1800-1806.
5. 2) binding site in the NH2-terminal domain of ezrin correlates with its altered cellular distribution. J. Cell Biol. 151, 1067-1079.
6. Begley, M. J., Taylor, G. S., Kim, S. A., Veine, D. M., Dixon, J. E. and Stuckey, J. A. (2003). Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome. Mol. Cell 12, 1391-1402.
7. Berger, P., Schaffitzel, C., Berger, I., Ban, N. and Suter, U. (2003). Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. Proc. Natl. Acad. Sci. USA 100, 12177-12182.
8. Berridge, M. J. (1984). Inositol trisphosphate and diacylglycerol as intracellular messengers. Biochem. J. 220, 345-360.
9. Bompard, G., Martin, M., Roy, C., Vignon, F. and Freiss, G. (2003). Membrane targeting of protein tyrosine phosphatase PTPL1 through its FERM domain via binding to phosphatidylinositol 4,5-bisphosphate. J. Cell Sci. 116, 2519-2530.
10. Bonifacino, J. S. and Traub, L. M. (2003). Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72, 395-447.
11. phox bound to phosphatidylinositol 3-phosphate. Mol. Cell 8, 829-839.
12. Burd, C. G. and Emr, S. D. (1998). Phosphatidylinositol 3-phosphate signaling mediated by specific binding to RING FYVE domains. Mol. Cell 2, 157-162.
13. Carman, C. V., Barak, L. S., Chen, C., Liu-Chen, L-Y., Onorato, J. J., Kennedy, S. P., Caron, M. G. and Benovic, J. L. (2000). Mutational analysis of Gβγ and phospholipid interaction with G protein-coupled receptor kinase 2. J. Biol. Chem. 275, 10443-10452.
14. Chaudhary, A., Chen, J., Gu, Q. M., Witke, W., Kwiatkowski, D. J. and Prestwich, G. D. (1998). Probing the phosphoinositide 4,5-bisphosphate binding site of human profilin. Chem. Biol. 5, 273-281.
15. Cheever, M. L., Sato, T. K., de Beer, T., Kutateladze, T. G., Emr, S. D. and Overduin, M. (2001). Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat. Cell Biol. 3, 613-618.
16. Christy, A. H., Kim, A. C., Marfatia, S. M., Lutchman, M., Hanspal, M., Jindal, H., Liu, S. C., Low, P. S., Rouleau, G. A., Mohandas, N. et al. (1998). The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem. Sci. 23, 281-282.
17. Collins, B. M., McCoy, A. J., Kent, H. M., Evans, P. R. and Owen, D. J. (2002). Molecular architecture and functional model of the endocytic AP2 complex. Cell 109, 523-535.
18. Cozier, G. E., Carlton, J., Bouyoucef, D. and Cullen, P. J. (2004). Membrane targeting by pleckstrin homology domains. Curr. Top. Microbiol. Immunol. 282, 49-88.
19. Dell'Acqua, M. L., Faux, M. C., Thorburn, J., Thorburn, A. and Scott, J. D. (1998). Membrane-targeting sequences on AKAP79 bind phosphatidylinositol 4,5-bisphosphate. EMBO J. 17, 2246-2260.
20. Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M. R. and de Camilli, P. (2002). Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin. Nature 420, 85-89.
21. DiNitto, J. P., Cronin, T. C. and Lambright, D. G. (2003). Membrane recognition and targeting by lipid-binding domains. Sci. STKE 213, 1-16.
22. Doerks, T., Strauss, M., Brendel, M. and Bork, P. (2000). GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Trends Biochem. Sci. 25, 483-485.
23. Dumas, J. J., Merithew, E., Sudharsan, E., Rajamani, D., Hayes, S., Lawe, D., Corvera, S. and Lambright, D. G. (2001). Multivalent endosome targeting by homodimeric EEA1. Mol. Cell 8, 947-958.
24. Edwards, S. D. and Keep, N. H. (2001). The 2.7A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation. Biochemistry 40, 7061-7068.
25. phox. Nat. Cell Biol. 3, 679-682.
