Lipid Replacement Therapy: A natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 6, 2014, Pages 1657-1679

  Nicolson, Garth L ^a   Ash, Michael E ^b  

^a INSTITUTE FOR MOLECULAR MEDICINE   (United States)

^b Clinical Education   (United Kingdom)

Author keywords

Degenerative illnesses; Fatigue; Inflammasome; Lipid oxidation; Membrane phospholipids; Mitochondrial function

Indexed keywords

DEGENERATIVE ILLNESSES; FATIGUE; INFLAMMASOME; LIPID OXIDATION; MEMBRANE PHOSPHOLIPIDS; MITOCHONDRIAL FUNCTION;

ANIMALS; BIOLOGICAL PRODUCTS; CELL MEMBRANE; DIETARY SUPPLEMENTS; HUMANS; MEMBRANE LIPIDS; NEOPLASMS; ORGANELLES;

EID: 84899439665     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.11.010     Document Type: Review

References (354)

1. K. Oette On the administration of phosphatidylcholine: metabolic and pharmacokinetic aspects in humans K.J. Gundermann, R. Schumacher, 50th Anniversary of Phospholipid Research (EPL) 1990 WbnPress Bingen/Rhine 35 48
2. K.J. Gundermann The "essential" phospholipids as a membrane therapeutic 1993 European Society of Biochemical Pharmacology Szcecin, Poland
3. P.L. Yeagle Lipid regulation of cell membrane structure and function FASEB J. 3 1989 1833 1842
4. M. Edidin Lipids on the frontier: a quarter century of cell-membrane bilayers Nat. Rev. Mol. Cell Biol. 4 2003 414 418
5. G.L. Nicolson Lipid replacement as an adjunct therapy in chronic fatigue, anti-aging and restoration of mitochondrial function J. Am. Nutraceut. Assoc. 6 3 2003 22 28
6. D. Küllenberg, L.A. Taylor, M. Schneider, and U. Massing Health effects of dietary phospholipids Lipids Health Dis. 11 3 2012 1 16
7. M.L. Diaz Membrane physiology and biophysics in the next decade: an open balcony to multiple scenarios Front. Physiol. 1 2010 1 2 (article 23)
8. X. Tekpli, J.A. Holme, O. Sergent, and D. Lagadic-Gossmann Role for membrane remodeling in cell death: implication for health and disease Toxicology 304 2013 141 157
9. G. van Meer, D.R. Voelker, and G.W. Feigenson Membrane lipids: where they are and how they behave Nat. Rev. Mol. Cell Biol. 9 2008 112 124
10. A. Shevchenko, and K. Simons Lipidomics: coming to grips with lipid diversity Nat. Rev. Mol. Cell Biol. 11 2010 593 598
11. P.A. Janmey, and P.K.J. Kinnunen Biophysical properties of lipids and dynamic membranes Trends Cell Biol. 16 2006 538 546
12. L.L.M. van Deenen Phospholipide: beziehungen zwischen ihrer chemischen struktur biomembranen Naturwissenschaften 59 1972 485 491
13. L.L. Holte, S.A. Peter, T.M. Sinnwell, and K. Gawrisch 2H Nuclear magnetic resonance order parameter profiles suggest a change of molecular shape for phosphatidylcholines containing a polyunsaturated acyl chain Biophys. J. 68 1995 2396 2403
14. M.S. Bretscher, and S. Munro Cholesterol and Golgi apparatus Science 261 1993 1280 1281
15. L. Cantu, M. Corti, P. Brocca, and E. Del Favero Structural aspects of ganglioside-containing membranes Biochim. Biophys. Acta 1788 2009 202 208
16. J.A.F. Op den Kamp Lipid asymmetry in membranes Annu. Rev. Biochem. 48 1979 47 71
17. A.A. Spector, and M.A. Yorek Membrane lipid composition and cellular function J. Lipid Res. 26 1985 1015 1035
18. P. Somerjarju, J.A. Virtanen, K.H. Cheng, and M. Hermansson The superlattice model of lateral organization of membranes and its implications on membrane lipid homeostasis Biochim. Biophys. Acta 1788 2009 12 23
19. L. Vigh, P.V. Escribá, A. Sonnleitner, M. Sonnleitner, S. Piotto, B. Maresca, I. Horváth, and J.L. Harwood The significance of lipid composition for membrane activity: new concepts and ways of assessing function Prog. Lipid Res. 44 2005 303 344
20. P.J. Quinn, and C. Wolf The liquid-ordered phase in membranes Biochim. Biophys. Acta 1788 2009 33 46
21. L.A. Bagatolli, J.H. Ipsen, A.C. Simonsen, and O.G. Mouritsen An outlook on organization of lipids in membranes: searching for a realistic connection with the organization of biological membranes Prog. Lipid Res. 49 2010 378 389
22. J. Zimmerberg, and K. Gawrich The physical chemistry of biological membranes Nat. Chem. Biol. 11 2006 564 567
23. E. Gorter, and F. Grendel On bimolecular layers of lipoids on the chyromocytes of the blood J. Exp. Med. 41 1925 439 443
24. R.F.A. Zwaal, R.A. Demel, B. Roelofsen, and L.L.M. van Deenen The lipid bilayer concept of cell membranes TIBS 10 1976 112 114
25. J.F. Danielli, and H. Davson A contribution to the theory of permeability of thin films J. Cell. Comp. Physiol. 5 1935 495 508
26. J.D. Robertson The ultrastructure of cell membranes and their derivatives Biochem. Soc. Symp. 16 1959 3 43
27. J.D. Robertson The molecular structure and contact relationships of cell membranes Prog. Biophys. Biophys. Chem. 10 1960 343 418
28. J.D. Robertson Membrane structure J. Cell Biol. 91 1981 191s 204s
29. S.J. Singer, and G.L. Nicolson The Fluid Mosaic Model of the structure of cell membranes Science 175 1972 720 731
30. G.L. Nicolson Transmembrane control of the receptors on normal and tumor cells. I. Cytoplasmic influence over cell surface surface components Biochim. Biophys. Acta 457 1976 57 108
31. G.L. Nicolson The Fluid-Mosaic Model of membrane structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than forty years Biochim. Biophys. Acta 1838 2013 Nov 1 10.1016/j.bbamem.2013.10.019 (pii: S0005-2736(13)00393-3, Epub ahead of print)
32. O.G. Mouritsen, and M. Bloom Mattress model of lipid-protein interactions in membranes Biophys. J. 46 1984 141 153
33. A.E. Drobnies, S.M. Davis, R. Kraayenhof, R.F. Epand, R.M. Epand, and R.B. Cornell CTP:phosphocholine cytidylytransferase and protein kinase C recognize different physical features of membranes: differential responses to an oxidized phosphatidylcoline Biochim. Biophys. Acta 1564 2002 82 90
34. F. Dumas, M.M. Sperotto, M.C. Lebrun, J.F. Tocanne, and O.G. Mouritsen Molecular sorting of lipids by bacteriorhodopsin in dilauroylphosphatidylcholine/distearoylphosphatidyl-choline lipid bilayer Biophys. J. 73 1997 1940 1953
35. C.D. Stubbs, and A.D. Smith The modification of mammalian membrane polyunsaturated fatty acid composition in relaation to membrane fluidity and function Biochim. Biophys. Acta 779 1984 89 137
36. D. Chapman Phase transitions and fluidity characteristics of lipids and cell membranes Q. Rev. Biophys. 8 1975 185 235
37. S.L. Pelech, and D.E. Vance Regulation of phosphatidylcholine biosynthesis Biochim. Biophys. Acta 779 1984 217 251
38. J.E. Vance, and G. Tasseva Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells Biochim. Biophys. Acta 1831 2013 543 554
39. J.L. Spees, S.D. Olson, M.J. Whitney, and D.J. Prockop Mitochondrial transfer between cells can rescue aerobic respiration Proc. Natl. Acad. Sci. U. S. A. 103 2006 1283 1288
40. N. Lane, and W. Martin The energetics of genome complexity Nature 467 2010 929 934
41. B.F. Lang, M.W. Gray, and G. Burger Mitochondrial genome evolution and the origin of eukaryotes Annu. Rev. Genet. 33 1999 351 397
42. J.P. Monteiro, P.J. Oliveira, and A.S. Jurado Mitochondrial membrane lipid remodeling in pathophysiology: a new target for diet and therapeutic interventions Prog. Lipid Res. 52 4 2013 513 528
43. R.J. Khairallah, J. Kim, K.M. O'Shea, K.A. O'Connell, B.H. Brow, T. Galvao, C. Daneault, C. Des Rosiers, B.M. Polster, C.L. Hoppel, and W.C. Stanley Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids PloS One 7 3 2012 e34402 (Epub)
