Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats

Free Radical Biology and Medicine

Volumn 32, Issue 12, 2002, Pages 1283-1292

  Rakonczay Jr , Zoltán ^a   Iványi, Béla ^a   Varga, Ilona ^a   Boros, Imre ^b   Jednákovits, Andrea ^c   Németh, Ilona ^a   Lonovics, János ^a   Takács, Tamás ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c Biorex Research and Development Co   (Hungary)

Author keywords

BRX 220; Cholecystokinin octapeptide; Coinducer; Free radicals; Heat shock protein; Pancreatitis

Indexed keywords

AMYLASE; BRX 220; CATALASE; CHOLECYSTOKININ; DNA; FREE RADICAL; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 72; MALEIC ACID DERIVATIVE; N [2 HYDROXY 3 (1 PIPERIDINYL)PROPYL]PYRIDINE 1 OXIDE 3 CARBOXIMIDOYLCHLORIDE MALEATE; PROTEIN; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL LIPASE; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; UNCLASSIFIED DRUG; BRX220; CHAPERONIN; CHOLECYSTOKININ OCTAPEPTIDE; GLUTATHIONE; HYDROXYLAMINE;

ABDOMINAL AORTA; ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; OXIDATION; PHYSIOLOGY; PRIORITY JOURNAL; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN INDUCTION; RAT; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; METABOLISM; PANCREAS; PANCREATITIS; RABBIT; WESTERN BLOTTING; WISTAR RAT;

ACUTE DISEASE; AMYLASES; ANIMAL; BLOTTING, WESTERN; CATALASE; CHAPERONIN 60; COMPARATIVE STUDY; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEAT-SHOCK PROTEINS; HYDROXYLAMINES; LIPASE; LIPID PEROXIDATION; MALE; PANCREAS; PANCREATITIS; RABBITS; RATS; RATS, WISTAR; SINCALIDE; SUPEROXIDE DISMUTASE; SUPPORT, NON-U.S. GOV'T; TRYPSINOGEN; ANIMALS; HSP72 HEAT-SHOCK PROTEINS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0037096195     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(02)00833-X     Document Type: Article

References (35)

1. The heat-shock response
2. Mammalian stress response: Cell physiology; Structure/function of stress proteins; And implications for medicine and disease
3. Induction of heat shock protein and prevention of cerulein-induced pancreatitis by water-immersion stress in rats
4. Differential induction of HSP60 and HSP72 by different stress situations in rats
5. Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats
6. Hyperthermia induces heat-shock protein expression; Reduces pancreatic injury; And improves survival in necrotizing pancreatitis
7. Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats
8. Water immersion pretreatment decreases pro-inflammatory cytokine production in cholecystokinin-octapeptide-induced acute pancreatitis in rats: Possible role of HSP72
9. Effect of hyperthermia on NF-κB binding activity in cerulein-induced acute pancreatitis
10. Caerulein pancreatitis increases mRNA but reduces protein levels of rat pancreatic heat shock proteins
11. Bimoclomol: A nontoxic; Hydoxilamine derivative with stress protein-inducing activity and cytoprotective effects
12. Micro biuret method for protein determination; Determination of total protein in cerebrospinal fluid
13. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
14. Ultastructural localization of HSP-72 examined with a new polyclonal antibody raised against the truncated variable domain of the heat shock protein
15. Time-course of changes in pancreatic size and enzyme composition in rats during starvation
16. Determination of nucleic acids in tissues by pentose analysis
17. An improved diphenylamine method for the estimation of deoxyribonucleic acid
18. Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct
19. Determination of carbonyl content in oxidatively modified proteins
20. Estimation of total; Protein-bound and non-protein sulfhydryl group in tissue with Ellman's reagent
21. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
22. Peroxide anyagcsere enzimek; Szuperoxid dizmutaz; Peroxidaz es katalaz meghatarozasa laboratoriumi anyagokban
23. Spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase
24. Purification and properties of rat lung soluble glutathione peroxidase
25. Stress kinases and heat shock proteins in the pancreas: Possible roles in normal function and disease
26. Course and regression of acute interstitial pancreatitis induced in rats by repeated serial subcutaneous cholecystokinin-octapeptide injections
27. Oxidative stress in acute pancreatitis
28. Heat shock proteins as cellular life guards
29. Heat shock proteins increase resistance to apoptosis
30. Heat shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and degree of myocardial protection
31. Role of HSP70 in cytokine production
32. Constitutive and inducible HSP70s are involved in oxidative resistance evoked by heat shock or ethanol
33. Heat shock protein 70 prevents secretagouge-induced cell injury in the pancreas by preventing intracellular trypsinogen activation
34. Does stress play a role in the development of severe pancreatitis in rats?
35. Role of local blood flow in the development of hemorrhagic pancreatitis induced by stress in rats