26. Ferguson, K. M., Lemmon, M. A., Schlessinger, J. and Sigler, P. B. (1995). structure of the high affinity complex of inositol trisphosphate with a phospholipase C plekstrin homology domain. Cell 83, 1037-1046.
27. Ferguson, K. M., Kavran, J. M., Sankaran, V. G., Fournier, E., Isakoff, S. J., Skolnik, E. Y. and Lemmon, M. A. (2000). Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol. Cell 6, 373-384.
28. Fievet, B. T., Gautreau, A., Roy, C., del Maestro, L., Mangeat, P., Louvard, D. and Arpin, M. (2004). Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J. Cell Biol. 164, 653-659.
29. Finnerty, C. M., Chambers, D., Ingraffea, J., Faber, H. R., Karplus, P. A. and Bretscher, A. (2004). The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J. Cell Sci. 117, 1547-1552.
30. 2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science 291, 1051-1055.
31. Ford, M. G. J., Mills, I. G., Peter, B. J., Vallis, Y., Praefcke, G. J. K., Evans, P. R. and McMahon, H. T. (2002). Curvature of clathrin-coated pits driven by epsin. Nature 429, 361-366.
32. Forman-Kay, J. D. and Pawson, T. (1999). Diversity in protein recognition by PTB domains. Curr. Opin. Struct. Biol. 9, 690-695.
33. 2 effector required for protein sorting to the multivesicular body. Dev. Cell 5, 499-511.
34. Gaidarov, I., Krupnick, J. G., Falck, J. R., Benovic, J. L. and Keen, J. H. (1999). Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J. 18, 871-881.
35. Garcia-Alvarez, B., de Pereda, J. M., Calderwood, D. A., Ulmer, T. S., Critchley, D., Campbell, I. D., Ginsberg, M. H. and Liddington, R. C. (2003). Structural determinants of integrin recognition by talin. Mol. Cell 11, 49-58.
36. Gozani, O., Karuman, P., Jones, D. R., Ivanov, D., Cha, J., Logovskoy, A. A., Baird, C. L., Zhu, H., Field, S. J., Lessnick, S. L. et al. (2003). The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114, 99-111.
37. Hamada, K., Shimizu, T., Matsui, T., Tsukita, S. and Hakoshima, T. (2000). Structural basis of the membrane targeting and unmasking mechanisms of the radixin FERM domain. EMBO J. 19, 4449-4462.
38. Hamada, K., Shimizu, T., Yonemura, S., Tsukita, S. and Hakoshima, T. (2003). Structural basis of adheson-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J. 22, 502-514.
39. Harlan, J. E., Hajduk, P. J., Yoon, H. S. and Fesik, S. W. (1994). Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371, 168-170.
40. Hawkins, P. T., Michell, R. H. and Kirk, C. J. (1984). Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques using 32P-labelled lipids from erythrocytes. Biochem. J. 218, 785-793.
41. Heldwein, E. E., Macia, E., Wang, J., Yin, H. L., Kirchhausen, T. and Harrison, S. C. (2004). Crystal structure of the clathrin adaptor protein 1 core. Proc. Natl. Acad. Sci. USA 101, 14108-14113.
42. Hiroaki, H., Ago, T., Sumimoto, H. and Kohda, D. (2001). Solution structure of the PX domain, a target of the SH3 domain. Nat. Struct. Biol. 8, 526-530.
43. Hirst, J., Motley, A., Haraski, K., Chew, S. Y. P. and Robinson, M. S. (2003). EpsinR: an ENTH domain-containing protein that interacts with AP-1. Mol. Biol. Cell 14, 625-641.
44. Hurley, J. H. and Meyer, T. (2001). Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13, 146-152.
45. Hyvonen, M., Macias, M. J., Nilges, M., Oschkinat, H., Saraste, M. and Wilmanns, M. (1995). Structure of the binding site for inositol phosphates in a PH domain. EMBO J. 14, 4676-4685.