44. J.R. Milligan, J.A. Aguilera, and J.F. Ward Variation of single strand break yield with scavenger concentration for the SV40 minichromosome irradiated in aqueous solution Radiat. Res. 133 1993 158 162
45. D.L. Croteau, and V.A. Bohr Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells J. Biol. Chem. 272 1997 25409 25412
46. I. Szabo, L. Leanza, E. Gulbins, and M. Zoratti Physiology of potassium channels in the inner membrane of mitochondria Pflugers Arch. 463 2012 231 246
47. M. Schlame Cardiolipin remodeling and the function of tafazzin Biochim. Biophys. Acta 1831 2013 582 588
48. A. Malhotra, Y. Xu, M. Ren, and M. Schlame Formation of molecular species of mitochondrial cardiolipin 1, A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species Biochim. Biophys. Acta 1791 2009 314 320
49. M. Schlame Formation of molecular species of mitochondrial cardiolipin 2. A mathematical model of pattern formation by phospholipid transacylation Biochim. Biophys. Acta 1791 2009 321 325
50. S. Papa Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications Biochim. Biophys. Acta 1276 1996 87 105
51. S.M. Cloonan, and A.M. Choi Mitochondria: sensors and mediators of innate immune receptor signaling Curr. Opin. Microbiol. 16 2013 327 338
52. M.R. Duchen, and G. Szabadkai Roles of mitochondria in human disease Essays Biochem. 47 2010 115 137
53. L. Galluzzi, O. Kepp, C. Trojel-Hansen, and G. Kroemer Mitochondrial control of cellular life, stress, and death Circ. Res. 111 2012 1198 1207
54. F.Y. Xu, H. McBride, D. Acehan, F.M. Vaz, R.H. Houtkooper, R.M. Lee, M.A. Mowat, and G.M. Hatch The dynamics of cardiolipin synthesis post-mitochondrial fusion Biochim. Biophys. Acta 1798 2010 1577 1585
55. A. Ortiz, J.A. Killian, A.J. Verkleij, and J. Wilschut Membrane fusion and the lamellar-to-inverted-hexagonal phase transition in cardiolipin vesicle systems induced by divalent cations Biophys. J. 77 1999 2003 2014
56. G. Petrosillo, F.M. Ruggiero, and G. Paradies Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria FASEB J. 17 15 2003 2202 2208
57. M. Schlame, D. Rua, and M.L. Greenberg The biosynthesis and functional role of cardiolipin Prog. Lipid Res. 39 2000 257 288
58. E. Lapuente-Brun, R. Moreno-Loshuertos, R. acin-Pérez, A. Latorre-Pellicer, C. Colás, E. Balsa, E. Perales-Clemente, P.M. Quirós, E. Calvo, M.A. Rodriguez-Hernández, P. Vavas, R. Cruz, A. Carracedo, C. López, A. Pérez-Martos, P. Fernández-Silva, E. Fernández-Vizarra, and J.A. Enriquez Supercomplex assembly determines electron flux in the mitochondrial electron transport chain Science 340 2013 1567 1570
59. C. Ligia Gomes, D. Giulietta, and B.L. Scorrano During autophagy mitochondria elongate, are spared from degradation and sustain cell viability Nat. Cell Biol. 13 2013 589 598
60. N. Lane Mitonuclear match: optimizing fitness and fertility over generations drives ageing within generations Bioessays 33 2011 860 869
61. P.S. Brookes, Y. Yoon, J.L. Robotham, M.W. Anders, and S.S. Sheu Calcium, ATP, and ROS: a mitochondrial love-hate triangle Am. J. Physiol. Cell Physiol. 287 2004 C817 C833
62. F. Bauernfeind, and V. Hornung Of inflammasomes and pathogens-sensing of microbes by the inflammasome EMBO Mol. Med. 5 2013 814 826
63. E. Latz, T.S. Xiao, and A. Stutz Activation and regulation of the inflammasomes Nat. Rev. Immunol. 13 2013 397 411
64. C. Dostert, V. Pétrilli, R. Van Bruggen, C. Steele, B.T. Mossman, and J. Tschopp Innate immune activation through NALP3 inflammasome sensing of asbestos and silica Science 320 2008 674 677
65. V. Hornung, F. Bauemfeind, A. Halle, E.O. Samstad, H. Kono, K.L. Rock, K.A. Fitzgerald, and E. Latz Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat. Immunol. 9 8 2008 847 856
66. T. Fernandes-Alnemri, J. Wu, J.W. Yu, P. Datta, B. Mille, W. Jankowski, S. Rosenberg, J. Zhang, and E.S. Alnemri The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation Cell Death Differ. 14 2007 1590 1604
67. R.M. Adibhatla, and J.F. Hatcher Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities Antioxid. Redox Signal. 12 2010 125 169
68. A. Catalá Lipid peroxidation modifies the picture of membranes from the "Fluid Mosaic Model" to the "Lipid Whisker Model" Biochimie 94 2012 101 109
69. B. Halliwell Oxidative stress and neurodegeneration: where are we now? J. Neurochem. 97 2006 1634 1658
70. V. Adam-Vizi, and C. Chinopoulos Bioenergetics and the formation of mitochondrial reactive oxygen species Trends Pharmacol. Sci. 27 2006 639 645
71. Y.H. Wei, and H.C. Lee Oxidative stress, mitochondrial DNA mutation and impairment of antioxidant enzymes in aging Exp. Biol. Med. 227 2002 671 682
72. M.M. Morales, A. Colel, C. García-Ruiz, N. Kaplowitz, and J.C. Fernández-Checa Mitochondrial glutathione: features, regulation and role in disease Biochim. Biophys. Acta 1830 2013 3317 3328
73. M.K. Shigenaga, T.M. Hagen, and B.N. Ames Oxidative damage and mitochondrial decay in aging Proc. Natl. Acad. Sci. U. S. A. 91 1994 10771 10778
74. G. Paradies, G. Petrosillo, V. Paradies, and F.M. Ruggiero Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin Neurochem. Int. 58 2011 447 457
75. D. Gems, and L. Partridge Stress-response hormesis and aging: that which does not kill us makes us stronger Cell Metab. 7 2008 200 203
76. K. Ueda, S. Shinohara, T. Yagami, K. Asakura, and K. Kawasaki Amyloid beta protein potentiates Ca2 + influx through L-type voltage-sensitive Ca2 + channels: a possible involvement of free radicals J. Neurochem. 68 1997 265 271
77. Y. Gilgun-Sherki, E. Melamed, and D. Offen The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy J. Neurol. 251 2004 261 268
78. T. Shibata, K. Iio, Y. Kawai, N. Shibata, M. Kawaguchi, S. Toi, M. Kobayashi, M. Kobayashi, K. Yamamoto, and K. Uchida Identification of a lipid peroxidation product as a potential trigger of the p53 pathway J. Biol. Chem. 281 2006 1196 1204
79. R.A. Simmons Developmental origins of diabetes: the role of oxidative stress Free Rad. Biol. Med. 40 2006 917 922
80. G. Davi, and A. Falco Oxidant stress, inflammation and atherogenesis Lupus 14 2005 1 5
81. A.J. Chicco, and G.C. Sparagna Role of cardiolipin alterations in mitochondrial dysfunction and disease Am. J. Physiol. Cell Physiol. 292 2007 C33 C44
82. M. Hashimoto, S. Hossain, H. Yamasaki, K. Yazawa, and S. Masumura Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells Lipids 34 1999 1287 1304
83. R.C. Valentine, and D.L. Valentine Omega-3 fatty acids in cellular membranes: a unified concept Prog. Lipid Res. 43 2004 383 402
84. A.J. Hulbert, and P.L. Else Membranes and the setting of energy demand J. Exp. Biol. 208 2005 1593 1599
85. W. Stillwell, L.J. Jenski, F.T. Crump, and W. Ehringer Effect of docosahexaenoic acid on mouse mitochondrial membrane properties Lipids 28 1993 103 108
86. B. Mignotte, and J.L. Vayssiere Mitochondria and apoptosis Eur. J. Biochem. 252 1998 1 15
87. K.H. Al-Gubory Mitochondria: omega-3 in the route of mitochondrial reactive oxygen species Int. J. Biochem. Cell Biol. 44 2012 1569 1573
88. 2 + and sustained opening the permeability transition pore J. Cell Sci. 115 2002 1175 1188
89. R.J. Khairallah, J. Kim, K.M. O'Shea, K.M. O'Connell, B.H. Brown, T. Galvao, C. Danealt, C. Des Rosiers, B.M. Polster, C.L. Hoppel, and W.C. Stanley Improved mitochondrial function with diet-induced increase in either docasahexaenoic acid or arachidonic acid in membrane phospholipids PloS One 7 2012 e34402
90. W.C. Stanley, R.J. Khairallah, and E.R. Dabkowski Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids Curr. Opin. Clin. Nutr. Metab. Care 15 2012 122 126
91. J. Iqbal, and M. Hussain Intestinal lipid absorption Am. J. Physiol. Endocrinol. Metab. 296 2009 E1183 E1194
92. M.C. Carey, D.M. Small, and C.M. Bliss Lipid digestion and absorption Annu. Rev. Physiol. 45 1983 651 677
93. T.H. Liao, P. Hamosh, and M. Hamosh Fat digestion by lingual lipase: mechanism of lipolysis in the stomach and upper small intestine Pediatr. Res. 18 1984 402 409
94. B.D. Maes, Y.F. Ghoos, B.J. Geypens, M.I. Hiele, and P.J. Rutgeerts Relation between gastric emptying rate and rate intraluminal lipolysis Gut 38 1996 23 27
95. J.S. Patton Gastrointestinal lipid digestion in physiology of the gastrointestinal tract L.R. Johnson, Physiology of the Gastrointestinal Tract 1981 Raven Press New York 1123 1146
96. O. Zierenberg, and S.M. Grundy Intestinal absorption of polyenephosphatidylcholine in man J. Lipid Res. 23 1982 1136 1142
97. O. Zierenberg Clinical and biochemical studies of the transport of polyenephosphatidylcholine in human serum and its physiological impact on cholesterol distribution between serum lipoproteins P. Avogaro, Phospholipids and Atherosclerosis 1983 Raven Press New York 175 189
98. E.E. Wollaeger Fat, faeces and the importance of the ileum Proc. Mayo Clin. 48 1973 833 843
99. G.A.F. Hendry Evolutionary origins and natural functions of fructans - a climatological, biogeographic and mechanistic appraisal New Phytol. 123 1993 3 14
100. I.J. Vereyken, V. Chupin, R.A. Demel, S.C.M. Smeekens, and B. De Druijff Fructans insert between the headgroups of phospholipids Biochim. Biophys. Acta 1310 2001 307 320
101. M.W. Rigler, R.E. Honkanen, and J.M. Patton Visualization by freeze fracture, in vitro and in vivo of the products of fat digestion J. Lipid Res. 27 1986 836 857
102. H.P. Porter, D.R. Saunders, C. Tytgat, O. Brunser, and C.E. Rubin Fat absorption in the bile fistula man: a morphological and biochemical study Gastroenterology 60 1971 1008 1019
103. S. Parthasarathy, P.V. Subbaiah, and J. Ganguly The mechanism of intestinal absorption of phosphotidylcholine in rats Biochem. J. 140 1974 503 508
104. W.O. Dobbins III Morphologic aspects of lipid absorption Am. J. Clin. Nutr. 22 1969 257 265
105. J. Rostgaard, and R.J. Barrnett Fine structural observations of the absorption of lipid particles in the small intestine of the rat Anat. Rec. 152 1965 325 349
106. G.B. Dermer Ultrastructural changes in the microvillous plasma membrane during lipid absorption and the form of absorbed lipid: an in vitro study at 37 °C J. Ultrastruct. Res. 20 1967 311 320
107. R. Ehehalt, A. Braun, M. Karner, J. Füllekrug, and W. Stremmel Phosphatidylcholine as a constituent in the colonic mucosal barrier - physiological and clinical relevance Biochim. Biophys. Acta 1801 2010 983 993
108. F.-X. Contreras, L. Sánchez-Magraner, A. Alonso, and F.M. Goñi Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes FEBS Lett. 584 2010 1779 1786
109. F.J. Sharom Flipping and flopping - lipids on the move IUBMB Life 63 2011 736 746
110. K. Tanaka, K. Fujimura-Kamada, and T. Yamamoto Functions of phospholipid flippases J. Biochem. 149 2011 131 143
111. S. Lev Non-vesicular lipid transport by lipid-transfer proteins and beyond Nat. Rev. Mol. Cell Biol. 11 2010 739 750
112. B.J. Clark The mammalian START domain protein family in lipid transport in health and disease J. Endocrinol. 212 2012 257 275
113. A. Penno, G. Hackenbroich, and C. Thiele Phospholipids and lipid droplets Biochim. Biophys. Acta 1831 2013 589 594
114. D.B. Zilversmit The composition and structure of lymph chylomicrons in dog, rat and man J. Clin. Invest. 44 1965 1610 1622
115. P. Child, J.J. Myher, F.A. Kuypers, J.A. Op den Kamp, and L.L. van Deenen Acyl selectivity in the transfer of molecular species of phosphatidylcholines from human erythrocytes Biochim. Biophys. Acta 812 1985 321 322
116. R. Welti, and G.M. Helmkamp Jr. Acyl chain specificity of phosphatidylcholine transfer protein from bovine liver J. Biol. Chem. 259 1984 6937 6941
117. L.L.M. van Deenen Phospholipide-beziehungen zwischen ihrer chemischen struktur und biomembranen Naturwissenschaften 59 1972 485 491
118. G. van Meer The lipid bilayer of the ER TIBS 11 1986 194 195
119. A.A. Rowland, and G.K. Voeltz Endoplasmic reticulum-mitochondria contacts: function of the junction Nat. Rev. Mol. Cell Biol. 13 2012 607 625
120. A. Rafuri, and T. Simmen Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM) Biochim. Biophys. Acta 1833 2013 213 224
121. K. Poloncová, and P. Griac Phospholipid transport and remodeling in health and disease Gen. Physiol. Biophys. 30 2011 S25 S35
122. C. Osman, D.R. Voelker, and T. Langer Making heads or tails of phospholipids in mitochondria J. Cell Biol. 192 2011 7 16
123. O. Zierenberg, G. Assmann, G. Schmitz, and M. Rosseneu Effect of polyenephosphatidylcholine on cholesterol uptake by human high density lipoprotein Atherosclerosis 39 1981 527 542
124. P. Child, J.A. op den Kamp, B. Roelofsen, and L.L. van Deenen Molecular species compositon of membrane phosphatidylcholine influences the rate of cholesterol efflux from human erythrocytes and vesicles of erythrocyte lipid Biochim. Biophys. Acta 814 1985 237 246
125. 32P-polyen-phosphatidylcholin in die leber von ratten and seine ausscheidung durch die galle Z. Naturforsch. 26 1971 1151 1158
126. H. Wagener Preparation, distribution and turnover of tritium-labeled "essential phospholipids" (EPL) G. Schettler, Phospholipids in Biochemistry: Experimental and Clinical Applications 1972 Thieme Press Stuttgart 59 69
127. D. Le Kim, and H. Betzing Intestinal absorption of polyunsaturated phosphatidylcholine in the rat Hoppe Seylers Z. Physiol. Chem. 357 1976 1321 1331
128. E.A. Borodin, M.E. Lanio, E.M. Khalilov, S.S. Markin, T.I. Thorkhovskaya, M.M. Rozkin, I.M. Sapelkina, S.N. Kulakova, M.M. Levechev, A.I. Archakov, and Y.M. Lopukhin Cholesterol removal from biological membranes by positively charged phosphatidylcholine micelles Bull. Exp. Biol. Med. 2 1985 164 166
129. M.A. Jimenez, M.L. Scarino, F. Vignolini, and E. Mengheri Evidence that polyunsaturated lecithin induces a reduction in plasma cholesterol levell and favorable changes in lipoprotein composition in hypercholesteroiemic rats J. Nutr. 120 1990 659 667
130. V. Blaton, F. Sateway, D. Vandamme, B. Decercq, and H. Peeters Activation of lipoprotein lipase in vitro by unsaturated phospholipids FEBS Lett. 44 1974 185 188
131. 3H-fatty acid labeled lecithin by normal and atherosclerotic intima in vivo and in vitro Atherosclerosis 26 1977 493 504
132. A.N. Howard, and J. Patelski Hydrolysis and synthesis of aortic cholesterol esters in atherosclerotic baboons: effect of polyunsaturated phosphatidylcholine on enzyme activity Atherosclerosis 20 1974 225 232
133. Z. Waligora, J. Patelski, B.D. Brown, and A.N. Howard Effect of a hypercholesterolaemic diet and a single injection of polyunsaturated phosphatidylcholine solution on the activities of lipotic enzymes Acyl CoA synthetase and Acyl CoA cholesterolacyl transferase in rabbit tissues Biochem. Pharm. 24 1975 2263 2287
134. A. Karaman, S. Demirbilek, N. Sezgin, N. Gürbüz, and I. Gürses Protective effect of polyunsaturated phosphatidylcholine on liver damage induced b biliary obstruction in rats J. Pediatr. Surg. 38 2003 1341 1347
135. K. Olbrich, W. Rawicz, D. Needham, and E. Evans Water permeability and mechanical strength of polyunsaturated lipid bilayers Biophys. J. 79 2000 321 327