46. Irvine, R. (2004). Inositol Lipids: To PHix or Not to PHix? Curr. Biol. 14, R308-R310.
47. Irvine, R. F. (2003). Nuclear lipid signalling. Nat. Rev. Mol. Cell. Biol. 4, 349-360.
48. Jelen, F., Oleksy, A., Smietana, K. and Otlewski, J. (2003). PDZ domains - common players in the cell signaling. Acta Biochem. Pol. 50, 985-1017.
49. Kanai, F., Liu, H., Field, S. J., Akbary, H., Matsuo, T., Brown, G. E., Cantley, L. C. and Yaffe, M. B. (2001). The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat. Cell Biol. 3, 675-678.
50. Kang, B. S., Cooper, D. R., Devedjiev, Y., Derewenda, U. and Derewenda, Z. S. (2003). Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm. Structure 11, 845-853.
51. phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J. 21, 5057-5068.
52. Kim, Y-M. and Benovic, J. L. (2002). Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking. J. Biol. Chem. 277, 30760-30768.
53. Kraulis, P. J. (1991). MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Cryst. 24, 946-950.
54. Krupnick, J. G., Goodman, O. B., Keen, J. H. and Benovic, J. L. (1997). Arrestin/clathrin interaction. J. Biol. Chem. 272, 15011-15016.
55. Krylova, I. N., Sablin, E. P., Moore, J., Xu, R. X., Waitt, G. M., MacKay, J. A., Juzumiene, D., Bynum, J. M., Madauss, K., Montana, V. et al. (2005). Structural analyses reveal phosphatidylinositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120, 343-355.
56. Kutateladze, T. G., Ogburn, K. D., Watson, W. T., deBeer, T., Emr, S. D., Burd, C. G. and Overduin, M. (1999). Phosphatidylinositol 3-Phosphate recognition by the FYVE domain. Mol. Cell 3, 805-811.
57. 2-adrenergic receptor into clathrin-coated pits. J. Biol. Chem. 275, 23120-23126.
58. Lawe, D. C., Patki, V., Heller-Harrison, R., Lambright, D. and Corvera, S. (2000). The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. J. Biol. Chem. 275, 3699-3705.
59. Lee, S-J. and Montell, C. (2004). Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron 43, 95-103.
60. Lee, S-J., Xu, H., Kang, L-W., Amzel, L. M. and Montell, C. (2003). Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron 39, 121-132.
61. Legendre-Guillemin, V., Wasiak, S., Hussain, N. K., Angers, A. and McPherson, P. S. (2004). ENTH/ANTH proteins and clathrin-mediated membrane budding. J. Cell Sci. 117, 9-18.
62. Legge, G. B., Martinez-Yamout, M., Hambly, D. M., Trinh, T., Lee, B. M., Dyson, H. J. and Wright, P. E. (2004). ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module. J. Mol. Biol. 343, 1081-1093.
63. Lemmon, M. A. (2003). Phosphoinositide recognition domains. Traffic 4, 201-213.
64. Lemmon, M. A. and Ferguson, K. M. (2000). Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350, 1-18.
65. Leslie, N. R., Bennett, D., Gray, A., Pass, I., Hoang-Xuan, K. and Downes, C. P. (2001). Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem. J. 357, 427-435.
66. Li, S. C., Zwachen, C., Vincent, S. J., McGlade, C. J., Kay, L. E., Pawson, T. and Forman-Kay, J. D. (1998). Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity. Nat. Struct. Biol. 5, 1075-1083.
67. Lietzke, S. E., Bose, S., Cronin, T., Klarlund, J., Chawla, A., Czech, M. P. and Lambright, D. G. (2000). Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol. Cell 6, 385-394.
68. Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J. and Tesmer, J. J. (2003). Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 300, 1256-1262.
69. Lu, M., Kinchen, J. M., Rossman, K. L., Grimsley, C., deBakker, C., Brugnera, E., Tosello-Trampont, A. C., Haney, L. B., Klingele, D., Sondek, J. et al. (2004). PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat. Struct. Mol. Biol. 11, 756-762.
70. Luttrell, L. M. (2003). "Location, location, location": activation and targeting of MAP kinases by G protein-coupled receptors. J. Mol. Endocrinol. 30, 117-126.