136. V. Buko, A. Artsukevich, A. Maltsev, V. Nikitin, K. Ignatenko, K.J. Gundermann, and R. Schumacher Effect of polyunsaturated phosphatidylcholine on lipid structure and camp-dependent signal transduction in the liver of rats chronically intoxicated with ethanol Exp. Toxicol. Pathol. 46 1994 375 382
137. W. Nierle, A. el Wahab, and el Baya Examination and composition of some legume seeds Z. lebensm. Unters. Forsch. 164 1977 23 27
138. W.S. Harris N-3 fatty acids and lipoproteins: comparison of results from human and animal studies Lipids 31 1996 243 252
139. W.E. Connor Importance of n-3 fatty acids in health and disease Am. J. Clin. Nutr. 71 2000 S171 S178
140. J. Schmidt, E.B. Skou, H.A. Christensen, and J.H. Dyerberg N-3 fatty acids from fish and coronary artery disease: implications for public health Public Health Nutr. 3 2000 91 98
141. W.C. Stanley, E.R. Dabkowski, R.F. Ribeiro Jr, and K.A. O'Connell Dietary fat and heart failure: moving from lipotoxicity to lipoprotection Circ. Res. 110 2012 764 776
142. G.C. Sparagna, and E.J. Lesnefsky Cardiolipin remodeling in the heart J. Cardiovasc. Pharmacol. 53 2009 290 301
143. 2 +-induced mitochondrial permeability transition J. Mol. Cell. Cardiol. 47 2009 819 827
144. G.L. Nicolson, and R. Ellithrope Lipid replacement and antioxidant nutritional therapy for restoring mitochondrial function and reducing fatigue in chronic fatigue syndrome and other fatiguing illnesses J. Chronic Fatigue Syndr. 13 1 2006 57 68
145. G.L. Nicolson, and K.A. Conklin Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by Molecular Replacement Therapy Clin. Expl. Metastasis 25 2008 161 169
146. G.L. Nicolson Lipid Replacement/Antioxidant Therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial function Pathol. Oncol. Res. 11 2005 139 144
147. G.L. Nicolson, R. Settineri, and R. Ellithorpe Lipid Replacement Therapy with a glycophospholipid formulation with NADH and CoQ10 significantly reduces fatigue in intractable chronic fatiguing illnesses and chronic Lyme disease Intern. J. Clin. Med. 3 3 2012 163 170
148. T. Cernacchi, T. Bertoldin, C. Farina, M.G. Flori, and G. Crepaldi Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on the efficacy of phosphatidylserine administration Aging (Milano) 5 1993 123 133
149. B.L. Jorissen, F. Brouns, M.P. Van Boxtel, R.W. Ponds, F.R. Verhey, J. Jolles, and W.J. Riedel The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment Nutr. Neurosci. 4 2001 121 134
150. Y. Sakakima, A. Hayakawa, T. Nagasaka, and A. Nakao Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments J. Hepatol. 47 2007 83 92
151. Federal Drug Administration Scientific literature reviews on generally recognized as safe (GRAS) food ingredients: Lecithins GRAS Report PB-241 970 1970
152. H.H. Wagener, R. Fontaine, and B. Neumann Pharmakologie "essentiele" phospholipide (EPL) Drug Res. 26 1976 1733 1743
153. M.D. Seidman, M.J. Khan, W.X. Tang, and W.S. Quirk Influence of lecithin on mitochondrial DNA and age-related hearing loss Otolaryngol. Head Neck Surg. 127 2002 138 144
154. V. Petera, and V. Prokop The compensated cirrhosis of the liver. Therapeutic experience with Essentiale® forte Therapiewoche 36 1986 540 544
155. N.R. Pandey, and D.L. Sparks Phospholipids as cardiovascular therapeutics Curr. Opin. Investig. Drugs 9 3 2008 281 285
156. R.R. Ellithorpe, R. Settineri, T. Ellithorpe, and G.L. Nicolson Blood homocysteine and fasting insulin levels are reduced and erythrocyte sedimentation rates are increased with a glycophospholipid-vitamin formulation: a retrospective study in older subjects Funct. Food Health Dis. 3 2013 (in press)
157. J.S. Cohn, E. Wat, A. Kamili, and S. Tandy Dietary phospholipids, hepatic metabolism and cardiovascular disease Curr. Opin. Lipidol. 19 2008 257 262
158. A.J. Polinsky, M. Ebert, E.D. Cain, and C.J. Bassich Cholinergic treatment in Tourette syndrome N. Engl. J. Med. 302 1980 1310 1311
159. C. López-Otín, M.A. Blasco, L. Partridge, M. Serrano, and G. Kroemer The hallmarks of aging Cell 153 2013 1194 1217
160. C. Franceschi, M. Bonafe, S. Valensin, F. Olivieri, M. De. Luca, E. Ottaviani, and G. De. Benedictis Inflamm-aging. An evolutionary perspective on immunosenescence Ann. N.Y. Acad. Sci. 908 2000 244 254
161. G. Zhang, J. Li, S. Purkayastha, Y. Tang, H. Zhang, Y. Yin, B. Li, G. Liu, and D. Cai Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH Nature 497 2013 211 216
162. K. Palikaras, and N. Tavernarakis Mitophagy in neurodegeneration and aging Front. Genet. 3 2012 297
163. T.R. Figueira, M.H. Barros, A.A. Camargo, R.F. Castilho, J.C. Ferreira, A.J. Kowaltowski, F.E. Sluse, N.C. Souza-Pinto, and A.E. Vercesi Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health Antioxid. Redox Signal. 18 2013 2029 2074
164. S. Gelino, and M. Hansen Autophagy - an emerging anti-aging mechanism J. Clin. Exp. Pathol. Suppl. 4 Jul. 12 2012
165. B.N. Ames, M.K. Shigenaga, and T.M. Hagen Mitochondrial decay in aging Biochim. Biophys. Acta 1271 1995 165 170
166. M. Agadjanyan, V. Vasilevko, A. Ghochikyan, P. Berns, P. Kesslak, R. Settineri, and G.L. Nicolson Nutritional supplement (NTFactor) restores mitochondrial function and reduces moderately severe fatigue in aged subjects J. Chronic Fatigue Syndr. 11 3 2003 23 36
167. C. Desler, T.L. Hansen, J.B. Frederiksen, M.L. Marcker, K.K. Singh, and L. Juel Rasmussen Is there a link between mitochondrial reserve respiratory capacity and aging? J. Aging Res. 2012 2012 192503 10.1155/2012/192503 (Epub 2012 Jun 5)
168. G. Paradies, V. Paradies, F.M. Ruggiero, and G. Petrosillo Changes in the mitochondrial permeability transition pore in aging and age-associated diseases Mech. Ageing Dev. 134 1 2013 1 9
169. U. Spiekerkoetter, J. Bastin, M. Gillingham, A. Morris, F. Wijburg, and B. Wilcken Current issues regarding treatment of mitochondrial fatty acid oxidation disorders J. Inherit. Metab. Dis. 33 2010 555 561
170. P. Matzinger Tolerance, danger, and the extended family Annu. Rev. Immunol. 12 1994 991 1045
171. Q. Zhang, M. Raoof, Y. Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, and C.J. Hauser Circulating mitochondrial DAMPs cause inflammatory responses to injury Nature 464 2010 104 107
172. J. Jiang, Z. Huang, Q. Zhao, W. Feng, N.A. Belikova, and V.E. Kagan Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis Biochem. Biophys. Res. Commun. 368 2008 145 150
173. F. Gonzalvez, F. Pariselli, P. Dupaigne, I. Budihardjo, M. Lutter, B. Antonsson, P. Diolez, S. Manon, J.C. Martinou, M. Goubern, X. Wang, S. Bernard, and P.X. Petit tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak Cell Death Differ. 12 2005 614 626
174. M. Sorice, A. Circella, I.M. Cristea, T. Garofalo, L. Di Renzo, C. Alessandri, G. Valesini, and M.D. Esposti Cardiolipin and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis Cell Death Differ. 11 2004 1133 1145
175. E. Marzetti, A. Csiszar, D. Dutta, G. Balagopal, R. Calvani, and C. Leeuwenburgh Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics Am. J. Physiol. Heart Circ. Physiol. 305 2013 H459 H476
176. I.G. Stavrovskaya, S.S. Bird, V.R. Marur, M.J. Sniatynski, S.V. Baranov, H.K. Greenberg, C.L. Porter, and B.S. Kristal Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins J. Lipid Res. 54 2013 2623 2635
177. J.J. Lemasters Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging Rejuvenation Res. 8 1 2005 3 5
178. K. Schroder, and J. Tschopp The inflammasomes Cell 140 2010 821 832
179. D.V. Krysko, P. Agostinis, O. Krysko, A.D. Garg, C. Bachert, B.N. Lambrecht, and P. Vandenabeele Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation Trends Immunol. 32 2011 157 164
180. A. Kaczmarek, P. Vandenabeele, and D.V. Krysko Necroptosis: the release of damage-associated molecular patterns and its physiological relevance Immunity 38 2013 209 223
181. M. Pelletier, T.S. Lepow, L.K. Billingham, M.P. Murphy, and R.M. Siegel New tricks from an old dog: mitochondrial redox signaling in cellular inflammation Semin. Immunol. 24 2012 384 392
182. R. Medzhitov Origin and physiological roles of inflammation Nature 454 2008 428 435
183. M. El Assar, J. Angulo, and L. Rodríguez-Mañas Oxidative stress and vascular inflammation in aging Free Radic. Biol. Med. 65C 2013 380 401
184. V.G. Grivennikova, A.V. Kareyeva, and A.D. Vinogradov What are the sources of hydrogen peroxide production by heart mitochondria? Biochim. Biophys. Acta 1797 2010 939 944
185. E. Hernandez-Cuellar, K. Tsuchiya, H. Hara, R. Fang, S. Sakai, I. Kawamura, S. Akira, and M. Mitsuyama Cutting edge: nitric oxide inhibits the NLRP3 inflammasome J. Immunol. 189 2012 5113 5117
186. G. Chen, M.H. Shaw, Y.G. Kim, and G. Nunez NOD-like receptors: role in innate immunity and inflammatory disease Annu. Rev. Pathol. Mech. Dis. 4 2009 365 398
187. E. Benetti, F. Chiazza, N.S. Patel, and M. Collino The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders Mediat. Inflamm. 2013 2013 678627 10.1155/2013/678627 [Epub 2013 Jun 13]
188. M.A. Rodgers, J.W. Bowman, Q. Liang, and J.U. Jung Regulation where autophagy intersects the inflammasome Antioxid. Redox Signal. May 5 2013 10.1089/ars.2013.5347 (Epub ahead of print)
189. S.J. Goldman, R. Taylor, Y. Zhang, and S. Jin Autophagy and the degradation of mitochondria Mitochondrion 10 2010 309 315
190. R. Zhou, A.S. Yazdi, P. Menu, and J. Tschopp A role for mitochondria in NLRP3 inflammasome activation Nature 469 2011 221 225
191. R. Marty-Roix, and E. Lien (De-)oiling inflammasomes Immunity 38 2013 1088 1090
192. Y. Yan, W. Jiang, T. Spinetti, A. Tardivel, R. Castillo, C. Bourquin, G. Guarda, Z. Tian, J. Tschopp, and R. Zhou Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation Immunity 38 2013 1154 1163
193. C.K. Glass, and J.M. Olefsky Inflammation and lipid signaling in the etiology of insulin resistance Cell Metab. 15 2012 635 645
194. R. Pearl The rate of living 1928 University of London Press UK
195. D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 330
196. F.L. Muller, M.S. Lustgarten, Y. Jang, A. Richardson, and H. Van Remmen Trends in oxidative aging theories Free Radic. Biol. Med. 43 2007 477 503
197. T.B. Kirkwood, and A. Kowald The free-radical theory of ageing - older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support Bioessays 34 2012 692 700
198. S.I. Liochev Reactive oxygen species and the free radical theory of aging Free Radic. Biol. Med. 60 2013 1 4
199. M. Lagouge, and N.G. Larsson The role of mitochondrial DNA mutations and free radicals in disease and ageing J. Intern. Med. 273 2013 529 543
200. D. Harman The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20 1972 145 147
201. J. Miquel, A.C. Economos, J. Fleming, and J.E. Johnson Jr. Mitochondrial role in cell aging Exp. Gerontol. 15 1980 575 591
202. N.G. Larsson Somatic mitochondrial DNA mutations in mammalian aging Annu. Rev. Biochem. 79 2010 683 706
203. C.H. Wang, S.B. Wu, Y.T. Wu, and Y.H. Wei Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging Exp. Biol. Med. (Maywood) 238 2013 450 460
204. F. Legros, A. Lombès, P. Frachon, and M. Rojo Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins Mol. Biol. Cell 13 2002 4343 4354
205. K. Nakada, K. Inoue, T. Ono, K. Isobe, A. Ogura, Y.I. Goto, I. Nonaka, and J.I. Hayashi Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA Nat. Med. 7 8 2001 934 940
206. I.G. Gazaryan, and A.M. Brown Intersection between mitochondrial permeability pores and mitochondrial fusion/fission Neurochem. Res. 32 2007 917 929
207. H. Huang, and M.A. Frohman Lipid signaling on the mitochondrial surface Biochim. Biophys. Acta 1791 2009 839 844
208. R.S. Sohal, and R. Weindruch Oxidative stress, caloric restriction, and aging Science 273 1996 59 63
209. D. Orsucci, M. Mancuso, E.C. Ienco, A. LoGerfo, and G. Siciliano Targeting mitochondrial dysfunction and neurodegeneration by means of coenzyme Q10 and its analogues Curr. Med. Chem. 18 2011 4053 4064
210. G.T. Vatassery, J.C. Lai, E.G. DeMaster, W.E. Smith, and H.T. Quach Oxidation of vitamin E and vitamin C and inhibition of brain mitochondrial oxidative phosphorylation by peroxynitrite J. Neurosci. Res. 75 2004 845 853
211. J.J. Kuo, H.H. Chang, T.H. Tsai, and T.Y. Lee Curcumin ameliorates mitochondrial dysfunction associated with inhibition of gluconeogenesis in free fatty acid-mediated hepatic lipoapoptosis Intern. J. Mol. Med. 30 3 2012 643 649
212. E. Maioli, L. Greci, K. Soucek, M. Hyzdalova, A. Pecorelli, V. Fortino, and G. Valacchi Rottlerin inhibits ROS formation and prevents NFκB activation in MCF-7 and HT-29 cells J. Biomed. Biotechnol. 2009 2009 742936 10.1155/2009/742936 (Epub ahead of print)
213. K. Kroenke, D.R. Wood, A.D. Mangelsdorff, N.J. Meier, and J.B. Powell Chronic fatigue in primary care. Prevalence, patient characteristics, and outcome JAMA 260 1998 929 934
214. L.B. Krupp, and D.A. Pollina Mechanisms and management of fatigue in progressive neurological disorders Curr. Opin. Neurol. 9 1996 456 460
215. G.L. Nicolson, and R. Settineri Lipid Replacement Therapy: a functional food approach with new formulations for reducing cellular oxidative damage, cancer-associated fatigue and the adverse effects of cancer therapy Funct. Foods Health Dis. 1 4 2011 135 160
216. S. Myhill, N.E. Booth, and J. McLaren-Howard Chronic fatigue syndrome and mitochondrial dysfunction Intern. J. Clin. Exp. Med. 2 2009 1 16
217. J.D. Morrison Fatigue as a presenting complaint in family practice J. Family Pract. 10 1980 795 801
218. A.C. Logan, and C. Wong Chronic fatigue syndrome: oxidative stress and dietary modifications Altern. Med. Rev. 6 2001 450 459
219. B. Manuel y Keenoy, G. Moorkens, J. Vertommen, and I. De Leeuw Antioxidant status and lipoprotein peroxidation in chronic fatigue syndrome Life Sci. 68 2001 2037 2049
220. S. Fulle, P. Mecocci, G. Fano, I. Vecchiet, D. Racciotti, A. Cherubini, E. Pizzigallo, L. Vecchiet, U. Senin, and M.F. Beal Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome Free Radic. Biol. Med. 29 2000 1252 1259
221. R.S. Richards, T.K. Roberts, N.R. McGregor, R.H. Dunstan, and H.L. Butt Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome Redox Rep. 5 2000 35 41
222. M.L. Pall Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome Med. Hypoth. 54 2000 115 125
223. M. Hofman, J.L. Ryan, C.D. Figueroa-Moseley, P. Jean-Pierre, and G.R. Morrow Cancer-related fatigue: the scale of the problem Oncologist 12 2007 4 10
224. G. Prue, J. Rankin, J. Allen, J. Gracey, and F. Cramp Cancer-related fatigue: a critical appraisal Eur. J. Cancer 42 2006 846 863
225. L.F. Brown, and K. Kroenke Cancer-related fatigue and its association with depression and anxiety: a systematic review Psychosomatic 50 2009 440 447
226. C.M. Bender, S.J. Engberg, and H.S. Donovan Symptom clusters in adults with chronic health problems and cancer as a comorbidity Oncol. Nurs. Forum 35 2008 E1 E11