71. Luttrell, L. M. and Lefkowitz, R. J. (2002). The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115, 455-465.
72. Macias, M. J., Musacchio, A., Ponstingl, H., Nilges, M., Saraste, M. and Oschkinat, H. (1994). Structure of the pleckstrin homology domain from beta-spectrin. Nature 369, 675-677.
73. Majerus, P. W., Kisseleva, M. V. and Norris, F. A. (1999). The role of phosphatases in inositol signaling reactions. J. Biol. Chem. 274, 10669-10672.
74. Mangeat, P., Roy, C. and Martin, M. (1999). ERM proteins in cell adhesion and membrane dynamics. Trends Cell Biol. 9, 187-192.
75. Mao, Y., Nickitenko, A., Duan, X., Lloyd, T. E., Wu, M. N., Bellen, H. and Quiocho, F. A. (2000). Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction. Cell 100, 447-456.
76. Mao, Y., Chen, J., Maynard, J. A., Zhang, B. and Quiocho, F. A. (2001). A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell 104, 433-440.
77. Martin, T. F. (1997). Phosphoinositides as spatial regulators of membrane traffic. Curr. Opin. Neurobiol. 7, 331-338.
78. Mills, I. G., Praefcke, G. J. K., Vallis, Y., Peter, B. J., Olesen, L. E., Gallop, J. L., Butler, P. J. G., Evans, P. R. and McMahon, H. T. (2003). EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. J. Cell Biol. 160, 213-222.
79. Misra, S. and Hurley, J. H. (1999). Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p. Cell 97, 657-666.
80. Mishra, S. K., Keyel, P. A., Hawryluk, M. J., Agostinelli, N. R., Watkins, S. C. and Traub, L. M. (2002a). Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 21, 4915-4926.
81. Mishra, S. K., Watkins, S. C. and Traub, L. M. (2002b). The autosomal recessive hypercholesterolemia (ARH) protein interfaces directly with the clathrin-coat machinery. Proc. Natl. Acad. Sci. USA 99, 16099-16104.
82. Morais-Cabral, J. H., Petosa, C., Sutcliffe, M. J., Raza, S., Byron, O., Poy, F., Marfatia, S. M., Chisti, A. H. and Liddington, R. C. (1996). Crystal structure of a PDZ domain. Nature 382, 649-652.
83. Nemoto, Y. and de Camilli, P. (1999). Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein. EMBO J. 18, 2991-3006.
84. Nourry, C., Grant, S. G. and Borg, J. P. (2003). PDZ domain proteins: plug and play. Sci STKE 179, 1-7.
85. Odom, A. R., Stahlberg, A., Wente, S. R. and York, J. D. (2000). A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 287, 2026-2029.
86. Owen, D. J. and Evans, P. R. (1998). A structural explanation for the recognition of tyrosine-based endocytotic signals. Science 282, 1327-1332.
87. Owen, D. J., Collins, B. M. and Evans, P. R. (2004). Adaptors for clathrin coats: structure and function. Annu. Rev. Cell. Dev. Biol. 20, 153-191.
88. Pascual, J., Martinez-Yamout, M., Dyson, H. J. and Wright, P. E. (2000). Structure of the PHD zinc finger from human Williams-Beuren Syndrome transcription factor. J. Mol. Biol. 304, 723-729.
89. Pearson, M. A., Reczek, D., Bretscher, A. and Karplus, P. A. (2000). Structure of the ERM protein moesin reveals the FERM domain fold and extended actin binding tail domain. Cell 101, 259-270.
90. Ponting, C. P. (1996). Novel domains in NADPH oxydase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? Prot. Sci. 5, 2353-2357.
91. Powell, D. J., Hajduch, E., Kular, G. and Hundal, H. S. (2003). Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCζ-dependent mechanism. Mol. Cell. Biol. 23, 7794-7808.
92. Prehoda, K. E., Lee, D. J. and Lim, W. A. (1999). Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly. Cell 97, 471-480.