227. L. Liu, M.R. Marler, B.A. Parker, V. Jones, S. Johnson, M. Cohen-Zion, L. Firoentino, G.R. Sadler, and S. Ancoli-Israel The relationship between fatigue and light exposure during chemotherapy Supp. Care Cancer 13 2005 1010 1017
228. E.F. Manzullo, and C.P. Escalante Research into fatigue Hematol. Oncol. Clin. N. Am. 16 2002 619 628
229. L. Colodny, K. Lynch, C. Farber, R. Papish, K. Phillips, M. Sanchez, K. Cooper, O. Pickus, D. Palmer, T.B. Percy, M. Faroqui, and J.B. Block Results of a study to evaluate the use of Propax to reduce adverse effects of chemotherapy J. Am. Nutraceutical Assoc. 3 1 2001 17 25
230. G.L. Nicolson, R.R. Ellithorpe, C. Ayson-Mitchell, B. Jacques, and R. Settineri Lipid Replacement Therapy with a glycophospholipid-antioxidant-vitamin formulation significantly reduces fatigue within one week J. Am. Nutraceutical Assoc. 13 1 2010 11 15
231. G.L. Nicolson, R. Settineri, and R.E. Ellithorpe Glycophospholipid formulation with NADH and CoQ10 significantly reduces intractable fatigue in Western blot-positive chronic Lyme disease patients: preliminary report Funct. Food Health Dis. 2 3 2012 35 47
232. I. Lenoir-Wijnkoop, P.F. Jones, R. Uauy, L. Segal, and J. Milner Nutrition economics - food as an ally of public health Br. J. Nutr. 109 2013 777 784
233. J. Suski, M. Lebiedzinska, N.G. Machado, P.J. Oliveira, P. Pinton, J. Duszynski, and M.R. Wieckowski Mitochondrial tolerance to drugs and toxic agents in ageing and disease Curr. Drug Targ. 12 2011 827 849
234. J. Neustadt, and S.R. Pieczenik Medication-induced mitochondrial damage and disease Mol. Nutr. Food Res. 52 2008 780 788
235. A. Rull, J. Camps, C. Alonso-Villaverde, and J. Joven Insulin resistance, inflammation, and obesity: role of monocyte chemoattractant protein-1 (or CCL2) in the regulation of metabolism Mediators Inflamm. 2012 2012 326580 10.1155/2010/326580 [Epub 2010 Sep 23]
236. F.G. Toledo, and B.H. Goodpaster The role of weight loss and exercise in correcting skeletal muscle mitochondrial abnormalities in obesity, diabetes and aging Mol. Cell. Endocrinol. 379 2013 30 34
237. F. Pintus, G. Floris, and A. Rufini Nutrient availability links mitochondria, apoptosis and obesity Aging 4 11 2012 1 8
238. D.M. Arduíno, A.R. Esteves, and S.M. Cardoso Mitochondria drive autophagy pathology via microtubule disassembly: a new hypothesis for Parkinson disease Autophagy 9 2013 112 114
239. J.A. Menendez, S. Cufi, C. Oliveras-Ferraros, L. Vellon, J. Joven, and A. Vazquez-Martin Gerosuppressant metformin: less is more Aging 3 2011 348 362
240. D. Bach, D. Naon, S. Pich, F.X. Soriano, N. Vega, J. Rieusset, M. Laville, C. Guillet, Y. Boirie, H. wlaberg-Henriksson, M. Manco, M. Calvani, M. Castagneto, M. Palacin, G. Mingrone, J.R. Sierath, H. Vidal, and A. Zorzano Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6 Diabetes 54 2005 2685 2693
241. S.I. Rattan Anti-ageing strategies: prevention or therapy? Showing ageing from within EMBO Rep. 6 2005 S25 S29
242. R.A. Smith, V.J. Adlam, F.H. Blaikie, A.R. Manas, C.M. Porteous, A.M. James, M.F. Ross, A. Logan, H.M. Cochemé, J. Trnka, T.A. Prime, I. Abakumova, B.A. Jones, A. Filipovska, and M.P. Murphy Mitochondria-targeted antioxidants in the treatment of disease Ann. N. Y. Acad. Sci. 1147 2008 105 111
243. S. Anton, and C. Leeuwenburgh Fasting or caloric restriction for healthy aging Exp. Gerontol. 48 2013 1003 1005
244. T. Ono, K. Isobe, K. Nakada, and J.I. Hayashi Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria Nat. Genet. 28 2001 272 275
245. N.R. Gough Focus issue: TOR signaling, a tale of two complexes Sci. Signal. 5 2012 212 217
246. T. Takahara, and T. Maeda Evolutionarily conserved regulation of TOR signaling Biochemistry 154 2013 1 10
247. J.J. Wu, C. Quijano, E. Chen, H. Liu, L. Cao, M.M. Fergusson, I.I. Rovira, S. Gutkind, M.P. Daniels, M. Komats, and T. Finkel Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy Aging 1 4 2009 425 437
248. C.M. McIver, T.P. Wycherley, and P.M. Clifton MTOR signaling and ubiquitin-proteosome gene expression in the preservation of fat free mass following high protein, calorie restricted weight loss Nutr. Metab. (Lond.) 9 1 2012 83
249. J.T. Cunningham, J.T. Rodgers, D.H. Arlow, F. Vazquez, V.K. Mootha, and P. Puigserver mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 450 2007 736 740
250. C. Ligia Gomes, G. Di Benedetto, and L. Scorrano During autophagy mitochondria elongate, are spared from degradation and sustain cell viability Nat. Cell Biol. 10 2011 589 598
251. R.A. Ellithorpe, R. Settineri, B. Jacques, and G.L. Nicolson Lipid Replacement Therapy functional food with NT Factor for reducing weight, girth, body mass, appetite, cravings for foods and fatigue while improving blood lipid profiles Funct. Food Health Dis. 2 1 2012 11 24
252. B.F. Piper, A.M. Linsey, and M.J. Dodd Fatigue mechanism in cancer Oncol. Nurs. Forum 14 1987 17 23
253. O. Vögler, A. López-Bellan, R. Alemany, S. Tofé, M. González, J. Quevedo, V. Pereg, F. Barceló, and P.V. Escribá Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats Int. J. Obes. 32 2008 464 473
254. Y. Richter, Y. Herzog, Y. Lifshitz, R. Hayun, and S. Zchut The effect of soybean phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study Clin. Interv. Aging 8 2013 557 563
255. A. Kato-Kataoka, M. Sukai, R. Ebina, C. Nonaka, T. Asano, and T. Miyamori Soybean-derived phosphatidylserine improves memory function of elderly Japanese subjects with memory complaints J. Clin. Biochem. Nutr. 47 2010 246 255
256. S.M. Grundy, H.B. Brewer, J.I. Cleeman, S.C. Smith, and C. Lenfant Definition of metabolic syndrome. report of the national heart, lung and blood institute/American heart association conference on scientific issues related to definition Circulation 109 2004 433 438
257. V.A. Fonseca The metabolic syndrome, hyperlipidemia and insulin resistance Clin. Cornerstone 7 2005 61 72
258. S.M. Grundy Does a diagnosis of metabolic syndrome have value in clinical practice? Am. J. Clin. Nutr. 83 2006 1248 1251
259. G.M. Reaven Role of insulin resistance in human disease (syndrome X) Annu. Rev. Med. 44 1993 121 131
260. Y.W. Park, S. Zhu, L. Palaniappan, S. Heska, M.R. Carenthon, and S.B. Heymsfield The metabolic syndrome. Prevalence and associated risk factor findings in the U.S. population form the Third National Health and Nutrition Examination Survey, 1988-1994 Arch. Intern. Med. 163 2003 427 436
261. D. Einhorn, G.M. Reaven, R.H. Cobin, E. Ford, O.P. Ganda, Y. Handelsman, R. Hellman, P.S. Jellinger, D. Kendall, R.M. Krauss, N.D. Neufeld, S.M. Petak, H.W. Rodbard, J.A. Siebel, D.A. Smith, and P.W. Wilson American College of Endocrinology position statement on the insulin resistance syndrome Endocr. Pract. 9 2003 237 252
262. R. Cifkova, S. Erdine, R. Fagard, C. Farsand, A.M. Heagerty, W. Kiolski, S. Kjeldsen, T. Luscher, J.M. Mallion, G. Mancia, N. Poulter, K.H. Rahn, J.L. Rodicio, L.M. Ruilope, B. Waeber, B. Williams, and A. Zanchetti Practice guidelines for primary care physicians: 2003 ESH/ESC hypertension guidelines J. Hypertens. 21 2003 1779 1786
263. J.A. Whitworth World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension J. Hypertens. 21 2003 1983 1992
264. G.M. Reaven The metabolic syndrome: is this diagnosis necessary? Am. J. Clin. Nutr. 83 2006 1237 1247
265. P. Dandona, A. Aljada, A. Chaudhuri, P. Mohanty, and R. Garg Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes and inflammation Circulation 111 2005 1448 1454
266. C. Chakraborty Biochemical and molecular basis of insulin resistance Curr. Protein Pept. Sci. 7 2006 113 131
267. M.C. Houston, and B.M. Egan The Metabolic Syndrome. Pathophysiology, diagnosis, clinical aspects, prevention and nonpharmacologic treatment: emphasis on lifestyle modifications, nutrition, nutritional supplements, vitamins, minerals, antioxidants, weight management and exercise J. Am. Nutraceutical Assoc. 8 2 2005 3 83
268. R. Zhou, A.S. Yazdi, P. Menu, and J. Tschopp A role for mitochondria in NLRP3 inflammasome activation Nature 469 2011 221 225
269. V. Halle, V. Hornung, G.C. Petzold, C.R. Stewart, B.G. Monks, T. Reinheckel, K.A. Fitzgerald, E. Latz, K.J. Moore, and D.T. Golenbock The NALP3 inflammasome is involved in the innate immune response to amyloid-β Nat. Immunol. 9 2008 857 865
270. H. Wen, D. Gris, Y. Lei, S. Jia, L. Zhang, M.T. Huang, W.J. Brickey, and J.P. Ting Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling Nat. Immunol. 12 5 2011 408 415
271. E. Benetti, F. Chiazza, N.S. Patel, and M. Collino The NLRP3 inflammasome as a novel player of the intercellular crosstalk in metabolic disorders Mediat. Inflamm. 2013 2013 678627 10.1155/2013/678627 (Epub 2013 Jun 13)
272. J. Henao-Mejia, E. Elinav, C. Jin, L. Hao, W.Z. Mehal, T. Strowig, C.A. Thiss, A.L. Kau, S.C. Eisenbarth, M.J. Jurczak, J.P. Camporez, G.I. Shulman, J.I. Gordon, H.M. Hoffman, and R.A. Flavell Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity Nature 482 2012 179 185
273. P. Schrauwen, and M.K.C. Hesselink Oxidative capacity, lipotoxicity and mitochondrial damage in type 2 diabetes Diabetes 53 2004 1412 1417
274. M. Krssak, and M. Roden The role of lipid accumulation in liver and muscle for insulin resistence and type 2 diabetes mellitus in humans Rev. Endocr. Metab. Disord. 5 2004 127 134
275. S.I. Itani, N.B. Ruderman, F. Schmieder, and G. Boden Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha Diabetes 51 2002 2005 2011
276. G.E. Sonnenberg, G.R. Krakower, and A.H. Kissebah A novel pathway to the manifestations of metabolic syndrome Obes. Res. 12 2004 180 186
277. D.E. Kelly, J. He, E.V. Menshikova, and V.B. Ritov Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes Diabetes 51 2002 2944 2950
278. S. Supale, N. Li, T. Brun, and P. Maechler Mitochondrial dysfunction in pancreatic β cells Trends Endocrinol. Metab. 23 2012 477 487
279. V.K. Vechoor, M.E. Patti, R. Saccone, and C.R. Kahn Coordinate patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 1087 1092
280. S.H. Schneider, L.F. Amorosa, A.K. Khachadurian, and N.B. Ruderman Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes Diabetologia 26 1984 355 360
281. D.E. Kelly, and J.A. Simoneau Impaired free fatty acid utilization by skeletal muscle in non-insulin dependent diabetes mellitus J. Clin. Invest. 94 1994 2349 2356
282. R.M. Touyz, and E.L. Schiffrin Reactive oxygen species in vascular biology: implications in hypertension Histochem. Cell Biol. 122 2004 339 352
283. A.W. Linnane, and H. Eastwood Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging Ann. N.Y. Acad. Sci. 1067 2006 47 55
284. P. Schrauwen Skeletal muscle uncoupling protein 3 (UCP3): mitochondrial uncoupling protein in search of a function Curr. Opin. Clin. Nutr. Metab. Care 5 2002 265 270
285. A.J. Vidal-Puig, D. Grujic, C.Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szcepanik, J. Wade, V. Mootha, R. Cortright, D.M. Muoio, and B.B. Lowell Energy metabolism in uncoupling protein 3 gene knockout mice J. Biol. Chem. 275 2000 16258 16266
286. P. Schrauwen, V. Schrauwen-Hinderling, J. Hoeks, and M.K. Hesselink Mitochondrial dysfunction and lipotoxicity Biochim. Biophys. Acta 1801 2010 266 271
287. M. Falck-Hansen, C. Kassiteridi, and C. Monaco Toll-like receptors in atherosclerosis Int. J. Mol Sci. 14 7 2013 14008 14023
288. P. Schrauwen, M.K. Hesselink, E.E. Blaak, L.B. Borgouts, G. Schaart, W.H. Saris, and H.A. Keizer Uncouplingprotein 3 content is decreased in skeletal muscle of patients with type 2 diabetes Diabetes 50 2001 2870 2873
289. K. Green, M.D. Brand, and M.P. Murphy Prevention of mitochondrial oxidative damage as a therpeutic strategy in diabetes Diabetes 53 Suppl. 1 2004 S110 S118
290. P. Rosen, P.P. Nawroth, G. King, W. Moller, H.J. Tritschler, and L. Packer The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society Diabetes Metab. Res. Rev. 17 2001 189 212
291. A. Ceriello New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy Diabetes Care 26 2003 1589 1596
292. E.C. Opara Oxidative stress, micronutrients, diabetes mellitus and its complications J. Roy. Soc. Health 122 2002 28 34
293. A.E. Butler, J. Janson, S. Bonner-Weir, R. Ritzel, R.A. Rizza, and P.C. Butler Beta-cell deficit and increased beta-cell apoptosis in humans with in type type 2 diabetes Diabetes 52 2003 102 110
294. E.C. Opara Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control J. Investig. Med. 52 2004 19 23
295. S.-S. Sheu, D. Nauduri, and M.W. Anders Targeting antioxidants to mitochondria: a new therapeutic direction Biochim. Biophys. Acta 1762 2006 256 265
296. G.L. Nicolson Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane oxidation and restore mitochondrial function J. Cell. Biochem. 100 2007 1352 1369
297. J.J. Strain Disturbances of micronutrient and antioxidant status in diabetes Proc. Nutr. Soc. 50 1991 591 604
298. H.G. Preuss The insulin system: influence of antioxidants J. Am. Coll. Nutr. 17 1998 101 102
299. E. Granot, and R. Kohen Oxidative stress in childhood - in health and disease states Clin. Nutr. 23 2003 3 11
300. S. Ueda, and K. Yasunari What we learned from randomized clinical trials and cohort studies of antioxidant vitamins. Focus on vitamin E and cardiovascular disease Curr. Pharm. Biotechnol. 7 2006 69 72
301. O. Zierenberg, G. Assmann, G. Schmitz, and M. Rosseneu Effect of polyenephosphatidylcholine on cholesterol uptake by human high density lipoprotein Atherosclerosis 39 1981 527 542
302. N. Shimizu, and S. Sakajiri Effects of EPL capsules on lipid in diabetic (part II) Jap. J. New Rem. Clin. 22 1973 2277 2283
303. V.K. Serkova Dynamics of blood lipids, parameters of lipid peroxidation and energy metabolism in patients with ischemic heart disease treated with Essentiale Klin. Med. (Moscow) 64 1986 91-85
304. G. Martines, G. Restori, C. Caffé, and R. Cortesi Relationship between glycide tolerance and polyunsaturated phosphatidylcholine (EPL) Terapia Moderna 4 1990 155 157
305. W.A. Hsueh, and M.J. Quiñones Role of endothelial dysfunction in insulin resistance Am. J. Cardiol. 92 Suppl. 4A 2003 10J 17J
306. A. Uittenbogaard, P.W. Shaul, I.S. Yuhanna, A. Blair, and E.J. Smart High-density lipoprotein prevents oxidized low-density lipoprotein-induced inhibition of endothelial nitric oxide synthase localization and activation in caveolae J. Biol. Chem. 275 2000 11278 11283
307. G.S. Hotamisligil, P. Peraldi, A. Budavari, R. Ellis, N.F. White, and B.M. Spiegelman IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance Science 271 1996 665 668
308. G.E. Sonnenberg, G.R. Krakower, and A.H. Kissebah A novel pathway to the manifestations of metabolic syndrome Obes. Res. 12 2004 180 186
309. T. Collins Endothelial nuclear factor NF-κB and the initiation of the atherosclerotic lesion Lab. Invest. 68 1993 499 508
310. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 2003 1796 1808
311. J.R. Sowers, and E.D. Frohlich Insulin and insulin resistance: impact on blood pressure and cardiovascular disease Med. Clin. North Am. 88 2004 63 82