93. Rameh, L. E., Arvidsson, A., Carraway III, K. L., Couvillon, A. D., Rathbun, G., Crompton, A., VanRentherghem, B., Czech, M. P., Ravichandran, K. S., Burakoff, S. J. et al. (1997). A comparative analysis of the phosphoinositide binding specificity of plekstrin homology domains. J. Biol. Chem. 272, 22059-22066.
94. Ray, P. and Strott, C. A. (1981). Cytosol stimulation of pregnenolone synthesis by isolated adrenal mitochondria. Life Sci. 28, 1529-1534.
95. Rescher, U. and Gerke, V. (2004). Annexins - unique membrane binding proteins with diverse functions. J. Cell Sci. 117, 2631-2639.
96. Rescher, U., Ruhe, D., Ludwig, C., Zobiak, N. and Gerke, V. (2004). Annexin 2 is a phosphatidylinositol 4,5-bisphosphate binding protein recruited to actin assembly sites at cellular membranes. J. Cell Sci. 117, 3473-3480.
97. Roy, A. and Levine, T. P. (2004). Multiple pools of phosphatidylinositol 4-phosphate detected using the pleckstrin homology domain of Osh2p. J. Biol. Chem. 279, 44683-44689.
98. Saito, K., Tolias, K. F., Saci, A., Koon, H. B., Humphries, L. A., Scharenberg, A., Rawlings, D. J., Kinet, J. P. and Carpenter, C. L. (2003). BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity 19, 669-678.
99. Sato, T. K., Overduin, M. and Emr, S. D. (2001). Location, location, location: membrane targeting directed by PX domains. Science 294, 1881-1885.
100. Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J-M., Brech, A., Callaghan, J., Toh, B-H., Murphy, C., Zerial, M. and Stenmark, H. (1998). EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394, 494-498.
101. Song, X., Xu, W., Zhang, A., Huang, G., Liang, X., Virbasius, J. V., Czech, M. P. and Zhou, G. W. (2001). Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry 40, 8940-8944.
102. Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chisti, A. H., Crompton, A., Chan, A. C., Anderson, J. M. and Cantley, L. C. (1997). Recognition of uniques carboxyl-terminal motifs by distinct PDZ domains. Science 275, 73-77.
103. 2 concentration monitored in living cells. Curr. Biol. 8, 343-346.
104. Stenmark, H., Aasland, R., Toh, B-H. and D'Arrigo, A. (1996). Endosomal localization of the autoantigen EEA1 is mediated by a Zinc-binding FYVE finger. J. Biol. Chem. 271, 24048-24054.
105. Stolt, P. C., Jeon, H., Song, H. K., Herz, J., Eck, M. J. and Blacklow, S. C. (2003). Origins of peptide selectivity and phosphoinositide binding revealed by structures of Disabled-1 PTB domain complexes. Structure 11, 569-579.
106. Tanaka, M., Konishi, H., Touhara, K., Sakane, F., Hirata, M., Ono, Y. and Kikkawa, U. (1999). Identification of myosin II as a binding protein to the PH domain of protein kinase B. Biochem. Biophys. Res. Commun. 255, 169-174.
107. Thomas, C. C., Deak, M., Alessi, D. R. and van Alten, D. M. (2002). High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate. Curr. Biol. 12, 1256-1262.
108. Toker, A. and Cantley, L. C. (1997). Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676.
109. Tsukada, S., Simon, M., Witte, O. and Katz, A. (1994). Binding of the βγ subunits of heterotrimeric G-proteins to the PH domain of Bruton's tyrosine kinase. Proc. Natl. Acad. Sci. USA 91, 11256-11260.
110. van Der Wal, J., Habets, R., Varnai, P., Balla, T. and Jalink, K. (2001). Monitoring Phospholipase C activation kinetics in live cells by FRET. J. Biol. Chem. 276, 15337-15344.
111. 3H]inositol-labeled phosphoinositide pools. J. Cell Biol. 143, 501-510.
112. Vetter, I. R., Nowak, C., Nishimoto, T., Kuhlmann, J. and Wittinghofer, A. (1999). Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature 398, 39-46.