312. L. Bergandi, F. Silvagno, I. Russo, C. Riganti, G. Anfossi, E. Aldieri, D. Ghigo, M. Trovati, and A. Bosia Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 23 2003 2215 2221
313. R. Wolk, A.S. Shamsuzzaman, and V.K. Somers Obesity, sleep apnea and hypertension Hypertension 42 2003 1067 1074
314. D. Battle, M. Jose Soler, and M. Ye ACE2 and diabetes: ACE of ACEs? Diabetes 59 2010 2994 2996
315. K. Irani Oxidant signaling in vascular cell growth, death and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling Circ. Res. 87 2000 179 183
316. A. Zambon, P. Pauletto, and G. Crepaldi The metabolic syndrome - a chronic cardiovascular inflammatory condition Aliment. Pharmacol. Ther. 22 Suppl. 2 2005 20 23
317. C.S. Stancu, L. Toma, and A.V. Sima Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis Cell Tissue Res. 349 2012 433 446
318. F.J. Sheedy, A. Grebe, K.J. Rayner, P. Kalantari, B. Ramkhelawon, S.B. Carpenter, C.E. Becker, H.N. Ediriweera, A.E. Mullick, D.T. Golenbock, L.M. Stuart, E. Latz, K.A. Fitzgerald, and K.J. Moore CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation Nat. Immunol. 14 8 2013 12 20
319. J.A. Berliner, and A.D. Watson A role for oxidized phospholipids in artherosclerosis N. Eng. J. Med. 353 2005 9 11
320. A. Chait, R.L. Brazg, D.L. Tribble, and R.M. Krauss Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the artherogenic lipoprotein phenotype, pattern B Am. J. Med. 94 1993 350 356
321. P. Libby Inflammation in atherogenesis Nature 420 2003 868 874
322. E. Bonora, S. Kiechi, J. Willeit, F. Oberhollenzer, G. Egger, R.C. Bonadonna, and M. Muggeo Metabolic syndrome: epidemiology and more extensive phenotypic description. Cross-sectional data from the Bruneck Study Int. J. Obes. 37 2003 1283 1289
323. C. Colomé, J. Martínez-Gonsález, F. Vidal, C. de Castellarnau, and L. Badimon Small oxidative changes in atherogenic LDL concentration irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A Atherosclerosis 149 2000 295 302
324. L. Badimon, R.E. Storey, and G. Vilahur Update on lipids, inflammation and atherothrombosis Thromb. Haemost. 105 Suppl. 1 2011 S34 S42
325. A.A. Bremer, and I. Jialal Adipose tissue dysfunction in nascent metabolic syndrome J. Obes. 2013 393192
326. G. Zierenberg, J. Odenthal, and H. Betzing Incorporation of PPC into serum lipoproteins after oral or i.v. administration Atherosclerosis 34 1979 259 276
327. E.A. Borodin, M.E. Lanio, E.M. Khalilov, S.S. Markin, T.I. Thorkhovskaya, M.M. Rozkin, I.M. Sapelkina, S.N. Kulakova, M.M. Levechev, A.I. Archakov, and Y.M. Lopukhin Cholesterol removal from biological membranes by positively charged phosphatidylcholine micelles Bull. Exp. Biol. Med. 2 1985 164 166
328. E.K. Wong, R.J. Nicolosi, P.A. Low, J.A. Herd, and K.C. Hayes Lecithin influenceon hyperlipemia in rhesus monkeys Lipids 15 1980 428 433
329. L. Samochowiec, J. Wójciki, M. Woyke, D. Kadlubowska, M. Jaworska, and B. Gawroska-Szklarz A model of experimental atherosclerosis in pigs. Part 1. Study on blood lipids and coagulation Pol. J. Pharmacol. Pharm. 33 1981 185 191
330. L. Samochowiec, D. Kadlubowska, M. Rozewicka, M. Kuzna, and K. Szyszka Investigations in experimental atherosclerosis. Part 2. The effect of phosphatidyicholine (EPL) on experimental atherosclerotic changes in miniature pigs Atherosclerosis 23 1976 319 331
331. O. Cynshi, and R. Stocker Inhibition of lipoprotein lipid oxidation Handb. Exp. Pharmacol. 170 2005 563 590
332. D. Steinberg, S. Parthasarathy, T.E. Carew, J.C. Khoo, and J.L. Witztum Modifications of low-density lipoprotein that increase its atherogenicity New Engl. J. Med. 320 1989 915 924
333. V.K. Serkova Dynamics of blood lipids, parameters of lipid peroxidation and energy metabolism in patients with ischemic heart disease treated with Essentiale Klin. Med. (Moscow) 64 7 1986 91 95
334. R. Kirsten, B. Heintz, K. Nelson, and G. Oremek Reduction of hyperlipidemia with 3-sn-polyenylphosphatidylcholine in dialysis patients, intern J. Clin. Pharmacol. Therapy Toxicol. 27 1989 129 134
335. G. Noseda, F. Suva, and C. Fragiacomo Modification of serum lipids, lipoproteins and apoproteins A1 and B in patients with hyperlipidemia type Iia and Iib using polyenylphosphatidylcholine Schweiz. Med. Wochenschr. 115 1985 1064 1070
336. G.L. Nicolson Mitochondrial dysfunction and chronic disease: treatment with natural supplements Alt. Ther. Health Med. 19 2013 at5027 (Epub ahead of print)
337. H. Wallnöfer, and M. Hanusch "Essential" phospholipids in the treatment of hepatic disease Med. Wschr. (Dtsch.) 27 1973 331 336
338. V. Kordac, M. Brodanová, Z. Marecek, and A. Jirásek Essentiale forte in the treatment of chronic active hepatitis Prakt. Lék. (Prague) 65 1985 834 837
339. C. Hirayama, M. Okurama, K. Tanikawa, and N. Kogawa The clinical effect of polyenephosphatidylcholine in chronic hepatitis in a double blind test. 2nd communication: investigation of the liver function test Jap. J. Clin. Exp. Med. 55 1978 194 198
340. M. Yano, M. Koya, S. Shirahama, T. Toda, Y. Ohta, and C. Hirayama Blind sssessment of liver biopsy findings in chronic hepatitis: drug efficacy trial of polyenephosphatidylcholine Diagn. Treat. (Jap.) 9 1978 1783 1789
341. A.P. Pogromov, L.I. Otbinskaya, N.I. Antonenko, N.P. Gitel, A. Smolyanitsky, and P.B. Verkhovskaya Use of Essentiale in the treatment of liver diseases Klin. Med. (Moscow) 10 1978 97 101
342. M. Kalab, and J. Cervinka Essential phospholipids in the treatment of cirrhosis of the liver Cas. Lek. Cesk. (Czech) 122 1983 266 269
343. P. Fassati, J. Horejsi, M. Fassati, Z. Jezkova, and J. Spizek The effect of essential choline phospholipids on HBsAg and on certain biochemical tests in cirrhosis of the liver Cas. Lek. Cesk. (Czech) 120 1981 56 60
344. N. di Paolo, U. Buoncristiani, L. Capotondo, E. Gaggiotti, M. de Mia, P. Rossi, E. Sansoni, and M. Bernini Phosphatidylcholine and peritoneal transport during peritoneal dialysis Nephron 44 1986 365 370
345. H. Graeff, R. von Hugo, and R. Schröck Recent aspects of hemostatis, hematology and hemorheology in preeclampsia-eclampsia Eur. J. Obstet. Gynecol. Reprod. Biol. 17 1984 91 102
346. R.I. Shalina, I.B. Kusch, V.P. Oreshkina, O.A. Azizova, A.V. Kozlov, and O.M. Panasenko Antioxidants as a part of combined treatment of patients with late gestosis Obstet. Gynecol. (Moscow) 65 1989 37 41
347. F. Bottiglioni, and R. Tirelli "Essentielle" Phospholipide in der Therapie der Spätgestosen Ärztl. Praxis 20 1968 2656 2657
348. A.A. Bremer, M. Mietus-Synder, and R.H. Lustig Toward a unifying hypothesis of metabolic syndrome Pediatrics 129 2012 557 570
349. R.J. Youle, and A.M. van der Bliek Mitochondrial fission, fusion, and stress Science 337 2012 1062 1065
350. R.W. Grant, and V.D. Dixit Mechanisms of disease: inflammasome activation and the development of type 2 diabetes Front. Immunol. 4 2013 50
351. P.V. Escribá Membrane-lipid therapy: a new approach in molecular medicine Trends Mol. Med. 12 2006 34 43
352. i proteins with nonlamellar membrane structures J. Biol. Chem. 279 2004 36540 36545
353. Q. Yang, R. Alemany, J. Casas, K. Kitajka, S.M. Lanier, and P.V. Escribá Influence of the membrane lipid structure on signal processing via G protein-coupled receptors Mol. Pharmacol. 68 2005 210 217
354. R.R. Ellithorpe, R. Settineri, and G.L. Nicolson Reduction of fatigue by use of a dietary supplement containing glycophospholipids J. Am. Nutraceutical Assoc. 6 1 2006 23 28