113. Voglmaier, S. M., Keen, J. H., Murphy, J. E., Ferris, C. D., Prestwich, G. D., Snyder, S. H. and Theibert, A. B. (1992). Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2. Biochem. Biophys. Res. Commun. 187, 158-163.
114. Vollert, C. S. and Uetz, P. (2004). The PX domain protein interaction network in yeast. Mol. Cell. Proteomics 3, 1053-1064.
115. Walker, S. A., Cozier, G. E. and Cullen, P. J. (2004). GFP fusion proteins to study signaling in live cells. Methods Mol. Biol. 273, 407-420.
116. Wang, J., Arbuzova, A., Hangyas-Mihalyne, G. and McLaughlin, S. (2001). The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 276, 5012-5019.
117. Wang, T., Pentyala, S., Rebecchi, M. J. and Scarlata, S. (1999). Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Biochemistry 38, 1517-1524.
118. Wang, Y. J., Wang, J., Sun, H. Q., Martinez, M., Sun,. Y. X., Macia, E., Kirschhausen, T., Albanesi, J. P., Roth, M. G. and Yin, H. L. (2003). Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell 114, 299-310.
119. Wenk, M. R. and de Camilli, P. (2004). Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals. Proc. Natl. Acad. Sci. USA 101, 8262-8269.
120. Xing, Y., Liu, D., Zhang, R., Joachimiak, A., Songyang, Z. and Xu, W. (2004). Structural basis of membrane targeting by the phox homology domain of cytokine-indpendent survival kinase (CISK-PX). J. Biol. Chem. 279, 30662-30669.
121. Yan, K. S., Kuti, M. and Zhou, M-M. (2002). PTB or not PTB-that is the question. FEBS Lett. 513, 67-70.
122. Yao, L., Suzuki, H., Ozawa, K., Deng, J., Lehel, C., Fukamachi, H., Anderson, W. B., Kawakami, Y. and Kawakami, T. (1997). Interactions between protein kinase C and pleckstrin homology domains. J. Biol. Chem. 272, 13033-13039.
123. Yu, J. W. and Lemmon, M. A. (2001). All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J. Biol. Chem. 276, 44179-44184.
124. Yu, J. W., Mendrola, J. M., Audhya, A., Singh, S., Keleti, D., DeWald, D. B., Murray, D., Emr, S. D. and Lemmon, M. A. (2004). Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Mol. Cell 13, 677-688.
125. Yun, M., Keshvara, L., Park, C-G., Zhang, Y-M., Dickerson, J. B., Zheng, J., Rock, C. O., Curran, T. and Park, H-W. (2003). Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J. Biol. Chem. 278, 36572-36581.
126. phox PX domains of NADPH oxydase target cell membranes via direct and indirect recruitment by phosphoinositides. J. Biol. Chem. 277, 4512-4518.
127. Zhang, G., Kazainetz, M. G., Blumberg, P. M. and Hurley, J. H. (1995). Crystal structure of the cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester. Cell 81, 917-924.
128. Zhou, C. Z., Li de la Sierra-Gallay, I., Cheruel, S., Collinet, B., Minard, P., Blondeau, K., Henkes, G., Aufrere, R., Leulliot, N., Graille, M. et al. (2003). Crystal Structure of the Yeast Phox Homology (Px) Protein Grd19P (Sorting Nexin 3) Complexed to Phosphatidylinositol-3 -Phosphate. J. Biol. Chem. 278, 50371-50376.
129. Zhou, M. M., Ravichandran, K. S., Olejniczak, E. F., Petros, A. M., Meadows, R. P., Sattler, M., Harlan, J. E., Wade, W. S., Burakoff, S. J. and Fesik, S. W. (1995). Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature 378, 584-592.
130. Zhou, M. M., Huang, B., Olejniczak, E. T., Meadows, R. P., Shuker, S. B., Miyazaki, M., Trub, T., Shoelson, S. E. and Fesik, S. W. (1996). Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat. Struct. Biol. 3, 388-393.
131. 2-PDZ domain binding controls association of syntenin with the plasma membrane. Mol. Cell 9, 1215-1225.